1
Supplemental Table S1. Genes upregulated by daptomycin
ID / Gene Symbol / Sub Category / Gene/Protein Name / Fold ChangeaAmino acid biosynthesis
SA1401 / tyrA / Aromatic amino acid family / prephenate dehydrogenase / 1.71
SA1362 / hom / Aspartate family / homoserine dehydrogenase / 5.73
SA1430 / dapA / Aspartate family / dihydrodipicolinate synthase / 3.76
SA1429 / asd / Aspartate family / aspartate-semialdehyde dehydrogenase / 3.24
SA1363 / thrC / Aspartate family / threonine synthase / 3.06
SA1431 / dapB / Aspartate family / dihydrodipicolinate reductase / 2.66
SA1364 / thrB / Aspartate family / homoserine kinase / 2.48
SA1435 / lysA / Aspartate family / diaminopimelate decarboxylase / 1.87
SA0600 / ilvE / Pyruvate family / branched-chain amino acid aminotransferase / 2.18
SA0503 / NA / Serine family / trans-sulfuration enzyme family protein / 2.80
SA0557 / cysK / Serine family / cysteine synthase / 2.28
SA0502 / NA / Serine family / cysteine synthase/cystathionine beta-synthase family protein / 2.00
SA2105 / glyA / Serine family / serine hydroxymethyltransferase / 1.92
Purines, pyrimidines, nucleosides, and nucleotides
SA0124 / deoB / Other / phosphopentomutase / 1.72
SA0926 / NA / Other / 5-nucleotidase family protein / 1.63
SA0123 / deoC1 / Other / deoxyribose-phosphate aldolase / 1.63
SA2129 / deoC2 / Other / deoxyribose-phosphate aldolase / 1.52
SA2130 / deoD2 / Salvage of nucleosides and nucleotides / purine nucleoside phosphorylase / 2.96
SA0121 / deoD1 / Salvage of nucleosides and nucleotides / purine nucleoside phosphorylase / 2.25
SA0225 / NA / Salvage of nucleosides and nucleotides / inosine-uridine preferring nucleoside hydrolase / 2.21
SA2128 / pdp / Salvage of nucleosides and nucleotides / pyrimidine-nucleoside phosphorylase / 1.92
Fatty acid and phospholipid metabolism
SA0426 / NA / Biosynthesis / acetyl-CoA acetyltransferase / 3.09
SA2482 / fabG2 / Biosynthesis / 3-oxoacyl-(acyl carrier protein) reductase, authentic point mutation / 2.46
SA1351 / cls1 / Biosynthesis / cardiolipin synthetase / 1.78
SA1244 / fabD / Biosynthesis / malonyl CoA-acyl carrier protein transacylase / 1.51
SA1814 / NA / Degradation / lysophospholipase, putative / 2.14
SA2694 / geh / Degradation / lipase / 1.65
SA1439 / NA / Other / acylphosphatase / 2.70
Biosynthesis of cofactors, prosthetic groups, and carriers
SA2105 / glyA / Folic acid / serine hydroxymethyltransferase / 1.92
SA1325 / gpxA1 / Glutathione and analogs / glutathione peroxidase / 1.67
SA2598 / NA / Heme, porphyrin, and cobalamin / cobalamin synthesis protein, putative / 1.89
SA2262 / mobA / Molybdopterin / molybdopterin-guanine dinucleotide biosynthesis protein A / 1.56
SA0236 / NA / Other / 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, putative / 2.88
SA0915 / sufD / Other / FeS assembly protein SufD / 2.01
SA2579 / NA / Other / phytoene dehydrogenase / 1.84
SA2561 / NA / Other / hydroxymethylglutaryl-CoA synthase / 1.83
SA0637 / mvaD / Other / mevalonate diphosphate decarboxylase / 1.69
SA0240 / NA / Other / 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, putative / 1.66
SA0638 / NA / Other / phosphomevalonate kinase / 1.64
SA1223 / coaBC / Pantothenate and coenzyme A / phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase / 2.06
SA1735 / coaE / Pantothenate and coenzyme A / dephospho-CoA kinase / 1.94
SA2614 / panC / Pantothenate and coenzyme A / pantoate--beta-alanine ligase / 1.89
SA2616 / NA / Pantothenate and coenzyme A / 2-dehydropantoate 2-reductase PanE, putative / 1.81
SA2615 / panB / Pantothenate and coenzyme A / 3-methyl-2-oxobutanoate hydroxymethyltransferase / 1.78
