BIOGRAPHICAL SKETCH

Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
Robert B. Livingston, MD / POSITION TITLE
Professor of Medicine
Hematology/Oncology
eRA COMMONS USER NAME
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION / DEGREE
(if applicable) / YEAR(s) / FIELD OF STUDY
University of Oklahoma, Norman, OK / B.A. / 1963 / History
University of Oklahoma, Oklahoma City, OK / M.D. / 1967 / Medicine

Rev 1.31.13 Page 1 Biographical Sketch Format Page

A. Professional Experience and Honors
Professional Experience
1967-1968 / Internship, Parkland Hospital, Southwestern Medical School, Dallas, TX
1968-70 / PHS, Special Assistant to Chief, National Cancer Institute, Bethesda, MD
1970-1971 / Medicine Residency, University of Oklahoma, Oklahoma City, OK
1971-1973 / Oncology Fellowship, University of Texas Systems Cancer Center, Houston, TX
07/73-09/73 / Faculty Associate, University of Texas Systems Cancer Center, Houston, TX
09/73-03/76 / Assistant Professor, University of Texas Systems Cancer Center, Houston, TX
04/76-09/77 / Assistant Professor, University of Texas Health Science Center, San Antonio, TX
04/76-09/79 / Staff Physician, Audie Murphy VA Hospital, San Antonio, TX
09/77-10/79 / Associate Professor, University of Texas Health Science Center, San Antonio, TX
10/79-06/82 / Chairman, Hematology & Medical Oncology, Cleveland Clinic Foundation, Cleveland, OH
07/82-10/06 / Professor of Medicine, University of Washington, Seattle, WA
04/86-07/98 / Head, Division of Oncology, University of Washington, Seattle, WA
07/97-10/06 / Section Head, Division of Oncology, Solid Tumor, University of Washington/SCCA
07/82-10/06 / Member, Fred Hutchinson Cancer Research Center, Seattle, WA
10/06-present / Professor of Medicine, Arizona Cancer Center, University of Arizona, University Medical Center, Tucson, Az
4/2007-7/2010
8/11-present / Director, Clinical Research Shared Services, Arizona Cancer Center, Tucson, AZ
Translational Clinical Research Training (Curriculum)
Honors and Responsibilities
1966 / Alpha Omega Alpha
1974-1997 / Chairman, Southwest Oncology Group Lung Cancer Committee
1975-present / American Society of Clinical Oncology: Constitution & By-Laws Comm. (1979-84); Program Comm. (1984, 89, 2002); Nominating Comm. (1989); Publications Comm. (1990-5)
1990-present / Fellow, American Association for the Advancement of Science
1996 / Member, ACS Clinical Research, Cancer Control and Epidemiology Committee
1996 / Member, National Cancer Institute PDQ Adult Treatment Editorial Board
2000-2008 / Chairman, Southwest Oncology Group Breast Cancer Committee

Specht JM, Tam SL, Kurland BF, Gralow JR, Livingston RL, Linden HM, Ellis GK, Schubert EK, Dunnwald LK, Mankoff DA. Serial 2-[18F] fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) to monitor treatment of bone-dominant metastatic breast cancer predicts time to progression (TTP). Breast Cancer Res Treat, Published Online, February 1, 2007.

Linden HM, Stekhova SA, Link JM, Lawton T, Livingston RB, Gralow JR, Ellis GK, Peterson LM, Krohn KA, Mankoff DA. Understanding resistance to hormonal therapy in estrogen avid breast cancer. Abstract No. 566 Poster Discussion presented at the meeting of the American Society of Clinical Oncology, Atlanta, GA June 2-6, 2006.

Linden HM, Stekhova SA, Link JM, Gralow JR, Livingston RB, Ellis GK, et al. Quantitative Fluoroestradiol

Positron Emission Tomography Imaging Predicts Response to Endocrine Treatment. J Clin Oncol. 2006 June 24(18):1-7.

