Research outputs
Listing of Research outputs
Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation
Doré, K. A., Kashiwakura, J., McDonnell, J. M., Gould, H. J., Kawakami, T., Sutton, B. J. & Davies, A. M. Jan 2018 In : Molecular Immunology. 93, p. 216-222 7 p.
Research output: Contribution to journal › Article
IgE Trimers Drive SPE-7 Cytokinergic Activity
Bax, H. J., Bowen, H., Beavil, R. L., Chung, R., Ward, M., Davies, A. M., Dodev, T. S., McDonnell, J. M., Beavil, A. J., Sutton, B. J. & Gould, H. J. 1 Dec 2017 In : Scientific Reports. 7, 1, 8164
Research output: Contribution to journal › Article
Thermal sensitivity and flexibility of the Cε3 domains in immunoglobulin E
Doré, K. A., Davies, A. M., Drinkwater, N., Beavil, A. J., McDonnell, J. M. & Sutton, B. J. 24 Aug 2017 In : BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS.
Research output: Contribution to journal › Article
Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab
Davies, A. M., Allan, E. G., Keeble, A. H., Delgado, J., Cossins, B. P., Mitropoulou, A. N., Pang, M. O. Y., Ceska, T., Beavil, A. J., Craggs, G., Westwood, M., Henry, A. J., McDonnell, J. M. & Sutton, B. J. 16 Jun 2017 In : Journal of Biological Chemistry. 292, 24, p. 9975–9987
Research output: Contribution to journal › Article
IgE binds asymmetrically to its B cell receptor CD23
Dhaliwal, B., Pang, M. O. Y., Keeble, A. H., James, L. K., Gould, H. J., McDonnell, J. M., Sutton, B. J. & Beavil, A. J. 31 Mar 2017 In : Scientific Reports. 7, 7 p., 45533
Research output: Contribution to journal › Article
IgY: A key isotype in antibody evolution
Zhang, X., Calvert, R. A., Sutton, B. J. & Doré, K. A. 16 Mar 2017 In : BIOLOGICAL REVIEWS.
Research output: Contribution to journal › Article
Ontogeny of Human IgE-expressing B Cells and Plasma Cells
Ramadani, F., Bowen, H., Upton, N., Hobson, P. S., Chan, Y-C., Chen, J-B., Chang, T. W., McDonnell, J. M., Sutton, B. J., Fear, D. J. & Gould, H. J. 1 Jan 2017 In : Allergy. 72, 1, p. 66-76 10 p.
Research output: Contribution to journal › Article
Room temperature structure of human IgG4-Fc from crystals analysed in situ
Davies, A. M., Rispens, T., Ooijevaar-de Heer, P., Aalberse, R. C. & Sutton, B. J. Jan 2017 In : Molecular Immunology. 81, p. 85-91 7 p.
Research output: Contribution to journal › Article
Antibodies and superantibodies in patients with chronic rhinosinusitis with nasal polyps
Chen, J. B., James, L. K., Davies, A. M., Wu, Y. C. B., Rimmer, J., Lund, V. J., Chen, J. H., McDonnell, J. M., Chan, Y. C., Hutchins, G. H., Chang, T. W., Sutton, B. J., Kariyawasam, H. H. & Gould, H. J. 19 Sep 2016 In : Journal of Allergy and Clinical Immunology.
Research output: Contribution to journal › Article
Antibody mimetics: Promising complementary agents to animal-sourced antibodies
Baloch, A. R., Baloch, A. W., Sutton, B. J. & Zhang, X. 3 Mar 2016 In : Critical Reviews in Biotechnology. 36, 2, p. 268-275 8 p.
Research output: Contribution to journal › Article
IgG4 Characteristics and Functions in Cancer Immunity
Crescioli, S., Correa, I., Karagiannis, P., Davies, A. M., Sutton, B. J., Nestle, F. O. & Karagiannis, S. N. 7 Jan 2016 In : CURRENT ALLERGY AND ASTHMA REPORTS. 16, 1, p. 7
Research output: Contribution to journal › Article
Human IgG4: a structural perspective
Davies, A. M. & Sutton, B. J. Nov 2015 In : Immunological Reviews. 268, 1, p. 139-159 21 p.
