Curriculum Vitae
Lotfollah Saghaie (PhD, King's College of London, 1996)
Position: Professor of Medicinal Chemistry
Telehone number: 0098-311-7922565
Fax: 0098-311-6680011
Email address:
Postal address: Department of Medicinal Chemistry,
School of Pharmacy, Isfahan University of Medical Sciences,Isfahan,IRAN.
Research interests: Design and synthesis of 3-hydroxppyridin-4one derivatives as orally active iron(III) chelators which are useful for treatment of iron overload in thalassaemia and sickle cell anaemia and also malaria.
Articles:
1- Hider RC, Choudhury R, Rai BL, Dhkordi LS, Singh S. Design of Orally Active Iron Chelators. Acta Haematol. 1996; 95: 9-12.
2- Hobgood , Liu , Dhkordi LS, Khodr HC, Abbott JA , Hider RC. Investigation into the Correlation between the Structure of Hydroxypyridinones and Blood-Brain Barrier Permeability. Biochemical Pharmacology. 1999; 57: 1305-10.
3- Rai BL, Dekhordi LS, Khodr H, Jin Y, Liu Z D, Hider RC. Synthesis, Physicochemical properties and evaluation of N-substituted-2 alkyl-3-hydroxy-4(1H)-pyridinones. J. Med. Chem., 1998, 41: 3347-3359.
4- Saghaie L. Synthesis of N-acetonitril and N-ethylamine-3-hydroxypyridinones as iron(III) chelators. Reaserch in Medical Sciences. 2000; 5(2): 24-29.
5- Saghaie P, Saghaie L. Study of some biochemical and heamatological serum parameters in suspicious intoxified workers with zinc. Urmia Medical Journal. 2002; 13(1): 33-40.
6- Saghaie L, Hider RC and Mostafavi S. Comparison automated continuous flow method with shake-flask method in determining partition coefficients of bidentate hydroxypyridinone ligands.Daru 2003; 11: 38-48.
7- Saghaie L , Houshfar G, Neishabor M. Synthesis and Determination of Partition Coefficients of Zinc Complexes with Clinical Potential. Iranin Journal of Pharmaceutical Reaserch, 204; 4 : 201-207.
8- Taher M, Saghaie L, Abrahilmi M. Investigation of intestinal bsorption of pyridinones in rat. Iranian Pharmaceutical Research 2004; 4: 201-207.
9- A Mostafavi, L Saghaie, M Taher and N Manteghi. Inhibition of Liver Toxicity by 2-Methyl-3-Hydroxypyridin-4-one in Iron Overloaded Rats. Iranin Journal of Pharmaceutical Sciences. 2006; 2(1): 35-40.
10- Foroumadi , Oboudiat M, Emami S, Karimollah A, Saghaie L, Moshafi MH, Shafiee A. Synthhesis and antibacterial activity of N-[2-[5-(methylthio)thiophen-2-yl]-2-oxoethyl] and N-[2-[5-(methylthio)thiophen-2-yl]-2-(oxyimino)ethyl]piperazinylquinolone derivatives. Bioorganic & Medicinal Chemistry . 2006; 14(10): 3421-27.
11. Saghaie L, Mirmohammad sadeghi M, Nikazma A. Synthesis and determination of partition coefficients of N-arylhydroxypyridinone derivatives as iron chelators. RPS 2006; 1: 40-48.
12- Jafarian Dehkordi A, Saghaie L and Rajabzadeh S. Ethyl Maltol as a New Ligand for Spectrophotometric Determination of Iron. Irnian Journal of Pharmaceutical Sciences. 2007; 3(2): 101-110.
13- Jafarian Dehkordi A, Saghaie L, Movahedi N. A new spectrophotometric method for direct determination of iron(III) in serum. DARU. 2008; 16(2): 76-82.
14- Saghaie L,. Hider RC. Synthesis and physico-chemical properties of a series of bidentate 3-hydroxypyridin-4-ones iron chelating agents. Research in Pharmaceutical Sciences (RPS. 2008; 3(1): 21-30.
15- Dehkordi LS, Liu Z D, Hider RC. Basic 3-Hydroxypyridin-4-ones: Potential Antimalarial Agents. Eur J Med Chem. 2008, 43 (5)) 1035-1047.