Linden H M, Krohn KA, Livingston RB, Mankoff D. Monitoring Targeted Therapy: is fluorodexylucose (FDG)

Uptake a Marker of Early Response? Invited editorial that has been accepted for publication in Clinical Cancer Research, American Association of Clinical Research, June 2006.

Gandara DR, Chansky K, Albain KS, Gaspar LE, Lara PN Jr, Kelly K, Crowley J, Livingston R. Long-term

survival with concurrent chemoradiation therapy followed by consolidation docetaxel in stage IIIB non-

small-cell lung cancer: a phase II SWOg study(S9504). Clin Lung Cancer. 2006 Sep;8(2):116-21

Specht JM, Tam SL, Kurland BF, Gralow JR, Livingston RL, Linden HM, Ellis GK, Schubert EK, Dunnwald LK,

Mankoff DA. Serial 2-[18F] fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) to monitor

treatment of bone-dominant metastatic breast cancer predicts time to progression (TTP). Breast Cancer

Res Treat, Published Online, February 1, 2007.

Linden HM, Haskell CM, Green SJ, Osborne CK, Sledge, Jr. GW, Shapiro CL, Ingle JN, Lew D, Hutchins LF,

Livingston RB, Martino S. Sequenced vs. simultaneous anthracycline and cyclophosphamide in high risk

stage I-II breast cancer: final analysis from INT-0137 (S9313). J Clin Oncol. 2007 Feb 20;25(6):656-661.

Pepe C, Hasan B, Winton T, Seymour L, Graham B, Livingston RB, Johnson D, Rigas J, Ding K, Shepard F.

Adjuvant Vinorelbine and Cisplatin in Elderly Patients: National Cancer Institute of Canada and Intergroup

Study JBR.10. J Clin Oncol. 2007 April 20:25(12):1553-1562Goss PE, Ingle JN, Martino S, Robert NJ, Muss HB, Piccart MJ, Castiglione M, Tu D, shepherd LE, Pritchard KI, Livingston RB, Davidson NE, Norton L, Perez EA,

Abrams JS, Cameron DA, Palmer MJ, Pater JL; National Cancer Institute of Canada Clinical Trials Group

MA.17. Efficacy of letrozole extended adjuvant therapy according to estrogen receptor and progesterone

receptor status of the primary tumor: National Cancer Institute of Canada Clinical Trials Group MA.17. J

Clin Oncol. 2007 May 20;25(15):2006-11.Moore HC, Green SJ, Gralow JR, Bearman, SI, Lew D, Barlow WE,Hudis C, Wolff AC, Ingle JN, Chew HK, Elias AD, Livingston RB, Martino S; Southwest Oncology

Group/Intergroup Study 9623. Intensive dose-dense compared with high-dose adjuvant chemotherapy for

high-risk operable breast cancer: Southwest Oncology Group/Intergroup Study 9623. J Clin Oncol.2007

May 1;25(13):1677-82

Goss PE, Ingle JN, Pater JL, Martino S, Robert NJ, Muss HB, Piccart MJ, Castiglione M, Shepherd LE,

Pritchard KI, Livingston RB, Davidson NE, Norton L, Perez EA, Abrams JS, Cameron DA, Palmer MJ, Tu

D. Late extended adjuvant treatment with letrozole improves outcome in women with early-stage breast

cancer who complete 5 years of tamoxifen. J Clin Oncol. 2008 Apr 20;26(12):1948-55. Epub 2008 Mar

10.

Dunnwald LK, Gralow JR, Ellis GK, Livingston RB, Linden HM, Specht JM, Doot RK, Lawton TJ, Barlow WE,

Kurland BF, Schubert EK, Mankoff DA. Tumor Metabolism and Blood Flow Changes by position

Emission Tomography: Relation to survival in Patients Treated with Neoadjuvant Chemotherapy for

Locally Advanced Breast Cancer. J Clin Oncol. 2008 Jul 17 (E-Pub)

Swart R, Downey L, Lang J, Thompson P, Livingston R, Stopeck A. Breast Cancer. E-Medicine Chapter, 2009, In publication.

