Article title: Anthropometric characteristics and risk of lymphoid and myeloid Leukemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Journal name: Cancer Causes and Control

Author names: Fatemeh Saberi Hosnijeh1,2, Isabelle Romieu3, Valentina Gallo 4, Elio Riboli4, Anne Tjønneland5, Jytte Halkjær5, Guy Fagherazzi6,7, Françoise Clavel-Chapelon6,7, Laure Dossus6,7, Annie Lukanova8, Rudolf Kaaks8, Antonia Trichopoulou9,10, Pagona Lagiou9,11, Michael Katsoulis10, Salvatore Panico12, Giovanna Tagliabue13, Catalina Bonet14, Miren Dorronsoro15, José María Huerta16,17, Eva Ardanaz17,18, Maria-José Sánchez 17,19, Dorthe Johansen20, Signe Borgquist21, Petra Peeters22, H. Bas Bueno-de-Mesquita23,24, Martine M Ros23,25, Ruth C. Travis26, Timothy J. Key26, Paolo Vineis4*, Roel Vermeulen1,22*

Affiliation: 1 Institute for Risk Assessment Sciences (IRAS), Division Environmental Epidemiology, Utrecht University, Netherlands; 2 Zanjan University of medical science, Zanjan, Iran; 3 International Agency for Research on Cancer (IARC-WHO), Lyon, France; 4Division of Epidemiology, Public Health and Primary Care, Faculty of Medicine,Imperial College, London, UK; 5Danish Cancer Society Research Center, Copenhagen, Denmark; 6Inserm, U1018, Gustave Roussy Institute, F-94805, Villejuif, France; 7Paris South University, UMRS 1018, F-94805, Villejuif, France; 8Division of Cancer Epidemiology German Cancer Research Centre Heidelberg, Germany; 9 WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece; 101 Hellenic Health Foundation, Athens, Greece; 11 Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece; 12 Department of Clinical and Experimental Medicine Federico II University, Naples, Italy; 13 Environmental Epidemiology and Cancer Registry Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; 14 Unit of Nutrition, Environment and Cancer,Catalan Institute of Oncology (ICO),Barcelona, Spain; 15 Public health Division of Gipuzkoa, Basque Regional Health Department and Biodonostia/Ciberesp,Spain; 16 Department of Epidemiology, Murcia Regional Health Authority, Murcia, Spain; 17 CIBER Epidemiología y Salud Pública (CIBERESP), Spain; 18 Navarre Public Health Institute,Pamplona,Spain; 19 AndalusianSchoolof Public Health, Granada (Spain); 20Department of Surgery, Malmö University Hospital, Lund University, Malmö, Sweden; 21Clinical Sciences, Department of Oncology, Lund University, Sweden;22 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Netherlands; 23National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands; 24 Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands; 25 Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands ;26 Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.

* Co-last authors

E-mail address of the corresponding author:

Roel Vermeulen

Institute for Risk Assessment Sciences

Division Environmental Epidemiology

Jenalaan 18D, PO Box 80178

3508 TD, Utrecht, The Netherlands

Tel: +31 30 253 9448

Fax: +31 30 253 9499

E-mail:

Online Resource 2 Sex-specific RR and 95% CI for leukemia/subtypes risk in relation to anthropometric characteristics (mutually adjusted models)

