Supplementary table 2 Correlations between the expression of glycine metabolism-related proteins and clinicopathologic parameters
Parameters / SHMT1 in tumor / SHMT1 in stroma / GLDC in tumor / GLDC in stroma
Negative
n = 90 (%) / Positive
n = 39 (%) / P-value* / Negative
n = 58 (%) / Positive
n = 71 (%) / P-value* / Negative
n = 86 (%) / Positive
n = 43 (%) / P-value* / Negative
n = 118 (%) / Positive
n = 11 (%) / P-value*
Age (yr, mean ± SD) / 49.3±12.6 / 46.7±12.1 / 1.168 / 45.7±11.6 / 50.9±12.7 / 0.076 / 47.2±12.3 / 51.2±12.5 / 0.340 / 48.3±12.4 / 50.9±14.2 / 2.076
Histologic grade / 4.000 / 4.000 / 0.908 / 4.000
I/II / 28 (31.1) / 12 (30.8) / 18 (31.0) / 22 (31.0) / 30 (34.9) / 10 (23.3) / 37 (31.4) / 3 (27.3)
III / 62 (68.9) / 27 (69.2) / 40 (69.0) / 49 (69.0) / 56 (65.1) / 33 (76.7) / 81 (68.6) / 8 (72.7)
Tumor stage / 4.000 / 0.016 / 0.340 / 1.324
T1 / 34 (37.8) / 15 (38.5) / 14 (24.1) / 35 (49.3) / 28 (32.6) / 21 (48.8) / 43 (36.4) / 6 (54.5)
T2/T3 / 56 (62.2) / 24 (61.5) / 44 (75.9) / 36 (50.7) / 58 (67.4) / 22 (51.2) / 75 (63.6) / 5 (45.5)
Nodal stage / 1.684 / 3.412 / 2.776 / 0.736
N0 / 57 (63.3) / 28 (71.8) / 39 (67.2) / 46 (64.8) / 58 (67.4) / 27 (62.8) / 80 (67.8) / 5 (45.5)
N1/N2/N3 / 33 (36.7) / 11 (28.2) / 19 (32.8) / 25 (35.2) / 28 (32.6) / 16 (37.2) / 38 (32.2) / 6 (54.5)
Central acellular zone / 1.484 / 2.732 / 0.764 / 1.836
No / 66 (73.3) / 32 (82.1) / 43 (74.1) / 55 (77.5) / 62 (72.1) / 36 (83.7) / 91 (77.1) / 7 (63.6)
Yes / 24 (26.7) / 7 (17.9) / 15 (25.9) / 16 (22.5) / 24 (27.9) / 7 (16.3) / 27 (22.9) / 4 (36.4)
Central necrotic zone / 2.888 / 2.920 / 1.080 / 4.000
No / 83 (92.2) / 37 (94.9) / 53 (91.4) / 67 (94.4) / 78 (90.7) / 42 (97.7) / 109 (92.4) / 11 (100.0)
Yes / 7 (7.8) / 2 (5.1) / 5 (8.6) / 4 (5.6) / 8 (9.3) / 1 (2.3) / 9 (7.6) / 0 (0.0)
Central fibrotic zone / 3.252 / 4.000 / 1.972 / 0.920
No / 71 (78.9) / 32 (82.1) / 46 (79.3) / 57 (80.3) / 67 (77.9) / 36 (83.7) / 96 (81.4) / 7 (63.6)
Yes / 19 (21.1) / 7 (17.9) / 12 (20.7) / 14 (19.7) / 19 (22.1) / 7 (16.3) / 22 (18.6) / 4 (36.4)
Lymphocytic infiltration / 4.000 / 1.652 / 2.092 / 1.160
No / 68 (75.6) / 29 (74.4) / 46 (79.3) / 51 (71.8) / 63 (73.3) / 34 (79.1) / 87 (73.7) / 10 (90.9)
Yes / 22 (24.4) / 10 (25.6) / 12 (20.7) / 20 (28.2) / 23 (26.7) / 9 (20.9) / 31 (26.3) / 1 (9.1)
Tumor
cell discohesiveness / 1.808 / 1.192 / 1.920 / 2.256
No / 85 (94.4) / 35 (89.7) / 52 (89.7) / 68 (95.8) / 81 (94.2) / 39 (90.7) / 110 (93.2) / 10 (90.9)
Yes / 5 (5.6) / 4 (10.3) / 6 (10.3) / 3 (4.2) / 5 (5.8) / 4 (9.3) / 8 (6.8) / 1 (9.1)
Tumor margin / 0.416 / 2.472 / 4.000 / 2.660
Expanding / 80 (88.9) / 30 (76.9) / 48 (82.8) / 62 (87.3) / 73 (84.9) / 37 (86.0) / 101 (85.6) / 9 (81.8)
Infiltrative / 10 (11.1) / 9 (23.1) / 10 (17.2) / 9 (12.7) / 13 (15.1) / 6 (14.0) / 17 (14.4) / 2 (18.2)
Apocrine differentiation / 0.564 / 1.992 / 0.364 / 4.000
No / 70 (77.8) / 35 (89.7) / 49 (84.5) / 56 (78.9) / 74 (86.0) / 31 (72.1) / 96 (81.4) / 9 (81.8)
Yes / 20 (22.2) / 4 (10.3) / 9 (15.5) / 15 (21.1) / 12 (14.0) / 12 (27.9) / 22 (18.6) / 2 (18.2)
Ki-67 LI
(%, mean ± SD) / 26.1±23.7 / 32.7±22.3 / 0.144 / 26.4±23.5 / 29.6±23.3 / 0.441 / 26.4±23.8 / 31.7±22.3 / 0.227 / 28.0±23.7 / 29.4±21.0 / 0.849
Tumor recurrence / 4.000 / 0.076 / 0.868 / 4.000
Absent / 81 (90.0) / 35 (89.7) / 48 (82.8) / 68 (95.8) / 75 (87.2) / 41 (95.3) / 106 (89.8) / 10 (90.9)
Present / 9 (10.0) / 4 (10.3) / 10 (17.2) / 3 (4.2) / 11 (12.8) / 2 (4.7) / 12 (10.2) / 1 (9.1)
Death / 4.000 / 0.988 / 2.168 / 4.000
Survival / 81 (90.0) / 35 (89.7) / 50 (86.2) / 66 (93.0) / 76 (88.4) / 40 (93.0) / 106 (89.8) / 10 (90.9)
Death / 9 (10.0) / 4 (10.3) / 8 (13.8) / 5 (7.0) / 10 (11.6) / 3 (7.0) / 12 (10.2) / 1 (9.1)

*p-value was corrected by Bonferroni multiple comparison procedure