PSYCHOPHARMACOLOGY
SUPPLEMENTARY MATERIAL – APPENDIX 1
Title
Profiling of hypothalamic and hippocampal gene expression in chronically stressed rats treated with St. John’s wort extract (STW3-VI) and fluoxetine
Authors
Peggy Jungkea,c, Gigi Ostrowb, Jason Lib, Sharon Nortonb, Karen Nieberc, Olaf Kelberd, Veronika Butterwecka*
Department of Pharmaceutics, College of Pharmacy, University of Florida, PO Box 100494, Gainesville, FL 32610, USAa,ICBR-Cancer Genetics Research Complex, University of Florida, PO Box 103622, Gainesville, FL 32610, USAb; Institut für Pharmazie, University of Leipzig, Talstraße 33, 04103 Leipzig, Germanyc, Steigerwald Arzneimittelwerk GmbH, Darmstadt, Germanyd
*Corresponding author:
Dr. Veronika Butterweck
College of Pharmacy, Department of Pharmaceutics, University of Florida
PO Box 100494, Gainesville, FL32610, USA
Phone: +1-352-273-7859, Email:
Appendix 1: A complete list of genes which were showed a change in expression levels of at least 2 fold in all treatment groups in the hypothalamus
Upregulated genes
Fold change / Gene symbol / Gene Title / p-value / Entrez Genestressed control vs. unstressed control upregulated
4,30 / Med13 / mediator complex subunit 13 / 0,0E+00 / 303403
3,46 / Mapk8 / Mitogen-activated protein kinase 8 / 2,4E-04 / 116554
3,39 / Enc1 / ectodermal-neural cortex 1 / 8,8E-04 / 294674
3,36 / Ddef1 / development and differentiation enhancing / 6,2E-04 / 314961
3,18 / Nrg1 / neuregulin 1 / 4,1E-03 / 112400
2,97 / RGD1307215 / similar to protein phosphatase 1, regulatory (inhibitory)
subunit 1C; thymocyte ARPP; DNA segment, Chr 9, Brigham & Womens Genetics 1012 expressed / 1,8E-02 / 363154
2,67 / Akap5 / A kinase (PRKA) anchor protein 5 / 3,0E-02 / 171026
2,60 / Topbp1 / topoisomerase (DNA) II binding protein 1 / 1,3E-03 / 315969
2,58 / Kcnma1 / potassium large conductance calcium-activated channel,
subfamily M, alpha member 1 / 6,1E-03 / 83731
2,49 / Zeb2 / zinc finger E-box binding homeobox 2 / 1,2E-02 / 311071
2,46 / RGD1562339 / RGD1562339 / 1,3E-03 / 498107
2,45 / Dpm1 / dolichol-phosphate (beta-D) mannosyltransferase 1 / 2,8E-03 / 296394
2,35 / Zbtb20 / zinc finger and BTB domain containing 20 / 1,3E-03 / 288105
2,33 / Usp7 / ubiquitin specific peptidase 7 / 1,2E-02 / 360471
2,32 / Tpr / translocated promoter region / 2,8E-02 / 304862
2,31 / Atrx / alpha thalassemia/mental retardation syndrome X-linked
homolog (human) / 1,8E-03 / 246284
2,31 / LOC683007 / similar to melanoma inhibitory activity 3 / 3,9E-04 / 683007
2,30 / Zfyve20 / zinc finger, FYVE domain containing 20 / 5,2E-04 / 312562
2,28 / Msi2 / Musashi homolog 2 (Drosophila) / 1,8E-03 / 360596
2,27 / Tox / Thymocyte selection-associated high mobility group box / 0,0E+00 / 362481
2,25 / LOC501546 / hypothetical protein LOC501546 / 2,3E-02 / 501546
