Online Supplementary Table 1. Description of Adverse Events and Inpatient Rehabilitation

Online Supplementary Materials

Online supplementary Table 1. Description of adverse events and inpatient rehabilitation

Database reference
Severe gastrointestinal adverse events (gastrointestinal hemorrhage, peptic ulcer, gastroinstestinal obstruction) / ATIH GHM: 06M04, 06M06, 06M10, 06M11
Cardiovascular adverse events / ATIH CMD 05
Renal adverse events (renal failure) / ATIH GHM: 11K02, 11M06
Inpatient rehabilitation / ATIH GME: 0841a0, 0841a1, 0841b0, 0841b1, 0841c1

ATIH: Agence Technique de l’Information sur l’Hospitalisation; GHM: Groupe Homogène de Malade (=DRG, DiagnosisRelated Group); CMD: Catégorie Majeure de Diagnostic (=MDC, Major DiagnosisCategory); GME: Groupe Médico-Économique (medico-economic group)

Online supplementary Table 2. Sensitivity analyses

Utilities / Outcomes
(probability of improvement in WOMAC score)
NPh option / Aids / 0.706 / 7%
PT / 0.757 / 25%
Others / 0.705 / 14%
NPPh option / Aids + Acetaminophen / 0.755 / 11.77%
Aids + NSAIDs (with PPI) / 0.764 / 27.82%
Aids + SYSADOAs / 0.763 / 36.38%
PT + Acetaminophen / 0.757 / 26.82%
PT + NSAIDs (with PPI) / 0.764 / 32.5%
PT + SYSADOAs / 0.763 / 36.75%
Other combination / 0.764 / 38.76%
Ph option / Acetaminophen / 0.755 / 11%
NSAIDs (with PPI) / 0.764 / 26%
SYSADOAs / 0.763 / 34%
Acetaminophen + NSAIDs (with PPI) / 0.610 / 28.86%
Acetaminophen + SYSADOAs / 0.763 / 37.74%
SYSADOAs + NSAIDs (with PPI) / 0.764 / 42.84%
Corticosteroid injections / 0.729 / 30%
HA injections / 0.665 / 40%
Opioids / 0.763 / 44%
Surg option / Arthroscopy / 0.631 / 36%
Osteotomy / 0.631 / 36%
UKR / 0.791 / 65%
TKR / 0.764 / 72%

NPh: non-pharmacological; NPPh: both non-pharmacological and pharmacological; Ph: pharmacological; Surg: surgical; PT: physiotherapy; NSAIDs:nonsteroidal anti-inflammatory drugs; SYSADOAs: symptomatic slow acting drugs for OA; HA: hyaluronic acid; UKR: unicompartimental knee replacement; TKR: total knee replacement

Online supplementary Table 3. Transitions: NPh option

Late TKR / Early TKR
Aids OR PT / Success / Death / tDeath(age) / tDeath(age)
NPh option / 0.80 / 0.80
NPPh option / 0.10 / 0.09
Ph option / By difference / By difference
Surg option / 0.00 / 0.01
Failure / Death / tDeath(age) / tDeath(age)
NPh option / By difference / By difference
NPPh option / 0.45 / 0.40
Ph option / 0.40 / 0.40
Surg option / 0.05 / 0.10
Others / Success / Death / tDeath(age) / tDeath(age)
NPh option / 0.80 / 0.80
NPPh option / 0.10 / 0.09
Ph option / By difference / By difference
Surg option / 0.00 / 0.01
Failure / Death / tDeath(age) / tDeath(age)
NPh option / By difference / By difference
NPPh option / 0.45 / 0.40
Ph option / 0.35 / 0.35
Surg option / 0.02 / 0.10

NPh: non-pharmacological; NPPh: both non-pharmacological and pharmacological; Ph: pharmacological; Surg: surgical; PT: physiotherapy

Online supplementary Table 4. Transitions: NPPh option

Late TKR / Early TKR
Aids + Acetaminophen
OR
Aids + SYSADOAs
OR
Other combination / Success / Death / tDeath(age) / tDeath(age)
NPh option / By difference / By difference
NPPh option / 0.80 / 0.80
Ph option / 0.10 / 0.09
Surg option / 0.00 / 0.01
Failure / Death / tDeath(age) / tDeath(age)
NPh option / By difference / By difference
NPPh option / 0.25 / 0.20
Ph option / 0.30 / 0.30
Surg option / 0.25 / 0.30
Aids + NSAIDs / Success / Death / tDeath(age)+ p_Death_NSAID / tDeath(age)+ p_Death_NSAID
NPh option / By difference / By difference
NPPh option / 0.80 / 0.80
Ph option / 0.10 / 0.09
Surg option / 0.00 / 0.01
Failure / Death / tDeath(age)+ p_Death_NSAID / tDeath(age)+ p_Death_NSAID
NPh option / By difference / By difference
NPPh option / 0.20 / 0.25
Ph option / 0.30 / 0.30
Surg option / 0.25 / 0.30
PT+ NSAIDs / Success / Death / tDeath(age)+ p_Death_NSAID / tDeath(age)+ p_Death_NSAID
NPh option / By difference / By difference
NPPh option / 0.80 / 0.80
Ph option / 0.10 / 0.09
Surg option / 0.00 / 0.01
Failure / Death / tDeath(age)+ p_Death_NSAID / tDeath(age)+ p_Death_NSAID
NPh option / By difference / By difference
NPPh option / 0.25 / 0.20
Ph option / 0.30 / 0.30
Surg option / 0.25 / 0.30
PT+ Acetaminophen
OR
PT+ SYSADOAs / Success / Death / tDeath(age) / tDeath(age)
NPh option / By difference / By difference
NPPh option / 0.80 / 0.80
Ph option / 0.10 / 0.09
Surg option / 0.00 / 0.01
Failure / Death / tDeath(age) / tDeath(age)
NPh option / By difference / By difference
NPPh option / 0.25 / 0.20
Ph option / 0.30 / 0.30
Surg option / 0.25 / 0.30