16- Fassihi A, Abedi D, Saghaie L, Sabet R, Fazeli H, Bostaki G, Deilami D, H Sadinpour H. Synthesis, antimicrobial evaluation and QSAR study of some 3-hydroxypyridine-4-one and 3-hydroxypyran-4-one derivatives. Eur J Med Chem. . 2009;44:2145-2157.
17- Fassihi A, Azadpour Z, Delbari N, Saghaie L,. Memarian HR, Sabet R, Alborzi A, Miri R, Pourabbas B, Mardaneh J, Mousavi P, Moeinifard B, Sadeghi-aliabadi H. Synthesis and antitubercular activity of novel 4-substituted imidazolyl-2,6-dimethyl-N3,N5-bisaryl-1,4-dihydropyridine-3,5-dicarboxamides. Eur J Med Chem. 2008; 44: 3253-3258.
18- Shahlaei M, Fassihi A, Saghaie L. Application of PC-ANN and PC-LS- SVM in QSAR of CCR1antagonist compounds: Acomparative study. Eur J Med Chem. 2010; 45: 1572–1582.
19- Saghaie L, Shahlaei M, Madadkar-Sobhani A , Fassihi A. Application of Partial Least Squares and Radial Basis Function Neural Networks in Multivariate Imaging Analysis-Quantitative Structure Activity Relationship: Study of Cyclin Dependent Kinase 4 Inhibitors. Journal of Molecular Graphics and Modelling. 2010; 29(4): 518-528.
20- Saghaie L, Shahlaei M, Fassihi A, Madadkar-Sobhani A , Fassihi A, Gholivand MB, Pourhossein A. QSAR analysis for some Diaryl Substituted Pyrazoles as CCR2 Inhibitors by GA-Stepwise MLR. Chem Biol Drug Des. 2011; 77: 75–85
21- Shahlaei M, Madadkar-Sobhani A, Mahnam K, Fassihi A, Saghaie L and Mansurian M. Homology modeling of human CCRS and analysis of its binding properties through molecular docking and molecular dynamics simulation. Biochim Biophys Acta. 2011 Mar; 1808 (3): 802-17
22- Shahlaei M,. Fassihi A,. Saghaie L,. Arkan E, and. Pourhossein A. A modeling study of aldehyde inhibitors of human cathepsin K using partial least squares method. Res Pharm Sci. 2011 Jul-Dec; 6(2): 71–80.
23 - Shahlaei M,. Fassihi A,. Saghaie L,. Arkan E, and. Pourhossein A .A QSAR study of some cyclobutendiones as CCR1 antagonists by artificial neural networks based on principal componeny analysis. DARU. 2011) 19(5):349–361
24 - Shahlaei M , Armin Madadkar- Sobhani A, Fassihi A, Saghaie L .Exploring a model of a chemokine receptor/ligand complex in an explicit membrane environment by molecular dynamics simulation: the human CCR1 receptor J. Chem. Inf. Model. 2011; 51 (10): 2717–2730.
25 - Saghaie L, Sadeghi-aliabadi H, and. Kafiri M. Synthesis and biological evaluation of bidentate 3-hydroxypyridin-4-ones iron chelating agents. Res Pharm Sci. 2011 Jul-Dec; 6(2): 117–122..
26 - Shahlaei M, Madadkar-Sobhani A, Fassihi A, Saghaie, L ,Shamshirian D,Sakhi H. Comparative quantitative structure-activity relationship study of some 1-aminocyclopentyl-3-carboxyamides as CCR2 inhibitors using stepwise MLR, FA-MLR, and GA'PLS. Med Chem Res.2012; 21: 100-115.
27 - Sabet R, Fassihi A, Hemmateenejad B, Saghaei S, MiriR, Gholami M. Computer-aided design of novel antibacterial 3-hydroxypyridine-4-ones: application of QSAR methods based on the MOLMAP Approach. J Comput Aided Mol Des (2012) 26:349–361.
28- Mohammadpour M, Sadeghi A, Fassihi A, Saghaie L, Movahedian A and Rostami M. Synthesis and antioxidant evaluation of some novel bidentate 3-hydroxypyridin-4-one iron chelators. RPS, 2012,7(3);159-169.
