Supplementary Table 1 Physiochemical properties of included CMAs

Agent / Shape / Surface charge / Composition / Surface coating
SPI-077 / Sphere ,110 nm diameter / ~ equal to PLD (-13.3 mV) / fully hydrogenated soy phosphatidylcholine (HSPC), cholesterol, Methoxypolyethylene glycol (MPEG) / Polyethelene Glycol (PEG)
S-CKD602 / Sphere, ~100 nm Diameter / ~ equal to PLD (-13.3 mV) / Distearoylphosphatidylcholine (DSPC), distearoylphosphatidylethanolamine (DSPE), MPEG / PEG
XMT-1001 / Polymer Conjugate / Not Available / approximately 60 kDa biodegradable hydrophilic polyacetal, poly (1-hydroxymethylethylene hydroxymethylformal) / none
PRINT-docetaxel / 200x200 nm cylinder / -3.4 ± 0.5 mV / poly(lactic-co-glycolic acid) (PLGA) / none
PRINT-docetaxel / 80x320 nm rod / -3.2 ± 0.5 mV / poly(lactic-co-glycolic acid) (PLGA) / none
CS0201 / Sphere ,110 nm diameter / ~ equal to PLD (-13.3 mV) / Not Available / PEG
Folate-CSO201 / Sphere ,110 nm diameter / ~ equal to PLD (-13.3 mV) / Not Available / PEG, folate
IHL-305 / Sphere, 70-120 nm diameter / 0.38 ± 1.4 mV / Cholesterol, HSPC, PEG5000DSPE / PEG
BTM-docetaxel / Sphere, 210-230 nm diameter / –5.52 ± 0.97 mV / Miglyol 812, Brij78, D-alpha tocopheryl polyethylene glycol
1000 succinate (TPGS) / none
BTM-paclitaxel / Sphere, 192 nm / –5.9 ± 1.78 mV / Miglyol 812, Brij78, TPGS / none
NK012 / Sphere , 20 nm diameter / Not Available / PEG, Poly(Glutamic Acid) / PEG
SP1049C / N/A / -2.28 ± 0.60 mV / polyethylene oxide polypropylene oxide block copolymers (Pluronic L61 and Pluronic F127) / N/A
ENZ-2208 / N/A / Not Available / four-arm 40-kDa PEG linked via a glycine residue / PEG
PLD / Sphere, 80-100 nm / -13.3 mV / HSPC, cholesterol, PEG / PEG
Liposomal daunorubicin / Sphere, 62 nm diameter / -2.0 ± 4.4 mV / DSPE, cholesterol / none
liposomal doxorubicin / Sphere, 170 nm diameter / -2.0 ± 4.4 mV / phosphatidylcholine, cholesterol / none
OSI-211 / unilamellar liposomes under 100 nm / -2.0 ± 4.4 mV / HSPC, cholesterol / none