PROGRAMME
TRANSLATIONAL MEDICINE: INNOVATIONS IN RENAL RESEARCH
Scenic Hotel, Blenheim, Marlborough, New Zealand
2-3 December, 2016
Joint international meeting of the Renal Scientists of the Australia and New Zealand Society of Nephrology and the Kidney in Health and Disease Network, University of Otago
Thursday, 1st December, 2016
6.30-8.00 pm Evening reception, Scenic Hotel Marlborough
Friday, 2nd December, 2016
9.30 am Registration
9.50 am Welcome Rob Walker and Stuart Smith, (MP for Kaikoura)
Session 1 Chair : Adam Ware with Fiona McDonald
10.00-10.20 am Adam W Ware, FJ McDonald, Department of Physiology, University of Otago
COMMD10: A novel regulator of ENaC endocytosis and recycling.
10.20-10.40 am Fiona J. McDonald, Cheung. T.T., Geda, A., Pilmore, E., Hamilton, K.L., Department of Physiology, University of Otago
Recycling of epithelial ion channels by Retromer with implications for water and salt homeostasis.
10.40-11.00 am Jan-Peter Baldin, Martin Fronius, Department of Physiology, University of Otago
Role of the β and γ subunit of the epithelial sodium channel (ENaC) in shear force sensation
11.00-11.20 am Michael Jennings, Zoe Ashley, Catherine Leader, Fiona McDonald, Ivan Sammut, Rob Walker, Martin Fronius, Departments of Physiology, Medicine, Pharmacology and Toxicology, University of Otago
The ultrastructure of mesenteric arteries in a hypertensive rat model
11.20-11.40 am Daniel Barth, Martin Fronius, Department of Physiology, University of Otago
The epithelial sodium channel is activated by shear force via glycosylated asparagines and the extracellular matrix.
11.40-12.00 am Stephen Bird, Department of Obstetrics and Gynaecology, University of Melbourne Intracellular calcium transients mediate mesothelial cell configuration in response to histamine. A prelude to EMT?
Lunch 12-1.00 pm
Session 2 Chair: Daniel Barth with Martin Fronius
1.00 – 1.30 pm Catherine Leader, Zoe Ashley, Ivan Sammut, Gerry Wilkins, Rob Walker, Departments of Medicine, Physiology, Pharmacology and Toxicology, University of Otago
Kidney injury following myocardial infarction in a hypertensive transgenic rat
1.30-2.00 pm Zoe Ashley, Catherine Leader, Ivan Sammut, Fiona McDonald, Rob Walker, Martin Fronius, Departments of Physiology, Medicine, Pharmacology and Toxicology, University of Otago
Role of ENaC in the dysfunction of resistance arteries in hypertension with/without the confounding factor of myocardial infarction.
2.00-2.10 pm Sama Mugloo, Zoe Ashley, Catherine Leader, Andrew Bahn, Ivan Sammut, Rob Walker, Fiona McDonald, Martin Fronius, Departments of Physiology, Pharmacology and Toxicology, Medicine, University of Otago
Epithelial Sodium Channel (ENaC) : an emerging regulator of vascular physiology
2.10 – 2.40 pm Colin Hutchison, Hawkes Bay District Health Board
The RemovalHD Study: why are middle molecules worth removing?
Afternoon tea 2.40 – 3.10 pm
Session 3 Chair: Rob Walker
3.10-3.40 pm Alan Davidson, Department of Molecular Medicine and Pathology, University of Auckland
Using organoids to model human kidney disease
3.40-4.10 pm MacGinley, R., Roberts, M., Lee, D., Huang, L., McMahon, L. Integrated Renal Service, Eastern Health Clinical School, Monash University
Studies explaining the link between pathways for FGF23- bone, anaemia and cardiac relationships.