SA1974 / nadE / Pyridine nucleotides / NH(3)-dependent NAD+ synthetase / 1.98
SA1818 / ribBA / Riboflavin, FMN, and FAD / 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II / 7.12
SA1820 / ribD / Riboflavin, FMN, and FAD / riboflavin biosynthesis protein RibD / 5.51
SA1819 / ribE / Riboflavin, FMN, and FAD / riboflavin synthase, alpha subunit / 5.11
SA1817 / ribH / Riboflavin, FMN, and FAD / riboflavin synthase, beta subunit / 4.89
SA0626 / thiD1 / Thiamine / phosphomethylpyrimidine kinase / 1.73
SA2085 / thiD2 / Thiamine / phosphomethylpyrimidine kinase / 1.51
Central intermediary metabolism
SA0616 / nagB / Amino sugars / glucosamine-6-phosphate isomerase / 2.46
SA2282 / ureC / Nitrogen metabolism / urease, alpha subunit / 2.41
SA2284 / ureF / Nitrogen metabolism / urease accessory protein UreF / 2.03
SA2283 / ureE / Nitrogen metabolism / urease accessory protein UreE / 2.00
SA2285 / ureG / Nitrogen metabolism / urease accessory protein UreG / 1.90
SA2280 / ureA / Nitrogen metabolism / urease, gamma subunit / 1.68
SA2570 / NA / Other / galactoside O-acetyltransferase / 2.89
SA0173 / ipdC / Other / indole-3-pyruvate decarboxylase / 1.93
SA2561 / NA / Other / hydroxymethylglutaryl-CoA synthase / 1.83
SA0637 / mvaD / Other / mevalonate diphosphate decarboxylase / 1.69
SA1920 / NA / Other / D-isomer specific 2-hydroxyacid dehydrogenase family protein / 1.63
SA2574 / NA / Other / D-isomer specific 2-hydroxyacid dehydrogenase family protein / 1.54
Energy metabolism
SA2569 / NA / Amino acids and amines / delta-1-pyrroline-5-carboxylate dehydrogenase, putative / 2.31
SA2323 / hutI / Amino acids and amines / imidazolonepropionase / 2.05
SA0960 / rocD2 / Amino acids and amines / ornithine aminotransferase / 1.85
SA2154 / rocF / Amino acids and amines / arginase / 1.84
SA2327 / hutG / Amino acids and amines / formiminoglutamase / 1.80
SA1816 / putA / Amino acids and amines / proline dehydrogenase / 1.79
SA1593 / NA / Amino acids and amines / glycine cleavage system P protein, subunit 2 / 1.72
SA0973 / NA / Amino acids and amines / fumarylacetoacetate hydrolase family protein / 1.67
SA1594 / NA / Amino acids and amines / glycine cleavage system P protein, subunit 1 / 1.63
SA1595 / gcvT / Amino acids and amines / glycine cleavage system T protein / 1.57
SA2186 / NA / Biosynthesis and degradation of polysaccharides / galactose-6-phosphate isomerase, LacA subunit / 1.74
SA2029 / cscA / Biosynthesis and degradation of polysaccharides / sucrose-6-phosphate hydrolase / 1.55
SA2180 / lacG / Biosynthesis and degradation of polysaccharides / 6-phospho-beta-galactosidase / 1.52
SA0875 / NA / Electron transport / thioredoxin, putative / 2.62
SA1094 / cydA / Electron transport / cytochrome d ubiquinol oxidase, subunit I / 2.49
SA0494 / nuoF / Electron transport / NADH dehydrogenase I, F subunit / 2.26
SA0829 / trxB / Electron transport / thioredoxin reductase / 2.14
SA1095 / cydB / Electron transport / cytochrome d ubiquinol oxidase, subunit II / 2.02
SA2534 / frp / Electron transport / NAD(P)H-flavin oxidoreductase / 1.95
SA0453 / NA / Electron transport / NAD(P)H-flavin oxidoreductase, putative / 1.88
SA0975 / NA / Electron transport / coenzyme A disulfide reductase / 1.83
SA2273 / fdhD / Electron transport / formate dehydrogenase accessory protein FdhD / 1.63
SA2114 / NA / Fermentation / aldehyde dehydrogenase / 4.39
SA0154 / aldA1 / Fermentation / aldehyde dehydrogenase / 4.26
SA2178 / NA / Fermentation / alcohol dehydrogenase, zinc-containing / 3.27
SA1984 / aldA2 / Fermentation / aldehyde dehydrogenase / 2.70
SA0241 / NA / Fermentation / alcohol dehydrogenase, zinc-containing / 2.34
