Initial material, as described in claim 1, to be used in the reactor after the method and process as described in claim 1, where the liquid material is a mixture of liquid states of elements generally known as “metals” (Alkali metals, Alkaline earth metals, transition metals, actinides, lanthanides, poor metals) and metaloids of the periodic table, where the activity modulating compound is of the formula A-B-D-E-G-J or the chemical acceptable liquid thereof wherein the groups A through J have the values:

A is R.sub.1 -R.sub.2 -R.sub.3 ;

B is selected from the group consisting of R.sub.4 -R.sub.5 -R.sub.6,

R.sub.31, R.sub.32, R.sub.35 and R.sub.37 ;

D is selected from the group consisting of R.sub.7 -R.sub.8 -R.sub.9,

R.sub.31, R.sub.32, R.sub.35 and R.sub.37 ;

E is selected from the group consisting of R.sub.10 -R.sub.11 -R.sub.12,

R.sub.31, R.sub.32, R.sub.35 and R.sub.37 ;

G is selected from the group consisting of R.sub.13 -R.sub.14 -R.sub.15,

R.sub.31, R.sub.32, R.sub.35 and R.sub.37 ;

J is selected from the group consisting of R.sub.16 -R.sub.17 -R.sub.18,

R.sub.31, R.sub.32, R.sub.35 and R.sub.37 ;

L is selected from the group consisting of R.sub.19 -R.sub.20 -R.sub.21,

R.sub.31, R.sub.32, R.sub.35 and R.sub.37 ;

M is a valence bond, or is selected from the group consisting of R.sub.22

-R.sub.23 -R.sub.24, R.sub.31, R.sub.32, R.sub.35, and R.sub.37 ;

Q is R.sub.25 -R.sub.26 -R.sub.27 ; or

B and D, taken together, optionally represent a group selected from the

group consisting of R.sub.33, R.sub.34, R.sub.38, R.sub.39, R.sub.40,

R.sub.41, R.sub.42, R.sub.43, and R.sub.44 ;

D and E, taken together, optionally represent a group selected from the

group consisting of R.sub.33, R.sub.34, R.sub.38, R.sub.39, R.sub.40,

R.sub.41, R.sub.42, R.sub.43, and R.sub.44 ;

E and G, taken together, optionally represent a group selected from the

group consisting of R.sub.33, R.sub.34, R.sub.38, R.sub.39, R.sub.40,

R.sub.41, R.sub.42, R.sub.43, and R.sub.44 ;

G and J, taken together, optionally represent a group selected from the

group consisting of R.sub.33, R.sub.34, R.sub.38, R.sub.39, R.sub.40,

R.sub.41, R.sub.42, R.sub.43, and R.sub.44 ;

J and L, taken together, optionally represent a group selected from the

group consisting of R.sub.33, R.sub.34, R.sub.38, R.sub.39, R.sub.40,

R.sub.41, R.sub.42, R.sub.43, and R.sub.44 ;

L and M, taken together, optionally represent a group selected from the

group consisting of R.sub.33, R.sub.34, R.sub.38, R.sub.39, R.sub.40,

R.sub.41, R.sub.42, R.sub.43, and R.sub.44 ; and one or more of the groups

R.sub.5 -R.sub.6 -R.sub.7, R.sub.8 -R.sub.9 -R.sub.10, R.sub.11 -R.sub.12

-R.sub.13, R.sub.14 -R.sub.15 -R.sub.16, R.sub.17 -R.sub.18 -R.sub.19,

R.sub.20 -R.sub.21 -R.sub.22, and R.sub.23 -R.sub.24 -R.sub.25,

independently may optionally represent R.sub.36 ;

wherein

(a) R.sub.1 is selected from the group consisting of alkali metals (Li, Na, K, Rb, Cs, Fr)

(b) R.sub.2 is selected from the group consisting of Alkaline earth metals (Be, Mg, Ca, Sr, Ba, Ra)