Research output: Contribution to journal › Article
Structure and dynamics of IgE-receptor interactions: FcεRI and CD23/FcεRII
Sutton, B. J. & Davies, A. M. Nov 2015 In : Immunological Reviews. 268, 1, p. 222-235 14 p.
Research output: Contribution to journal › Article
Intrinsic Properties of Germinal Centre-derived B cells Promote their Enhanced Class Switching to IgE
Ramadani, F., Upton, N. E. G., Hobson, P. S., Chan, Y-C., Mzinza, D., Bowen, H., Kerridge, C., Sutton, B. J., Fear, D. J. & Gould, H. J. 25 Oct 2015 In : Allergy. 70, 10, p. 1269-1277 9 p.
Research output: Contribution to journal › Article
Validating the GTP cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches.
Hussein, D. A. A., Starr, A., Heikal, L., McNeill, E., Channon, K. M., Brown, P. R., Sutton, B. J., McDonnell, J. M. & Nandi, M. 1 Aug 2015 In : British journal of pharmacology. 172, 16, p. 4146-4157 25 p.
Research output: Contribution to journal › Article
Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class
Dodev, T. S., Bowen, H., Shamji, M. H., Bax, H. J., Beavil, A. J., McDonnell, J. M., Durham, S. R., Sutton, B. J., Gould, H. J. & James, L. K. 1 Jun 2015 In : Allergy. 70, 6, p. 720-724 5 p.
Research output: Contribution to journal › Article
Mechanism of the antigen-independent cytokinergic SPE-7 IgE activation of human mast cells in vitro
Bax, H. J., Bowen, H., Dodev, T. S., Sutton, B. J. & Gould, H. J. 20 Apr 2015 In : Scientific Reports. 5, 9538
Research output: Contribution to journal › Article
Generation and Characterization of Chicken-Sourced Single-Chain Variable Fragments (scFvs) against porcine interferon-gamma (pIFN-γ)
Chen, H. X., He, F., Sun, Y., Luo, Y., Qiu, H. J., Zhang, X. Y. & Sutton, B. J. 2 Jan 2015 In : Journal of Immunoassay and Immunochemistry. 36, 1, p. 27-44 18 p.
Research output: Contribution to journal › Article
Dynalets: A new method for modelling and compressing biological signals. Applications to physiological and molecular signals
Demongeot, J., Hansen, O., Hamie, A., Franco, C., Sutton, B. & Cohen, É. P. 1 Nov 2014 In : COMPTES RENDUS BIOLOGIES. 337, 11, p. 609-624 16 p.
Research output: Contribution to journal › Article
Crystal structure of deglycosylated human IgG4-Fc
Davies, A. M., Jefferis, R. & Sutton, B. J. Nov 2014 In : Molecular Immunology. 62, 1, p. 46-53 8 p.
Research output: Contribution to journal › Article
Distribution of rat neonatal Fc receptor in the principal organs of neonatal and pubertal rats
Tian, Z., Sutton, B. J. & Zhang, X. Apr 2014 In : Journal of Receptor and Signal Transduction Research. 34, 2, p. 137-142 6 p., N/A
Research output: Contribution to journal › Article
Human immunoglobulin E flexes between acutely bent and extended conformations
Drinkwater, N., Cossins, B. P., Keeble, A. H., Wright, M., Cain, K., Hailu, H., Oxbrow, A., Delgado, J., Shuttleworth, L. K., Kao, M. W-P., McDonnell, J. M., Beavil, A. J., Henry, A. J. & Sutton, B. J. Apr 2014 In : NATURE STRUCTURAL AND MOLECULAR BIOLOGY. 21, 4, p. 397-404 8 p., N/A
Research output: Contribution to journal › Article
A range of C epsilon 3-C epsilon 4 interdomain angles in IgE Fc accommodate binding to its receptor CD23
Dhaliwal, B., Pang, M. O. Y., Yuan, D., Beavil, A. J. & Sutton, B. J. Mar 2014 In : Acta Crystallographica Section F-Structural Biology And Crystallization Communications. 70, 3, p. 305-309 5 p., N/A
Research output: Contribution to journal › Article
Structural Determinants of Unique Properties of Human IgG4-Fc
Davies, A. M., Rispens, T., Ooijevaar-de Heer, P., Gould, H. J., Jefferis, R., Aalberse, R. C. & Sutton, B. J. 6 Feb 2014 In : Journal of Molecular Biology. 426, 3, p. 630-644 15 p.