SA2177 / NA / Fermentation / alcohol dehydrogenase, zinc-containing / 1.99
SA2367 / NA / Fermentation / alcohol dehydrogenase, zinc-containing / 1.95
SA2527 / NA / Glycolysis/gluconeogenesis / fructose-1,6-bisphosphatase, putative / 2.45
SA2622 / fdaB / Glycolysis/gluconeogenesis / fructose-bisphosphate aldolase, class I / 2.38
SA0840 / tpiA / Glycolysis/gluconeogenesis / triosephosphate isomerase / 2.19
SA0838 / gapA1 / Glycolysis/gluconeogenesis / glyceraldehyde 3-phosphate dehydrogenase / 2.12
SA0758 / fruK / Glycolysis/gluconeogenesis / 1-phosphofructokinase / 2.08
SA0842 / eno / Glycolysis/gluconeogenesis / enolase / 1.94
SA0841 / pgm / Glycolysis/gluconeogenesis / phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent / 1.75
SA2117 / fbaA / Glycolysis/gluconeogenesis / fructose-bisphosphate aldolase, class II / 1.66
SA0839 / pgk / Glycolysis/gluconeogenesis / phosphoglycerate kinase / 1.59
SA2618 / ldh2 / Glycolysis/gluconeogenesis / L-lactate dehydrogenase / 1.59
SA2435 / NA / Other / glycerate kinase / 5.02
SA2624 / NA / Other / acetyl-CoA synthetase, putative / 2.80
SA1783 / acs / Other / acetyl-CoA synthetase / 2.67
SA2553 / NA / Other / pyruvate oxidase / 2.18
SA0805 / NA / Other / glycerate kinase family protein / 1.71
SA0123 / deoC1 / Other / deoxyribose-phosphate aldolase / 1.63
SA1321 / glpD / Other / aerobic glycerol-3-phosphate dehydrogenase / 1.61
SA2129 / deoC2 / Other / deoxyribose-phosphate aldolase / 1.52
SA1831 / tal / Pentose phosphate pathway / transaldolase / 3.02
SA1549 / zwf / Pentose phosphate pathway / glucose-6-phosphate 1-dehydrogenase / 2.25
SA1377 / tkt / Pentose phosphate pathway / transketolase / 1.52
SA0617 / NA / Sugars / hexulose-6-phosphate synthase, putative / 3.44
SA2149 / mtlD / Sugars / mannitol-1-phosphate 5-dehydrogenase / 2.21
SA0598 / NA / Sugars / L-ribulokinase, putative / 1.81
SA2028 / NA / Sugars / fructokinase, putative / 1.67
SA2515 / gntK / Sugars / gluconokinase / 1.51
SA1742 / gltA / TCA cycle / citrate synthase / 2.05
Transport and binding proteins
SA2452 / NA / Amino acids, peptides and amines / amino acid ABC transporter, permease protein / 3.34
SA2453 / NA / Amino acids, peptides and amines / amino acid ABC transporter, ATP-binding protein / 3.09
SA0781 / NA / Amino acids, peptides and amines / osmoprotectant ABC transporter, ATP-binding protein, putative / 2.69
SA2451 / NA / Amino acids, peptides and amines / amino acid ABC transporter, amino acid-binding protein / 2.65
SA2176 / opuD2 / Amino acids, peptides and amines / osmoprotectant transporter, BCCT family / 2.36
SA2450 / NA / Amino acids, peptides and amines / amino acid ABC transporter, permease protein / 2.22
SA0783 / opuBB / Amino acids, peptides and amines / osmoprotectant ABC transporter, permease protein / 2.17
SA2411 / NA / Amino acids, peptides and amines / amino acid ABC transporter, permease protein / 1.80
SA2619 / NA / Amino acids, peptides and amines / amino acid permease / 1.59
SA1457 / NA / Carbohydrates, organic alcohols, and acids / PTS system, IIA component / 2.92
SA2148 / NA / Carbohydrates, organic alcohols, and acids / PTS system, mannitol-specific IIA component / 2.11
SA0759 / NA / Carbohydrates, organic alcohols, and acids / PTS system, fructose-specific IIABC component, authentic frameshift / 2.11
SA2514 / gntP / Carbohydrates, organic alcohols, and acids / gluconate transporter, permease protein / 1.91
SA0454 / NA / Carbohydrates, organic alcohols, and acids / sodium:dicarboxylate symporter family protein / 1.88
SA0224 / NA / Carbohydrates, organic alcohols, and acids / PTS system, IIBC components / 1.66
SA0825 / hprK / Carbohydrates, organic alcohols, and acids / HPr kinase/phosphatase / 1.65