2,21 / S1pr1 / sphingosine-1-phosphate receptor 1 / 3,1E-03 / 29733
2,21 / RGD1307525 / similar to intracellular protein transport like (XM453) / 9,4E-03 / 308053
2,21 / Egfr / epidermal growth factor receptor / 7,7E-03 / 24329
2,20 / LOC680231 / similar to chromodomain helicase DNA binding protein 9 / 4,0E-03 / 680231
2,19 / Abp10 / annexin V-binding protein ABP-10 / 3,5E-03 / 207118
2,18 / Wdr33 / WD repeat domain 33 / 9,0E-05 / 307524
2,16 / RGD1310950 / similar to KIAA1078 protein / 1,9E-04 / 289400
2,15 / Zfp451 / zinc finger protein 451 / 9,0E-05 / 316312
2,14 / Tmed5 / transmembrane emp24 protein transport domain containing 5 / 1,1E-03 / 289883
2,09 / Meis2 / Meis1, myeloid ecotropic viral integration site 1 homolog 2 / 5,5E-03 / 311311
2,06 / Apbb1ip / amyloid beta (A4) precursor protein-binding, family B,
member 1 interacting protein / 3,4E-03 / 307171
2,05 / Bat2d / BAT2 domain containing 1 / 6,4E-03 / 360865
2,04 / Gpr61 / G protein-coupled receptor 61 / 2,2E-04 / 310780
2,03 / Slain2 / SLAIN motif family, member 2 / 4,3E-03 / 305310
2,02 / RGD1559930 / similar to mKIAA0256 protein / 3,5E-03 / 296115
2,01 / Brd4 / bromodomain containing 4 / 1,1E-02 / 362844
2,00 / N4bp1 / Nedd4 binding protein 1 / 1,7E-02 / 291921
2,00 / Jam2 / junction adhesion molecule 2 / 8,7E-03 / 619374
fluoxetine 10 mg/kg vs. stressed control
3,75 / Icam5 / intercellular adhesion molecule 5, telencephalin / 3,2E-02 / 313785
3,72 / Gna14 / guanine nucleotide binding protein, alpha 14 / 4,1E-03 / 309242
3,24 / Wfs1 / Wolfram syndrome 1 homolog (human) / 2,3E-02 / 83725
3,16 / Ampd2 / adenosine monophosphate deaminase 2 (isoform L) / 2,0E-05 / 362015
3,07 / Mas1 / MAS1 oncogene / 4,5E-02 / 25153
3,03 / Ak1 / adenylate kinase 1 / 1,1E-04 / 24183
2,81 / Dgkg / diacylglycerol kinase, gamma / 8,2E-03 / 25666
2,65 / Rbp1 / retinol binding protein 1, cellular / 3,3E-02 / 25056
2,53 / Slc9a2 / solute carrier family 9 (sodium/hydrogen exchanger),
member 2 / 6,3E-03 / 24783
2,46 / Hpca / hippocalcin / 4,5E-02 / 29177
2,44 / Plekhg5 / pleckstrin homology domain containing, family G
(with RhoGef domain) member 5 / 3,7E-02 / 310999
2,41 / Gldc / glycine decarboxylase / 3,9E-03 / 309312
2,40 / Tnfrsf25 / tumor necrosis factor receptor superfamily, member 25 / 4,1E-02 / 500592
2,39 / Ctxn1 / cortexin 1 / 3,5E-04 / 29145
2,39 / Ksr1 / kinase suppressor of ras 1 / 1,1E-02 / 360573
2,39 / Wfs1 / Wolfram syndrome 1 homolog (human) / 2,9E-02 / 83725
2,38 / Ly6e / lymphocyte antigen 6 complex, locus E / 4,3E-04 / 362934
2,36 / Bet1l / blocked early in transport 1 homolog (S. cerevisiae) like / 5,3E-04 / 54400
2,34 / Crym / crystallin, mu / 4,3E-02 / 117024
2,33 / Rab11b / RAB11B, member RAS oncogene family / 2,6E-03 / 79434
2,32 / Hpcal1 / hippocalcin-like 1 / 2,5E-03 / 50871
