Supplementary material 2

Species / 5’UTR / Exon3 / 5’ Intron 3 3’ / Exon 4 / 5’ Intron 4
Human / taaaaattttgctgaaaaaa / ATG // TTG / gtgagtactttcatttattt //aaatcaattttttattctag / GTA // CCA / gtgagtattttttaaatgtt
Mouse / atg...g...tggtg....c / ATG // CTG / ...... tgc..cccat..g // t.....g....a...... / GTA // CCA / ...... acgcctgtgt
Rabbit / atg...a...tggtg..... / ATG // TTG / ...... t...... c.... // ..t.t.gc...g.g...c.. / GTA // CCC / ...... c.g..tg.
Cow / atg...a...tggtg..... / ATG // TTG / ...... t...... at... // ..tc.gg....gc....c.. / GTA // CCA / ...... a......
Horse / atg...a...tggtg..... / ATG // TTG / ...... t...... c.... // ..tc..g....g.....c.. / GTA // CCA / ...... aaacatttttt
Dog / .tc...a...tggtg..... / ATG // TTG / ...... t...... c.... // ..tc..g....g.....c.. / GTA // CCA / ...... caaaa.tt.t..
Shrew / atg...g...tggtg..... / ATG // TTT / ...... t...a..cc.... // g.ta.gg....g....gc.. / GTA // CCA / ...... t.gc..cttt.taa
Elephant / atg.cta...tggtg..... / ATG // TTG / ...... t...... c.... // ..t....c...g.....c.. / GCA // CCA / ...... aaaa...aa.a
Opossum / ..tg..aac.tt.cc...g. / ATG // GTG / ..a...ct.cct....gc..// ...... ccc..c.c..a... / GTC // CCT / ..a....a.gaagtttacag
Platypus / ..tg..ag..t.gctgg... / ATG // CTG / ...... tt.cctt.ccg.c.// cct.ggccc.cc.t...c.. / ATA // CCG / ...... acaggtctct.g

Intron 4 3’

/ Exon5 / 5’ Intron 5 3’ / Exon 6 / 5’ Intron 6
Human / tgacattctcttacttccag / ATG // GAG / gtatgtacgttcagtctcag // atggattcctttggttgcag / ATG// CAT / gtaagtttttctttatgtta
Mouse / catttc..c..c.g...... / ATG // GAG / ...... tta.attctgt.c // ...... ca..t... / ATG // CCA / ...... cc..ta.ac....t
Rabbit / ...t..g....c.t...... / ATG // GAG / ...... ta...... g.... //...... / ATG // CAT / ...... cc...... c...
Cow / .ct.tca..tcc.g..g... / ATG // GAG / ...... t...... // ...a...... ca... / ATG // CAT / ...... aca...atat.a.
Horse / ca...c.....cc...... / ATG // GAG / ...... t...... t. // ...... t....t..ca... / ATG // CAT / ...... cca....t.a...
Dog / ca.t.....t.c...a.... / ATG // GAG / ...... ta..a.t.aagtc // t...... t...... ca... / ATG // CAT / ...... ccg....g.a..c
Shrew / cc.t...t...c....t... / ATG // GAG / ...... t.a.t.t...ttc // ...a...t.c.....ca... / ATG // CAT / ...... cc.a....tat..t
Elephant / atg.tcctctcac...... / ATG // GAG / ...... t....g.....tt // .at.g...t....a.ca... / ATG // CAT / ...... c..t..atat.at
Opossum / a.gggc.....gt...... / ATG // GAG / ...... gtagc.tct.ctgt// .ca..cct.....c.ca... / ATG // CAC / ...... cc.cg.caa.g.
Platypus / atgtc.ctct..ttcca... / ATG // GAG / ...g...t.gc..cctctt.// cg.at..gt...t..ca... / ATG // CAC / ..t.ag..cc.c..tcaacc

Intron 6 3’

/ Exon7 / 5’ Intron 7 3’ / Exon 8 / 5’ Intron 8
Human / attatttgctaccctttcag / ATG // CAG / gtgagacttgcacagaaaaa // gattctttctttctctctag / GCA // CAG / gtgagaaatttttttttctt
Mouse / tgct...... g.t...... / ATG // CAG / .....g..a.ag...... c// t.a.t.g...... t..... / CCA // CAG / ..a....c...c.a.atgct
Rabbit / gcct...... t...... / ATG // CAG / .....g...att....g...// ctg.ga...... / ACA // CAG / ..a....t...... c.t.a
Cow / tgtta..tacta..c.a... / TTG // CAG / .....g..c.tc...c.... // ctc.ga...c..tgt..... / GCA // CAT / .....tgt....cccttaaa
Horse / gc...... t..cg... / ATG // CAG / .....g.....c...cg... // ...... c...... / GCA // CAC / .....ttt.....c...a.a
Dog / g...... t.t..g... / ATG // CAG / .....g.....c.t.c.... // .....c.g...... t... / GCA // CAC / .....ttt....c...atac
Shrew / gac...... c...... / ATG // CAG / ...... ttgag...... // nnnnnnnnnnnnnnnnnnnn / NNN // NNN / nnnnnnnnnnnnnnnnnnnn
Elephant / g...... t...... / ATG // CGG / .....g.....c...... c.// ...... / GCA // CAG / ...... t.a....c..taa
Opossum / ca.tg...tcc.....c... / ATG // CCA / ..a.atg..tact.ctt.g.// ctccaaa...c.t....c.. / CAA // CAG / .....tg.a.gc.ggc.t..
Platypus / cc.tcc.ct.ctttccc... / ATG // CAA / ..a..c.c..gc.tcggg.c// tca.accgt.....t..c.. / ATG // CCG / .....tgccacc.ccgaac.

Intron 8 3’

/ Exon9 / 5’ Intron 9 3’ / Exon 10 / 3' UTR
Human / ctgtgtttttcacttctcag / AGG // GGG / gtaagtacaagtaaaactac // ttccattttctttcctacag / AAT // TAG / gggttatccaaccaagcatt
Mouse / .....c.c....tc.t.... / AGG // GGA / ...... g...ggct..gt // tc.tg.c...... t.. / AAT // TAG / ..a.cgcttc.a.tgaaca.
Rabbit / t.t...... c.tg... / AGG // GGG / ...... a.cagcgtt.cc. // .....a...... / AAT // TAG / ..a.....t...... a..c
Cow / t.a..g...... c.t.... / AAG // GGG / ...... g....// ..t.ca.c.tc...... / AAC // TAG / .aa.c...tccagc.agta.
Horse / ...... c.t.... / AGG // GGG / ...... gtc.t // ...tg.c...... / AAT // TAG / ..a....ttc.a.c.tgga.
Dog / t.a...... g...a.t.t.. / AGG // GGG / ..g....t.....g.g.... // .....cc.....c...... / AAT // TAG / ..a....tgc.a...aacac
Shrew / a.tgtgg...... c.t.... / AGG // GGG / ...... a...tg.... // gattt.a...... a.... / AAT // TAG / ..a.a.cttc.a.g.ag.ac
Elephant / tg.gt...... tc.t.... / AGG // GGA / ...... t..agct.ca.tt // ...tg.c...... / AAT // TAG / ..a.c...tc.a.c.agca.
Opossum / .ct...... gtc.a.t.... / CGA // GGG / ...... g..t.tt.g.c.t // c.tct....tc.c...... / AAT // TAG / ..aag..aattggc.c.t.a
Platypus / ...a.....gt..c.t.... / CAA // GGG / ...... tcctct.a..t// .ct.c.c...c.c.tg.... / AAT / /TAG / .a..ccg.ag....cc.cc.