Supplementary Table 2 –Univariatelinear regression for overall survival for all patients
Covariate / N / Event / Median OS (95%CI) / Rate at 5 Years (95%CI) / Rate at 10 Years(95%CI) / P-value336 / 124 / 130.22 ( 122.6 , 144.45 ) / 0.732 ( 0.683 , 0.784 ) / 0.6 ( 0.538 , 0.668 )
Treatment / Upfront Cystectomy / 205 / 80 / 122.6 ( 90.54 , NA ) / 0.688 ( 0.623 , 0.759 ) / 0.548 ( 0.466 , 0.644 ) / 0.034
Primary BCG with Delayed RC / 131 / 44 / 140.8 ( 126.81 , NA ) / 0.798 ( 0.729 , 0.874 ) / 0.674 ( 0.586 , 0.776 )
Gender / Male / 284 / 105 / 130.22 ( 121.12 , 141.1 ) / 0.737 ( 0.684 , 0.794 ) / 0.592 ( 0.525 , 0.668 ) / 0.767
Female / 52 / 19 / 188.86 ( 122.86 , NA ) / 0.708 ( 0.589 , 0.849 ) / 0.648 ( 0.521 , 0.807 )
Ethnicity / White / 295 / 110 / 127.79 ( 122.6 , NA ) / 0.729 ( 0.677 , 0.785 ) / 0.603 ( 0.539 , 0.674 ) / 0.117
Black / 13 / 6 / 79.53 ( 67.41 , NA ) / 0.746 ( 0.533 , 1 )
Hispanic / 27 / 7 / 144.45 ( 140.8 , NA ) / 0.795 ( 0.647 , 0.976 ) / 0.795 ( 0.647 , 0.976 )
Asian / 1 / 1 / 30.22 ( NA , NA )
Smoking Status / Never / 109 / 42 / 122.86 ( 86.99 , NA ) / 0.694 ( 0.604 , 0.797 ) / 0.54 ( 0.429 , 0.679 ) / 0.505
Active / 61 / 28 / 137.22 ( 81.77 , NA ) / 0.75 ( 0.644 , 0.873 ) / 0.577 ( 0.449 , 0.742 )
Former / 161 / 53 / NA ( 124.28 , NA ) / 0.738 ( 0.67 , 0.813 ) / 0.637 ( 0.557 , 0.729 )
Unknown / 1 / 1 / 137.19 ( NA , NA ) / 1 ( 1 , 1 ) / 1 ( 1 , 1 )
ASA Status / 1 / 4 / 2 / 99.31 ( 30.22 , NA ) / 0.75 ( 0.426 , 1 ) / 0.002
2 / 39 / 5 / NA ( NA , NA ) / 0.892 ( 0.797 , 0.998 ) / 0.842 ( 0.719 , 0.987 )
3 / 231 / 84 / 130.22 ( 121.06 , NA ) / 0.715 ( 0.655 , 0.781 ) / 0.595 ( 0.523 , 0.677 )
4 / 24 / 15 / 56.27 ( 32.98 , NA ) / 0.487 ( 0.32 , 0.741 ) / 0.433 ( 0.268 , 0.699 )
ECOG Performance Status / 0 / 326 / 118 / 130.22 ( 122.86 , 144.45 ) / 0.745 ( 0.696 , 0.797 ) / 0.61 ( 0.548 , 0.678 ) / 0.002
1 / 9 / 5 / 27.2 ( 24.97 , NA ) / 0.219 ( 0.043 , 1 )
2 / 1 / 1 / 26.08 ( NA , NA )
BMI / <30 / 185 / 67 / 130.22 ( 121.06 , NA ) / 0.703 ( 0.636 , 0.778 ) / 0.612 ( 0.536 , 0.699 ) / 0.906
30 / 100 / 36 / 137.19 ( 124.28 , NA ) / 0.744 ( 0.66 , 0.838 ) / 0.623 ( 0.519 , 0.749 )
TURBT Adenocarcinoma / Absent / 334 / 124 / 127.79 ( 122.6 , 141.1 ) / 0.73 ( 0.681 , 0.783 ) / 0.597 ( 0.535 , 0.666 ) / 0.263
Present / 2 / 0 / NA ( NA , NA ) / 1 ( 1 , 1 ) / 1 ( 1 , 1 )
TURBT -Glandular features / Absent / 313 / 116 / 127.79 ( 122.6 , 141.1 ) / 0.733 ( 0.682 , 0.787 ) / 0.6 ( 0.536 , 0.671 ) / 0.702