2,31 / RGD1560137 / similar to expressed sequence AU021034 / 1,3E-02 / 290372
2,27 / Kcnh3 / potassium voltage-gated channel, subfamily H (eag-related),
member 3 / 1,8E-02 / 27150
2,25 / Trpc6 / transient receptor potential cation channel, subfamily C,
member 6 / 6,2E-03 / 89823
2,25 / Col6a1 / collagen, type VI, alpha 1 / 1,8E-02 / 294337
2,25 / Gpc4 / glypican 4 / 1,3E-03 / 317322
2,19 / Pmm2 / phosphomannomutase 2 / 5,3E-04 / 302915
2,17 / Trpc4 / transient receptor potential cation channel, subfamily C,
member 4 / 5,7E-03 / 84494
2,15 / Gzmm / granzyme M (lymphocyte met-ase 1) / 1,6E-02 / 29252
2,12 / Mospd3 / motile sperm domain containing 3 / 7,3E-04 / 288557
2,11 / Serpinf1 / serine (or cysteine) peptidase inhibitor, clade F, member 1 / 3,1E-02 / 287526
2,09 / Hspb8 / heat shock protein 8 / 2,1E-02 / 113906
2,07 / Cst6 / cystatin E/M / 8,4E-03 / 171096
2,07 / Eng / endoglin / 2,6E-04 / 497010
2,06 / Smpd2 / sphingomyelin phosphodiesterase 2, neutral / 1,4E-02 / 83537
2,05 / Hapln4 / hyaluronan and proteoglycan link protein 4 / 9,8E-03 / 361129
2,04 / Eepd1 / endonuclease/exonuclease/phosphatase family domain
containing 1 / 2,9E-03 / 315500
2,03 / Zfp536 / zinc finger protein 536 / 4,0E-04 / 292820
2,02 / Rgs14 / regulator of G-protein signaling 14 / 4,2E-02 / 114705
2,02 / Rras / Harvey rat sarcoma oncogene, subgroup R / 8,6E-03 / 361568
2,01 / Pde2a / phosphodiesterase 2A, cGMP-stimulated / 8,9E-03 / 81743
SJW 250mg/kg vs. stressed control
3,53 / Hspb8 / heat shock protein 8 / 3,6E-04 / 113906
3,16 / Pygm / muscle glycogen phosphorylase / 2,0E-04 / 24701
3,03 / Dgkg / diacylglycerol kinase, gamma / 5,1E-03 / 25666
3,02 / Gnai3 / guanine nucleotide binding protein (G protein), alpha
inhibiting 3 / 5,0E-05 / 25643
2,92 / Rab11b / RAB11B, member RAS oncogene family / 3,0E-04 / 79434
2,78 / Hes5 / hairy and enhancer of split 5 (Drosophila) / 4,4E-04 / 79225
2,73 / Ntf3 / neurotrophin 3 / 2,3E-02 / 81737
2,72 / Eif3s6ip / eukaryotic translation initiation factor 3, subunit 6 interacting
protein / 3,0E-05 / 300069
2,70 / Dlgap1 / discs, large (Drosophila) homolog-associated protein 1 / 3,8E-03 / 65040
2,70 / Max / Max protein / 2,9E-03 / 60661
2,63 / Kcnip2 / Kv channel-interacting protein 2 / 3,6E-02 / 56817
2,60 / Hpca / hippocalcin / 3,4E-02 / 29177
2,58 / Blcap / bladder cancer associated protein homolog (human) / 3,8E-04 / 171113
2,55 / Ampd2 / adenosine monophosphate deaminase 2 (isoform L) / 2,0E-04 / 362015
2,52 / Abhd8 / abhydrolase domain containing 8 / 9,1E-03 / 306338
2,50 / Hpcal4 / hippocalcin-like 4 / 1,8E-03 / 50872
2,48 / Cadm4 / cell adhesion molecule 4 / 2,3E-04 / 365216
2,48 / Pmm2 / phosphomannomutase 2 / 1,1E-04 / 302915
2,48 / Mxi1 / Max interacting protein 1 / 1,5E-04 / 25701