Bezjak A, Lee CW, Ding K, Brundage M, Winton T, Graham B, Whitehead M, Johnson DH, Livingston RB, Seymour L, Shepherd FA.Quality-of-life outcomes for adjuvant chemotherapy in early-stage non-small-cell lung cancer: results from a randomized trial, JBR.10. J Clin Oncol. 2008 Nov 1;26(31):5052-9. Epub 2008 Sep 22. PMID: 18809617 [PubMed - indexed for MEDLINE]

Hershman DL, Unger JM, Barlow WE, Hutchins LF, Martino S, Osborne CK, Livingston RB, Albain KS.

Treatment Quality and Outcomes of African American Versus White Breast Cancer Patients: Retrospective Analysis of Southwest Oncology Studies S8814/S8897. Clin Oncol. 2009 Mar 23. [Epub
Christine B Ambrosone, William E Barlow, Wanda Reynolds, Robert B Livingston, I-Tien Yeh, Ji-Yeob Choi, Warren Davis, James M. Rae, Li Tang, Laura Hutchins, Peter Ravdin, Silvana Martino, C. Kent Osborne, Martin Abeloff, Alan P Lyss, Daniel F Hayes, and Kathy S AlbainMyeloperoxidase Genotypes and Enhanced Efficacy of Chemotherapy for Early Stage Breast Cancer in SWOG 8897. ahead of print] PMID: 19307504 [PubMed - as supplied by publisher] JCO/2009/218669

Slovak ML, Bedell V, Lew D, Albain KS, Ellis GK, Livingston RB, Martino S, Perez EA, Hortobagyi GN, Sher D, Stock W. Screening for clonal hematopoiesis as a predictive marker for development of therapy- related myeloid neoplasia (t-MN) following neoadjuvant therapy for breast cancer: a Southwest Oncology Group study (S0012). Breast Cancer Res Treat. 2009 Oct 23

Albain KS, Barlow WE, Ravdin PM, Farrar WB, Burton GV, Ketchel SJ, Cobau CD, Levine EG, Ingle JN, Pritchard KI, Lichter AS, Schneider DJ, Abeloff MD, Henderson IC, Muss HB, Green SJ, Lew D, Livingston RB, Martino S, Osborne CK; Adjuvant chemotherapy and timing of tamoxifen in postmenopausal patients with endocrine-responsive, node-positive breast cancer: a phase 3, open-label, randomised controlled trial. For The Breast Cancer Intergroup of North AmericLancet. . [Epub ahead of print]PMID: 20004966 [PubMed - as supplied by publisher

Albain KS, Barlow WE, Shak S, Hortobagyi GN, Livingston RB, Yeh IT, Ravdin P, Bugarini R, Baehner FL, Davidson NE, Sledge GW, Winer EP, Hudis C, Ingle JN, Perez EA, Pritchard KI, Shepherd L, Gralow JR, Yoshizawa C, Allred DC, Osborne CK, Hayes DF; Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial. For The Breast Cancer Intergroup of North America. Lancet Oncol. . [Epub ahead of print]

Downey L, Livingston RB, Koehler M, Arbushites M, Williams L, Santiago A, Guzman R, Villalobos I, Di Leo A, Press MF. Chromosome 17 polysomy without human epidermal growth factor receptor 2 amplification does not predict response to lapatinib plus paclitaxel compared with paclitaxel in metastatic breast cancer. Clin Cancer Res. 2010 Feb 15;16(4):1281-8. Epub 2010 Feb 9.PMID: 20145176 [PubMed - in process]

