126 study: 12 month manuscript22 December 2014
Supplementary Table 4 Univariate analysis of baseline covariates that may be determinants of 12month persistence in Greece
Covariate / Na / Persistence (%) / OR (95% CI)b / pvaluePatients PMO support tools and/or programs
Active reminderc
Passive reminderd
No reminder / 48
76
174 / 97.9
96.1
92.5 / Reference
0.52 (0.05–5.13)
0.26 (0.03–2.07) / 0.3026
Body mass index
>25 kg/m2
≤25 kg/m2 / 163
114 / 95.7
91.2 / Reference
0.47 (0.17–1.27) / 0.1342
Age at menopause (median=49.0 years)
≤Median
>Median / 162
137 / 95.1
93.4 / Reference
0.74 (0.28–1.97) / 0.5452
Cause of menopause
Natural onset
Clinically/surgically induced
Not available / 271
24
4 / 94.1
95.8
100.0 / Reference
1.44 (0.18–11.38)
NE / 0.9411
Height loss since maximal height
No
Yes / 151
140 / 94.0
94.3 / Reference
1.05 (0.39–2.79) / 0.9288
Height loss (median=4.0 cm)
≤Median
>Median / 72
62 / 98.6
91.9 / Reference
0.16 (0.02–1.41) / 0.0993
Time since most recent historical fracture to first injection
<12 months
≥12 months / 35
67 / 94.3
92.5 / Reference
0.75 (0.14–4.09) / 0.7410
Historical fracture
No
Yes / 188
112 / 94.1
93.8 / Reference
0.93 (0.35–2.48) / 0.8881
Historical hip fracture
No
Yes / 287
13 / 93.7
100.0 / Reference
NE / NE
Historical vertebral fracture
No
Yes / 266
34 / 93.6
97.1 / Reference
2.25 (0.29–17.48) / 0.4373
≥2 historical fractures
No
Yes / 274
26 / 94.5
88.5 / Reference
0.44 (0.12–1.65) / 0.2246
Hospitalization for osteoporotic fracture before enrollment
No
Yes / 279
20 / 94.6
90.0 / Reference
0.51 (0.11–2.41) / 0.3966
≥1 falls in the last 12 months
No
Yes / 250
49 / 95.2
89.8 / Reference
0.44 (0.15–1.32) / 0.1445
≥1 occurrence of immobility experienced during the past 12 months
No
Yes / 284
15 / 94.4
93.3 / Reference
0.84 (0.10–6.76) / 0.8664
Parental history of fractured hip
No
Yes
Unknown / 192
52
55 / 93.2
96.2
96.4 / Reference
1.82 (0.40–8.31)
1.92 (0.42–8.80) / 0.5636
Current smoker
No
Yes / 252
47 / 94.8
91.5 / Reference
0.58 (0.18–1.88) / 0.3674
Former smoker
No
Yes / 275
24 / 94.5
91.7 / Reference
0.63 (0.14–2.96) / 0.5623
Prior glucocorticoid use
No
Yes / 268
31 / 94.4
93.5 / Reference
0.86 (0.19–3.95) / 0.8459
Prior secondary osteoporosis
No
Yes / 276
23 / 94.2
95.7 / Reference
1.35 (0.17–10.68) / 0.7742
≥3 units of alcohol per day
No / 299 / 94.3 / Reference / NE
Total hip T-score
>−2.5
≤−2.5 / 37
15 / 97.3
100.0 / Reference
NE / 0.9556
Femoral neck T-score
>−2.5
≤−2.5 / 63
101 / 100.0
95.0 / Reference
NE / 0.9483
LumbarspineT-score
>−2.5
≤−2.5 / 59
149 / 94.9
94.6 / Reference
0.94 (0.24–3.69) / 0.9342
Age group
<65 years
65–74 years
≥75 years / 136
104
60 / 95.6
96.2
86.7 / Reference
1.15 (0.32–4.20)
0.30 (0.10–0.91) / 0.0398*
Time since PMO diagnosis (median=5.0 years)
≤Median
>Median / 160
136 / 93.1
96.3 / Reference
1.93 (0.65–5.71) / 0.2325
Number of prescription medications taken at baseline (median=2.0)
≤Median
>Median / 181
119 / 93.9
94.1 / Reference
1.04 (0.39–2.75) / 0.9447
Number of comorbidities (median=2.0)
≤Median
>Median / 171
129 / 94.7
93.0 / Reference
0.74 (0.29–1.92) / 0.5373
Mental illness
No
Yes / 262
38 / 93.1
100.0 / Reference
NE / NE
Any chronic medical condition
No
Yes / 27
273 / 88.9
94.5 / Reference
2.15 (0.58–7.96) / 0.2514
Number of chronic medical conditions
0
1
2
3
4 / 27
87
112
64
10 / 88.9
96.6
94.6
93.8
80.0 / Reference
3.50 (0.66–18.47)
2.21 (0.52–9.46)
1.88 (0.39–9.01)
0.50 (0.07–3.55) / 0.2809
Ever exposed to prior PMO therapy
No
Yes / 53
244 / 96.2
94.3 / Reference
0.64 (0.14–2.92) / 0.5688
Exposed to prior PMO therapy during the 12 months prior toenrollment
No
Yes / 81
216 / 95.1
94.4 / Reference
