MIAMI-DADE COUNTY PUBLIC SCHOOLS
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BIOLOGY I Course Code: 200031001
TOPIC XXVIII: FACTORS THAT AFFECT HUMAN HEALTH – Genetic Diseases and Human GeneticsESSENTIAL CONTENT / OBJECTIVES / INSTRUCTIONAL TOOLS
A. Human Genetic Disorders
1. Molecule to Phenotype
2. Chromosomal Disorders
B. Human Genome
1. Manipulating DNA
2. The Human Genome Project
C. Causes of Genetic diseases
1. Non-disjunction during meiosis
2. Damaged Chromosomes (duplication, deletion, inversion, and translocation)
3. Gene mutation (e.g. Tay-Sachs disease)
D. Chromosomal Disorders
1. Autosomal Chromosomes (Down Syndrome or Trisomy 21)
2. Sex Chromosomes (Turner’s Syndrome, Klinefelter’s Syndrome & other Trisomy conditions)
E. Sex-Linked Genes
1. Definition
2. Disorders (Colorblindness and Hemophilia)
3. Punnett square problems / · Recognize that DNA contains hereditary information and the importance & application of the Human Genome Project.
· Describe how chromosomes can be damaged.
· Identify the gene or chromosomal mutation involved in human disorders such as Down’s syndrome, Huntington’s disease, Hemophilia and Tay-Sachs disease.
· Recognize disorders caused by sex-linked genes and predict outcomes using Punnett squares.
· Identify chromosomal disorders by looking at a karyotype.
· Identify types of diseases and/or disorders and list their effects upon the human body (degenerative, deficiency, hereditary, and contagious).
· Describe the inheritance of a sex-linked gene such as color-blindness. / Core Text Book: Chapter 14
Vocabulary: (See p. 2)
DNA, Sex-linked gene, Nondisjunction, Sex chromosome, Autosome, Dominant, Recessive, Karyotype, Pedigree, Human Genome Project, Duplication, Deletion, Inversion, Translocation
Technology: (see p.2)
1. Untamed Science Video: What Color are My Genes?
2. Art Review: A Human Karyotype
3. Art Review: A Human Karyotype
4. Art in Motion: Non Disjunction Disorders
5. Bozeman Podcast: Chromosomal Genetics
6. HippoCampus Biology: Chromosomal Abnormalities
7. Edgenuity
8. Extended Learning Modules
SC.912.L.16.2 / Human Karyotyping
Standard: SC.912.L.15.15 / / Video / · The Human Genome Project
· Heredity: How Our Parents' Genes Affect Us
· DNA and the Human Genome Project
· Nondisjunction / · Choromosomal Alteration That May Occur During Meiosis: Investigating the Process of Nondisjunction
· Introduction: Chromosomal Alterations
· Discovery of Down Syndrome / · Closing Remarks: Sex-Linked Inheritance
· The Effects Produced by Chromosomal Alterations
· Genetic Disease
/ Audio / · Evolution: Sources of Variability: Recombination
Standard: SC.912.L.16.2 / / Video / · Patterns of Inheritance
· Survey and Data Analysis: Dominant and Recessive Traits for Hairline, Thumb, and Earlobes
· Research Results
· Introduction: Sex-Linked Inheritance
· Research on the Genetic Make-up of the Fruit Fly Drosophila
· Karyotype: A Key to the Study of Sex-Linked Inheritance / · Inherited Human Traits and Patterned Sex-Linked Inheritance
· Color Blindness
· Organizing Information About Sex-Linked Inheritance in Pedigree Charts
· Hemophylia
· Closing Remarks: Sex-Linked Inheritance / · Sex-Linked Traits
· Single Gene Disorders
· Incomplete Dominance in Snapdragons
· Incomplete Dominance in Humans and Plants
· Reviewing Key Terms That Relate to Patterns of Inheritance
· Multiple Alleles and Co-Dominance in Human Blood Types
· Rabbit Breeding
/ Audio / · Evolution: Sources of Genetic Variability: Mutation
· Heredity: Sex-Linked Genetic Conditions in Humans / · Heredity: Sex Linkage
· Heredity: Problems Using Sex Chromosomes & Sex Linkage
Standard: SC.912.L.16.2 / / Image / · Mosaic Down syndrome; nondisjunction in early embryo
· Human trisomies
· Mutation types; protein changes
· Translocation Mutation
· DNA sequence; nature of mutation
· Base pairing errors; generation of mutations / · Base substitution mutation
· Insertion and deletion mutations
· Down syndrome; distinguishing between types
· Mosaic Down syndrome; nondisjunction in early embryo
· Down syndrome; mapping effects of extra DNA
· Trisomy; gene dosage effects / · Human trisomies
· X-linked dominant trait; pedigrees
· Colorblindness pedigrees; X-linked recessive trait
· Probability of colorblind child - Punnett square
· Probability of colorblind child - answer
· Karyotype
· Chromosomes
Standard: HE.912.C.1.7 / / Video / · Multifactorial Disorders
· Heredity: How Our Parents' Genes Affect Us
· Basic Facts About Cancer
· Obesity / · Hunting Down the Genes Involved in Disease
· DNA and the Genetics of Cancer
· Families and Genetic Disease
· Genetic Case Study: Addison's Disease
· Cystic Fibrosis
· Diabetes / · Risk Factors for Heart Disease
· DNA Screening
· High & Low Risks for Cancer
· High & Low Risks for Cardiovascular Disease
· High & Low Risks for Diabetes
/ Video / · Mapping the Human Genome
· No Interest in the Gym? It May Be Genetic
· Gene Therapy Offers New Hope to Cancer Patients
· Researchers Discover Genes Linked to Deadly Cancers
· For Mixed Race Patients, Few Bone Marrow Donors
· Researchers Map DNA of Fetus from Blood and Saliva of Parents
· Genetic Test Can Help Tailor Breast Cancer Treatment
· Cracking the Genetic Code: The First "Book of Life"
· Human Chromosome #21 Mapped, Linked to Down Syndrome
· Scientists Discover New Gene That Could Help Pinpoint Cause of Alzheimer's Disease
· Searching Genes, Genome, for Health Predispositions
· Researchers Map First Human Chromosome: #22
· "Fountain of Youth" Anti-Aging Gene Found in Earthworms
· Dawn of the "Genetics Age" May Help Those With Inherited Diseases
· No Bull: Genetic Manipulation Lets Breeders Select for Female Cows
· Scientists Isolate Specific Gene That Causes Muscular Dystrophy
· Efforts Using Gene-Splicing to Develop Bacteria-Produced Insulin