1

Supplemental Table 1S. Minor Allele Frequencies rs6232, rs6234 and rs6235 PCSK1 SNPs in Different Populations

Continent / Country / N / rs62632 / rs6234 / rs6235 / References
Europeans / Denmark / 5782 / 0.064 / - / 0.277 / (Benzinou et al. 2008)
Denmark / 6164 / 0.064 / - / 0.292 / (Gjesing et al. 2011)
United Kingdom / 20249 / 0.055 / - / 0.271 / (Kilpelainen et al. 2009)
France / 2310 / 0.052 / - / 0.288 / (Benzinou et al. 2008)
Germany / 996 / 0.062 / - / 0.255 / (Benzinou et al. 2008)
Germany / 1498 / 0.062 / - / 0.261 / (Heni et al. 2010)
Greece / 979 / 0.055 / 0.280 / - / (Rouskas et al. 2011)
Switzerland / 1071 / 0.056 / 0.285 / (Benzinou et al. 2008)
Multi-country[1] / 697 / - / - / 0.249 / (Corpeleijn et al. 2010)
Multi-country / 743 / - / - / 0.216 / (Goossens et al. 2009)
Multi-country[2] / 32387 / 0.03 / - / - / (Willer et al. 2009)
Asians / Han Chinese / 3210 / - / 0.320 / - / (Qi et al. 2010)
Chinese / 1094 / - / - / 0.345 / (Chang et al. 2010)
West Africans / Multi-country[3] / 513 / 0.001 / - / - / (our study)
Yoruba / 120 / - / 0.167 / 0.100 / (dbSNP)

N = number of participants


References

Benzinou M, Creemers JW, Choquet H et al. (2008). Common nonsynonymous variants in PCSK1 confer risk of obesity. Nat Genet, 40:943-945

Chang YC, Chiu YF, Shih KC et al. (2010). Common PCSK1 haplotypes are associated with obesity in the Chinese population. Obesity (Silver Spring), 18:1404-1409

Corpeleijn E, Petersen L, Holst C et al. (2010). Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese Europeans: the NUGENOB study. Obesity (Silver Spring), 18:1369-1377

Gjesing AP, Vestmar MA, Jorgensen T et al. (2011). The effect of PCSK1 variants on waist, waist-hip ratio and glucose metabolism is modified by sex and glucose tolerance status. PLoS One, 6:e23907

Goossens GH, Petersen L, Blaak EE et al. (2009). Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB study. Int J Obes (Lond), 33:669-679

Heni M, Haupt A, Schafer SA et al. (2010). Association of obesity risk SNPs in PCSK1 with insulin sensitivity and proinsulin conversion. BMC Med Genet, 11:86

Kilpelainen TO, Bingham SA, Khaw KT, Wareham NJ, Loos RJ. (2009). Association of variants in the PCSK1 gene with obesity in the EPIC-Norfolk study. Hum Molec Genet, 18:3496-3501

Qi Q, Li H, Loos RJ et al. (2010). Association of PCSK1 rs6234 with obesity and related traits in a Chinese Han population. PLoS One, 5:e10590

Rouskas K, Kouvatsi A, Paletas K et al. (2011). Common Variants in FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 Show Evidence of Association With Adult Obesity in the Greek Population. Obesity, doi:10.1038/oby.2011.177

Willer CJ, Speliotes EK, Loos RJ et al. (2009). Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet, 41:25-34

dbSNP: http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=rs6234 and http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=rs6235

[1] Denmark, Netherlands, Sweden, United Kingdom, Czech Republic, France, Spain.

[2] Finland, Germany, Holland, Italy, Sardinia, United Kingdom, United States, etc.

[3] Benin, Burkina-Faso, and Togo