Present / 23 / 8 / NA ( 66.56 , NA ) / 0.721 ( 0.554 , 0.939 ) / 0.588 ( 0.398 , 0.868 )
TURBT - Micropapillary / Absent / 304 / 114 / 137.19 ( 122.93 , 144.45 ) / 0.716 ( 0.664 , 0.772 ) / 0.61 ( 0.549 , 0.678 ) / 0.726
Present / 32 / 10 / 119.25 ( 86.99 , NA ) / 0.892 ( 0.782 , 1 ) / 0.415 ( 0.173 , 0.995 )
TURBT -Nested Variant / Absent / 335 / 123 / 130.22 ( 122.6 , 144.45 ) / 0.731 ( 0.682 , 0.783 ) / 0.598 ( 0.536 , 0.666 ) / 0.62
Present / 1 / 1 / 122.93 ( NA , NA ) / 1 ( 1 , 1 ) / 1 ( 1 , 1 )
TURBT - Sarcomatoid / Absent / 327 / 118 / 130.22 ( 122.86 , 144.45 ) / 0.743 ( 0.694 , 0.796 ) / 0.609 ( 0.547 , 0.678 ) / 0
Present / 9 / 6 / 30.22 ( 9.79 , NA ) / 0.333 ( 0.132 , 0.84 )
TURBT -Signet ring / Absent / 334 / 122 / 130.22 ( 122.6 , 144.45 ) / 0.73 ( 0.681 , 0.783 ) / 0.601 ( 0.539 , 0.669 ) / 0.701
Present / 2 / 2 / 132.92 ( 76.97 , NA ) / 1 ( 1 , 1 ) / 0.5 ( 0.125 , 1 )
TURBT - Lymphoepithelioma / Absent / 334 / 123 / 130.22 ( 122.6 , 141.1 ) / 0.734 ( 0.685 , 0.786 ) / 0.6 ( 0.538 , 0.669 ) / 0.763
Present / 2 / 1 / 131.41 ( 42.35 , NA ) / 0.5 ( 0.125 , 1 ) / 0.5 ( 0.125 , 1 )
TURBT- Squamous / Absent / 311 / 113 / 130.22 ( 122.6 , 144.45 ) / 0.745 ( 0.695 , 0.798 ) / 0.601 ( 0.537 , 0.673 ) / 0.122
Present / 25 / 11 / 137.35 ( 30.29 , NA ) / 0.566 ( 0.393 , 0.816 ) / 0.566 ( 0.393 , 0.816 )
TURBT - Plasmacytoid / Absent / 334 / 122 / 130.22 ( 122.6 , 144.45 ) / 0.736 ( 0.688 , 0.789 ) / 0.603 ( 0.542 , 0.672 ) / < 0.0001
Present / 2 / 2 / 15.13 ( 7.29 , NA )
TURBT -Clear Cell / Absent / 335 / 124 / 130.22 ( 122.6 , 144.45 ) / 0.731 ( 0.682 , 0.784 ) / 0.599 ( 0.538 , 0.667 ) / 0.622
Present / 1 / 0 / NA ( NA , NA )
Any intravesicalTx / Absent / 157 / 56 / 137.22 ( 78.48 , NA ) / 0.686 ( 0.611 , 0.769 ) / 0.567 ( 0.483 , 0.667 ) / 0.268
Present / 179 / 68 / 130.22 ( 122.86 , 144.45 ) / 0.77 ( 0.707 , 0.837 ) / 0.633 ( 0.553 , 0.725 )
BCG with IFN / None / 315 / 116 / 130.22 ( 122.6 , 188.86 ) / 0.731 ( 0.68 , 0.785 ) / 0.586 ( 0.522 , 0.658 ) / 0.74
Given / 19 / 7 / 127.79 ( 121.12 , NA ) / 0.778 ( 0.608 , 0.996 ) / 0.778 ( 0.608 , 0.996 )
Unknown / 1 / 0 / NA ( NA , NA ) / 1 ( 1 , 1 )
Number of Induction BCG Courses / 0 / 163 / 59 / 137.22 ( 81.77 , NA ) / 0.693 ( 0.62 , 0.774 ) / 0.581 ( 0.498 , 0.676 ) / 0.392
1 / 138 / 48 / 137.35 ( 124.28 , NA ) / 0.751 ( 0.679 , 0.832 ) / 0.666 ( 0.58 , 0.764 )
2 / 35 / 17 / 122.86 ( 91.82 , NA ) / 0.822 ( 0.702 , 0.962 ) / 0.518 ( 0.349 , 0.77 )
Received optimal BCG maintenance / No / 267 / 97 / 130.22 ( 122.86 , NA ) / 0.724 ( 0.669 , 0.784 ) / 0.607 ( 0.542 , 0.68 ) / 0.914