2,45 / Tle4 / transducin-like enhancer of split 4, homolog of Drosophila E(
spl) / 1,0E-05 / 25565
2,42 / Rae1 / RAE1 RNA export 1 homolog (S. pombe) / 8,7E-04 / 362281
2,41 / Wfs1 / Wolfram syndrome 1 homolog (human) / 2,7E-02 / 83725
2,39 / Gcdh / glutaryl-Coenzyme A dehydrogenase / 1,8E-03 / 364975
2,36 / Trpc4 / transient receptor potential cation channel, subfamily C,
member 4 / 2,6E-03 / 84494
2,35 / Nrip3 / nuclear receptor interacting protein 3 / 3,8E-02 / 361625
2,33 / Tmem28 / transmembrane protein 28 / 1,4E-02 / 498667
2,31 / RGD1306613 / similar to RIKEN cDNA 1600012F09 / 1,6E-04 / 306994
2,31 / Pfn2 / profilin 2 / 1,9E-04 / 81531
2,31 / Vamp1 / vesicle-associated membrane protein 1 / 4,8E-04 / 25624
2,29 / Rasgrf2 / RAS protein-specific guanine nucleotide-releasing factor 2 / 1,3E-02 / 114513
2,29 / RGD1312005 / similar to DD1 / 4,0E-04 / 291580
2,28 / Mapk1 / mitogen activated protein kinase 1 / 2,0E-05 / 116590
2,27 / Tpm3 / tropomyosin 3, gamma / 3,6E-04 / 117557
2,25 / Ak1 / adenylate kinase 1 / 2,2E-03 / 24183
2,25 / Tpm3 / tropomyosin 3, gamma / 3,4E-04 / 117557
2,24 / Nmt1 / N-myristoyltransferase 1 / 5,7E-04 / 259274
2,23 / Ss18 / synovial sarcoma translocation, Chromosome 18 / 1,0E-05 / 361295
2,22 / Nedd4 / neural precursor cell expressed, developmentally
down-regulated gene 4 / 5,1E-04 / 25489
2,20 / Dnd1 / dead end homolog 1 (zebrafish) / 1,1E-02 / 307492
2,20 / Top1 / topoisomerase (DNA) I / 3,0E-04 / 64550
2,20 / Hpcal1 / hippocalcin-like 1 / 4,1E-03 / 50871
2,19 / Bet1l / blocked early in transport 1 homolog (S. cerevisiae) like / 1,2E-03 / 54400
2,17 / Camk1g / calcium/calmodulin-dependent protein kinase I gamma / 1,4E-02 / 171358
2,17 / Scn1b / sodium channel, voltage-gated, type I, beta / 2,9E-02 / 29686
2,17 / Tpm3 / tropomyosin 3, gamma / 2,0E-04 / 117557
2,17 / Pigt / phosphatidylinositol glycan anchor biosynthesis, class T / 6,3E-03 / 296360
2,14 / Dnm3 / dynamin 3 / 3,7E-04 / 171574
2,14 / Kidins220 / kinase D-interacting substrate of 220 kDa / 1,1E-04 / 116478
2,14 / Eif4g2_predicted / eukaryotic translation initiation factor 4, gamma 2 (predicted) / 3,0E-05 / 361628
2,13 / Thy1 / thymus cell antigen 1, theta / 2,4E-03 / 24832
2,13 / Slc9a2 / solute carrier family 9 (sodium/hydrogen exchanger),
member 2 / 2,2E-02 / 24783
2,12 / Tpm3 / tropomyosin 3, gamma / 6,0E-05 / 117557
2,12 / Rnf4 / ring finger protein 4 / 1,6E-04 / 29274
2,12 / Ddx17 / DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 / 2,8E-04 / 315133
2,11 / LOC680445 / similar to muscleblind-like 2 isoform 1 / 2,9E-02 / 680445
2,11 / Ankrd40 / ankyrin repeat domain 40 / 2,0E-05 / 690586
2,09 / Fam107a / family with sequence similarity 107, member A / 4,1E-02 / 361018
2,09 / Rab5a / RAB5A, member RAS oncogene family / 1,5E-04 / 64633