29- Sabet R, Behjati M, Vahabpour R, Memarnejadian A, Rostami M, Fassihi A, Aghasadeghi MR, Saghaie L, Miri R. Iron chelation afforded cardioprotection against H2O2-induced H9C2 cell injury: Application of novel 3-hydroxy pyridine-4-one derivatives. Int J Cardiol. 2012 Dec 15;162(1): 60-3.
30- Mansourian,M, Madadkar-SobhaniA Mahnam K, Fassihi A, Lotfollah Saghaie Characterization of adenosine receptor in its native environment: insights from molecular dynamics simulations of palmitoylated/glycosylated, membrane-eintegrated
human A2B adenosine receptor, Journal of Molecular Modeling (J Mol Model). 2012; 18(9):4309-24.
31-Bahri Najafi R, Saghaie L, Babaeimehr. Preparation and Pharmaceutical Evaluation of Ferrous Sulfate and Ascorbic acid Floating Matrix Table for Prevention of Anemia. Journal of Reports in Pharmaceutical Sciences. 2012, 1(2): 65-72.
32- Rafieepour S, Saghaie L, Fassihi A. Conformational Properties of Novel 1,2,3,4- Tetrahydropyridinone (thione) Derivatives: A DFT study.. JRPS 2012, 1(2): 110-118.
33- Sedaghati B, Arbabi S, RanjbarM, Abedi D, Fassihi A, Memarian HR, Saghaie L, Omidi A, Sardari AR, Jalali M. Synthesis and antimicrobial activity of novel derivatives of Biginelli pyrimidines. Medicinal Chemistry Research, 2012, 21: 3973-3983.
34- Saghaie L , Shahlaei M, . Fassihi A. Quantitative structure activities relationships of some 2-mercaptoimidazoles as CCR2 inhibitors using genetic algorithm-artificial neural networks. RPS. 2013; 8(2): 97-112.
35- Saghaie L, Sakhi H, Sabzyan H, Shahlaei M and. Shamshirian D. Stepwise MLR and PCR QSAR study of the pharmaceutical activities of antimalarial 3-hydroxypyridinone agents using B3LYP/6-311++G** descriptors. Med Chem Res
2013, 22:1679–1688
36- Sadeghi-aliabadi H, Saghaie L, Tadayonnia N, Mirian M. Hydroxypyridinone derivatives: synthesis and cytotoxic evaluation. JRPS 2013, 2(1): 5-15.
37 - Mohsen Shahlaei, Afshin Fassihi, Lotfollah Saghaie, Elham Arkan, Armin Madadkar-Sobhani, Alireza Pourhossein. Computational evaluation of some indenopyrazole derivatives as anticancer compounds; application of QSAR and docking methodologies. Journal of Enzyme Inhibition and Medicinal Chemistry. 2013, 28 (1): 16-.32
38- Saghaie L, Sadeghi-aliabadi H, Ashaehshoar M. Synthesis, analysis and cytotoxic evaluation of some hydroxypyridinone derivatives on HeLa and K562 cell lines.RPS. 2013; 8(3). 185-195.
39- Saghaie L,. Pourfarzam M,. Fassihi A, SartippourB. Synthesis and tyrosinase inhibitory properties of some novel derivatives of kojic acid. RPS. 2013; 8(4): 233-242.
40-Badii A,Nekouei N, Mostafavi A, Saghaie L, Khodarahmi QA, Valadian S. Evaluation and comparison of zinc absorption level from 2-Alkyle 3-Hydroxy pyranon-zinc complexes and zinc sulfate in rat in vivo. Advanced Biomedical Research. 2013; 2(2): 139-142.
41- Mansourian M, Saghaie L, Fassihi A, Madadkar-SobhaniA Mahnam K. Linear and nonlinear QSAR modeling of 1,3,8-substituted-9-deazaxanthines as potential selective A2BAR antagonists. Med Chem Res.Accepted: 26 December 2012.
42-Hajhashemi V, Saghaie L, Fassihi A, Mojiri-Froshani H. A study on analgesic effects on four new derivatives of 3-hydroxy pyridine-4-one. RPS. 2012; 7(1): 37-42.