SA2181 / lacE / Carbohydrates, organic alcohols, and acids / PTS system, lactose-specific IIBC components / 1.62
SA2246 / NA / Carbohydrates, organic alcohols, and acids / sugar transporter, putative / 1.58
SA2067 / kdpB / Cations and iron carrying compounds / potassium-transporting P-type ATPase, B subunit / 2.55
SA2066 / kdpC / Cations and iron carrying compounds / potassium-transporting ATPase, C subunit / 2.33
SA2068 / kdpA / Cations and iron carrying compounds / potassium-transporting ATPase, A subunit / 2.03
SA0799 / NA / Cations and iron carrying compounds / transferrin receptor / 1.91
SA2721 / nixA / Cations and iron carrying compounds / high-affinity nickel-transport protein / 1.80
SA0705 / NA / Cations and iron carrying compounds / iron compound ABC transporter, permease protein / 1.78
SA0952 / mnhD / Cations and iron carrying compounds / Na+/H+ antiporter, MnhD component / 1.63
SA2375 / NA / Cations and iron carrying compounds / transporter, CorA family / 1.60
SA0706 / NA / Cations and iron carrying compounds / iron compound ABC transporter, permease protein / 1.58
SA0955 / mnhA / Cations and iron carrying compounds / Na+/H+ antiporter, MnhA component / 1.55
SA0954 / mnhB / Cations and iron carrying compounds / Na+/H+ antiporter, MnhB component / 1.54
SA0098 / sirB / Cations and iron carrying compounds / iron compound ABC transporter, permease protein SirB / 1.52
SA2416 / NA / Cations and iron carrying compounds / cation efflux family protein / 1.50
SA2413 / NA / Other / drug resistance transporter, EmrB/QacA subfamily / 2.69
SA0754 / norA / Other / multi drug resistance protein (norA) / 2.09
SA2252 / NA / Other / AcrB/AcrD/AcrF family protein / 2.04
SA0694 / NA / Other / tagH protein, teichoic acid ABC transporter protein, putative / 1.89
SA0122 / NA / Other / tetracycline resistance protein, putative / 1.88
SA1007 / NA / Other / protozoan/cyanobacterial globin family protein / 1.68
SA0695 / NA / Other / tagG protein, teichoic acid ABC transporter protein, putative / 1.62
SA0744 / NA / Unknown substrate / ABC transporter, ATP-binding protein, MsbA family / 2.48
SA0745 / NA / Unknown substrate / ABC transporter, ATP-binding protein, MsbA family / 2.35
SA0883 / NA / Unknown substrate / ABC transporter, permease protein / 2.33
SA0882 / NA / Unknown substrate / ABC transporter, ATP-binding protein / 2.00
SA0700 / abcA / Unknown substrate / ABC transporter, ATP-binding/permease protein / 1.77
SA2471 / NA / Unknown substrate / transporter, putative / 1.73
SA2279 / NA / Unknown substrate / transporter, putative / 1.71
SA1893 / NA / Unknown substrate / ABC transporter, ATP-binding protein / 1.66
SA0506 / NA / Unknown substrate / ABC transporter, substrate-binding protein / 1.56
SA0884 / NA / Unknown substrate / ABC transporter, substrate-binding protein / 1.54
DNA metabolism
SA1513 / hup / Chromosome-associated proteins / DNA-binding protein HU / 1.54
SA1955 / dinP / DNA replication, recombination, and repair / DNA-damage-inducible protein P / 2.44
SA1224 / priA / DNA replication, recombination, and repair / primosomal protein N` / 2.04
SA1736 / fpg / DNA replication, recombination, and repair / formamidopyrimidine-DNA glycosylase / 1.96
SA1303 / NA / DNA replication, recombination, and repair / competence/damage-inducible protein CinA / 1.94
SA0522 / recR / DNA replication, recombination, and repair / recombination protein RecR / 1.83
SA1489 / recU / DNA replication, recombination, and repair / recombination protein U / 1.80
SA0970 / rexB / DNA replication, recombination, and repair / exonuclease RexB / 1.78