Yes / 67 / 26 / 137.19 ( 119.25 , NA ) / 0.755 ( 0.654 , 0.872 ) / 0.6 ( 0.463 , 0.779 )
Unknown / 2 / 1 / 90.54 ( NA , NA ) / 1 ( 1 , 1 )
Response / Responsive / 0 / 0 / NA( NA , NA ) / < 0.0001
Refractory / 99 / 30 / 188.86 ( 124.28 , NA ) / 0.781 ( 0.698 , 0.874 ) / 0.656 ( 0.544 , 0.793 )
Early Relapse / 52 / 25 / 121.12 ( 90.54 , NA ) / 0.736 ( 0.622 , 0.871 ) / 0.588 ( 0.454 , 0.763 )
Intolerant / 11 / 3 / NA ( 126.81 , NA ) / 0.909 ( 0.754 , 1 ) / 0.758 ( 0.506 , 1 )
Unknown / 2 / 2 / 32.98 ( NA , NA )
Late Relapse / 12 / 6 / 137.19 ( 73.03 , NA ) / 0.733 ( 0.515 , 1 ) / 0.642 ( 0.413 , 0.996 )
Progressed to T1HG on or post BCG / No / 284 / 102 / 137.22 ( 122.93 , NA ) / 0.741 ( 0.688 , 0.797 ) / 0.617 ( 0.553 , 0.688 ) / 0.103
Yes / 51 / 22 / 119.25 ( 73.32 , NA ) / 0.675 ( 0.55 , 0.827 ) / 0.475 ( 0.301 , 0.748 )
Reresection / No / 83 / 31 / 126.81 ( 121.06 , NA ) / 0.729 ( 0.636 , 0.836 ) / 0.632 ( 0.529 , 0.756 ) / 0.007
Yes / 252 / 92 / 137.19 ( 122.6 , NA ) / 0.736 ( 0.68 , 0.797 ) / 0.594 ( 0.522 , 0.676 )
Unknown / 1 / 1 / 16.1 ( NA , NA )
Disease at re-resection / No / 46 / 11 / NA ( 127.79 , NA ) / 0.798 ( 0.68 , 0.935 ) / 0.675 ( 0.509 , 0.894 ) / 0.003
Yes / 205 / 80 / 137.19 ( 121.12 , NA ) / 0.729 ( 0.666 , 0.796 ) / 0.584 ( 0.507 , 0.673 )
Persistent T1HG at re-resection / No / 95 / 29 / 130.22 ( 122.86 , NA ) / 0.804 ( 0.722 , 0.896 ) / 0.647 ( 0.531 , 0.788 ) / 0.001
Yes / 156 / 62 / 137.22 ( 119.25 , NA ) / 0.701 ( 0.629 , 0.782 ) / 0.565 ( 0.475 , 0.671 )
Tumor at dome / No / 288 / 108 / 130.22 ( 122.6 , 141.1 ) / 0.731 ( 0.679 , 0.788 ) / 0.61 ( 0.546 , 0.681 ) / 0.716
Yes / 45 / 15 / NA ( 91.82 , NA ) / 0.743 ( 0.617 , 0.895 ) / 0.508 ( 0.324 , 0.796 )
Tumor at Trigone or Bladder Neck / No / 215 / 74 / 137.35 ( 122.6 , NA ) / 0.738 ( 0.678 , 0.804 ) / 0.606 ( 0.528 , 0.695 ) / 0.484
Yes / 119 / 49 / 122.93 ( 91.82 , NA ) / 0.724 ( 0.643 , 0.814 ) / 0.589 ( 0.495 , 0.702 )
Extensive invasion beyond lamina propria / No / 229 / 85 / 137.22 ( 122.86 , NA ) / 0.759 ( 0.702 , 0.82 ) / 0.615 ( 0.545 , 0.693 ) / 0.202
Yes / 105 / 38 / 122.6 ( 119.25 , NA ) / 0.673 ( 0.582 , 0.779 ) / 0.548 ( 0.415 , 0.724 )
Muscularis Mucosa Involvement / No / 270 / 99 / 130.22 ( 121.12 , 141.1 ) / 0.745 ( 0.691 , 0.803 ) / 0.598 ( 0.529 , 0.676 ) / 0.716
Yes / 64 / 24 / 188.86 ( 90.54 , NA ) / 0.683 ( 0.574 , 0.812 ) / 0.606 ( 0.485 , 0.757 )