4.10-4.25 pm John Leader, Jennifer Bedford, Leunie van der Tholen, David Weiner, Rob Walker Department of Medicine, University of Otago; University of Florida, USA; Radboud University, The Netherlands
Lithium in the renal cortex
Posters 4.25 pm -
Cheung. T.T., Geda, A., Pilmore, E., Hamilton, K.L., McDonald, F.J., Department of Physiology, University of Otago
How is epithelial ion transport maintained? Implications for hypertension.
G.C. Gobe, E.P. Owens, Z.H. Endre, J.S. Coombes, H.G. Healy, R. Wilkinson, K.S. Tan, A. Cameron, W.E. Hoy, NHMRC CKD.CRE, Brisbane, Queensland; School of Medicine, University of Queensland;
Kidney Health Services (RBWH); Metro North Hospital and Health Service, Brisbane; School of Human Movement and Nutrition Sciences (HMNS), University of Queensland; School of Medicine, University of NSW (UNSW); Department of Nephrology, Prince of Wales Hospital, Sydney; Translational Research Institute, Brisbane; QIMR Berghofer Medical Research Institute, Brisbane;
Renal Services (Logan), Metro South Hospital and Health Service, Brisbane
Use of quality biobanking for translational medicine in chronic kidney disease
Carol Bussey, Sama Mugloo, Jeff Erickson, Martin Fronius, Zoe Ashley, Department of Physiology, University of Otago
β-blockers rescue flow-mediated responses of carotid arteries in diabetes through a reduction in vascular ENaC activity?
Dinner, at Arbour, 7.00 pm Bus leaves at 6.45 pm from Chateau Marlborough
Saturday, 3rd December
Session 1 Chair : Catherine Leader with Rob Walker
9.00-9.20 am MacGinley, R., Roberts, M., Lee, D., Brumby, C., McMahon, L. Integrated Renal Service, Eastern Health Clinical School, Monash University Melbourne
Clinical utility of new non-invasive pulse wave measures in studies of patients with renal disease or high CVS risk.
9.20-9.40 am Stephen D. Bird, Department of Obstetrics and Gynaecology, The University of Melbourne
Artificial placentation: respiratory, renal and nutritional support for extreme preterm infants.
9.40-10.00 am Tristan Chien, Robert Ellis, Christudas Morais, Luis Vitetta, Glenda Gobe
Centre for Kidney Disease Research, University of Queensland; Medlab Biotechnology, Sydney
Nephrotoxic effects of cis-diamminedichloroplatinium II (cisplatin) can be ameliorated using Coenzyme Q10
10.00-10.30 am Wilson, L.C., Wilkins, G.T., Cotter, J.D., Manning, P., Walker R.J. Department of Medicine, School of Physical Education, Sports and Sports Science, University of Otago
What aspects of altered cerebral vascular function can be implicated in the elevated risk of cerebrovascular disease in those with type 2 diabetes. Can six-months of high-intensity interval training improve cerebral vascular function?
Morning tea 10.30-11.00 am
Session 2 Chair: Kim O’Sullivan with Richard Kitching
11.00-11.30 am Hu, C-C., Katerelos, M., Choy, S-W., Crosthwaite, A., Mount, P., Cook, N., Paizis, K., Power, D.A. Department of Nephrology, Austin Health; Mercy Hospital for Women; University of Melbourne, Kidney Laboratory, Austin Health
Renal tubular sodium transporter expression and phosphorylation is altered in pre-eclampsia
11.30-11.40 am T. Putt, J. Schollum, R. Walker, J. Leishman, S. Duffull, D. Wright Department of Medicine, School of Pharmacy, University of Otago
Pharmacokinetics of Metformin in setting of CKD
11.40-12.10 pm Wilkinson, R., Wang, X., Kassianos, A.J., Kildey, K,. Potriquet, J., Lobb, R., Cloonan, N., Healy, H. Department of Pathology, University of Queensland; Department of Renal Medicine, Royal Brisbane and Women’s Hospital; Institute of Health and Biomedical Innovation, Queensland University of Technology; School of Medicine, University of Queensland; QIMR Berghofer Medical Research Institute, Brisbane
Molecular profiling of exosomes derived from primary human proximal tubule epithelial cells (PTEC) under normal and diseased conditions
12.10-12.30 pm Grace Li, Hywel S. Lloyd, John Schollum, Murray W. Tilyard, Andy Tomlin, Robert Walker, Departments of Medicine, General Practice and Rural Health, University of Otago; Southern District Health Board, Dunedin Hospital
The prevalence of Chronic Kidney Disease in primary health care in the southern region of New Zealand.
