This page contains a list of current and completed clinical trials run mainly through the Royal Surrey County Hospital. Patients wishing to consider entry to current trials should note that a referral to the Royal Surrey County Hospital will be required as patients cannot be recruited directly from the Guildford Nuffield Hospital.
The research team at the Royal Surrey County Hospital consists of Mr Taylor, Senior Research Nurse Katherine Atkins () and Research Co-ordinator Fay Done (). The Royal Surrey research office is available at 01483 571122 Ext. 2525.
If you would like to join our research mailing list, please click here.
Retinovascular disease (retinal vein occlusion, diabetic eye disease)
Name / Opening Date / Status / Condition / Aim of TrialLEAVO / 2015 / Not yet open / Retinal Vein Occlusion / Comparison of intravitreal Avastin, Lucentis and Eylea
CANDLE / 2015 / Not yet open / Diabetic Maculopathy / Trial determining the efficacy of a novel eye mask to reduce requirements for intravitreal therapy
IRISS / 2014 / Actively recruiting / Diabetic Maculopathy / Outcomes of the Iuvien implant in chronic diabetic macular oedema
VEGF in DME / 2014 / Actively recruiting / Diabetic Maculopathy / Assessment of the systemic complications of intravitreal therapy with Avastin or Lucentis in patients with diabetes
LUMINOUS / 2013 / Actively recuiting / Diabetic Maculopathy / Assessment of real-world efficacy of intravitreal Luventis in DMO
LUMINOUS / 2013 / Actively recruiting / Retinal Vein Occlusion / Assessment of real-world efficacy of intravitreal Luventis in RVO
POLARIS / 2013 / Closed to recruitment / Diabetic Maculopathy / Assessment of real-world efficacy of intravitreal therapy with Lucentis in diabetic maculopathy
COMO / 2013 / Closed to recruitment / Branch Retinal Vein Occlusion / Head-to-head comparison of Lucentis and Ozurdex in BRVO
CONSTANCE / 2013 / Closed to recruitment / Retinal Vein Occlusion / Assessment of real-world efficacy of intravitreal therapy in RVO
COMRADE C / 2011 / In close-out / Central Retinal Vein Occlusion / Head-to-head comparison of Lucentis and Ozurdex in CRVO
COMRADE B / 2011 / Completed / Branch Retinal Vein Occlusion / Head-to-head comparison of Lucentis and Ozurdex in BRVO
Macular degeneration (age-related and non-age-related)
Name / Opening Date / Status / Condition / Aim of TrialTREND / 2014 / Actively recruiting / Wet AMD / Assessment of treat-and-extend retreatment protocol vs. monthly injections
LUMINOUS / 2013 / Actively recruiting / Myopic CNV / Assessment of real-world efficacy of intravitreal Lucentis in myopic choroidal neovascularisation
SAFARI / 2014 / Actively recruiting / Wet AMD / Identification, phenotyping and genotyping of primary non-responders to anti-VEGF therapy
OCTAVE / 2013 / Closed to recruitment / Wet AMD / Assessment of visual acuity-guided vs. OCT guided retreatment criteria
LUMINOUS / 2011 / Closed to recruitment / Wet AMD / Assessment of real-world efficacy of intravitreal Lucentis in wet AMD
ASH / 2012 / In close-out / Wet AMD / Assessment of real-world efficacy of intravitreal Eylea in wet AMD
Uveitis and ocular/orbital inflammation
Name / Opening Date / Status / Condition / Aim of TrialCEUS / 2015 / Not yet open / Orbital inflammation / Ultrasound assessment of active orbital inflammation
ILUVIEN in CAR / 2015 / Not yet open / Autoimmune retinopathy (including CAR/MAR) / Determine efficacy of intravitreal steroid in the management of AR
CONSTANCE / 2013 / Closed to recruitment / Uveitis with CMO / Assessment of real-world efficacy of Ozurdex in uveitis
METHOTREXATE II / 2010 / Completed / Uveitis with CMO / Multicentre study of efficacy of intravitreal methotrexate in uveitis
METHOTREXATE / 2007 / Completed / Uveitis / Pilot study of intravitreal methotrexate in uveitis
IFN in BD / 2007 / Completed / Behcet’s disease / Determine efficacy of interferon in managing Behcet’s disease
MUST / 2007 / Completed / Severe uveitis / Compare local therapy in the form of Retisert implants with systemic therapy
Vitreomacular diseases and surgery
Name / Opening Date / Status / Condition / Aim of TrialINJECT / 2014 / Actively recruiting / Vitreomacular traction and macular hole / Determine real-world efficacy of intravitreal ocriplasmin in the management of VMT and MH
MeMO / 2014 / Actively recruiting / Vitreomacular traction and macular hole / Determine natural history of symptomatic VMT and MH
Other studies
Name / Opening Date / Status / Condition / Aim of TrialEye-CU / 2014 / Actively recruiting / Patients following an ITU stay / Determine frequency of ocular problems following ITU admission