Multifocal tumor / No / 117 / 43 / 126.81 ( 99.31 , NA ) / 0.735 ( 0.654 , 0.828 ) / 0.599 ( 0.5 , 0.718 ) / 0.743
Yes / 219 / 81 / 137.19 ( 122.86 , NA ) / 0.73 ( 0.67 , 0.795 ) / 0.6 ( 0.525 , 0.686 )
Architecture / No / 272 / 101 / 126.81 ( 121.06 , 188.86 ) / 0.734 ( 0.68 , 0.792 ) / 0.583 ( 0.514 , 0.662 ) / 0.977
Yes / 63 / 23 / 137.22 ( 121.12 , NA ) / 0.716 ( 0.605 , 0.846 ) / 0.659 ( 0.537 , 0.808 )
LVI at TURBT / No / 298 / 112 / 130.22 ( 121.12 , 141.1 ) / 0.729 ( 0.678 , 0.785 ) / 0.593 ( 0.528 , 0.666 ) / 0.454
Yes / 38 / 12 / 236.33 ( 122.6 , NA ) / 0.752 ( 0.615 , 0.92 ) / 0.663 ( 0.507 , 0.866 )
CIS at TURBT / No / 177 / 61 / 122.93 ( 121.12 , NA ) / 0.704 ( 0.634 , 0.782 ) / 0.625 ( 0.54 , 0.723 ) / 0.845
Yes / 159 / 63 / 137.19 ( 99.31 , NA ) / 0.76 ( 0.694 , 0.832 ) / 0.582 ( 0.499 , 0.678 )
Abnormal EUA / No / 307 / 112 / 127.79 ( 122.6 , 188.86 ) / 0.744 ( 0.694 , 0.798 ) / 0.601 ( 0.537 , 0.673 ) / 0.342
Yes / 29 / 12 / 137.22 ( 49.74 , NA ) / 0.589 ( 0.419 , 0.828 ) / 0.589 ( 0.419 , 0.828 )
Pre-Op Hydro / No / 299 / 107 / 137.19 ( 122.6 , NA ) / 0.746 ( 0.695 , 0.801 ) / 0.608 ( 0.544 , 0.68 ) / 0.072
Yes / 35 / 16 / 126.81 ( 49.74 , NA ) / 0.632 ( 0.484 , 0.825 ) / 0.527 ( 0.337 , 0.823 )
Unknown / 2 / 1 / 84.63 ( 55.91 , NA ) / 0.5 ( 0.125 , 1 )
Muscle in Specimen / No / 32 / 10 / NA ( 58.74 , NA ) / 0.641 ( 0.484 , 0.85 ) / 0.641 ( 0.484 , 0.85 ) / 0.937
Yes / 304 / 114 / 127.79 ( 122.6 , 141.1 ) / 0.741 ( 0.69 , 0.795 ) / 0.596 ( 0.532 , 0.668 )
Prostatic Duct Involvement / No / 306 / 112 / 137.19 ( 122.6 , 144.45 ) / 0.74 ( 0.689 , 0.794 ) / 0.606 ( 0.542 , 0.678 ) / 0.267
Yes / 29 / 12 / 76.97 ( 56.67 , NA ) / 0.62 ( 0.448 , 0.86 ) / 0.483 ( 0.298 , 0.783 )
Size on Endoscopy / <1cm / 8 / 0 / NA ( NA , NA ) / 1 ( 1 , 1 ) / 1 ( 1 , 1 ) / 0.004
1-4cm / 99 / 36 / 140.8 ( 124.28 , NA ) / 0.825 ( 0.75 , 0.907 ) / 0.669 ( 0.567 , 0.789 )
>4cm / 136 / 54 / 121.06 ( 86.1 , NA ) / 0.707 ( 0.631 , 0.792 ) / 0.536 ( 0.439 , 0.654 )
unknown / 56 / 22 / 137.84 ( 52.2 , NA ) / 0.52 ( 0.386 , 0.699 ) / 0.52 ( 0.386 , 0.699 )
Number of resections / 2 or less / 139 / 48 / 137.84 ( 86.99 , NA ) / 0.693 ( 0.614 , 0.782 ) / 0.564 ( 0.47 , 0.678 ) / 0.42
> 2 / 197 / 76 / 130.22 ( 122.6 , 144.45 ) / 0.757 ( 0.697 , 0.823 ) / 0.624 ( 0.549 , 0.711 )
Complete resection / No / 39 / 17 / 81.77 ( 56.27 , NA ) / 0.6 ( 0.449 , 0.801 ) / 0.454 ( 0.294 , 0.699 ) / 0.073
Yes / 287 / 105 / 130.22 ( 122.86 , 188.86 ) / 0.743 ( 0.692 , 0.799 ) / 0.614 ( 0.548 , 0.687 )