SA0572 / radA / DNA replication, recombination, and repair / DNA repair protein RadA / 1.75
SA1150 / rnhC / DNA replication, recombination, and repair / ribonuclease HIII / 1.72
SA1737 / polA / DNA replication, recombination, and repair / DNA polymerase I / 1.71
SA1157 / uvrC / DNA replication, recombination, and repair / excinuclease ABC, C subunit / 1.70
SA1492 / nth / DNA replication, recombination, and repair / endonuclease III / 1.53
SA0547 / mfd / DNA replication, recombination, and repair / transcription-repair coupling factor / 1.52
SA1966 / pcrA / DNA replication, recombination, and repair / ATP-dependent DNA helicase PcrA, FRAMESHIFT / 1.50
Protein synthesis
SA1516 / rpsA / Ribosomal proteins: synthesis and modification / ribosomal protein S1 / 2.88
SA1635 / prmA / Ribosomal proteins: synthesis and modification / ribosomal protein L11 methyltransferase / 2.14
SA1292 / rpsO / Ribosomal proteins: synthesis and modification / ribosomal protein S15 / 1.56
SA2232 / rplP / Ribosomal proteins: synthesis and modification / ribosomal protein L16 / 1.50
SA1257 / rplS / Ribosomal proteins: synthesis and modification / ribosomal protein L19 / 1.50
SA0815 / NA / Translation factors / ribosomal subunit interface protein / 2.30
SA1282 / proS / tRNA aminoacylation / prolyl-tRNA synthetase / 2.07
SA0576 / cysS / tRNA aminoacylation / cysteinyl-tRNA synthetase / 1.57
SA1012 / NA / tRNA and rRNA base modification / ribosomal large subunit pseudouridine synthases, RluD subfamily / 1.85
Protein fate
SA0570 / clpC / Degradation of proteins, peptides, and glycopeptides / ATP-dependent Clp protease, ATP-binding subunit ClpC, authentic frameshift / 3.98
SA0979 / clpB / Degradation of proteins, peptides, and glycopeptides / ATP-dependent Clp protease, ATP-binding subunit ClpB / 3.87
SA2563 / NA / Degradation of proteins, peptides, and glycopeptides / ATP-dependent Clp protease, putative / 3.68
SA1777 / NA / Degradation of proteins, peptides, and glycopeptides / serine protease HtrA, putative / 3.06
SA0833 / clpP / Degradation of proteins, peptides, and glycopeptides / ATP-dependent Clp protease, proteolytic subunit ClpP / 2.97
SA0595 / NA / Degradation of proteins, peptides, and glycopeptides / peptidase, M20/M25/M40 family / 2.37
SA2463 / pepA2 / Degradation of proteins, peptides, and glycopeptides / glutamyl-aminopeptidase / 2.09
SA1005 / pepF / Degradation of proteins, peptides, and glycopeptides / oligoendopeptidase F / 2.06
SA1555 / NA / Degradation of proteins, peptides, and glycopeptides / peptidase, M20/M25/M40 family / 1.98
SA1281 / NA / Degradation of proteins, peptides, and glycopeptides / membrane-associated zinc metalloprotease, putative / 1.88
SA1795 / pepA1 / Degradation of proteins, peptides, and glycopeptides / glutamyl aminopeptidase / 1.76
SA0085 / NA / Degradation of proteins, peptides, and glycopeptides / peptidase, M20/M25/M40 family / 1.66
SA1721 / clpX / Degradation of proteins, peptides, and glycopeptides / ATP-dependent Clp protease, ATP-binding subunit ClpX / 1.57
SA1937 / pepS / Degradation of proteins, peptides, and glycopeptides / aminopeptidase PepS / 1.53
SA1897 / NA / Protein and peptide secretion and trafficking / protein export protein PrsA, putative / 9.59
SA0969 / spsB / Protein and peptide secretion and trafficking / signal peptidase IB / 2.56
SA0418 / NA / Protein and peptide secretion and trafficking / mttA/Hcf106 family protein / 2.14
SA0816 / secA / Protein and peptide secretion and trafficking / preprotein translocase, SecA subunit / 1.90
SA0968 / spsA / Protein and peptide secretion and trafficking / signal peptidase IA, inactive / 1.71
SA2671 / NA / Protein and peptide secretion and trafficking / secA family protein / 1.65