2,08 / Stx6 / syntaxin 6 / 1,7E-04 / 60562
2,07 / MGC105830 ///
rCG_48149 / similar to Ras-related protein Rab-1B /// RAB1B,
member RAS oncogene family / 6,1E-03 / 100126191 ///
361706
2,05 / Pclo / piccolo (presynaptic cytomatrix protein) / 2,1E-04 / 56768
2,05 / Rnf187 / ring finger protein 187 / 2,6E-03 / 360533
2,04 / Klhl22 / kelch-like 22 (Drosophila) / 1,5E-04 / 303792
2,04 / RGD1561455 / similar to Ras GTPase-activating-like protein IQGAP2 / 4,9E-02 / 364885
2,03 / Pik3r3 / phosphatidylinositol 3 kinase, regulatory subunit,
polypeptide 3 (p55) / 1,5E-02 / 60664
2,02 / Impact / imprinted and ancient / 1,8E-03 / 497198
2,02 / Tollip / toll interacting protein / 2,0E-05 / 361677
2,02 / MGC105830 ///
rCG_48149 / similar to Ras-related protein Rab-1B /// RAB1B,
member RAS oncogene family / 2,3E-03 / 100126191 ///
361706
2,02 / MGC105830 ///
rCG_48149 / similar to Ras-related protein Rab-1B /// RAB1B, member
RAS oncogene family / 1,6E-02 / 100126191 ///
361706
2,02 / Ppp1r3c / protein phosphatase 1, regulatory (inhibitor) subunit 3C / 1,6E-04 / 309513
2,01 / Wsb2 / WD repeat and SOCS box-containing 2 / 2,0E-05 / 288692
2,01 / Zfp68 / zinc finger protein 68 / 9,9E-03 / 304337
2,01 / Gjc2 / gap junction protein, gamma 2 / 3,9E-03 / 497913
2,00 / Tufm / Tu translation elongation factor, mitochondrial / 3,0E-03 / 293481
SJW 500 mg/kg vs. stressed control
3,50 / Hspb8 / heat shock protein 8 / 3,8E-04 / 113906
3,40 / Rab11b / RAB11B, member RAS oncogene family / 7,0E-05 / 79434
3,34 / Tmem28 / transmembrane protein 28 / 9,9E-04 / 498667
3,05 / Bet1l / blocked early in transport 1 homolog (S. cerevisiae) like / 3,0E-05 / 54400
3,01 / Slc18a2 / solute carrier family 18 (vesicular monoamine), member 2 / 2,9E-02 / 25549
2,90 / Dusp1 / dual specificity phosphatase 1 / 1,6E-03 / 114856
2,89 / Pmm2 / phosphomannomutase 2 / 2,0E-05 / 302915
2,89 / Hpcal1 / hippocalcin-like 1 / 2,9E-04 / 50871
2,86 / Zfp68 / zinc finger protein 68 / 3,6E-04 / 304337
2,81 / Cadm4 / cell adhesion molecule 4 / 5,0E-05 / 365216
2,77 / Hes5 / hairy and enhancer of split 5 (Drosophila) / 4,6E-04 / 79225
2,76 / LOC689619 / similar to nuclear receptor interacting protein 2 / 6,4E-04 / 689619
2,73 / Ampd2 / adenosine monophosphate deaminase 2 (isoform L) / 9,0E-05 / 362015
2,71 / Ak1 / adenylate kinase 1 / 3,4E-04 / 24183
2,68 / Camk1g / calcium/calmodulin-dependent protein kinase I gamma / 2,8E-03 / 171358
2,67 / Blcap / bladder cancer associated protein homolog (human) / 2,7E-04 / 171113
2,63 / Max / Max protein / 3,6E-03 / 60661
2,59 / Abhd8 / abhydrolase domain containing 8 / 7,3E-03 / 306338
2,58 / Dnd1 / dead end homolog 1 (zebrafish) / 3,0E-03 / 307492
2,55 / Irx3 / Iroquois related homeobox 3 (Drosophila) / 4,1E-03 / 307721
2,53 / Vamp1 / vesicle-associated membrane protein 1 / 1,6E-04 / 25624
