Table S2 All the genome-wide association studies (GWAS) of Parkinson’s disease and relevant meta-analyses

No. / First Author / Year / Publication type / Ethnicity
[1] / Maraganore DM / 2005 / Article / Mixed
[2] / Bertoli-Avella AM / 2006 / Article / Caucasians
[3] / Fung HC / 2006 / Article / Caucasians
[4] / Evangelou E / 2007 / Meta-analysis / Mixed
[5] / Gonzalez-Perez A / 2009 / Article / Caucasians
[6] / Pankratz N / 2009 / Meta-analysis / Caucasians
[7] / Simon-Sanchez J / 2009 / Article / Caucasians
[8] / Satake W / 2009 / Article / Asians (Japanese)
[9] / Edwards TL / 2010 / Meta-analysis / Caucasians
[10] / Hamza TH / 2010 / Meta-analysis / Caucasians
[11] / Dumitriu A / 2011 / Meta-analysis / Caucasians
[12] / Saad M / 2011 / Article / Caucasians
[13] / Simon-Sanchez J / 2011 / Article / Caucasians
[14] / International Parkinson's Disease Genomics C / 2011 / Meta-analysis / Caucasians
[15] / Consortium UKPsD / 2011 / Article / Caucasians
[16] / Liu X / 2011 / Article / Caucasians
[17] / Do CB / 2011 / Article / Caucasians
[18] / International Parkinson Disease Genomics C / 2011 / Meta-analysis / Caucasians
[19] / Hernandez DG / 2012 / Article / Caucasians
[20] / Keller MF / 2012 / Meta-analysis / Caucasians
[21] / Ahmed I / 2012 / Meta-analysis / Caucasians
[22] / Lill CM / 2012 / Meta-analysis / Mixed
[23] / Pankratz N / 2012 / Meta-analysis / Caucasians

Table S3 Meta-analyses of GWAS and their involving original papers

Meta-analysis / Involving original papers
2007 [4] / 2005 [1]; 2006 [3]
2009 [6] / 2006 [3]; 2009 [6]
2010 [9] / 2006 [3]; 2009 [6]; 2010 [9]
2010 [10] / 2009 [6]; 2010 [10]
2011 [11] / 2006 [3]; 2009 [6]; 2009 [7]; 2011 [11]
2011 [14] / 2009 [6]; 2009 [7]; 2011 [12]; 2011 [13]; 2011 [15]; 2011 [18]; 2011 [14]
2011 [18] / 2009 [6]; 2009 [7]; 2011 [12]; 2011 [13]; 2011 [15]; replication 2011 [18]
2012 [20] / 2006 [3]; 2009 [6]; 2009[7]; 2011 [12]; 2011 [13]; 2011 [14]; 2011 [18]
2012 [21] / 2009 [6]; 2009 [7]; 2010 [10]; 2011 [17]; 2012 [21]
2012 [22] / 2005 [1]; 2006 [3]; 2009 [6];2009 [8]; 2009 [7]; 2010 [9]; 2010 [10]; 2011 [15]; 2011 [12]; 2011 [13]
2012 [23] / 2006 [3]; 2009 [6]; 2009 [7]; 2010 [9]; 2010 [10]; replication 2012 [23]

Reference

1. Maraganore DM, de Andrade M, Lesnick TG et al. (2005) High-resolution whole-genome association study of Parkinson disease. Am J Hum Genet 77:685-693.

2. Bertoli-Avella AM, Dekker MC, Aulchenko YS et al. (2006) Evidence for novel loci for late-onset Parkinson's disease in a genetic isolate from the Netherlands. Hum Genet 119:51-60.

3. Fung HC, Scholz S, Matarin M et al. (2006) Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data. Lancet Neurol 5:911-916.

4. Evangelou E, Maraganore DM, Ioannidis JP (2007) Meta-analysis in genome-wide association datasets: strategies and application in Parkinson disease. PLoS One 2:e196.

5. Gonzalez-Perez A, Gayan J, Marin J et al. (2009) Whole-genome conditional two-locus analysis identifies novel candidate genes for late-onset Parkinson's disease. Neurogenetics 10:173-181.

6. Pankratz N, Wilk JB, Latourelle JC et al. (2009) Genomewide association study for susceptibility genes contributing to familial Parkinson disease. Hum Genet 124:593-605.

7. Simon-Sanchez J, Schulte C, Bras JM et al. (2009) Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet 41:1308-1312.

8. Satake W, Nakabayashi Y, Mizuta I et al. (2009) Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nat Genet 41:1303-1307.

9. Edwards TL, Scott WK, Almonte C et al. (2010) Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. Ann Hum Genet 74:97-109.

10. Hamza TH, Zabetian CP, Tenesa A et al. (2010) Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease. Nat Genet 42:781-785.

11. Dumitriu A, Pacheco CD, Wilk JB et al. (2011) Cyclin-G-associated kinase modifies alpha-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study. Hum Mol Genet 20:1478-1487.

12. Saad M, Lesage S, Saint-Pierre A et al. (2011) Genome-wide association study confirms BST1 and suggests a locus on 12q24 as the risk loci for Parkinson's disease in the European population. Hum Mol Genet 20:615-627.

13. Simon-Sanchez J, van Hilten JJ, van de Warrenburg B et al. (2011) Genome-wide association study confirms extant PD risk loci among the Dutch. Eur J Hum Genet 19:655-661.

14. International Parkinson's Disease Genomics C, Wellcome Trust Case Control C (2011) A two-stage meta-analysis identifies several new loci for Parkinson's disease. PLoS Genet 7:e1002142.

15. Consortium UKPsD, Wellcome Trust Case Control C, Spencer CC et al. (2011) Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21. Hum Mol Genet 20:345-353.

16. Liu X, Cheng R, Verbitsky M et al. (2011) Genome-wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population. BMC Med Genet 12:104.

17. Do CB, Tung JY, Dorfman E et al. (2011) Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. PLoS Genet 7:e1002141.

18. International Parkinson Disease Genomics C, Nalls MA, Plagnol V et al. (2011) Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet 377:641-649.

19. Hernandez DG, Nalls MA, Ylikotila P et al. (2012) Genome wide assessment of young onset Parkinson's disease from Finland. PLoS One 7:e41859.

20. Keller MF, Saad M, Bras J et al. (2012) Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease. Hum Mol Genet 21:4996-5009.

21. Ahmed I, Tamouza R, Delord M et al. (2012) Association between Parkinson's disease and the HLA-DRB1 locus. Mov Disord 27:1104-1110.

22. Lill CM, Roehr JT, McQueen MB et al. (2012) Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. PLoS Genet 8:e1002548.

23. Pankratz N, Beecham GW, DeStefano AL et al. (2012) Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. Ann Neurol 71:370-384.