CURRICULUM VITAE

NAME: Daniela Taverna

PLACE AND DATE OF BIRTH: Torino, Italy, 13 October 1963

CITIZENSHIP: Italian

CIVIL STATUS: Married, two children

1988 Laurea in Bs. Sciences, University of Torino, 110/110 cum laude and thesis selected for publication.

1988-1989 A.I.R.C. fellowship, University of Torino.

1989-1993 Ph.D. Student, F.M.I., Basel University (Schweizerische Krebsliga, EMBO and FMI salaries).

1994-2002 Post-doc fellow, associate and instructor, MIT, Cambridge, MA, USA (Swiss National Foundation/Ciba-Geigy, E.M.B.O., MIT-Program of Excellence and Howard Hughes Medical Institute salaries).

1999 Researcher consultant, EIO, Milano, Italy.

2002-2010 Assistant Professor, Universtity of Torino, Facoltà Sc. M.F:S. Previously at IRCC, Candiolo (TO); now at the MBC, Via Nizza, 52, Torino

2010-Present Associate Professor, Universtity of Torino, Facoltà Sc. M.F:S. MBC, Via Nizza, 52, Torino

Major research: microRNA and adesion molecules in tumor progression

PUBLICATIONS

RESEARCH ARTICLES:

(1) C. Dati, S. Antoniotti, D. Taverna, I. Perroteau & M. De Bortoli, (1990). Inhibition of c-erbB-2 oncogene expression by estrogens in human breast cancer cells. Oncogene 5: 1001-1006.

(2) N.E. Hynes, D. Taverna, I.M. Harwerth, F. Ciardiello, D.S. Salomon, T. Yamamoto & B. Groner, (1990). Epidermal growth factor receptor, but not c-erbB2, activation prevents lactogenic hormone induction of the beta-casein gene in mouse mammary epithelial cells. Mol. Cell. Biol. 10: 4027-4034.

(3) D. Taverna, B. Groner & N.E. Hynes, (1991). Epidermal growth factor receptor, platelet-derived growth factor receptor, and c-erbB-2 receptor activation all promote growth but have distinctive effects upon mouse mammary epithelial cell differentiation. Cell Growth & Diff. 2: 145-154.

(4) T. Venesio, D. Taverna, N.E. Hynes, D. MacAllan, F. Ciardiello, D.S. Salomon, R. Callahan & G. Merlo, (1992). The int-2 gene product acts as a growth factor and substitutes for bFGF in promoting the differentiation of a normal mouse mammary epithelial cell line. Cell Growth & Diff. 3: 63-71.

(5) E. Kornilova, D. Taverna, W. Hoeck & N.E. Hynes, (1992). Surface expression of c-erbB2 protein is post-transcriptionally regulated in mammary epithelial cells by EGF and by the culture density. Oncogene 7: 511-519.

(6) N.E. Hynes, D. Taverna, N. Cella & R. Chammas, (1992). The effect of extracellular matrix upon HC11 mammary epithelial cell differentiation. Ciencia e cultura 44: 253-256.

(7) D. Taverna, B. Mulatero & A. Fasolo, (1993). Co-occurrence of Substance P and enkephalin-like immunoreactivities in the prosencephalon of two amphibians. Eur. J. Histochemistry 37: 33-42.

(8) G.R. Merlo, T.Venesio, D.Taverna, R. Callahan & N.E.Hynes (1993). Growth suppression of normal mammary epithelial cells by wild-type p53. Ann. N.Y. Acad. Sci. 698: 108-113.

(9) G.R. Merlo, T. Venesio, D. Taverna, B.M. Marte, R. Callahan & N.E. Hynes (1994). Growth suppression of normal mammary epithelial cells by wild-type p53. Oncogene 9: 443-453.

(10) D. Taverna, S. Antoniotti, P. Maggiora, C. Dati, M. De Bortoli & N.E. Hynes (1994). erbB-2 expression in estrogen receptor positive breast tumor cells is regulated by growth modulatory agents. Int. J. Cancer 56: 522-528.

(11) R. Chammas*, D. Taverna*, N. Cella*, C. Santos & N.E. Hynes (1994). Laminin and tenascin assembly and expression regulate HC11 mouse mammary cell differentiation. J. Cell Science 107: 1031-1040. * These authors contributed equally.

(12) S. Antoniotti, D. Taverna, P. Maggiora, M.L. Sapei, N.E. Hynes & M. DeBortoli (1994). Estrogens and EGF down-regulate the c-erbB-2 oncogene protein in breast cancer cells by different mechanisms. Br. J. Cancer 70: 1095-1101.

