TABLE 1A. Patient Characteristics, Tumor Sites and mutations in MPNST in NF1 Patients (n=34).

ID / Sex / Age / Location / TP53 / TERT / BRAF
29 / M / 67 / head temporal / No / No / No
103 / F / 37 / Neck / No / No / No
163 / M / 44 / Axilla / Nd / No / No
73 / F / 7 / L upper arm / No / No / No
135 / M / 50 / L upper arm / No / Nd / Nd
162 / F / 54 / R upper arm / Nd / No / No
2 / M / 18 / R buttock / No / Nd / Nd
94 / F / 66 / Buttock / No / No / No
105 / M / 21 / Buttock / Nd / No / No
63 / M / 27 / L upper leg / No / No / No
6 / M / 40 / L upper leg / 247insH / No / No
112 / M / 49 / upper leg / D281A / No / No
4 / F / 33 / L lower leg / Splice / No / No
16 / F / 26 / L lower leg / No / No / No
125 / F / 30 / lower leg / L330F / No / No
146 / M / 46 / L leg / Nd / No / No
108 / F / 45 / Leg / E171X / No / No
152 / M / 29 / Leg / Nd / No / No
14 / M / 16 / thoracic wall / No / No / No
82 / F / 35 / thoracic wall / No / No / No
87 / F / 32 / thoracic wall / No / Nd / Nd
102 / M / 69 / thoracic wall / No / No / No
150 / F / 27 / Thoracic wall / Nd / No / No
12 / F / 21 / Abdomen / No / No / No
126 / F / 17 / Abdomen / Nd / Nd / Nd
100 / F / 2 / Retroperit. / No / No / No
46 / F / 14 / Spine / No / No / No
118 / M / 55 / Spine / No / No / No
85 / M / 14 / Pelvis / No / No / No
153 / M / 48 / Pelvis / Nd / No / No
27 / M / 38 / Presacral / No / No / No
10 / F / 40 / Sacrum / Nd / No / No
148 / M / 9 / Sacrum / Nd / No / No
151 / F / 17 / Sacrum / Nd / No / No

TABLE 1B. Patient Characteristics, Tumor Sites and mutations in Sporadically Occurring MPNST (n=76).

ID / Sex / Age / Location / TP53 / TERT / BRAF
119 / M / 16 / Brain / Nd / No / V600E
160 / M / 3 / Brain / Nd / No / No
58 / F / 74 / L facial n. / No / Nd / Nd
13 / M / 46 / L vest. n. / No / No / No
53 / F / 26 / L vest. n. / No / No / No
11 / M / 33 / R vest. n. / No / No / No
89 / F / 2 / vest. N. / No / No / No
40 / M / 63 / R eyelid / S261N / Nd / No
44 / M / 82 / L max. sinus / No / No / No
76 / F / 72 / L max. sinus / R175H / No / No
81 / F / 39 / max. sinus / No / No / No
86 / M / 46 / max. sinus / No / No / No
17 / M / 59 / sinus pirif. / No / No / No
59 / M / 78 / R parotis / Nd / C228T / Nd
83 / F / 84 / nose bridge / No / C250T / No
106 / F / 71 / Orbit / No / Nd / No
121 / F / 78 / L cheek / Nd / C228T / Nd
47 / M / 60 / L mandible / D207D / No / No
139 / M / 28 / R neck / S183X / No / No
147 / M / 1 / Neck / Nd / C250T / Nd
33 / M / 21 / R shoulder / Nd / No / Nd
136 / F / 41 / R shoulder / Nd / No / Nd
9 / M / 59 / R upper arm / R213T / Nd / Nd
28 / M / 58 / R upper arm / No / No / V600E
142 / F / 66 / R elbow / Nd / No / Nd
20 / F / 46 / R lower arm / No / Nd / Nd
93 / F / 13 / lower arm / No / No / No
30 / M / 66 / L arm / No / No / No
159 / F / 86 / R arm / Nd / No / No
71 / M / 47 / Arm / Nd / No / No
69 / M / 76 / L groin / R196X / No / No
107 / M / 25 / Buttock / Nd / No / Nd
96 / F / 76 / L upper leg / G266V / No / No
5 / F / 83 / R upper leg / No / No / No
19 / F / 10 / R upper leg / No / Nd / Nd
36 / M / 60 / R upper leg / No / C228T / No
39 / M / 53 / R upper leg / No / No / No
117 / F / 66 / R upper leg / Nd / No / Nd
99 / M / 50 / upper leg / Nd / No / No
143 / M / 21 / upper leg / No / No / No
109 / F / 54 / L lower leg / No / No / No
7 / F / 50 / R lower leg / No / Nd / Nd
132 / F / 39 / R lower leg / Nd / Nd / Nd
156 / M / 67 / L leg / Nd / Nd / Nd
78 / F / 83 / Leg / No / No / No
111 / M / 48 / Leg / Q331X / No / No
22 / M / 4 / thoracic wall / No / No / No
37 / M / 53 / thoracic wall / Nd / C250T / V600E
116 / F / 49 / thoracic wall / No / No / Nd
134 / F / 48 / thoracic wall / No / No / Nd
128 / F / 53 / Mediastinum / P316L / No / Nd
155 / M / 45 / L lung / Nd / No / No
80 / F / 56 / Vagus n. / N239S / No / No
56 / M / 13 / L flank / No / No / No
91 / F / 70 / Flank / No / C228T / No
141 / M / 68 / abd. Wall / S241F / C228T / No
158 / F / 45 / Omentum / Nd / No / No
21 / M / 62 / Retroperit. / No / Nd / Nd
145 / F / 33 / Retroperit. / No / No / No
157 / F / 55 / Ischiad n. / Nd / No / No
138 / M / 63 / Liver / Nd / C228T / No
54 / F / 46 / Uterus / C176F / No / No
165 / F / 78 / Cervix / Nd / No / Nd
161 / M / 4 / Prostate / Nd / No / No
149 / M / 61 / Penis / Nd / No / No
49 / M / 42 / L testis / No / No / No
137 / F / 77 / Back / No / Nd / Nd
64 / F / 31 / Spine / No / No / No
65 / M / 58 / Spine / No / No / No
101 / M / 4 / Spine / Nd / No / No
130 / M / 35 / Spine / P318S / No / No
131 / F / 32 / Spine / No / Nd / Nd
154 / F / 64 / Spine / Nd / No / No
164 / M / 67 / Spine / Nd / No / No
70 / M / 1 / Myelum / No / No / No
42 / F / 46 / Sacrum / No / Nd / No

ID, case number; F, female; M, male; L, left; R, right; n., nerve; max., maxillary; vest., vestibular; pirif., piriformis; abd., abdominal; retroperit., retroperitoneum;ND, not determined;TP53, TP53 mutation; TERT, TERT promoter mutation; BRAF, BRAF mutation. TP53 mutations have been publishedearlier (reference 12: Verdijk RM, den Bakker MA, Dubbink HJ, Hop WC, Dinjens WN, Kros JM (2010) TP53 mutation analysis of malignant peripheral nerve sheath tumors. J Neuropathol Exp Neurol 69: 16-26).