Lunch 12.30-1.30
Session 3 Chair : Zoe Ashley with David Power
1.30—2.00 pm Joshua D. Ooi, Jan Petersen, Yu H. Tan, Megan Huynh, Zoe J. Willett, Nadine L. Dudek, Peter J. Eggenhuizen, Khai L. Loh, Katherine A. Watson, Poh-Y. Gan, Andreas Handel, Billy G. Hudson, Lars Fugger, David A. Power, Stephen G. Holt, Patrick T. Coates, Anthony W. Purcell, Jon W. Gregersen, Stephen R. Holdsworth, Nicole L. La Gruta, Hugh H. Reid, Jamie Rossjohn, A Richard Kitching Centre for Inflammatory Diseases, Monash University; Infection and Immunity Program, Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne; Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, USA; Department of Medicine, Vanderbilt University;. MRC Human Immunology Unit, John Radcliffe Hospital, University of Oxford; Department of Nephrology, Austin Health; Department of Nephrology, The Royal Melbourne Hospital; Central Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital; Department of Medicine, Viborg Regional Hospital, Denmark; Department of Nephrology, Monash Health; Institute of Infection and Immunity, Cardiff University School of Medicine; Department of Pediatric Nephrology, Monash Health
Dominant protection from HLA-associated autoimmune kidney disease is conferred by antigen specific regulatory T cells
2.00-2.20 pm O’Sullivan, K.M, Kitching, A.R.,, Holdsworth, S.R. Centre for Inflammatory Diseases, Department Of Medicine, Monash University; Department of Nephrology, Monash Health
Increased Toll like receptor 2, 4 and 9 expression correlates with histological and functional injury in kidneys from patients with anti-neutrophil cytoplasmic antibody vasculitis
2.20-2.40 pm Maliha Alikhan, Kazuya Kishimoto, Stephen R. Holdsworth, Joshua D. Ooi, A. Richard Kitching Centre for Inflammatory Diseases, Department of Medicine, Monash University; Department of Nephrology, Monash Health
The IL-7Ra on CD8+ cell: a potential therapeutic target in ANCA-associated glomerulonephritis
Afternoon tea 2.40 -3.10 pm
Session 4 Chair: Luke Wilson with Glenda Gobe
3.10-3.40 pm Andrew Salmon, Janos Peti-Peterdi, Steve Harper, Dave Bates, Joanne Ferguson, Leslie Sage, Kai Betteridge, Amy Russell, Sara Desideri, Chris Neal, Yan Qiu, Raina Ramnath, Kenton Arkill, Bridget Wills, Simon Satchell, Becky Foster Renal Service, Waitemata DHB, Auckland; Keck School of Medicine, University of Southern California; Renal Service, North Bristol NHS Trust; School of Physiology and Pharmacology, University of Bristol; Faculty of Medicine and Health Sciences, University of Nottingham; Nuffield Dept of Medicine, University of Oxford; School of Clinical Sciences, University of Bristol
Kidney disease, microvascular permeability and the endothelial glycocalyx
3.40 – 4.00 pm Fenja Knöpp, Zoe Ashley, Daniel Barth, Jan-Peter Baldin, Martin Fronius, Department of Physiology, University of Otago, New Zealand; and Institute of Animal Physiology, Justus-Liebig-University Giessen, Germany
Epithelial Na+ channel and the extracellular matrix – an intimate relationship that facilitates shear force responsiveness