Yao S, Barlow WE, Albain KS, Choi JY, Zhao H, Livingston RB, Davis W, Rae JM, Yeh IT, Hutchins LF, Ravdin PM, Martino S, Lyss AP, Kent Osborne C, Abeloff MD, Hortobagyi GN, Hayes DF, Ambrosone CB. Manganese superoxide dismutase polymorphism, treatment-related toxicity and disease-free survival in SWOG 8897 clinical trial for breast cancer. Breast Cancer Res Treat. 2010 Mar 23. [Epub ahead of print]

Specht JM, Kurland BF, Montgomery SK, Dunnwald LK, Doot RK, Gralow JR, Ellis GK, Linden HM, Livingston RB, Allison KH, Schubert EK, Mankoff DA. Tumor metabolism and blood flow as assessed by positron emission tomography varies by tumor subtype in locally advanced breast cancer. Clin Cancer Res. 2010 May 15;16(10):2803-10. Epub 2010 May 11.PMID: 20460489 [PubMed - in process]

Yao S, Barlow WE, Albain KS, Choi JY, Zhao H, Livingston RB, Davis W, Rae JM, Yeh IT, Hutchins LF, Ravdin PM, Martino S, Lyss AP, Osborne CK, Abeloff M, Hortobagyi GN, Hayes DF, Ambrosone CB. Gene Polymorphisms in Cyclophosphamide Metabolism Pathway,Treatment-Related Toxicity, and Disease-Free Survival in SWOG 8897 Clinical Trial for Breast Cancer. Clin Cancer Res. 2010 Dec 15;16(24):6169- 6176.PMID: 21169260 [PubMed - as supplied by publisher]

Swain SM, Jeong JH, Geyer CE Jr, Costantino JP, Pajon ER, Fehrenbacher L, Atkins JN, Polikoff J, Vogel VG, Erban JK, Rastogi P, Livingston RB, Perez EA, Mamounas EP, Land SR, Ganz PA, Wolmark N.Longer therapy, iatrogenic amenorrhea, and survival in early breast cancer. N Engl J Med. 2010 Jun 3;362(22):2053-65.PMID: 20519679 [PubMed - indexed for MEDLINE]Free PMC ArticleGanz PA, Land SR, Geyer CE Jr, Cecchini RS, Costantino JP, Pajon ER, Fehrenbacher L, Atkins JN, Polikoff JA, Vogel VG, Erban JK, Livingston RB, Perez EA, Mamounas EP, Wolmark N, Swain SM. Menstrual History and Quality- of-Life Outcomes in Women With Node-Positive Breast Cancer Treated With Adjuvant Therapy on the NSABP B-30 Trial. J Clin Oncol. 2011 Feb 7.

Ellis GK, Barlow WE, Gralow JR, Hortobagyi GN, Russell CA, Royce ME, Perez EA, Lew D, Livingston RB. Phase III Comparison of Standard Doxorubicin and Cyclophosphamide Versus Weekly Doxorubicin and Daily Oral Cyclophosphamide Plus Granulocyte Colony-Stimulating Factor As Neoadjuvant Therapy for Inflammatory and Locally Advanced Breast Cancer: SWOG 0012. J Clin Oncol. 2011 Jan 10. [Epub ahead of print]

Dunnwald LK, Doot RK, Specht JM, Gralow JR, Ellis GK, Livingston RB, Linden HM, Gadi VK, Kurland BF, Schubert EK, Muzi M, Mankoff DA. PET tumor metabolism in locally advanced breast cancer patients undergoing neoadjuvant chemotherapy: value of static versus kinetic measures of fluorodeoxyglucose uptake. Clin Cancer Res. 2011 Apr 15;17(8):2400-9. Epub 2011 Mar 1.

Livingston RB, Barlow WE, Kash JJ, Albain KS, Gralow JR, Lew DL, Flaherty LE, Royce ME, Hortobagyi GN. SWOG S0215: a phase II study of docetaxel and vinorelbine plus filgrastim with weekly trastuzumab for HER2-positive, stage IV breast cancer. Breast Cancer Res Treat. 2011 Aug 9.