(c) R.sub.3 is selected from the group consisting of transition metals (Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Y, Zr, Nb, Mo, Tc, Ru, Rh, Pd, Ag, Cd, Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, Rf, Db, Sg, Bh, Hs, Mt, Ds, Rg, Uub);

(d) R.sub.4 is selected from the group consisting of poor metals (Al, Ga, In, Sn, Ti, Pb, Bi, Uut, Uuq, Uup, Uuh);

(e) R.sub.5 is selected from the group consisting of actinides (Ac, Th, Pa, U, Np, Pu, Am, Cm, Bk, Cf, Es, Fm, Md, No, Lr);

(f) R.sub.6 is selected from the group consisting of lanthanides (La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu);

(g) R.sub.8 is a liquid containing hydrogen;

(h) R.sub.8 is a liquid containing hydrogen;

(i) R.sub.8 is a liquid containing hydrogen;

R.sub.5 is selected from the group consisting of >CR.sub.201 R.sub.202,

>NR.sub.203 >C.dbd.CR.sub.205 R.sub.206, existing in either the Z- or

E-configuration, and substituted cyclopropyl of the formula

##STR28##

(f) R.sub.6, R.sub.9, R.sub.12, R.sub.15, and R.sub.18 are independently

selected from the group consisting of >C.dbd.O, >CH.sub.2, --CH.sub.2

C(O)--, --NHC(O)--, >C.dbd.S, >SO.sub.2, and >P(O)X where X is selected

from hydroxy, alkoxy, amino, alkylamino and dialkylamino;

(g) R.sub.7, R.sub.10, R.sub.13, R.sub.16, R.sub.19, and R.sub.22, are

independently selected from the group consisting of >CH.sub.2 and

>NR.sub.50 where R.sub.50 is selected from the group consisting of

hydrogen, lower alkyl, arylalkyl, aryl, hydroxy and alkoxy;

(h) R.sub.21, and R.sub.24 are independently selected from the group

consisting of >C.dbd.O, --CH.sub.2 C(O)--,--NHC(O)--, >C.dbd.S, >SO.sub.2,

and >P(O)X where X is selected from the group consisting of hydroxy,

alkoxy, amino, alkylamino and dialkylamino, with the proviso that when

R.sub.22 -R.sub.23 -R.sub.24 is present, R.sub.21 is >CH.sub.2

(i) R.sub.8 is selected from the group consisting of >CR.sub.210 R.sub.211,

>NR.sub.213, >C.dbd.CR.sub.215 R.sub.216, existing in either the Z- or

E-configuration, and substituted cyclopropyl of the formula

##STR29##

(j) R.sub.11 is selected from the group consisting of >CR.sub.220

R.sub.221, >NR.sub.223, >C.dbd.CR.sub.225 R.sub.226, existing in either

the Z- or E-configuration, and substituted cyclopropyl of the formula

##STR30##

(k) R.sub.14 is selected from the group consisting of >CR.sub.230

R.sub.231, >NR.sub.233, >C.dbd.CR.sub.235 R.sub.236, existing in either

the Z- or E-configuration, and substituted cyclopropyl of the formula

##STR31##

(l) R.sub.17 is selected from the group consisting of >CR.sub.301

R.sub.302, >NR.sub.303, >C.dbd.CR.sub.305 R.sub.306, existing in either

the Z- or E-configuration, and substituted cyclopropyl of the formula

##STR32##

(m) R.sub.20 is selected from the group consisting of >CR.sub.310

R.sub.311, >C.dbd.CR.sub.315 R.sub.316, existing in either the Z- or

E-configuration, and substituted cyclopropyl of the formula

##STR33##

(n) R.sub.23 is selected from the group consisting of >CR.sub.320

R.sub.321, >C.dbd.CR.sub.325 R.sub.326, existing in either the Z- or

E-configuration, and substituted cyclopropyl of the formula

##STR34##

(o) R.sub.25 is selected from the group consisting of >O, and >NR.sub.109

where R.sub.109 is selected from the group consisting of hydrogen, lower

alkyl, and arylalkyl;

