Table 4.SPMresult showing a positive correlation between MMSE scores and pAV-45 SUVR images in MCI and AD subjects (voxel-wise uncorrected p<0.005, Extend voxel50)

Correlation of pAV-45 and MMSE scores
Cluster Level / voxel level / Coordinates
p(cl-cor) / equivk / p(cl-unc) / p(FDR-cor) / T / equivZ / p(unc) / x / y / z / Region / Brodmann area
pAV-45 correlated to MMSE in MCI subjects
<0.001 / 2357 / 0.000 / 0.018 / 6.46 / 5.08 / <0.001 / -36 / -82 / 34 / L / Superior Occipital Gyrus / 19
0.018 / 6.30 / 4.99 / <0.001 / -48 / -60 / 46 / L / Inferior Parietal Lobule / 40
0.029 / 5.00 / 4.23 / <0.001 / -50 / -76 / 14 / L / Middle Temporal Gyrus / 19
<0.001 / 1653 / 0.000 / 0.029 / 5.35 / 4.45 / <0.001 / 44 / -76 / 18 / R / Middle Temporal Gyrus / 19
0.029 / 5.27 / 4.40 / <0.001 / 56 / -50 / 42 / R / Inferior Parietal Lobule / 40
0.029 / 5.00 / 4.23 / <0.001 / 42 / -66 / 44 / R / Inferior Parietal Lobule / 7
<0.001 / 1116 / 0.000 / 0.029 / 5.30 / 4.42 / <0.001 / 32 / 30 / 42 / R / Middle Frontal Gyrus / 8
0.029 / 5.14 / 4.32 / <0.001 / 42 / 18 / 42 / R / Middle Frontal Gyrus / 8
0.030 / 4.37 / 3.81 / <0.001 / 36 / 42 / 32 / R / Middle Frontal Gyrus / 9
<0.001 / 1537 / 0.000 / 0.029 / 5.14 / 4.32 / <0.001 / -10 / -68 / 32 / L / Cuneus / 7
0.029 / 4.75 / 4.07 / <0.001 / 8 / -72 / 54 / R / Precuneus / 7
0.029 / 4.46 / 3.88 / <0.001 / 12 / -70 / 38 / R / Precuneus / 7
<0.001 / 2243 / 0.000 / 0.029 / 4.95 / 4.20 / <0.001 / -42 / 26 / 34 / L / Middle Frontal Gyrus / 9
0.029 / 4.88 / 4.15 / <0.001 / -38 / 22 / 0 / L / Inferior Frontal Gyrus / *
0.029 / 4.65 / 4.00 / <0.001 / -30 / 14 / 60 / L / Middle Frontal Gyrus / 6
0.086 / 404 / 0.003 / 0.029 / 4.79 / 4.10 / <0.001 / 50 / 16 / 12 / R / Inferior Frontal Gyrus / 44
0.037 / 3.72 / 3.34 / <0.001 / 48 / 20 / 22 / R / Middle Frontal Gyrus / 46
0.044 / 3.41 / 3.11 / 0.001 / 40 / 22 / 4 / R / Inferior Frontal Gyrus / 45
0.980 / 84 / 0.130 / 0.029 / 4.71 / 4.04 / <0.001 / 62 / -28 / 12 / R / Superior Temporal Gyrus / 42
0.643 / 179 / 0.034 / 0.029 / 4.52 / 3.92 / <0.001 / 40 / 50 / 18 / R / Superior Frontal Gyrus / 10
0.321 / 262 / 0.013 / 0.032 / 4.24 / 3.73 / <0.001 / -46 / 4 / -14 / L / Middle Temporal Gyrus / 38
0.033 / 4.20 / 3.69 / <0.001 / -48 / -4 / -8 / L / Superior Temporal Gyrus / 38
0.015 / 603 / 0.000 / 0.035 / 3.93 / 3.50 / <0.001 / -20 / -18 / -20 / L / Parahippocampal Gyrus / 28
0.039 / 3.62 / 3.27 / 0.001 / -28 / -12 / -18 / L / Parahippocampal Gyrus / Hippocampus
0.041 / 3.50 / 3.18 / 0.001 / -20 / -34 / -4 / L / Parahippocampal Gyrus / 27
0.997 / 61 / 0.192 / 0.044 / 3.43 / 3.13 / 0.001 / -2 / 50 / -8 / L / Medial Frontal Gyrus / 10
0.999 / 55 / 0.214 / 0.049 / 3.28 / 3.01 / 0.001 / -6 / 30 / 34 / L / Medial Frontal Gyrus / 6
0.957 / 98 / 0.104 / 0.053 / 3.19 / 2.94 / 0.002 / -44 / -20 / 10 / L / Superior Temporal Gyrus / 13
0.998 / 56 / 0.210 / 0.055 / 3.15 / 2.91 / 0.002 / 62 / -32 / -22 / R / Inferior Temporal Gyrus / 20
pAV-45 correlated to MMSE in AD subjects
0.510 / 223 / 0.027 / 0.615 / 4.92 / 3.94 / <0.001 / -52 / 22 / 12 / L / Inferior Frontal Gyrus / 45
0.615 / 4.87 / 3.91 / <0.001 / -54 / 10 / 10 / L / Precentral Gyrus / 44
0.615 / 3.35 / 2.95 / 0.002 / -40 / 16 / 0 / L / Insula / 13
0.998 / 59 / 0.225 / 0.615 / 4.49 / 3.69 / <0.001 / -34 / 32 / 40 / L / Middle Frontal Gyrus / 8
0.968 / 95 / 0.129 / 0.615 / 4.09 / 3.44 / <0.001 / -14 / 56 / 30 / L / Superior Frontal Gyrus / 9
0.615 / 3.68 / 3.18 / 0.001 / -8 / 64 / 20 / L / Superior Frontal Gyrus / 10
0.615 / 3.24 / 2.87 / 0.002 / -14 / 48 / 40 / L / Superior Frontal Gyrus / 8
0.999 / 50 / 0.263 / 0.615 / 4.06 / 3.43 / <0.001 / -56 / 0 / -18 / L / Middle Temporal Gyrus / 21
0.991 / 74 / 0.176 / 0.615 / 3.97 / 3.37 / <0.001 / -40 / 4 / 50 / L / Middle Frontal Gyrus / 6
0.710 / 174 / 0.046 / 0.615 / 3.81 / 3.26 / 0.001 / -46 / 48 / -2 / L / Inferior Frontal Gyrus / 10
0.615 / 3.45 / 3.02 / 0.001 / -38 / 46 / 6 / L / Middle Frontal Gyrus / 46
0.985 / 81 / 0.158 / 0.615 / 3.68 / 3.18 / 0.001 / -56 / -58 / 24 / L / Superior Temporal Gyrus / 39
0.996 / 64 / 0.207 / 0.615 / 3.18 / 2.83 / 0.002 / -50 / -28 / -12 / L / Inferior Temporal Gyrus / 20
0.615 / 3.11 / 2.77 / 0.003 / -44 / -38 / -6 / L / Fusiform Gyrus / 37

p(cl-cor): P corrected at cluster level; p(cl-unc): P without correction at cluster level; p(FDR-cor): P with False Discovery Rate correction at voxellevel; p(unc): P without correction at voxel level.