Supplementary Table 1. Incidence of Cardiovascular Disease During Eight Years of Follow-Up

Supplementary Table 1. Incidence of Cardiovascular Disease During Eight Years of Follow-up

Characteristic / No. of Events / No. at Risk / Person-Years At Risk / Age- and Sex-Adjusted Rate % (95% CI)
Referent*
All
No office-based subclinical disease†
Any office-based subclinical disease† present / 61/1249
53/1156
8/93 / 9138
8489
649 / 5.90 (3.69-8.03)
5.61 (3.42-7,72)
8.25 (2.14-13.84)
Metabolic syndrome‡
All
No office-based subclinical disease†
Any office-based subclinical disease† present / 59/581
42/500
17/81 / 4113
3750
543 / 9.82 (6.17-13.26)
8.49 (5.02-11.79)
16.83 (7.45-24.99)
Diabetes
All
No office-based subclinical disease†
Any office-based subclinical disease† present / 19/115
11/80
8/35 / 767
541
225 / 13.74 (6.65-20.10)
11.42 (4.07-18.02)
19.58 (5.26-31.13)

* No Metabolic syndrome or diabetes.

†Defined as left ventricular hypertrophy by Cornell criteria, ankle-brachial index ≤0.9, or microalbuminuria.

‡ No Diabetes.

Supplementary Table 2. Presence of the Metabolic Syndrome, Diabetes and Office-Based Subclinical Vascular Disease and Risk of Cardiovascular Disease

Age and Sex-Adjusted Models / Multivariable Adjusted Models*
Hazards Ratio (95% CI) / p / Hazards Ratio (95% CI) / p
Model A. CVD risks associated with metabolic syndrome and diabetes, not adjusting for office-based subclinical disease†
Referent group‡ / Referent / Referent
Metabolic syndrome§ / 1.70 (1.19-2.45) / 0.004 / 1.61 (1.12-2.33) / 0.01
Diabetes / 2.52 (1.49-4.26) / 0.0005 / 2.37 (1.55-3.60) / 0.003
Model B. CVD risks associated with metabolic syndrome and diabetes, adjusting for office-based subclinical disease† as a dichotomous variable (office-based subclinical disease† in at least 1 territory)
Referent group‡ / Referent / Referent
Metabolic syndrome§ / 1.62 (1.13-2.34) / 0.009 / 1.55 (1.07-2.24) / 0.02
Diabetes / 2.21 (1.29-3.77) / 0.004 / 2.10 (1.19-3.71) / 0.01
Subclinical disease present / 1.82 (1.20-2.75) / 0.005 / 1.74 (1.14-2.66) / 0.01
Model C. CVD risks associated with metabolic syndrome and diabetes adjusting for office-based subclinical disease† as a continuous variable (sum of affected territories)
Referent group‡ / Referent / Referent
Metabolic syndrome§ / 1.62 (1.12-2.33) / 0.01 / 1.55 (1.07-2.24) / 0.02
Diabetes / 2.19 (1.28-3.74) / 0.004 / 2.06 (1.16-3.64) / 0.01
Subclinical disease sum / 1.72 (1.22-2.43) / 0.002 / 1.63 (1.15-2.32) / 0.006
Model D. CVD risks associated with metabolic syndrome and diabetes, by presence versus absence of office-based subclinical disease†
Referent group‡, subclinical disease absent / Referent / Referent
Referent group‡, subclinical disease present / 1.63 (0.77-3.45) / 0.20 / 1.38 (0.65-2.95) / 0.40
Metabolic syndrome§, subclinical disease absent / 1.56 (1.04-2.34) / 0.04 / 1.47 (0.98-2.23) / 0.07
Metabolic syndrome§, subclinical disease present / 3.14 (1.77-5.55) / <0.0001 / 2.71 (1.51-4.86) / 0.0008
Diabetes, subclinical disease absent / 2.26 (1.17-4.36) / 0.02 / 1.79 (0.84-3.80) / 0.13
Diabetes, subclinical disease present / 3.77 (1.78-8.01) / 0.0006 / 4.07 (1.91-8.64) / 0.001

Values are Cox proportional hazards ratios (95% confidence intervals).

* Adjusted for age, sex, low-density lipoprotein and smoking, in addition to the metabolic syndrome, diabetes and subclinical vascular disease.

† Defined as left ventricular hypertrophy by Cornell criteria, ankle-brachial index ≤0.9, or microalbuminuria.

‡No Metabolic syndrome or diabetes.

§No Diabetes.

Abbreviations: CVD, cardiovascular disease.

Supplementary Table 3. Comparisonof mean levels of CVD risk factors in the Study Sample with that in Individuals Excluded Due To Missing Data

Characteristic / Study Sample
(N=1945) / Excluded Due To Missing Data
(N=1172)
Age, years / 57±9 / 60±10
Women, % / 59% / 50%
Systolic BP, mmHg / 127±19 / 130±18
Diastolic BP, mmHg / 75±9 / 76±10
Total cholesterol, mg/dL / 207±38 / 207±42
LDL cholesterol, mg/dL / 127±34 / 129±33
HDL cholesterol, mg/dL / 53±16 / 50±16
Triglycerides, mg/dL / 133±90 / 147±180
Fasting blood glucose mg/dL / 100±23 / 106±30
Body mass index, kg/m2 / 27±5 / 29± 6
Current smokers, % / 14% / 16%

Values are means ± standard deviations or percentages.