Supplemental Table 1:Hazard Rate Ratio (HR) and 95% Confidence Intervals (CI) for Colon Cancer in relation to selected pesticide use among men by body mass index (BMI)

BMI (kg/m2) / N / HR1 / 95%CI1 / N / HR1 / 95%CI1
INSECTICIDE
Organochlorines
No Organochlorine / Organochlorine 2
<25 / 9 / 1.00 / Ref / 11 / 1.28 / 0.46-3.55
25-29.9 / 41 / 1.00 / Ref / 37 / 0.60 / 0.36-0.98
>=30 / 20 / 1.00 / Ref / 26 / 0.97 / 0.50-1.89
No DDT / DDT 4
<25 / 11 / 1.00 / Ref / 9 / 2.03 / 0.73-5.60
25-29.9 / 52 / 1.00 / Ref / 24 / 0.81 / 0.47-1.38
>=30 / 26 / 1.00 / Ref / 18 / 1.38 / 0.70-2.73
Organophosphates
No Organophosphate / Organophosphate3
<25 / 17 / 1.00 / Ref / 28 / 0.71 / 0.34-1.49
25-29.9 / 33 / 1.00 / Ref / 79 / 0.67 / 0.42-1.06
>=30 / 20 / 1.00 / Ref / 53 / 0.83 / 0.46-1.49
No Terbufos / Terbufos
<25 / 29 / 1.00 / Ref / 7 / 0.61 / 0.26-1.44
25-29.9 / 61 / 1.00 / Ref / 33 / 0.88 / 0.57-1.37
>=30 / 40 / 1.00 / Ref / 21 / 0.81 / 0.46-1.42
No Fonofos / Fonofos
<25 / 31 / 1.00 / Ref / 9 / 1.24 / 0.56-2.78
25-29.9 / 69 / 1.00 / Ref / 26 / 1.19 / 0.77-1.93
>=30 / 42 / 1.00 / Ref / 21 / 1.83 / 1.05-3.18
No Chlorpyrifos / Chlorpyrifos
<25 / 27 / 1.00 / Ref / 17 / 1.29 / 0.65-2.55
25-29.9 / 74 / 1.00 / Ref / 32 / 0.63 / 0.40-0.99
>=30 / 40 / 1.00 / Ref / 30 / 1.17 / 0.70-1.95
No Malathion / Malathion 4
<25 / 9 / 1.00 / Ref / 11 / 1.02 / 0.38-2.76
25-29.9 / 33 / 1.00 / Ref / 43 / 0.75 / 0.45-1.25
>=30 / 20 / 1.00 / Ref / 25 / 0.82 / 0.42-1.60
No Dichlorvos / Dichlorvos
<25 / 30 / 1.00 / Ref / 8 / 1.89 / 0.77- 4.65
25-29.9 / 82 / 1.00 / Ref / 10 / 0.95 / 0.47-1.89
>=30 / 50 / 1.00 / Ref / 11 / 2.09 / 1.07-4.06
Carbamate
No Carbofuran / Carbofuran
<25 / 31 / 1.00 / Ref / 7 / 0.53 / 0.22-1.29
25-29.9 / 66 / 1.00 / Ref / 28 / 0.79 / 0.49-1.27
>=30 / 38 / 1.00 / Ref / 24 / 1.37 / 0.80-2.35
No Carbaryl / Carbaryl 4
<25 / 11 / 1.00 / Ref / 9 / 0.95 / 0.37-2.44
25-29.9 / 45 / 1.00 / Ref / 31 / 0.82 / 0.50-1.36
>=30 / 23 / 1.00 / Ref / 22 / 1.13 / 0.59-2.17
Pyrethroid
No Permethrin / Permethrin (crops or animal)
<25 / 33 / 1.00 / Ref / 7 / 0.98 / 0.40-2.39
25-29.9 / 78 / 1.00 / Ref / 21 / 1.09 / 0.65-1.84
>=30 / 47 / 1.00 / Ref / 19 / 1.74 / 0.97-3.14
HERBICIDE
Triazine
No Atrazine / Atrazine
<25 / 20 / 1.00 / Ref / 24 / 0.71 / 0.36-1.41
25-29.9 / 35 / 1.00 / Ref / 69 / 0.74 / 0.48-1.15
