Hazard Ratios Denoted in Bold Indicate Significance at the Alpha Level of 0.05

Supplemental Table 1. Age- and multivariable-adjusted associations between self-reported aspirin frequency, duration, and dose and incident aspirin-sensitive cancers, separately for colon cancer and breast, pancreatic and ovarian cancer, IWHS 2004-2011

Colon Cancer / Breast, Pancreatic or Ovarian Cancer
Aspirin Metric / No. cancer cases / Model 1
HR (95% CI)a / Model 2
HR (95% CI)b / No. cancer cases / Model 1
HR (95% CI)a / Model 2
HR (95% CI)b
Dose
Non-users / 61 / 1.00 (reference) / 1.00 (reference) / 148 / 1.00 (reference) / 1.00 (reference)
Low dosec / 75 / 1.04 (0.74-1.46) / 0.98 (0.70-1.40) / 182 / 1.03 (0.83-1.28) / 1.02 (0.82-1.27)
Regular/high dosec / 81 / 1.08 (0.78-1.51) / 1.03 (0.73-1.44) / 161 / 0.88 (0.70-1.10) / 0.81 (0.64-1.02)
Total: 217 / Ptrend=0.64 / Ptrend=0.87 / Total: 491 / Ptrend=0.24 / Ptrend=0.067
Frequency
Non-users / 61 / 1.00 (reference) / 1.00 (reference) / 148 / 1.00 (reference) / 1.00 (reference)
≤1 time/week / 31 / 1.13 (0.73-1.74) / 1.00 (0.63-1.59) / 57 / 0.83 (0.61-1.13) / 0.82 (0.60-1.12)
2-5 times/week / 23 / 1.10 (0.68-1.78) / 1.07 (0.65-1.75) / 48 / 0.95 (0.68-1.31) / 0.88 (0.62-1.24)
≥6 times/week / 103 / 1.02 (0.75-1.41) / 0.98 (0.71-1.35) / 241 / 0.98 (0.80-1.21) / 0.94 (0.76-1.16)
Total: 218 / Ptrend=0.96 / Ptrend=0.90 / Total: 494 / Ptrend=0.92 / Ptrend=0.72
Duration
Non-users / 61 / 1.00 (reference) / 1.00 (reference) / 148 / 1.00 (reference) / 1.00 (reference)
<5 years / 79 / 1.04 (0.75-1.46) / 1.01 (0.72-1.42) / 178 / 0.96 (0.77-1.20) / 0.95 (0.76-1.18)
5-9 years / 33 / 0.99 (0.65-1.51) / 0.88 (0.56-1.37) / 79 / 0.97 (0.74-1.28) / 0.88 (0.66-1.18)
≥10 years / 43 / 1.16 (0.78-1.71) / 1.10 (0.74-1.65) / 82 / 0.90 (0.68-1.17) / 0.86 (0.65-1.14)
Total: 216 / Ptrend=0.54 / Ptrend=0.84 / Total: 487 / Ptrend=0.46 / Ptrend=0.24
Aspirin dose per year (quartiles)
Non-user / 61 / 1.00 (reference) / 1.00 (reference) / 148 / 1.00 (reference) / 1.00 (reference)
0<-25,000 mg / 43 / 1.23 (0.83-1.82) / 1.14 (0.76-1.72) / 78 / 0.90 (0.68-1.18) / 0.85 (0.64-1.14)
25,001<-60,000 mg / 64 / 0.94 (0.66-1.33) / 0.89 (0.62-1.28) / 170 / 1.02 (0.81-1.27) / 1.03 (0.82-1.28)
>60,000 mg / 49 / 1.12 (0.77-1.63) / 1.08 (0.74-1.59) / 95 / 0.90 (0.69-1.16) / 0.78 (0.60-1.03)
Total: 217 / Ptrend=0.90 / Ptrend=0.97 / Total: 491 / Ptrend=0.64 / Ptrend=0.27
Lifetime aspirin dose (quartiles)
Non-user / 61 / 1.00 (reference) / 1.00 (reference) / 148 / 1.00 (reference) / 1.00 (reference)
0<-95,000 mg / 59 / 1.01 (0.71-1.45) / 0.98 (0.68-1.42) / 144 / 1.00 (0.80-1.26) / 0.99 (0.78-1.25)
95,000<-280,000 mg / 41 / 1.08 (0.73-1.60) / 0.90 (0.59-1.38) / 90 / 0.97 (0.75-1.26) / 0.97 (0.74-1.26)
>280,000 mg / 38 / 1.17 (0.78-1.76) / 1.15 (0.76-1.73) / 78 / 0.98 (0.74-1.28) / 0.87 (0.65-1.16)
Total: 199 / Ptrend=0.42 / Ptrend=0.69 / Total: 460 / Ptrend=0.80 / Ptrend=0.37