0.88 (0.28–2.82) / 0.8339
Calcium and/or vitamin D supplementation at baseline
No
Yes / 179
121 / 93.3
95.0 / Reference
1.38 (0.50–3.77) / 0.5340
History of discontinuation of prescription osteoporosis therapy
No
Yes
Not applicable / 215
47
37 / 95.8
97.9
81.1 / Reference
2.01 (0.25–16.26)
0.19 (0.06–0.54) / 0.0035*
SF-12 Physical Component Summary score at baseline (median=47.8)e
≤Median
>Median / 120
119 / 93.3
97.5 / Reference
2.76 (0.71–10.68) / 0.1408
SF-12 Mental Component Summary score at baseline (median=45.5)e
≤Median
>Median / 120
119 / 93.3
97.5 / Reference
2.76 (0.71–10.68) / 0.1408
MMAS-8 summary score at baseline (median=6.8)f
≤Median
>Median / 131
119 / 96.2
95.0 / Reference
0.75 (0.22–2.52) / 0.6381
Physician specialty
Endocrinology
Orthopedics
Rheumatology
Internal medicine
Not available / 131
85
74
5
5 / 96.9
91.8
90.5
100.0
100.0 / Reference
0.35 (0.10–1.24)
0.30 (0.09–1.07)
NE
NE / 0.4306
Physician gender
Male
Female / 230
70 / 94.8
91.4 / Reference
0.59 (0.21–1.63) / 0.3057
Physician years of practice
≥10 years
5–9 years / 197
103 / 93.4
95.1 / Reference
1.38 (0.48–4.00) / 0.5475
Sole physician or group
Sole
Group / 146
154 / 95.9
92.2 / Reference
0.51 (0.19–1.39) / 0.1865
Physician practice reminder
Yes
No / 125
172 / 96.8
93.0 / Reference
0.44 (0.14–1.40) / 0.1648
Center type
Public
Private / 159
141 / 92.5
95.7 / Reference
1.84 (0.67–5.03) / 0.2369
Center academic or non-academic based
Academic
Non-academic
Both
Not available / 77
198
20
5 / 94.8
92.9
100.0
100.0 / Reference
0.72 (0.23–2.26)
NE
NE / 0.9567
Participating in the Prolong patient support program
Yes
No / 20
201 / 95.0
95.5 / Reference
1.12 (0.13–9.35) / 0.9147
Size of the clinic (number of physicians)
2–3
4–5
>10 / `
79
65
10 / 89.9
98.5
70.0 / Reference
7.21 (0.88–59.21)
0.26 (0.06–1.22) / 0.0233
Geographic region
Urban / 300 / 94.0 / Reference / NE
Type of healthcare insurance
Private
Public / 13
286 / 100.0
94.1 / Reference
NE / NE
Highest education
University
No formal education
Elementary education
Secondary education
Not available / 43
5
109
98
43 / 93.0
100.0
91.7
98.0
93.0 / Reference
NE
0.83 (0.21–3.24)
3.60 (0.58–22.37)
1.00 (0.19–5.26) / 0.4893
Living situation
At home with spouse/family
At home with care/support
At home alone
Not available / 236
2
51
10 / 95.8
100.0
88.2
90.0 / Reference
NE
0.33 (0.11–0.96)
0.40 (0.05–3.46) / 0.2228
Employment status
Employed
Self employed
Unemployed
Retired / 30
20
47
201 / 96.7
100.0
93.6
93.5 / Reference
NE
0.51 (0.05–5.10)
0.50 (0.06–3.96) / 0.9323
Marital status
Married
Never married
Divorced
Widowed / 210
15
13
60 / 94.8
93.3
92.3
95.0 / Reference
0.77 (0.09–6.43)
0.66 (0.08–5.57)
1.05 (0.28–3.89) / 0.9762
Proximity to clinic/practice (median =30.0 min)
≤Median
>Median / 193
99 / 94.8
92.9 / Reference
0.72 (0.26–1.95) / 0.5153
Method of transport to health provider
Own vehicle
Walk
Cycle
Public transport
Other / 127
31
2
108
26 / 97.6
100.0
100.0
90.7
84.6 / Reference
NE
NE
0.24 (0.06–0.89)
0.13 (0.03–0.64) / 0.1431
*Statistically significant: p0.05
aN is the number of patients in the full analysis set within the covariate group
bUnivariate logistic regression: odds ratio <1 favors the reference category
cActive reminder includes telephone call, mailing, and e-mail or SMS
dPassive reminder includes appointment card, sticker from drug package, and magazine
eAnalyzed by QualityMetric Health Outcomes Scoring Software V4.5
fScore calculated using data from patients who answered all questions
BMD, bone mineral density; CI, confidence interval; MMAS, Morisky Medication-taking Adherence Scale;NE, not estimable; OR, odds ratio; PMO, postmenopausal osteoporosis
1