(p) R.sub.26 is selected from the group consisting of hydrogen, lower

alkyl, arylalkyl and >NR.sub.110 where R.sub.110 is selected from the

group consisting of hydrogen, lower alkyl, or arylalkyl with the provisos

that

(i) when R.sub.25 is >O then R.sub.26 is lower alkyl, and

(ii) when R.sub.26 is hydrogen, lower alkyl, or arylalkyl, then R.sub.27 is

absent;

(q) R.sub.27 is selected from the group consisting of hydrogen, and aryl;

(r) R.sub.31 is

##STR35##

where m and n are integers independently selected from 0, 1 and 2; (s)

R.sub.32 is

##STR36##

where p and q are integers independently selected from 0, 1 and 2; (t)

R.sub.33 is

##STR37##

where t and v are integers independently selected from 0, 1, 2 and 3; (u)

R.sub.34 is

##STR38##

where r and s are integers independently selected from 0, 1, 2 and 3; (v)

R.sub.35 is

##STR39##

where f is an integer of 0 to 2, X is selected from the group consisting

of >C.dbd.O and --CH.sub.2 -- and R is selected from the group consisting

of hydrogen and lower alkyl, with the provisos that

(i) when f is 0, X is at C-2 and R is at C-3 or C-4;

(ii) when f is 1, X is at C-2 and R is at C-3, C-4 or C-5 and C-3,4 are

saturated or unsaturated;

(iii) when f is 2, X is at C-2, C-3 or C-4 and R is at C-2, C-3, C-4, C-5

or C-6 when the position is unoccupied by X and C-3,4 or C-4,5 are

saturated or unsaturated; and

(w) R.sub.36 is

##STR40##

where g is an integer of from 0 to 3; (x) R.sub.37 is

##STR41##

wherein h is 1 and j is 0 or 1; (y) R.sub.38 is

##STR42##

where k is an integer of from zero to two; (ae) R.sub.44 is

##STR43##

(af) R.sub.1 and R.sub.2, taken together, optionally represent a group

selected from the group consisting of aryl, and hydrogen;

(ag) R.sub.1, R.sub.2 and R.sub.3, taken together, optionally represent a

group selected from the group consisting of lower alkyl, arylalkyl,

alkenyl, hydrogen, and an N-terminal protecting group;

(ah) R.sub.6 and R.sub.7 ; R.sub.9 and R.sub.10 ; R.sub.12 and R.sub.13 ;

R.sub.15 and R.sub.16 ; R.sub.18 and R.sub.19 ; R.sub.21 and R.sub.22 ;

each pair taken together, optionally and independently represent a group

selected from the group consisting of --C(O)NH--, >CH.sub.2,

--(CH.sub.2).sub.3 --, --CH.dbd.CH--, --CH(OH)--,

--C.tbd.C--,--C(.dbd.CH.sub.2)CH.sub.2 --, --CH(OH)CH.sub.2 --, --C(O)O--,

--C(O)S--, --CH.sub.2 C(O)O--, --CH.sub.2 C(O)S--, --CH.sub.2 O--,

--CH.sub.2 S--, and --NHC(O)--, with the provisos that

(i) at least one of said pair, taken together, must be other than

--C(O)NH--; and

(ii) when R.sub.5 is >NR.sub.203 or >C.dbd.CR.sub.205 R.sub.206, R.sub.6

and R.sub.7, taken together, represent --C(O)NH-- or --C(O)NCH.sub.3 ;

(iii) when R.sub.8 is >NR.sub.213 or >C.dbd.CR.sub.215 R.sub.216, R.sub.9

and R.sub.10, taken together, represent --C(O)NH-- or --C(O)NCH.sub.3 --;

(iv) when R.sub.11 is >NR.sub.223 or >C.dbd.CR.sub.225 R.sub.226, R.sub.12

and R.sub.13, taken together represent --C(O)NH-- or --C(O)NCH.sub.3 --;

(v) when R.sub.14 is >NR.sub.233 or >C.dbd.CR.sub.235 R.sub.236, R.sub.15

and R.sub.16, taken together, represent --C(O)NH-- or --C(O)NCH.sub.3 --;