Hazard ratios denoted in bold indicate significance at the alpha level of 0.05.

aAdjusted for age

bAdjusted for age, smoking, BMI, and non-aspirin NSAIDs use.

cLow dose=81 mg; regular dose=325mg; high dose= 650mg

Supplemental Table 2. Age- and multivariable-adjusted associations between self-reported aspirin frequency, duration, and dose and aspirin-sensitive cancers, stratified by history of heart disease, IWHS 2004-2011

History of Heart Disease (N=3,748) / No History of Heart Disease (N=10.638)
Aspirin Metric / No. cancer cases / Model 1
HR (95% CI)a / Model 2
HR (95% CI)b / No. cancer cases / Model 1
HR (95% CI)a / Model 2
HR (95% CI)b
Dose
Non-users / 40 / 1.00 (reference) / 1.00 (reference) / 169 / 1.00 (reference) / 1.00 (reference)
Low dosec / 68 / 1.18 (0.80-1.74) / 1.10 (0.73-1.64) / 189 / 1.00 (0.81-1.23) / 0.99 (0.80-1.22)
Regular/high dosec / 65 / 1.14 (0.77-1.70) / 1.00 (0.66-1.50) / 177 / 0.89 (0.72-1.09) / 0.85 (0.70-1.05)
Total: 173 / Ptrend=0.55 / Ptrend=0.93 / Total: 535 / Ptrend=0.25 / Ptrend=0.13
Frequency
Non-users / 40 / 1.00 (reference) / 1.00 (reference) / 169 / 1.00 (reference) / 1.00 (reference)
≤1 time/week / 5 / 0.48 (0.19-1.21) / 0.46 (0.18-1.18) / 83 / 0.95 (0.73-1.24) / 0.91 (0.69-1.20)
2-5 times/week / 14 / 1.38 (0.75-2.54) / 1.17 (0.61-2.25) / 57 / 0.92 (0.68-1.24) / 0.89 (0.65-1.21)
≥6 times/week / 115 / 1.21 (0.84-1.73) / 1.09 (0.75-1.58) / 229 / 0.93 (0.77-1.14) / 0.91 (0.75-1.12)
Total: 174 / Ptrend=0.15 / Ptrend=0.39 / Total: 538 / Ptrend=0.49 / Ptrend=0.41
Duration
Non-users / 40 / 1.00 (reference) / 1.00 (reference) / 169 / 1.00 (reference) / 1.00 (reference)
<5 years / 52 / 0.97 (0.64-1.46) / 0.94 (0.62-1.43) / 205 / 0.99 (0.81-1.22) / 0.98 (0.79-1.20)
5-9 years / 41 / 1.28 (0.83-1.97) / 1.06 (0.67-1.68) / 71 / 0.88 (0.67-1.16) / 0.83 (0.62-1.10)
≥10 years / 38 / 1.34 (0.86-2.08) / 1.22 (0.77-1.93) / 87 / 0.87 (0.68-1.13) / 0.85 (0.65-1.12)
Total: 171 / Ptrend=0.10 / Ptrend=0.35 / Total: 532 / Ptrend=0.22 / Ptrend=0.14
Aspirin dose per year (quartiles)
Non-user / 40 / 1.00 (reference) / 1.00 (reference) / 169 / 1.00 (reference) / 1.00 (reference)
0<-25,000 mg / 16 / 1.06 (0.60-1.90) / 0.91 (0.49-1.68) / 105 / 0.97 (0.76-1.24) / 0.93 (0.72-1.20)
25,001<-60,000 mg / 57 / 1.06 (0.70-1.58) / 1.01 (0.67-1.53) / 177 / 0.98 (0.80-1.21) / 0.98 (0.79-1.22)
>60,000 mg / 60 / 1.32 (0.88-1.96) / 1.13 (0.75-1.72) / 84 / 0.83 (0.64-1.08) / 0.78 (0.60-1.02)
Total: 173 / Ptrend=0.20 / Ptrend=0.53 / Total: 535 / Ptrend=0.26 / Ptrend=0.17
Lifetime aspirin dose (quartiles)
Non-user / 40 / 1.00 (reference) / 1.00 (reference) / 169 / 1.00 (reference) / 1.00 (reference)
0<-95,000 mg / 36 / 0.95 (0.61-1.50) / 0.95 (0.60-1.50) / 167 / 1.02 (0.82-1.26) / 1.00 (0.80-1.24)
95,000<-280,000 mg / 35 / 1.05 (0.67-1.66) / 0.94 (0.59-1.52) / 96 / 1.00 (0.78-1.29) / 0.97 (0.75-1.25)
>280,000 mg / 40 / 1.56 (1.01-2.42) / 1.34 (0.85-2.14) / 76 / 0.89 (0.68-1.16) / 0.84 (0.64-1.12)
Total: 151 / Ptrend=0.053 / Ptrend=0.28 / Total: 508 / Ptrend=0.45 / Ptrend=0.27

