Supplementary Table S3.ORs (95% CIs) of CRC by quartile of plasma DMG:betaineratioa

Quartiles of DMG:betaine ratio / P-trendb
1(≤0.07) / 2(>0.07-0.09) / 3(>0.09-0.12) / 4(>0.12)
n / 403 / 430 / 402 / 433
All participants
Age-adjusted / 1 / 1.10 (0.84, 1.45) / 0.96 (0.72, 1.28) / 1.13 (0.85, 1.50) / 0.54
Multivariablec / 1 / 1.07 (0.77, 1.47) / 0.89 (0.64, 1.25) / 1.08 (0.76, 1.55) / 0.78
By tumor site
Proximal
Age-adjusted / 1 / 1.08 (0.75, 1.54) / 0.87 (0.60, 1.27) / 1.04 (0.72, 1.51) / 0.98
Multivariablec / 1 / 1.04 (0.68, 1.59) / 0.90 (0.58, 1.38) / 0.94 (0.59, 1.48) / 0.67
Distal
Age-adjusted / 1 / 0.85 (0.45, 1.58) / 1.02 (0.52, 1.98) / 1.08 (0.57, 2.04) / 0.64
Multivariablec / 1 / 0.77 (0.37, 1.61) / 0.78 (0.34, 1.82) / 1.06 (0.45, 2.51) / 0.73
Rectal
Age-adjusted / 1 / 1.38 (0.73, 2.63) / 1.23 (0.65, 2.31) / 1.53 (0.79, 2.94) / 0.25
Multivariablec / 1 / 2.01 (0.85, 4.73) / 1.32 (0.56, 3.11) / 2.56 (0.98, 6.64) / 0.09
By stage
Local/regional
Age-adjusted / 1 / 0.99 (0.73, 1.34) / 0.94 (0.69, 1.29) / 1.06 (0.78, 1.45) / 0.67
Multivariablec / 1 / 0.95 (0.66, 1.36) / 0.88 (0.61, 1.27) / 1.07 (0.72, 1.58) / 0.69
Metastatic
Age-adjusted / 1 / 1.70 (0.84, 3.42) / 0.96 (0.45, 2.05) / 1.78 (0.82, 3.91) / 0.28
Multivariablec / 1 / 1.55 (0.63, 3.82) / 0.79 (0.26, 2.39) / 1.48 (0.49, 4.48) / 0.66

aORs (95% CIs) of CRC were determined by conditional logistic regression.

bMedians for each quartile used in trend test: quartile 1 = 0.06, quartile 2 = 0.08, quartile 3 = 0.10and quartile 4 = 0.15.

cMultivariable analyses were adjusted for age, baseline BMI, pack-years of smoking, moderate or strenuous physical activity (min/wk), use of postmenopausal-hormone-therapy, history of colonoscopy, RBC folate, plasma PLP, plasma vitamin B12, and plasma homocysteine.