>=30 / 14 / 1.00 / Ref / 58 / 1.50 / 0.80-2.83
No Cyanazine / Cyanazine
<25 / 27 / 1.00 / Ref / 14 / 0.73 / 0.35-1.51
25-29.9 / 58 / 1.00 / Ref / 37 / 0.86 / 0.56-1.33
>=30 / 33 / 1.00 / Ref / 31 / 1.37 / 0.81-2.32
No Metribuzin / Metribuzin4
<25 / 13 / 1.00 / Ref / 6 / 1.10 / 0.40-3.01
25-29.9 / 55 / 1.00 / Ref / 23 / 0.72 / 0.43-1.23
>=30 / 32 / 1.00 / Ref / 12 / 0.56 / 0.20-1.19
Chloroacetanilide
No Metolachlor / Metolachor
<25 / 28 / 1.00 / Ref / 12 / 0.60 / 0.29-1.26
25-29.9 / 57 / 1.00 / Ref / 36 / 0.77 / 0.50-1.19
>=30 / 31 / 1.00 / Ref / 35 / 1.44 / 0.86-2.41
No Alachlor / Alachlor
<25 / 24 / 1.00 / Ref / 14 / 0.46 / 0.22-0.94
25-29.9 / 40 / 1.00 / Ref / 53 / 1.01 / 0.66-1.55
>=30 / 25 / 1.00 / Ref / 41 / 1.33 / 0.77-2.30
Dinotroaniline
No Pendimethalin / Pendimethalin4
<25 / 12 / 1.00 / Ref / 7 / 1.27 / 0.48-3.40
25-29.9 / 57 / 1.00 / Ref / 20 / 0.63 / 0.36-1.11
>=30 / 29 / 1.00 / Ref / 15 / 0.73 / 0.35-1.53
No Trifluralin / Trifluralin
<25 / 21 / 1.00 / Ref / 16 / 0.94 / 0.45-1.94
25-29.9 / 46 / 1.00 / Ref / 49 / 0.92 / 0.60-1.40
>=30 / 23 / 1.00 / Ref / 43 / 1.82 / 1.04-3.17
Thiocarbamate
No EPTC / EPTC
<25 / 32 / 1.00 / Ref / 6 / 1.23 / 0.50-3.02
25-29.9 / 73 / 1.00 / Ref / 19 / 1.17 / 0.70-1.96
>=30 / 47 / 1.00 / Ref / 16 / 1.73 / 0.96-3.12
Imidazolinone
No Imazethapyr / Imazethapyr
<25 / 28 / 1.00 / Ref / 11 / 0.86 / 0.39-1.89
25-29.9 / 56 / 1.00 / Ref / 37 / 1.05 / 0.68-1.62
>=30 / 38 / 1.00 / Ref / 28 / 1.32 / 0.78-2.24
Phosphinic
No Glyphosate / Glyphosate
<25 / 11 / 1.00 / Ref / 34 / 0.92 / 0.44-1.94
25-29.9 / 26 / 1.00 / Ref / 81 / 1.15 / 0.71-1.86
>=30 / 18 / 1.00 / Ref / 53 / 1.26 / 0.69-2.30
Urea
No Chlorimuron-ethyl / Chlorimuron-ethyl 4
<25 / 14 / 1.00 / Ref / 5 / 1.08 / 0.38-3.08
25-29.9 / 54 / 1.00 / Ref / 24 / 1.11 / 0.65-1.88
>=30 / 26 / 1.00 / Ref / 18 / 1.70 / 0.87-3.33
Benzoic
No Dicamba / Dicamba
<25 / 22 / 1.00 / Ref / 17 / 1.13 / 0.56-2.30
25-29.9 / 45 / 1.00 / Ref / 49 / 0.92 / 0.60-1.42
>=30 / 35 / 1.00 / Ref / 30 / 0.99 / 0.58-1.68
FUMIGANT
No Methyl Bromide / Methyl Bromide
<25 / 34 / 1.00 / Ref / 10 / 1.39 / 0.65-3.00
25-29.9 / 88 / 1.00 / Ref / 17 / 0.81 / 0.44-1.49
>=30 / 57 / 1.00 / Ref / 14 / 1.14 / 0.59-2.20

1 Based on Cox regression using age as time-dependent variable; models adjusted for race, education, family history colon cancer