SA1693 / yajC / Protein and peptide secretion and trafficking / preprotein translocase, YajC subunit / 1.57
SA2016 / groEL / Protein folding and stabilization / chaperonin, 60 kDa / 3.81
SA1637 / dnaK / Protein folding and stabilization / dnaK protein / 3.68
SA1638 / grpE / Protein folding and stabilization / heat shock protein GrpE / 3.28
SA2017 / groES / Protein folding and stabilization / chaperonin, 10 kDa / 2.84
SA0556 / NA / Protein folding and stabilization / chaperonin, 33 kDa / 2.15
SA1271 / hslU / Protein folding and stabilization / heat shock protein HslVU, ATPase subunit HslU / 2.12
SA2385 / NA / Protein folding and stabilization / heat shock protein, Hsp20 family / 2.04
SA1636 / dnaJ / Protein folding and stabilization / dnaJ protein / 1.90
SA0957 / NA / Protein folding and stabilization / peptidyl-prolyl cis-trans isomerase, cyclophilin-type / 1.71
SA1459 / NA / Protein modification and repair / peptide methionine sulfoxide reductase, degenerate / 3.08
SA1034 / NA / Protein modification and repair / lipoate-protein ligase A family protein / 2.48
SA1100 / def1 / Protein modification and repair / polypeptide deformylase / 1.78
SA1397 / msrA / Protein modification and repair / peptide methionine sulfoxide reductase / 1.72
SA0826 / lgt / Protein modification and repair / prolipoprotein diacylglyceryl transferase / 1.67
SA1946 / NA / Protein modification and repair / methionine aminopeptidase, type I / 1.66
Regulatory functions
SA1639 / hrcA / DNA interactions / heat-inducible transcription repressor HrcA / 3.58
SA2147 / NA / DNA interactions / transcriptional antiterminator, BglG family/DNA-binding protein / 2.39
SA2517 / NA / DNA interactions / transcriptional regulator, MerR family / 2.18
SA2349 / NA / DNA interactions / transcriptional regulator, TetR family / 2.14
SA0837 / gapR / DNA interactions / gap transcriptional regulator / 2.09
SA0731 / NA / DNA interactions / transcriptional regulator, LysR family / 1.91
SA2646 / NA / DNA interactions / DNA-binding response regulator / 1.90
SA0567 / ctsR / DNA interactions / transcriptional regulator CtsR / 1.86
SA0757 / NA / DNA interactions / transcriptional regulator, DeoR family / 1.81
SA2193 / NA / DNA interactions / transcriptional regulator, MerR family / 1.73
SA1272 / codY / DNA interactions / transcriptional regulator CodY / 1.63
SA2302 / NA / Other / transcriptional regulator, putative / 3.57
SA1398 / NA / Other / transcriptional regulator, putative / 3.17
SA1003 / NA / Other / negative regulator of competence MecA, putative / 2.96
SA2140 / NA / Other / lytic regulatory protein, authentic frameshift / 1.92
SA1065 / NA / Other / transcriptional regulator, putative / 1.85
SA2585 / NA / Other / regulatory protein, putative / 1.57
SA1891 / NA / Protein interactions / RNAIII-activating protein TRAP / 2.05
SA2646 / NA / Protein interactions / DNA-binding response regulator / 1.90
SA2070 / kdpD / Protein interactions / sensor histidine kinase KdpD / 1.52
SA2147 / NA / RNA interactions / transcriptional antiterminator, BglG family/DNA-binding protein / 2.39
SA0691 / sirR / Small molecule interactions / iron-dependent repressor / 1.63
Signal transduction
SA1457 / NA / PTS / PTS system, IIA component / 2.92
SA2148 / NA / PTS / PTS system, mannitol-specific IIA component / 2.11
SA0759 / NA / PTS / PTS system, fructose-specific IIABC component, authentic frameshift / 2.11
SA0224 / NA / PTS / PTS system, IIBC components / 1.66
SA0825 / hprK / PTS / HPr kinase/phosphatase / 1.65
SA1942 / vraR / Two-component systems / DNA-binding response regulator VraR / 10.39