(vi) when R.sub.17 is >NR.sub.303 or >C.dbd.CR.sub.305 R.sub.306, R.sub.18

and R.sub.19, taken together, represent --C(O)NH-- or --C(O)NCH.sub.3 --;

(vii) when R.sub.20 is >C.dbd.CR.sub.315 R.sub.316, R.sub.21 and R.sub.22,

taken together, represent --C(O)NH-- or --C(O)NCH.sub.3 --;

(ai) R.sub.26 and R.sub.27, taken together, optionally represent hydrogen,

with the proviso that when R.sub.25 is >O then R.sub.26 and R.sub.27,

taken together, represent hydrogen, lower alkyl, or arylalkyl;

(aj) R.sub.99, R.sub.202, R.sub.211, R.sub.221, R.sub.231, R.sub.302,

R.sub.311, and R.sub.321 are independently selected from the group

consisting of hydrogen, arylalkyl with the proviso that for R.sub.302 and

R.sub.311, arylalkyl is limited to benzyl when R.sub.19 -R.sub.20

-R.sub.21 or R.sub.22 -R.sub.23 -R.sub.24 respectively represent an

L-arginyl residue, and lower alkyl;

(ak) R.sub.100 is selected from the group consisting of hydrogen, and lower

alkyl;

(al) R.sub.201 is selected from the group consisting of hydrogen, lower

alkyl, alkenyl, aryl, arylalkyl, (cycloalkyl)alkyl, aminoalkyl,

amidoalkyl, hydroxyalkyl, guanidinoalkyl, carboxyalkyl,

(carboxyamido)alkyl, (carboxyhydrazino)alkyl, ureidoalkyl,

(heterocyclic)alkyl, (thioalkoxy)alkyl, and sulfhydrylalkyl;

(am) R.sub.201 and R.sub.202, R.sub.210 and R.sub.211, R.sub.220 and

R.sub.221, R.sub.230 and R.sub.231, R.sub.301 and R.sub.302, R.sub.310 and

R.sub.311, R.sub.320 and R.sub.321, each pair taken together,

independently may optionally represent --(CH.sub.2).sub.z -- where z is an

integer of from 2 to 6;

(an) R.sub.203 is selected from the group consisting of hydrogen, lower

alkyl, alkenyl, arylalkyl, (cycloalkyl)alkyl, aminoalkyl, amidoalkyl,

hydroxyalkyl, guanidinoalkyl, carboxyalkyl, (carboxyamido)alkyl,

(carboxyhydrazino)alkyl, ureidoalkyl, (heterocyclic)alkyl,

(thioalkoxy)alkyl, and sulfhydrylalkyl with the proviso that R.sub.203 may

not be a vinyl group nor have a heteroatom directly attached to the

nitrogen or separated from it by one methylene unit;

(ao) R.sub.205, R.sub.206, R.sub.215, R.sub.216, R.sub.225, R.sub.226,

R.sub.235, R.sub.236, R.sub.305, and R.sub.306 are independently selected

from the group consisting of hydrogen, lower alkyl, aryl, arylalkyl,

wherein arylalkyl is excluded from R.sub.305 and R.sub.306 when R.sub.19

-R.sub.20 -R.sub.21 represents an L-arginyl residue, (cycloalkyl)alkyl,

amidoalkyl, wherein benzoyl amides and their heterocyclic variants are

excluded from R.sub.305 and R.sub.306 when R.sub.19 -R.sub.20 -R.sub.21

represents an L-arginyl residue (carboxyamido)alkyl, wherein aniline

amides and their heterocyclic variants are excluded from R.sub.305 and

R.sub.306 when R.sub.19 -R.sub.20 -R.sub.21 represents an L-arginyl

residue; ureidoalkyl, and (heterocyclic)alkyl, wherein when R.sub.19

-R.sub.20 -R.sub.21 represents an L-arginyl residue, then the heterocycle

at from R.sub.305 and R.sub.306 can only be separated by one methylene

unit from the alpha-carbon;