NPh: non-pharmacological; NPPh: both non-pharmacological and pharmacological; Ph: pharmacological; Surg: surgical; PT: physiotherapy; NSAIDs:nonsteroidal anti-inflammatory drugs; SYSADOAs: symptomatic slow acting drugs for OA; HA: hyaluronic

Online supplementary Table 5. Transitions: Ph option

Late TKR / Early TKR
Acetaminophen / Success / Death / tDeath(age) / tDeath(age)
NPh option / By difference / By difference
NPPh option / 0.10 / 0.09
Ph option / 0.80 / 0.80
Surg option / 0.00 / 0.01
Failure / Death / tDeath(age) / tDeath(age)
NPh option / By difference / By difference
NPPh option / 0.25 / 0.20
Ph option / 0.30 / 0.30
Surg option / 0.30 / 0.35
NSAIDs
OR
Acetaminophen
+NSAIDs
OR
SYSADOAs
+NSAIDs / Success / Death / tDeath(age)+ p_Death_NSAID / tDeath(age)+ p_Death_NSAID
NPh option / By difference / By difference
NPPh option / 0.10 / 0.09
Ph option / 0.80 / 0.80
Surg option / 0.00 / 0.01
Failure / Death / tDeath(age)+ p_Death_NSAID / tDeath(age)+ p_Death_NSAID
NPh option / By difference / By difference
NPPh option / 0.25 / 0.20
Ph option / 0.30 / 0.30
Surg option / 0.35 / 0.40
SYSADOAs
OR
Acetaminophen
+SYSADOAs / Success / Death / tDeath(age) / tDeath(age)
NPh option / By difference / By difference
NPPh option / 0.10 / 0.09
Ph option / 0.80 / 0.80
Surg option / 0.00 / 0.01
Failure / Death / tDeath(age) / tDeath(age)
NPh option / By difference / By difference
NPPh option / 0.25 / 0.20
Ph option / 0.30 / 0.30
Surg option / 0.35 / 0.40
Corticosteroid injection
OR
HA injection / Success / Death / tDeath(age) / tDeath(age)
NPh option / By difference / By difference
NPPh option / 0.10 / 0.09
Ph option / 0.80 / 0.80
Surg option / 0.00 / 0.01
Failure / Death / tDeath(age) / tDeath(age)
NPh option / By difference / By difference
NPPh option / 0.20 / 0.15
Ph option / 0.25 / 0.25
Surg option / 0.45 / 0.50
Opioids / Success / Death / tDeath(age) + p_Death_opioid / tDeath(age) + p_Death_opioid
NPh option / By difference / By difference
NPPh option / 0.10 / 0.09
Ph option / 0.80 / 0.80
Surg option / 0.00 / 0.01
Failure / Death / tDeath(age) + p_Death_opioid / tDeath(age) + p_Death_opioid
NPh option / By difference / By difference
NPPh option / 0.09 / 0.09
Ph option / 0.10 / 0.09
Surg option / 0.70 / 0.72

NPh: non-pharmacological; NPPh: both non-pharmacological and pharmacological; Ph: pharmacological; Surg: surgical; NSAIDs:nonsteroidal anti-inflammatory drugs; SYSADOAs: symptomatic slow acting drugs for OA; HA: hyaluronic acid

Online supplementary Table 6. Transitions: Surg option

Late TKR / Early TKR
Non prosthetic surgery
(arthroscopy, osteotomy) / Success / Death / tDeath(age) / tDeath(age)
NPh option / By difference / By difference
NPPh option / 0.25 / 0.25
Ph option / 0.20 / 0.20
Surg option / 0.00 / 0.00
Failure / Death / tDeath(age) / tDeath(age)
NPh option / By difference / By difference
NPPh option / 0.05 / 0.05
Ph option / 0.05 / 0.05
Surg option / 0.80 / 0.80
UKR / Success / Death / tDeath(age)
+p_Death_chir / tDeath(age)
+p_Death_chir
NPh option / By difference / By difference
NPPh option / 0.15 / 0.15
Ph option / 0.15 / 0.15
Surg option / 0.00 / 0.00
Failure / Death / tDeath(age)
+p_Death_chir / tDeath(age)
+p_Death_chir
NPh option / By difference / By difference
NPPh option / 0.10 / 0.10
Ph option / 0.10 / 0.10
Surg option / 0.70 / 0.70
TKR / Success / Death / tDeath(age)
+p_Death_chir / tDeath(age)
+p_Death_chir
NPh option / By difference / By difference
NPPh option / 0.20 / 0.20
Ph option / 0.20 / 0.20
Surg option / 0.00 / 0.00
Failure / Death / tDeath(age)
+p_Death_chir / tDeath(age)
+p_Death_chir
NPh option / By difference / By difference
NPPh option / 0.20 / 0.20
Ph option / 0.20 / 0.20
Surg option / 0.01 / 0.01

NPh: non-pharmacological; NPPh: both non-pharmacological and pharmacological; Ph: pharmacological; Surg: surgical;UKR: unicompartimental knee replacement; TKR: total knee replacement