Hazard ratios denoted in bold indicate significance at the alpha level of 0.05.

aAdjusted for age

bAdjusted for age, smoking, BMI, and non-aspirin NSAIDs use.

cLow dose=81 mg; regular dose=325mg; high dose= 650mg

Supplemental Table 3. Age- and multivariable-adjusted associations between self-reported aspirin frequency, duration, and dose with all-cancer death, IWHS 2004-2011

Aspirin Metric / No. cancer deaths / Model 1
HR (95% CI)a / Model 2
HR (95% CI)b
Dose
Non-users / 176 / 1.00 (reference) / 1.00 (reference)
Low dosec / 177 / 0.84 (0.68-1.04) / 0.87 (0.70-1.08)
Regular/high dosec / 191 / 0.88 (0.72-1.08) / 0.87 (0.71-1.08)
Total: 544 / Ptrend=0.26 / Ptrend=0.22
Frequency
Non-users / 176 / 1.00 (reference) / 1.00 (reference)
≤1 time/week / 64 / 0.80 (0.60-1.07) / 0.82 (0.61-1.11)
2-5 times/week / 53 / 0.87 (0.64-1.19) / 0.91 (0.66-1.25)
≥6 times/week / 259 / 0.89 (0.74-1.08) / 0.89 (0.73-1.08)
Total: 552 / Ptrend=0.34 / Ptrend=0.34
Duration
Non-users / 176 / 1.00 (reference) / 1.00 (reference)
<5 years / 188 / 0.86 (0.70-1.05) / 0.89 (0.72-1.10)
5-9 years / 81 / 0.84 (0.65-1.09) / 0.83 (0.63-1.10)
≥10 years / 100 / 0.93 (0.73-1.19) / 0.90 (0.69-1.16)
Total: 545 / Ptrend=0.47 / Ptrend=0.29
Aspirin dose per year (quartiles)
Non-user / 176 / 1.00 (reference) / 1.00 (reference)
0<-25,000 mg / 86 / 0.85 (0.66-1.10) / 0.87 (0.67-1.14)
25,001<-60,000 mg / 164 / 0.83 (0.67-1.02) / 0.84 (0.68-1.05)
>60,000 mg / 118 / 0.94 (0.74-1.18) / 0.91 (0.72-1.16)
Total: 544 / Ptrend=0.35 / Ptrend=0.30
Lifetime aspirin dose (quartiles)
Non-user / 176 / 1.00 (reference) / 1.00 (reference)
0<-95,000 mg / 129 / 0.76 (0.61-0.95) / 0.80 (0.63-1.00)
95,000<-280,000 mg / 110 / 1.00 (0.79-1.27) / 1.04 (0.81-1.33)
>280,000 mg / 86 / 0.92 (0.71-1.19) / 0.90 (0.68-1.17)
Total: 501 / Ptrend=0.83 / Ptrend=0.80

Hazard ratios denoted in bold indicate significance at the alpha level of 0.05.

aAdjusted for age

bAdjusted for age, smoking, BMI, and non-aspirin NSAIDs use.

cLow dose=81 mg; regular dose=325mg; high dose= 650mg