Workshop on Systematic Reviews and Meta-Analyses in
Cognitive Ageing and Cognitive Epidemiology Research
Monday 27th November, 2017
Room 7.01, Dugald Stewart Building, School of PPLS, University of Edinburgh
09.00 – 09.30 Introduction to systematic reviews
Susan Shenkin
Geriatric Medicine, University of Edinburgh Medical School
09.30 – 10.30 Introduction to Literature Searching for Systematic Reviews
Anne Donnelly
Academic Support Librarian (Philosophy, Psychology & Language Sciences), University of Edinburgh
10.30 – 10.45 Coffee / Tea
10.45 – 11.15 Data extraction, quality assessment, and writing up
Rebecca Woodfield
Geriatric Medicine, NHS Lothian
11.15 – 11.30 Practical hints and tips
Ellen Backhouse/Caroline McHutchison
Centre for Clinical Brain Sciences, University of Edinburgh
11.30 – 12.30 Introduction to meta-analysis
Mike Allerhand
CCACE, University of Edinburgh
12.30 – 13.30 Lunch
Greenfield Computer Lab, George Square
13.30 – 14.00 Introduction to meta-analysis (continued)
Mike Allerhand
CCACE, University of Edinburgh
14.00 - 16.00 Workshop on literature searching for systematic reviews
Anne Donnelly
16.00 – 16.10 Round-up and questions
Resources
Systematic Review Guidelines and Methodology
Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE: slides and resources from this course http://www.ccace.ed.ac.uk/research/software-resources/systematic-reviews-and-meta-analyses Or http://tinyurl.com/sysrev1
Cochrane UK has a wealth of useful information, with focus on intervention studies for healthcare: http://uk.cochrane.org/author-resources
The Centre for Reviews and Dissemination provides useful information for the review of medical studies. Systematic Reviews: CRD’s guidance for undertaking reviews in health care
http://www.york.ac.uk/inst/crd/index_guidance.htm
The Campbell Collaboration website lists useful links to methodology sites, with focus on evidence based policy and practice: http://www.campbellcollaboration.org/resources/research/Methods_Links.php
The Evidence for Policy and Practice Information and Co-ordinating Centre (EPPI-Centre) provides an online evidence library, and methods and tools for completing systematic reviews relevant to public policy: http://eppi.ioe.ac.uk/cms/
The EQUATOR Network website seeks to improve reliability and value of medical research literature by promoting transparent and accurate reporting of research studies: http://www.equator-network.org/
The International prospective register of systematic reviews (PROSPERO) website, administered by the Centre for Reviews and Dissemination (CRD) at the University of York, provides information on registering systematic reviews in healthcare, and provides links to useful webpages on methodology and reporting: http://www.crd.york.ac.uk/PROSPERO/
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) provides a minimum set of evidence-based items that all authors should comply with in reporting their systematic review and/or meta-analysis: http://www.prisma-statement.org/
The Scottish Intercollegiate Guidelines Network (SIGN) provides information on how to conduct a systematic literature review, and helpfully has assessment checklists for cohort and case-control studies: http://www.sign.ac.uk/guidelines/fulltext/50/section6.html
Online Second Edition of Systematic Reviews in Health Care: Meta-Analysis in Context (Egger, Davey Smith, & Altman, 2008): http://www.blackwellpublishing.com/medicine/bmj/systreviews/default.asp
References
Overview:
Egger M, Davey Smith G, Altman DG (eds). (2001). Systematic Reviews in Health Care: Meta-Analysis in Context. London: BMJ Books.
Gough D, Oliver S, Thomas J. (2012). An Introduction to Systematic Reviews. SAGE Publications Ltd.
Pettricrew M, Roberts H. (2006). Systematic Reviews in the Social Sciences: A Practical Guide. Wiley-Blackwell.
Epidemiology in medicine. Hennekens and BuringHarvard Medical School, Boston (1987)
Khan K S, Kunz R, Kleijnen J, Antes G Systematic Reviews to support Evidence Based Medicine London: Hodder Arnold 2011
Shenkin SD et al Systematic reviews: guidance relevant for studies of older people Age and Ageing, 46(5): 722–728 https://doi.org/10.1093/ageing/afx105
Critical appraisal/risk of bias assessment:
The pocket guide to critical appraisal. Crombie BMJ Publishing Group, London. (1996)
ROBIS: A new tool to assess risk of bias in systematic reviews was developed Whiting et al 2016 Journal of Clinical Epidemiology 69: 225-234 http://www.sciencedirect.com/science/article/pii/S089543561500308X
Testing a tool for assessing the risk of bias for nonrandomized studies showed moderate reliability and promising validity (ROBANS) Kim et al JCE 2013 http://dx.doi.org/10.1016/j.jclinepi.2012.09.016 http://www.jclinepi.com/article/S0895-4356(12)00322-8/abstract
Harrison JK et al Using quality assessment tools to critically appraise ageing research: a guide for clinicians Age and Ageing 46(3): 359–365, https://doi.org/10.1093/ageing/afw223
Literature searching:
Booth A. ‘Unpacking your literature search toolbox: on search styles and tactics’. Health Information and Libraries Journal 2008; 25(4): 313-7.
Cheng, K., C. Preston, et al. (1998). "Time to publication as full reports of abstracts of randomized controlled trials in cystic fibrosis." Pediatric Pulmonology 26(2): 101-105.
Egger, M., P. Juni, et al. (2003). "How important are comprehensive literature searches and the assessment of trial quality in systematic reviews? Empirical study." Health Technology Assessment 7(1): 1-76.
Hopewell S, McDonald S, Clarke MJ, Egger M. Grey literature in meta-analyses of randomized trials of health care interventions. Cochrane Database of Systematic Reviews 2007, Issue 2. Art. No.: MR000010. DOI: 10.1002/14651858.MR000010.pub3.
Savoie, I., D. Helmer, et al. (2003). Beyond Medline: reducing bias through extended systematic review search. International Journal of Technology Assessment in Health Care 19(1): 168-78.
Meta-Analysis
Borenstein M., Hedges L., Higgins J., Rothstein H. (2009). Introduction to Meta-Analysis.
John Wiley & Sons Ltd.
Tierney J. F., et. al. (2007) Practical methods for incorporating summary time-to-event data into meta-analysis.
Trials 2007, 8:16
http://handbook-5-1.cochrane.org/
https://www.meta-analysis.com/
http://www.metafor-project.org/
Susan / Shenkin / Clinical Senior Lecturer and Honorary Consultant in Geriatric Medicine
School of Clinical Sciences and Community Health
University of Edinburgh Medical School
Mike / Allerhand / Statistician
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology
University of Edinburgh
Anne / Donnelly / Academic Support Librarian (Philosophy, Psychology & Language Sciences)
University of Edinburgh
Rebecca / Woodfield / Postdoctoral Researcher and Specialty Registrar, Geriatric Medicine
NHS Lothian
Ellen / Backhouse / PhD student
Centre for Clinical Brain Sciences
University of Edinburgh