Research output: Contribution to journal › Article
Human IgE against the major allergen Bet v 1: defining an epitope with limited cross-reactivity between different PR-10 family proteins
Levin, M., Davies, A. M., Liljekvist, M., Carlsson, F., Gould, H. J., Sutton, B. J. & Ohlin, M. Feb 2014 In : Clinical and Experimental Allergy. 44, 2, p. 288-299 12 p.
Research output: Contribution to journal › Article
Dynamics of inter-heavy chain interactions in human IgG subclasses studied by kinetic Fab arm exchange
Rispens, T., Davies, A. M., Ooijevaar-de Heer, P., Absalah, S., Bende, O., Sutton, B. J., Vidarsson, G. & Aalberse, R. C. 2014 In : Journal of Biological Chemistry. 289, 9, p. 6098-6109
Research output: Contribution to journal › Article
Conformational plasticity at the IgE-binding site of the B-cell receptor CD23
Dhaliwal, B., Pang, M. O. Y., Yuan, D., Yahya, N., Fabiane, S., McDonnell, J. M., Gould, H. J., Beavil, A. J. & Sutton, B. J. 31 Dec 2013 In : Molecular Immunology. 56, 4, p. 693-697 5 p., N/A
Research output: Contribution to journal › Article
IMMUNOLOGY Allergy's Achilles' heel?
Sutton, B. J. Dec 2013 In : Nature Chemical Biology. 9, 12, p. 756-759 4 p., N/A
Research output: Contribution to journal › Comment/debate
Ca2+-dependent structural changes in the B-cell receptor CD23 increase its affinity for human immunoglobulin E
Yuan, D., Keeble, A. H., Hibbert, R. G., Fabiane, S., Gould, H. J., McDonnell, J. M., Beavil, A. J., Sutton, B. J. & Dhaliwal, B. 26 Jul 2013 In : Journal of Biological Chemistry. 288, 30, p. 21667-21677 11 p.
Research output: Contribution to journal › Article
Crystal structure of the human IgG4 C(H)3 dimer reveals the role of Arg409 in the mechanism of Fab-arm exchange
Davies, A. M., Rispens, T., den Bleker, T. H., McDonnell, J. M., Gould, H. J., Aalberse, R. C. & Sutton, B. J. May 2013 In : Molecular Immunology. 54, 1, p. 1-7 7 p.
Research output: Contribution to journal › Article
A redundant role for propeptide in human thyroid peroxidase protein for its cellular, enzymatic and immunological activity
Godlewska, M., Góra, M., Buckle, A. M., Porebski, B. T., Kemp, E. H., Sutton, B. J., Czarnocka, B. & Banga, P. S. 2013 In : Thyroid. -, -
Research output: Contribution to journal › Article
Mapping of the CD23 Binding Site on Immunoglobulin E (IgE) and Allosteric Control of the IgE-Fc epsilon RI Interaction
Borthakur, S., Hibbert, R. G., Pang, M. O. Y., Yahya, N., Bax, H. J., Kao, M. W., Cooper, A. M., Beavil, A. J., Sutton, B. J., Gould, H. J. & McDonnell, J. M. 7 Sep 2012 In : Journal of Biological Chemistry. 287, 37, p. 31457-31461 5 p.