Sucheston LE, Zhao H, Yao S, Zirpoli G, Liu S, Barlow WE, Moore HC, Thomas Budd G, Hershman DL, Davis W, Ciupak GL, Stewart JA, Isaacs C, Hobday TJ, Salim M, Hortobagyi GN, Gralow JR, Livingston RB, Albain KS, Hayes DF, Ambrosone CB. Genetic predictors of taxane-induced neurotoxicity in a SWOG phase III intergroup adjuvant breast cancer treatment trial (S0221). Breast Cancer Res Treat. 2011 Jul 16.

Linden HM, Kurland BF, Peterson LM, Schubert EK, Gralow JR, Specht JM, Ellis GK, Lawton TJ, Livingston RB, Petra PH, Link JM, Krohn KA, Mankoff DA. Fluoroestradiol positron emission tomography reveals differences in pharmacodynamics of aromatase inhibitors, tamoxifen, and fulvestrant in patients with metastatic breast cancer. Clin Cancer Res. 2011 Jul 15;17(14):4799-805. Epub 2011 Jul 12.

Livingston RB, Barlow WE, Kash JJ, Albain KS, Gralow JR, Lew DL, Flaherty LE, Royce ME, Hortobagyi GN. SWOG S0215: a phase II study of docetaxel and vinorelbine plus filgrastim with weekly trastuzumab for HER2-positive, stage IV breast cancer. Breast Cancer Research and Treatment Volume 130, Number 1, 123-131

Schott AF, Barlow WE, Albain KS, Chew HK, Wade JL 3rd, Lanier KS, Lew DL, Hayes DF, Gralow JR, Livingston RB, Hortobagyi GN. Phase II Trial of Simple Oral Therapy with Capecitabine and Cyclophosphamide in Patients with Metastatic Breast Cancer: SWOG S0430. Oncologist. 2012 Jan 20.

Kurland BF, Gadi VK, Specht JM, Allison KH, Livingston RB, Rodler ET, Peterson LM, Schubert EK, Chai X, Mankoff DA, Linden HM.. Feasibility study of FDG PET as an indicator of early response to aromatase inhibitors and trastuzumab in a heterogeneous group of breast cancer patients. EJNMMI Res. 2012 Jun 25;2(1):34.

Combination Anastrozole And Fulvestrant In Metastatic Breast Cancer. Mehta RS, Barlow WE, Albain KS, Vandenberg TA, Dakhil SE, Tirumali NR, Lew DL, Hayes DF, Gralow JR, Livingston RB, Hortobagyi GN. N Engl J Med. 2012 Aug 2;367(5):435-44. Doi: 10.1056/Nejmoa1201622.

C. Research Support

Neo-Adjuvant Therapy with Exemestane plus Pazopanib in Stage II and III ER+ Breast Cancer
12/13/10-12/12/13 / 5% / PI / GSK:
$400,950.00
CA125627 (Gillies)
Imaging Biomarkers for Response to AntiCancer Therapy
The overall goal of this grant is to investigate MR imaging endpoints to predict and monitor anti-cancer drug response. Two agents will be investigated, PX-866 a PI3Kinase inhibitor and Sunitinib, a VEGFR inhibitor. Breast cancer tumor xenografts with differential sensitivities to these drugs will be used as the model system. Primary goals of this work are to: (1) determine which of these MR imaging biomarkers are most useful for each drug; and (2) whether imaging biomarker responses can differentiate between these drug classes. Aim 1 will investigate this by assessing tumor and molecular responses to PX-866 and sunitinib. Aim 2 will assess the imaging responses to these drugs to determine which imaging endpoints are most appropriate as response biomarkers and Aim 3 will retrospectively analyze the pre-therapy images to determine if any biomarker (or combination) would have been useful in predicting response.
02/01/08-01/31/2013 / 5% / Co:PI / NIH/NCI:
$250,000

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