43- Shahlaei M, Zare A, Saghaie L, Fassihi, A. A. Prediction of partition coefficient for some 3-hydroxy pyridine-4-one derivatives using combined partial least square regression and genetic algorithm. RPS. 2014; 9(2): 143-153.
44- Oftadeha M, Saghaie L, Pirialama S. Theoretical evaluation of medicinal properties for some of N-aryl-3-hydroxypyridine-4-ones derivative compounds. Iran. Chem. Commun. 2 (2014) 82-92
45- Shahlaei M, Saghaie L .Prediction of p38 Inhibitory activity of 3,4-Dihydropyrido[3,2-d] pyrimidone derivatives using an expert system based on principal component analysis and least square support vector machine. RPS. 2014; 9(6): 471-488
46- Shahlaeia M, Hassanzadehb F, Emamic J, Sohrabib E, Saghaie L. Simultaneous Spectrophotometric Determination of Amlodipine and Metoprolol by Principal Component Regression Multivariate Calibration and Comparison with HPLC. JRPS. 2013, 2(2): 179-189.
47- Bahri Najafi R, Saghaie L, Mollabashi N. .Formulation and pharmaceutical evaluation of ferric-maltol floating tablet. JRPS.2014 (In Press)
48- Sepehri S, Gharagani S• Saghaie L. Aghasadeghi MR • Fassihi A•QSAR and docking studies of some 1,2,3,4-tetrahydropyrimidines: evaluation of gp41 as possible target for anti-HIV-1 activity. Med Chem Res 2014, On line(Acceptance)
49- Mansourian M, Fassihi A, Saghaie L, Madadkar-Sobhani A, Mahnam K, Abbasi M.. QSAR and docking analysis of A2B adenosine receptor antagonists based on non-xanthine scaffold. Med Chem Res 2014, On line(Acceptance)
50-Sirous N H, Zabihollahi R,. Aghasadeghi MR, Sadat SM , Saghaie L, Fassihi A. Docking studies of some5-hydroxypyridine-4-one derivatives: Evaluation of integrase and ribonuclease H domain of reverse transcriptase as possible targets for anti-HIV-1 activity. Medicinal Chemistry Research, Accepted.
013, 2(2), 179-189 2013, 2(2), 179-189 2013, 2(2), 179-189
کتابها:
الف) تالیف
1- لطف الله سقایی و سید فرید رحیم پور. شیمی تجزیه (برای دانشجویان داروسازی، علوم پایه و مهندسی). انتشارات دانشگاه علوم پزشکی اصفهان، 576 ص. 1388.
2- - سید فرید رحیم پور و لطف الله سقایی . کار ایمن در آزمایشگاه. انتشارات دانشگاه علوم پزشکی اصفهان، 156 ص. 1390.
ب) ترجمه
1- سید فرید رحیم پورو لطف الله سقایی. شیمی برای علوم زیستی. انتشارات دانشگاه علوم پزشکی اصفهان، 266 ص. 1379
Abstracts:
1- L Saghaie. Iron Chelators as Antimalarial Drugs. The sixth congress of pharmaceutical sciences of Iran. Isfahan 1998.
2- L Saghaie. 1-Hydroxyalkyl Derivatives HPOs as Alternative to Deaferal. The sixth congress of pharmaceutical sciences of Iran. Isfahan 1998.
3- M Taher, L Saghaie and M Norozy. The Effect of Barium Chloride on Liver and Kidney Functions Rat. 7th Iranan Seminar of Pharmaceutical Sciences. Mashhad 2000.
4- L Saghaie, G Hoshfar and M Neishabori. Synthesis of Zinc Complexes with clinical Potential. 7th Iranan Seminar of Pharmaceutical Sciences. Mashhad 2000.
5- L Saghaie. Synthesis of N-acetonitril and N-ethylamine Pyridinone. 7th Iranan Seminar of Pharmaceutical Sciences. Mashhad 2000.
6- A Mostafavi, L Saghaie, M taher and N Manteghi. Liver Toxicity of 2-Methyl-3-Hydroxypridinone in Iron Overloaded Rats. AAPS 2002, Canada.