Tumor in Diverticulum / No / 305 / 115 / 127.79 ( 121.12 , 141.1 ) / 0.735 ( 0.684 , 0.79 ) / 0.593 ( 0.529 , 0.665 ) / 0.553
Yes / 25 / 8 / 140.8 ( 140.8 , NA ) / 0.684 ( 0.512 , 0.912 ) / 0.684 ( 0.512 , 0.912 )
NAC / No / 310 / 118 / 127.79 ( 121.12 , 141.1 ) / 0.721 ( 0.67 , 0.776 ) / 0.584 ( 0.52 , 0.656 ) / 0.08
Yes / 26 / 6 / 236.33 ( 122.6 , NA ) / 0.871 ( 0.745 , 1 ) / 0.809 ( 0.654 , 1 )
Number of Variant Histologies / 0 / 254 / 91 / 137.19 ( 122.86 , NA ) / 0.739 ( 0.684 , 0.799 ) / 0.616 ( 0.549 , 0.693 ) / 0.098
1 / 69 / 27 / 121.06 ( 86.99 , NA ) / 0.733 ( 0.631 , 0.851 ) / 0.554 ( 0.411 , 0.747 )
2 / 11 / 4 / NA ( 16.1 , NA ) / 0.583 ( 0.34 , 1 ) / 0.583 ( 0.34 , 1 )
3 / 2 / 2 / 42.13 ( 7.29 , NA ) / 0.5 ( 0.125 , 1 )
Any Variant Histology present / No / 254 / 91 / 137.19 ( 122.86 , NA ) / 0.739 ( 0.684 , 0.799 ) / 0.616 ( 0.549 , 0.693 ) / 0.345
Yes / 82 / 33 / 121.06 ( 86.99 , NA ) / 0.708 ( 0.612 , 0.82 ) / 0.538 ( 0.407 , 0.711 )
Number of HRF / 0 / 159 / 57 / 137.19 ( 122.86 , NA ) / 0.765 ( 0.699 , 0.838 ) / 0.615 ( 0.531 , 0.712 ) / 0.01
1 / 140 / 48 / 126.81 ( 121.06 , NA ) / 0.741 ( 0.667 , 0.824 ) / 0.621 ( 0.523 , 0.736 )
2 / 32 / 18 / 66.56 ( 30.98 , NA ) / 0.515 ( 0.357 , 0.742 ) / 0.412 ( 0.255 , 0.665 )
3 / 4 / 1 / 84.63 ( 55.91 , NA ) / 0.5 ( 0.125 , 1 )
Number of HRF / 0 / 159 / 57 / 137.19 ( 122.86 , NA ) / 0.765 ( 0.699 , 0.838 ) / 0.615 ( 0.531 , 0.712 ) / 0.009
1 / 140 / 48 / 126.81 ( 121.06 , NA ) / 0.741 ( 0.667 , 0.824 ) / 0.621 ( 0.523 , 0.736 )
2 / 36 / 19 / 66.56 ( 54.99 , NA ) / 0.526 ( 0.372 , 0.742 ) / 0.43 ( 0.276 , 0.67 )
ASA – American society of Anesthesiology classification, BMI – Body mass index, ECOG – eastern cooperative group performance status, BCG – BacillisCalmette-Guerin, IFN- Interferon, TURBT – transurethral resection of bladder tumor, LVI – Lymphovascular invasion, cis – Carcinoma in situ, EUA – exam under anesthesia, NAC- neoadjuvant chemotherapy, HRF – High Risk Features. High risk features are defined as the presence of lymphovascular invasion, variant histology (excluding neuroendocrine), and presence of tumor associated hydronephrosis and thickening or induration felt on exam under anesthesia. *Extensive involvement beyond lamina propria is a subjective outcome referring to any pathologist comment referring to significant depth of penetration beyond lamina propria. Most common terms used to describe this include extensive, significant, deep involvement or approaching but not touching muscularispropria.