(13) B.M. Marte, D. Graus-Porta, M. Jeschke, D. Fabbro, N.E. Hynes & D. Taverna (1995). NDF/Heregulin activates MAP kinase and p70/p85 S6 kinase during proliferation or differentiation of mammary epithelial cells. Oncogene 10: 167-175.

(14) B.M. Marte, M. Jeschke, D. Graus-Porta, D. Taverna, P. Hofer, Y. Yarden & N.E. Hynes (1995). Neu differentiation factor/heregulin modulates growth and differentiation of HC11 mammary epithelial cells. Mol. Endocrinology 9: 14-23.

(15) G.R. Merlo, D. Graus-Porta, N. Cella, B.M. Marte, D. Taverna, N.E. Hynes. (1996). Growth, differentiation and survival of HC11 mammary epithelial cells: diverse effects of receptor tyrosine kinase-activating peptide growth factors. Eur. J. Cell Biol. 70/1: A-4292.

(16) D. Taverna, M. Ullman-Cullere, H. Rayburn, R.T Bronson, & R.O. Hynes. (1998). A test of the role of alpha 5 integrin/fibronectin interactions in tumorigenesis. Cancer Res. 58: 848-853.

(17) D. Taverna, M.H. Disatnik, H. Rayburn, R.T. Bronson, J. Yang, T.A. Rando & R.O. Hynes. (1998). Dystrophic muscle in mice chimeric for expression of alpha 5 integrin. J. Cell Biology 143/3: 849-859.

(18) A.G. Arroyo, D. Taverna, C. Whittaker, U.G. Strauch, B.L. Bader, H. Rayburn, D. Crowley, C.M. Parker & R.O. Hynes. (2000). In vivo roles of integrins during leukocyte development and traffic: insights from the analysis of mice chimeric for a5-/-, av-/- and a4-/- integrins. J. Immunology 165: 4667-4675.

(19) D. Taverna & R.O. Hynes. (2001). Reduced blood vessel formation and tumor growth in alpha 5 integrin-negative teratomas and embryoid bodies. Cancer Res. 61: 5255-5261.

(20) L.E Reynolds, L. Wyder, J.C. Lively, D. Taverna, S.D. Robinson, X. Huang, D. Sheppard, R.O. Hynes & K.M. Hodivala-Dilke. (2002). Enhanced pathological angiogenesis in mice lacking b3-integrin or b3- and b5-integrins. Nature Medicine 8: 27-34.

(21) Hynes, R.O., Lively, J.C., McCarty, J.H., Taverna, D., Xiao, Q. and Hodivala-Dilke, K. (2002). Diverse roles of integrins and their ligands in angiogenesis. Cold Spring Harbor Symp. Quant. Biol. 67: 143-153.

(22) Taverna D, Moher H, Crowley D, Borsig L, Varki A, Hynes RO. (2004). Increased primary tumor growth in mice null for beta3- or beta3/beta5-integrins or selectins. Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):763-8.

(23) Taverna D, Crowley D, Connolly M, Bronson RO and Richard Hynes. (2005) A direct test of potential roles for b3 and b5 integrins in growth and metastasis of murine mammary carcinomas. Cancer Res. Nov 15; 65(22):10324-9

…See medline…

BOOK CHAPTERS:

(1) P. Putzolu, S. Ferraresi, M. Rabino, D. Taverna, G. Bordini & A. Fasolo, (1989). Application of microcomputer-aided image analysis and immunocytochemical (ICC) methods to studies on the colocalization of neuroactive substances in the central nervous system (CNS). Image Analysis in neurohistology: 129-139, Direzione Atenei, CSI Piemonte, Torino.

(2) N.E. Hynes, M.C. NicMhuiris, U. Stifel, D. Taverna, R. Ball, B. Happ, M. Schmitt-Ney & B. Groner; T. Venesio & G. Merlo, (1992). The v-raf and Ha-ras oncogenes inhibit transcription from the beta-casein gene promoter by interfering with a mammary gland specific transcription factor. Hormonal Carcinogenesis, Springer-Verlag: 164-171, J.J. Li, S. Nandi & S.A. Li, eds.

(3) B. Groner, R. Ball, D.Taverna, M. Schmitt-Ney & N.E. Hynes, (1992). EGF, Glucocorticoid Hormones and Prolactin act sequentially in the induction of milk protein

gene expression. European School of Oncology Monograph "Control of Growth Factors and Prevention of Cancer": 27-36, M.B. Sporn, eds.

2