MSc. VeronikaHrabcova
Birth Date: 17/08/1989
Nationality:Czech republic
personal:
professional:, ,
Research Focus:
Biochemical evaluation of potential insecticides based on the inhibition of acetylcholinesterase (AChE). Isolation and purification AChE from head of Muscadomestica. Recombinant production of insect AChE from Anopheles gambiae. Purification and further biochemical evaluation of recombinant AChE.
Education:
2013 – ongoingPhD degree at Faculty of Science, University of Hradec Kralove
2011-2013MSc. degree at Charles University in Prague, Faculty of Pharmacy, study program Healthcare bioanalytics
Diploma thesis title: BRAF mutations in metastatic malignant melanoma.
2008-2011Bc. degreeat Charles University in Prague, Faculty of Pharmacy, study program Healthcare bioanalytics
Bachelor thesis title: Mites and allergy.
Professional Training:
9/2015Course: Regulating and functional peptides and proteins for tissue
engineering- its preparing and usage. University of Pardubice
2013 – ongoingPhD student, Department of Biology, Faculty of Science, University of Hradec Kralove
12/2013 – ongoingresearch assistant, Biomedical Research Center, University Hospital Hradec
Kralove
8/2013 to 12/2013laboratory technician, Biomedical Research Center, University Hospital
Hradec Kralove
Teaching experience:
2014 – 2016Practical lessons in the subject “Basics of molecular and cellular biology” at
Department of Biology, Faculty of Science, University of Hradec Kralove
External Experience:
9/2016 to 11/2016Evaluationsof semi-synthetic alkaloids at Plasmodium liver stage.Within Erasmus+ project-LLP at Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Portugal (3 months)
4/2012 to 8/2012Evaluation of polyoxometalates and related metal cluster compound as P2X receptor antagonists. Within Erasmus project-LLP at Pharmaceutical institute, University of Bonn, Germany (4 months)
Projects:
Title: Development of new environment friendly insecticides against malaria
mosquito
Provider:Grant Agency for Health Research of the Czech Republic
Project duration:4/2016 – 12/2019
Role:co-investigator
Title:Development of insecticides targeted to acetylcholinesterase
Provider:Internal foundation of University Hospital Hradec Kralove
Project duration:4/2016 – 12/2016
Role:co-investigator
Title:Development of insecticides inhibitingacetylcholinesterase
Provider:Internal foundation of University of Hradec Kralove(No. SV/UHK 2107)
Project duration:3/2015 – 12/2015
Role:investigator
Title:Development of insecticides based on inhibition of cholinesterases
Provider:Internal foundation of University of Hradec Kralove (No. SV/UHK2109)
Project duration:3/2014 – 12/2014
Role:investigator
Publications:
2016
Hrabcova V, Korabecny J, Manyova B, Matouskova L, KuceraT,Dolezal R, Musilek K, Gorecki L, Nepovimova E, Kuca K, Jun D.: Bis-isoquinolinium and bis-pyridiniumacetylcholinesterase inhibitors: in vitro screening to find new selective insecticides (just submitted)
2013
Zitko J, Servusová B, Paterová P, Mandíková J, Kubíček V, Kučera R, Hrabcová V, Kuneš J, Soukup O, Doležal M.: Synthesis, antimycobacterial activity and in vitro cytotoxicity of 5-chloro-N-phenylpyrazine-2-carboxamides, Molecules Dec. 2013: 14807-14825.
DOI: 10.3390/molecules181214807
Selected talks/posters
27/9 – 1/10/201512th International Meeting on Cholinesterases - Sixth International
PosterConference on Paraoxonases
Non-acylatingacetylcholinesterase inhibitors as new potential environment
friendly pesticides
VeronikaHrabcova, Daniel Jun, KaterinaBabkova, Jan Korabecny, KamilKuca
Toxicology Unit . Institute of Bioengineering, University Miguel Hernández of
Elche (Alicante, Spain)
25/5/2016Kvetina day, Interdisciplinary workshops for young pharmacologists and
Oral presentationtoxicologists
New selective insecticides based on acetylcholinesterase inhibitors
VeronikaHrabcova, BrigitaManyova, LenkaMatouskova, Daniel Jun, Jan
Korabecny, KamilKuca
Department of Human Pharmacology and Toxicology, Faculty of Pharmacy,
University ofVeterinaryandPharmaceuticalSciences Brno (Czechrepublic)
Languages:
Czech (native)
English (fluent)
German (elementary understanding)