Multivariate model
All leukemia / Myeloid leukemia / Lymphoid leukemia
Female / n / RR (95% CI) / n / RR (95% CI) / n / RR (95% CI)
Body mass index
<22.48
22.48-24.96
24.97-28.23
≥28.24
P-trend / 42
84
96
79 / Ref.
1.73 (1.15-2.61)
1.79 (1.12-2.87)
1.21 (0.69-2.13)
0.61 / 20
30
48
41 / Ref.
1.29 (0.69-2.40)
1.74 (0.87-3.50)
0.99 (0.44-2.26)
0.99 / 18
50
40
37 / Ref.
2.35 (1.30-4.26)
1.78 (0.89-3.58)
1.69 (0.74-3.84)
0.46
Waist circumference
<73.1
73.1-79.9
80.0-88
≥88.1
P-trend / 63
62
78
84 / Ref.
0.79 (0.53-1.16)
0.80 (0.52-1.24)
1.09 (0.65-1.82)
0.76 / 27
28
29
50 / Ref.
0.90 (0.50-1.64)
0.75 (0.38-1.49)
1.77 (0.83-3.77)
0.16 / 30
31
43
32 / Ref.
0.77 (0.45-1.34)
0.89 (0.49-1.61)
0.74 (0.35-1.59)
0.58
WHR
<0.76
0.76-0.79
0.80-0.84
≥0.85
P-trend / 67
78
67
75 / Ref.
1.04 (0.75-1.45)
0.75 (0.53-1.07)
0.93 (0.64-1.34)
0.34 / 23
35
36
40 / Ref.
1.35 (0.79-2.30)
1.18 (0.68-2.03)
1.48 (0.84-2.60)
0.28 / 38
40
27
31 / Ref.
0.94 (0.60-1.48)
0.53 (0.32-0.88)
0.65 (0.38-1.10)
0.03
Male
Body mass index
<24.22
24.22-26.30
26.31-29.72
≥29.73
P-trend / 88
94
94
83 / Ref.
0.77 (0.59-1.09)
0.72 (0.48-1.07)
0.53 (0.33-0.87)
0.02 / 33
38
37
34 / Ref.
0.79 (0.45-1.38)
0.71 (0.37-1.34)
0.54 (0.25-1.16)
0.13 / 46
52
50
41 / Ref.
0.85 (0.53-1.37)
0.79 (0.46-1.37)
0.55 (0.28-1.09)
0.11
Waist circumference
<88.5
88.5-94.9
95-101.9
≥102
P-trend / 66
84
91
92 / Ref.
1.32 (0.92-1.90)
1.55 (1.03-2.35)
1.92 (1.17-3.14)
0.01 / 24
35
36
37 / Ref.
1.54 (0.86-2.75)
1.78 (0.91-3.47)
2.28 (1.03-5.02)
0.05 / 36
45
46
47 / Ref.
1.24 (0.76-2.01)
1.32 (0.75-2.32)
1.68 (0.85-3.29)
0.15
WHR
<0.91
0.91-0.94
0.95-0.98
≥0.99
P-trend / 63
95
89
86 / Ref.
1.45 (1.04-2.01)
1.37 (0.96-1.94)
1.46 (1.00-2.12)
0.11 / 25
43
28
36 / Ref.
1.66 (0.99-2.77)
1.07 (0.60-1.92)
1.58 (0.87-2.86)
0.40 / 32
46
54
42 / Ref.
1.36 (0.85-2.17)
1.61 (1.01-2.59)
1.37 (0.81-2.33)
0.20
Female / AML / CML / CLL
Body mass index
<22.48
22.48-24.96
24.97-28.23
≥28.24
P-trend / 10
17
30
17 / Ref.
1.26 (0.53-3.01)
1.74 (0.67-4.49)
0.63 (0.20-1.94)
0.41 / 7
6
11
10 / Ref.
1.00 (0.31-3.17)
2.49 (0.72-8.64)
2.74 (0.51-14.82)
0.15 / 16
41
35
32 / Ref.
2.32 (1.23-4.38)
1.93 (0.92-4.08)
1.76 (0.73-4.25)
0.38
Waist circumference
<73.1
73.1-79.9
80.0-88
≥88.1
P-trend / 13
15
19
26 / Ref.
1.00 (0.44-2.32)
1.07 (0.43-2.68)
2.52 (0.91-6.97)
0.06 / 10
9
3
8 / Ref.
0.64 (0.22-1.86)
0.12 (0.02-0.56)
0.24 (0.05-1.25)
0.03 / 27
25
37
29 / Ref.
0.66 (0.37-1.20)
0.78 (0.41-1.48)
0.68 (0.30-1.52)
0.46
WHR
<0.76
0.76-0.79
0.80-0.84
≥0.85
P-trend / 8
21
22
22 / Ref.
2.34 (1.03-5.31)
2.13 (0.92-4.89)
2.56 (1.08-6.10)
0.07 / 11
8
6
5 / Ref.
0.62 (0.25-1.57)
0.37 (0.13-1.05)
0.31 (0.09-1.01)
0.02 / 33
33
25
27 / Ref.
0.90 (0.55-1.47)
0.56 (0.33-0.96)
0.64 (0.36-1.12)
0.04
Male
Body mass index
<24.22
24.22-26.30
26.31-29.72
≥29.73
P-trend / 17
18
24
15 / Ref.
0.62 (0.28-1.39)
0.67 (0.28-1.61)
0.29 (0.10-0.87)
0.05 / 8
10
5
9 / Ref.
0.94 (0.30-2.97)
0.54 (0.13-2.32)
1.08 (0.22-5.37)
0.91 / 42
51
41
39 / Ref.
0.92 (0.56-1.51)
0.71 (0.39-1.27)
0.56 (0.28-1.14)
0.09
Waist circumference
<88.5
88.5-94.9
95-101.9
≥102
P-trend / 12
15
20
21 / Ref.
1.36 (0.59-3.13)
2.00 (0.78-5.09)
3.22 (1.10-9.45)
0.03 / 7
8
8
7 / Ref.
1.13 (0.35-3.67)
1.39 (0.35-5.48)
1.06 (0.19-5.82)
0.87 / 33
41
40
44 / Ref.
1.21 (0.73-2.01)
1.28 (0.71-2.30)
1.72 (0.85-3.50)
0.16
WHR
<0.91
0.91-0.94
0.95-0.98
≥0.99
P-trend / 12
22
13
21 / Ref.
1.68 (0.81-3.47)
1.03 (0.45-2.37)
1.92 (0.85-4.33)
0.28 / 5
9
10
6 / Ref.
1.97 (0.64-6.11)
2.12 (0.65-6.99)
1.58 (0.40-6.16)
0.53 / 29
44
45
40 / Ref.
1.42 (0.87-2.30)
1.47 (0.89-2.42)
1.41 (0.81-2.44)
0.26

RR: relative risks; CI: confidence intervals; AML: acute myeloid leukemia; CML: chronic myeloid leukemia; CLL: chronic lymphoid leukemia; Multivariate models adjusted for recruitment age and study country; Multivariate models for BMI were further adjusted for WC; Multivariate models for waist circumference and waist to hip ratio (WHR) were further adjusted for body mass index; Tests of linear trend across categories were conducted by fitting a model treating the quartile categories as a single ordinal variable.