7- L Saghaiem M Taher and M Ebrahimi. Investigation of Intestinal Absorption of Pyridinones in Rat. 7th Iranan Seminar of Pharmaceutical Sciences. Mashhad 2000.
8- L Saghaie, M Jalili, A Abdolahi and M Dadkhah.Determination of Partition Coefficient of Pyridinones. 7th Iranan Seminar of Pharmaceutical Sciences. Mashhad 2000.
9- L Saghaie. Design and Synthesis of Ideal Orally Active Iron Chelators. 7th Iranan Seminar of Pharmaceutical Sciences. Mashhad 2000.
10- L Saghaie and RC Hider. Brain Penetration of Hydroxypyridinones in Rat. 7th Iranan Seminar of Pharmaceutical Sciences. Mashhad 2000.
11- L Saghaie, M Mirmohammad sadeghi and A Nikazma. Synthesis of Arylhydroxypyridinones as Iro(III) Chelators. Shiraz 2002.
12- GH Khodarahmi, L Saghaie and A Karimian. Synthesis and Lipophilicity Study of Aluminium Complexes. 8th Iranan Seminar of Pharmaceutical Sciences. Shiraz 2002.
13- A Jafarian, L Saghaie and S Rajabzadeh. A New Spectophotometric method for Determination of Iron. Shiraz 2002.
14- A Badiei, L Saghaie and Sh Ebrahimi. Surveying the absorption level off complexes ethyl an methyl-3-harroxypyran-4-one and its comparison with the zin; sulfate available from market by using the invitro method. Australia 2004.
15- A Palizban, L Saghaie and M Yaran. Evaluation of Iron Uptake by Apo-transferin from Iron(III) hydroxypyranone Complex In Vitro. Iran, Tabriz 2004.
16- A Jafarian, L Saghaie and N Movahedi. A New Spectrophotometric method for the Determination of Iron in Water and Biological Fluids. 9th Iranan Seminar of Pharmaceutical Sciences. Iran, Tabriz 2004.
17- L Saghaie. Treatment of iron overload patients with newly synthesized iron chelating agents. First Congress of trace elements. Iran, Thran 2006.
18- A Fassihi and L Saghaie. Synthesis of some novel derivatives of 4[1-methyl-1H-5-imidazollyl] or 4-(2-thenyl)-2, 6-dimethyl-3,5-bis-N-[substituted phenyl)(pyridyl)] carbamoyl-1,4-dihydro pyridines as potential antitubercular agents. 10th Iranan Seminar of Pharmaceutical Sciences. Iran, Thran 2006.
19- L Saghaie, A Fassihi. Synthesis and determination of partion coefficient of some 3-hydroxypyridin-4-ones as potential antimalarial agents. 10 th Iranan Seminar of Pharmaceutical Sciences. Iran, Thran 2006.
20- L Saghaie and A Badii. Synthesis Intestinal Absorption and Toxicity of 3-Hydroxypyridinones in Rats. he 9th Iranian Congress of Biochemistry & 2nd InternationalCongress of Biochemistry and Molecular Biology Shiraz-Iran,Oct-29-Nov, 1, 2007.
21- A Fasihi, L saghaie, D Abedi, H fazeli, G Bostaki, G Dailami and S Sadinpour. Synthesis and Evaluation of Antimicrobial and Antifungal Activity of some Novel Derivatives of Metal Chelating Agents. 18th Iranian congress of Physiology & Pharmacology Mashhad-Iran August 26-30,2007.
22- L Saghaie and RC Hider. Synthesis and determination of antimalarial activity of hydroxypyridinone-containing chloroquine analogues. 18th Iranian congress of Physiology & Pharmacology Mashhad-Iran August 26-30,2007.
23- L Saghaie and RC Hider. Synthesis and determination of physico-chemical properties of 3-hydroxypyridin-4-ones as iron (III) chelating agents. 11th Iranian Pharmaceutical Sciences Conference Kerman-Iran August, 18-21, 2008.
24- Abedi D, Saghaie L, Fassihi A, Fazeli M, Bostaki G, Deilami O and Sadinpour H. Synthesis and antimicrobial evaluation of some novel derivatives of 3-hydroxypyridinones. 11th Iranian Pharmaceutical Sciences Conference Kerman-Iran August, 18-21, 2008.