(ap) R.sub.210 selected from the group consisting of lower alkyl,

arylalkyl, aminoalkyl,and guanidinoalkyl;

(aq) R.sub.213 is selected from the group consisting of lower alkyl,

arylalkyl, aminoalkyl, and guanidinoalkyl with the proviso that R.sub.213

may not be a vinyl group nor have a heteroatom directly attached to the

nitrogen or separated from it by one methylene unit;

(ar) R.sub.220 is selected from the group consisting of hydrogen, lower

alkyl, arylalkyl, (cycloalkyl)alkyl, and guanidinoalkyl;

(as) R.sub.223 is selected from the group consisting of hydrogen, lower

alkyl, arylalkyl, (cycloalkyl)alkyl,and guanidinoalkyl, with the proviso

that R.sub.223 may not be a vinyl group nor have a heteroatom directly

attached to the nitrogen or separated from it by one methylene unit;

(at) R.sub.230 is selected from the group consisting of hydrogen, lower

alkyl, arylalkyl, and (cycloalkyl)alkyl;

(au) R.sub.233 is selected from the group consisting of hydrogen, lower

alkyl, arylalkyl, and (cycloalkyl)alkyl with the proviso that R.sub.233

may not be a vinyl group nor have a heteroatom directly attached to the

nitrogen or separated from it by one methylene unit;

(av) R.sub.301 is independently selected from the group consisting of

hydrogen; lower alkyl; alkenyl; aryl; arylalkyl, wherein arylalkyl is

limited to benzyl, when R.sub.19 -R.sub.20 -R.sub.21 represents an

L-arginyl residue; (cycloalkyl)alkyl; aminoalkyl, wherein aryl and

arylalkyl amines are excluded when R.sub.19 -R.sub.20 -R.sub.21 represents

an L-arginyl residue; amidoalkyl, wherein benzoyl amides and their

heterocyclic variants are excluded when R.sub.19 -R.sub.20 -R.sub.21

represents an L-arginyl residue; hydroxyalkyl; guanidinoalkyl;

carboxyalkyl; (carboxyamido)alkyl, wherein aniline amides of aspartyl

residues and heterocyclic variants are excluded when R.sub.19 -R.sub.20

-R.sub.21 represents an L-arginyl residue; carboxyhydrazino)alkyl;

ureidoalkyl; (heterocyclic)alkyl, wherein when R.sub.19 -R.sub.20

-R.sub.21 represents an L-arginyl residue, then the heterocycle can only

be separated by one methylene unit from the alpha-carbon;

(thioalkoxy)alkyl, and sulfhydrylalkyl;

(aw) R.sub.303 is independently selected from the group consisting of lower

alkyl, arylalkyl, wherein arylalkyl is limited to benzyl when R.sub.19

-R.sub.20 -R.sub.21 represents an L-arginyl residue, and

(cycloalkyl)alkyl, with the proviso that R.sub.303 may not be a vinyl

group or have a heteroatom directly attached to the nitrogen or separated

from it by one methylene unit;

(ax) R.sub.304 is independently selected from the group consisting of

hydrogen; lower alkyl; alkenyl; aryl, arylalkyl, wherein arylalkyl is

excluded when R.sub.19 -R.sub.20 -R.sub.21 represents an L-arginyl

residue; (cycloalkyl)alkyl; aminoalkyl, wherein aryl and arylalkyl amines

are excluded when R.sub.19 -R.sub.20 -R.sub.21 represents an L-arginyl

residue; amidoalkyl, wherein benzoyl amides and their heterocyclic

variants are excluded when R.sub.19 -R.sub.20 -R.sub.21 represents an

L-arginyl residue; hydroxyalkyl; guanidinoalkyl; carboxyalkyl;

(carboxyamido)alkyl, wherein aniline amides and heterocyclic variants are

excluded when R.sub.19 -R.sub.20 -R.sub.21 represents an L-arginyl

residue; (carboxyhydrazino)alkyl; ureidoalkyl; (heterocyclic)alkyl,

wherein (heterocyclic)alkyl is excluded when R 19-R.sub.20 -R.sub.21

represents an L-arginyl residue; (thioalkoxy)alkyl; and sulfhydrylalkyl;