SA1943 / vraS / Two-component systems / sensor histidine kinase VraS / 9.57
SA2646 / NA / Two-component systems / DNA-binding response regulator / 1.90
SA0766 / saeR / Two-component systems / DNA-binding response regulator SaeR / 1.81
SA0765 / saeS / Two-component systems / sensor histidine kinase SaeS / 1.62
SA2070 / kdpD / Two-component systems / sensor histidine kinase KdpD / 1.52
Cell envelope
SA1522 / NA / Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides / elastin binding protein, putative / 2.39
SA0548 / NA / Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides / polysaccharide biosynthesis protein / 1.90
SA0764 / NA / Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides / glycosyl transferase, group 2 family protein / 1.89
SA1498 / NA / Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides / glycosyl transferase, group 1 family protein / 1.54
SA0243 / NA / Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides / glycosyl transferase, group 2 family protein / 1.52
SA1066 / NA / Biosynthesis of murein sacculus and peptidoglycan / fmt protein / 4.93
SA2116 / murAB / Biosynthesis of murein sacculus and peptidoglycan / UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2 / 4.14
SA0248 / lrgB / Biosynthesis of murein sacculus and peptidoglycan / lrgB protein / 3.56
SA2352 / tcaA / Biosynthesis of murein sacculus and peptidoglycan / tcaA protein / 3.03
SA0247 / lrgA / Biosynthesis of murein sacculus and peptidoglycan / holin-like protein LrgA / 2.70
SA1490 / pbp2 / Biosynthesis of murein sacculus and peptidoglycan / penicillin-binding protein 2 / 2.21
SA0263 / lytM / Biosynthesis of murein sacculus and peptidoglycan / peptidoglycan hydrolase / 2.20
SA1161 / murI / Biosynthesis of murein sacculus and eptidoglycan / glutamate racemase / 1.99
SA2074 / NA / Biosynthesis of murein sacculus and peptidoglycan / D-alanine--D-alanine ligase / 1.82
SA0694 / NA / Biosynthesis of murein sacculus and peptidoglycan / tagH protein, teichoic acid ABC transporter protein, putative / 1.75
SA0693 / tagA / Biosynthesis of murein sacculus and peptidoglycan / UDP-N-acetyl-D-mannosamine transferase / 1.70
SA0238 / NA / Biosynthesis of murein sacculus and peptidoglycan / teichoic acid biosynthesis protein, putative / 1.70
SA0697 / tagX / Biosynthesis of murein sacculus and peptidoglycan / teichoic acid biosynthesis protein X / 1.65
SA2151 / glmM / Biosynthesis of murein sacculus and peptidoglycan / phosphoglucosamine mutase GlmM / 1.65
SA0695 / NA / Biosynthesis of murein sacculus and peptidoglycan / tagG protein, teichoic acid ABC transporter protein, putative / 1.62
SA2253 / femX / Biosynthesis of murein sacculus and peptidoglycan / femX protein / 1.53
SA2451 / NA / Other / amino acid ABC transporter, amino acid-binding protein / 2.65
SA2554 / NA / Other / membrane protein, putative / 2.03
SA2668 / sasF / Other / LPXTG cell wall surface anchor family protein / 1.92
SA0799 / NA / Other / transferrin receptor / 1.91
SA1589 / NA / Other / lipoprotein, putative / 1.77
SA1762 / NA / Other / thiol peroxidase, putative / 1.66
SA2694 / geh / Other / lipase / 1.65
SA2539 / srtA / Other / sortase / 1.64
SA0466 / NA / Other / membrane protein, putative / 1.57
SA1021 / NA / Other / membrane protein, putative / 1.56
SA2520 / NA / Other / membrane protein, putative / 1.54
Cellular processes
SA1759 / NA / Adaptations to atypical conditions / universal stress protein family / 2.74
SA0958 / NA / Adaptations to atypical conditions / general stress protein 13 / 2.14
SA1010 / relA1 / Adaptations to atypical conditions / GTP pyrophosphokinase / 2.07
SA1437 / NA / Adaptations to atypical conditions / cold shock protein, CSD family / 1.68