2 Used at least one of the following: Lindane, Aldrin, Chlordane, Dieldrin, DDT, Heptachlor,Toxaphene

3 Used at least one of the following: Terbufos,Fonofos, Trichlorfon,Chlorpyrifos, Malathion, Parathion, Diazinon, Phorate, Coumaphos,Dichlorvos

4 Data available from take-home questionnaire only

Supplemental Table 2:Hazard Rate Ratio (HR) and 95% Confidence Intervals (CI) for Breast Cancer in relation to BMI at enrollment by ever/never use of pesticides among postmenopausal women

BMI (kg/m2) / N / HR1 / 95%CI1 / N / HR1 / 95%CI1 / p-interaction2
INSECTICIDES
Organochlorines2
No Organochlorines / Organochlorines3
<25 / 161 / 1.00 / Ref / 21 / 1.00 / Ref
25-29.9 / 133 / 1.27 / 0.95-1.71 / 13 / 0.76 / 0.34-1.69
>=30 / 99 / 1.52 / 1.09-2.12 / 12 / 1.23 / 0.55-2.76
trend 1 / 1.24 / 1.05-1.46 / 0.01 / 1.06 / 0.70-1.63 / 0.77 / 0.74
Organophosphates3
No Organophosphates / Organophosphates4
<25 / 127 / 1.00 / Ref / 64 / 1.00 / Ref
25-29.9 / 106 / 1.25 / 0.89-1.76 / 50 / 1.17 / 0.74-1.85
>=30 / 93 / 1.76 / 1.23-2.54 / 24 / 0.99 / 0.56- 1.75
trend 1 / 1.32 / 1.10-1.59 / 0.003 / 1.02 / 0.78-1.34 / 0.86 / 0.15
No Malathion / Malathion
<25 / 130 / 1.00 / Ref / 52 / 1.00 / Ref
25-29.9 / 111 / 1.25 / 0.90-1.73 / 38 / 1.14 / 0.69-1.89
>=30 / 92 / 1.68 / 1.18-2.40 / 19 / 1.00 / 0.53-1.84
trend 1 / 1.29 / 1.08-1.55 / 0.01 / 1.02 / 0.76-1.38 / 0.89 / 0.22
No Diazinon / Diazinon
<25 / 158 / 1.00 / Ref / 21 / 1.00 / Ref
25-29.9 / 124 / 1.14 / 0.85-1.54 / 22 / 1.84 / 0.86-3.97
=30 / 99 / 1.49 / 1.07-2.07 / 11 / 1.59 / 0.65-3.88
trend 1 / 1.21 / 1.03-1.43 / 0.02 / 1.31 / 0.86-1.00 / 0.20 / 0.56
Carbamate
No Carbaryl / Carbaryl
<25 / 123 / 1.00 / Ref / 58 / 1.00 / Ref
25-29.9 / 96 / 1.04 / 0.74-1.46 / 53 / 1.64 / 1.02-2.65
>=30 / 81 / 1.50 / 1.04-2.15 / 29 / 1.41 / 0.79-2.53
trend 1 / 1.21 / 1.00-1.46 / 0.05 / 1.22 / 0.93-1.61 / 0.15 / 0.73
HERBICIDES
Phosphinic
No Glyphosate / Glyphosate
<25 / 130 / 1.00 / Ref / 54 / 1.00 / Ref
25-29.9 / 105 / 1.21 / 0.87-1.67 / 44 / 1.30 / 0.76-2.21
>=30 / 85 / 1.40 / 0.97-2.01 / 28 / 1.69 / 0.94-3.04
trend 1 / 1.20 / 0.99-1.43 / 0.06 / 1.28 / 0.96-1.72 / 0.09 / 0.62

1 Based on Cox regression using age as time-dependent variable; test of trend calculated using continuous BMI; models adjusted for diabetes, vitamin supplement, parity, family history of breast cancer.

2 Interaction calculated using never/ever pesticide use and continuous BMI

3 Used at least one of the following: Lindane, Aldrin, Chlordane, Dieldrin, DDT, Heptachlor,Toxaphene

4 Used at least one of the following: Terbufos,Fonofos, Trichlorfon,Chlorpyrifos, Malathion, Parathion, Diazinon, Phorate, Coumaphos,Dichlorvos