(ay) R.sub.307 and R.sub.317 are independently selected from hydrogen;

lower alkyl; aryl and arylalkyl, wherein arylalkyl is excluded for

R.sub.307 and R.sub.317 when R.sub.19 -R.sub.20 -R.sub.21 and R.sub.22

-R.sub.23 -R.sub.24 respectively represent an L-arginyl residue;

(az) R.sub.310 is independently selected from the group consisting of

hydrogen; lower alkyl; alkenyl; aryl; arylalkyl, wherein arylalkyl is

limited to benzyl when R.sub.22 -R.sub.23 -R.sub.24 represents an

L-arginyl residue; (cycloalkyl)alkyl; aminoalkyl, aryl and arylalkyl

amines are excluded when R.sub.22 -R.sub.23 -R.sub.24 represents an

L-arginyl residue; amidoalkyl, wherein benzoyl amides and their

heterocyclic variants are excluded, when R.sub.22 -R.sub.23 -R.sub.24

represents an L-arginyl residue; hydroxyalkyl; guanidinoalkyl;

(carboxyamido)alkyl, wherein aniline amides of aspartyl residues and

heterocyclic variants are excluded when R.sub.22 -R.sub.23 -R.sub.24

represents an L-arginyl residue; (carboxyhydrazino)alkyl; ureidoalkyl;

(heterocyclic)alkyl, wherein when R.sub.22 -R.sub.23 -R.sub.24 represents

an L-arginyl residue, then the heterocycle can only be separated by one

methylene unit from the alpha-carbon; and sulfhydrylalkyl;

(ba) R.sub.312 is independently selected from the group consisting of

hydrogen; lower alkyl; alkenyl; aryl; arylalkyl, wherein arylalkyl is

excluded when R.sub.22 -R.sub.23 -R.sub.24 represents an L-arginyl

residue; (cycloalkyl)alkyl; aminoalkyl, wherein aryl and arylalkyl amines

are excluded when R.sub.22 -R.sub.23 -R.sub.24 represents an L-arginyl

residue; amidoalkyl, wherein benzoyl amides and their heterocyclic

variants are excluded when R.sub.22 -R.sub.23 -R.sub.24 represents an

L-arginyl residue; hydroxyalkyl; guanidinoalkyl; carboxyalkyl;

(carboxyamido)alkyl, wherein aniline amides and heterocyclic variants are

excluded when R.sub.22 -R.sub.23 -R.sub.24 represents an L-arginyl

residue; (carboxyhydrazino)alkyl; ureidoalkyl; (heterocyclic)alkyl,

wherein (heterocyclic)alkyl is excluded when R.sub.22 -R.sub.23 -R.sub.24

represents an L-arginyl residue; (thioalkoxy)alkyl; and sulfhydrylalkyl;

(bb) R.sub.315 and R.sub.316 are independently selected from the group

consisting of hydrogen, lower alkyl, arylalkyl, wherein arylalkyl is

excluded when R.sub.22 -R.sub.23 -R.sub.24 represents an L-arginyl

residue, and (cycloalkyl)alkyl;

(bc) R.sub.310 is is selected from the group consisting of hydrogen, lower

alkyl, arylalkyl, alkenyl, (cycloalkyl)alkyl, aminoalkyl, and

guanidinoalkyl;

(bd) R.sub.325 and R.sub.326 are independently selected from the group

consisting of hydrogen, lower alkyl, aryl, arylalkyl, and

(cycloalkyl)alkyl;

all of the foregoing with the provisos that

(i) when more than one sulfhydrylalkyl is present in the compound, the

compound exists in the oxidized disulfide form producing a cyclic

molecule, or the two sulfhydryl moieties are connected by a C.sub.2 to

C.sub.8 alkylene chain and

(ii) when the compound contains a free amino group and carboxyl group, they

can be cyclized to give the corresponding lactam.