Research output: Contribution to journal › Article
Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor FcεRI
Dhaliwal, B., Yuan, D., Pang, M. O. Y., Henry, A. J., Cain, K., Oxbrow, A., Fabiane, S. M., Beavil, A. J., McDonnell, J. M., Gould, H. J. & Sutton, B. J. 31 Jul 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 31, p. 12686-12691 6 p.
Research output: Contribution to journal › Article
A Fluorescent Biosensor Reveals Conformational Changes in Human Immunoglobulin E Fc: IMPLICATIONS FOR MECHANISMS OF RECEPTOR BINDING, INHIBITION, AND ALLERGEN RECOGNITION
Hunt, J., Keeble, A. H., Dale, R. E., Corbett, M. K., Beavil, R. L., Levitt, J., Swann, M. J., Suhling, K., Ameer-Beg, S., Sutton, B. J. & Beavil, A. J. 18 May 2012 In : Journal of Biological Chemistry. 287, 21, p. 17459-17470 12 p.
Research output: Contribution to journal › Article
Synthesis and Incorporation into Cyclic Peptides of Tolan Amino Acids and Their Hydrogenated Congeners: Construction of an Array of A-B-loop Mimetics of the C epsilon 3 Domain of Human IgE
Offermann, D. A., McKendrick, J. E., Sejberg, J. J. P., Mo, B., Holdom, M. D., Helm, B. A., Leatherbarrow, R. J., Beavil, A. J., Sutton, B. J. & Spivey, A. C. 6 Apr 2012 In : JOURNAL OF ORGANIC CHEMISTRY. 77, 7, p. 3197 - 3214 18 p.
Research output: Contribution to journal › Article
Soluble CD23 Controls IgE Synthesis and Homeostasis in Human B Cells
Cooper, A. M., Hobson, P. S., Jutton, M. R., Kao, M. W., Drung, B., Schmidt, B., Fear, D. J., Beavil, A. J., McDonnell, J. M., Sutton, B. J. & Gould, H. J. 1 Apr 2012 In : Journal of Immunology. 188, 7, p. 3199 - 3207 9 p.
Research output: Contribution to journal › Article
Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI
Holdom, M. D., Davies, A. M., Nettleship, J. E., Bagby, S. C., Dhaliwal, B., Girardi, E., Hunt, J., Gould, H. J., Beavil, A. J., McDonnell, J. M., Owens, R. J. & Sutton, B. J. May 2011 In : NATURE STRUCTURAL AND MOLECULAR BIOLOGY. 18, 5, p. 571 - 576 6 p.
Research output: Contribution to journal › Article
Synthesis of the C19 methyl ether of aspercyclide A via germyl-Stille macrocyclisation and ELISA evaluation of both enantiomers following optical resolution
Carr, J. L., Sejberg, J. J. P., Saab, F., Holdom, M. D., Davies, A. M., White, A. J. P., Leatherbarrow, R. J., Beavil, A. J., Sutton, B. J., Lindell, S. D. & Spivey, A. C. 2011 In : Organic and Biomolecular Chemistry. 9, 19, p. 6814-6824
Research output: Contribution to journal › Article
Mutations in an avian IgY-Fc fragment reveal the locations of monocyte Fc receptor binding sites
Taylor, A. I., Sutton, B. J. & Calvert, R. A. Feb 2010 In : Developmental and Comparative Immunology. 34, 2, p. 97 - 101 5 p.
Research output: Contribution to journal › Article
Total synthesis of (+/-)-aspercyclide A and its C19 methyl ether
Carr, J. L., Offermann, D. A., Holdom, M. D., Dusart, P., White, A. J. P., Beavil, A. J., Leatherbarrow, R. J., Lindell, S. D., Sutton, B. J. & Spivey, A. C. 2010 In : CHEMICAL COMMUNICATIONS- ROYAL SOCIETY OF CHEMISTRY. 46, 11, p. 1824 - 1826 3 p.