2,50 / Thy1 / thymus cell antigen 1, theta / 4,4E-04 / 24832
2,50 / Eif3s6ip / eukaryotic translation initiation factor 3, subunit 6 interacting
protein / 8,0E-05 / 300069
2,48 / Pygm / muscle glycogen phosphorylase / 1,9E-03 / 24701
2,48 / RGD1312005 / similar to DD1 / 1,5E-04 / 291580
2,45 / Tle4 / transducin-like enhancer of split 4, homolog of Drosophila
E(spl) / 1,0E-05 / 25565
2,41 / LOC680445 / similar to muscleblind-like 2 isoform 1 / 1,2E-02 / 680445
2,40 / Impact / imprinted and ancient / 2,4E-04 / 497198
2,40 / Irx2 / Iroquois related homeobox 2 (Drosophila) / 2,2E-02 / 306657
2,39 / Ckap4 / cytoskeleton-associated protein 4 / 1,5E-04 / 362859
2,38 / Rab5a / RAB5A, member RAS oncogene family / 2,0E-05 / 64633
2,38 / LOC683722 / similar to Fgfr1 oncogene partner / 1,0E-05 / 683722
2,37 / Gcdh / glutaryl-Coenzyme A dehydrogenase / 1,9E-03 / 364975
2,35 / Timp2 / tissue inhibitor of metalloproteinase 2 / 2,4E-04 / 29543
2,31 / Rae1 / RAE1 RNA export 1 homolog (S. pombe) / 1,4E-03 / 362281
2,31 / Kidins220 / kinase D-interacting substrate of 220 kDa / 4,0E-05 / 116478
2,30 / Armcx3 / armadillo repeat containing, X-linked 3 / 1,8E-03 / 367902
2,29 / RGD1306613 / similar to RIKEN cDNA 1600012F09 / 1,9E-04 / 306994
2,28 / Vapb / vesicle-associated membrane protein, associated protein
B and C / 1,6E-04 / 60431
2,26 / Alg2 / asparagine-linked glycosylation 2 homolog
(yeast, alpha-1,3-mannosyltransferase) / 7,0E-05 / 313231
2,26 / Mapk1 / mitogen activated protein kinase 1 / 3,0E-05 / 116590
2,26 / Nkx2-1 / NK2 homeobox 1 / 2,5E-02 / 25628
2,24 / Gdpd1 / glycerophosphodiester phosphodiesterase domain containing 1 / 7,7E-04 / 303407
2,23 / Nedd4 / neural precursor cell expressed, developmentally
down-regulated gene 4 / 4,9E-04 / 25489
2,23 / Pfn2 / profilin 2 / 3,0E-04 / 81531
2,23 / Hpcal4 / hippocalcin-like 4 / 5,1E-03 / 50872
2,22 / Nmt1 / N-myristoyltransferase 1 / 6,2E-04 / 259274
2,22 / Pigt / phosphatidylinositol glycan anchor biosynthesis, class T / 5,0E-03 / 296360
2,21 / Scoc / short coiled-coil protein / 5,0E-05 / 364981
2,20 / Grem2 / gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis) / 4,0E-03 / 289264
2,20 / Tpm3 / tropomyosin 3, gamma / 5,4E-04 / 117557
2,20 / Pde4dip / phosphodiesterase 4D interacting protein (myomegalin) / 2,6E-04 / 64183
2,19 / Mapk9 / mitogen-activated protein kinase 9 / 4,2E-04 / 50658
2,18 / Cops7a / COP9 (constitutive photomorphogenic) homolog, subunit 7a
(Arabidopsis thaliana) / 3,8E-04 / 312710
2,17 / Dlgap1 / discs, large (Drosophila) homolog-associated protein 1 / 1,9E-02 / 65040
2,16 / Grinl1a / glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A / 2,4E-04 / 192147
2,16 / Tufm / Tu translation elongation factor, mitochondrial / 1,3E-03 / 293481
2,16 / Elovl5 / ELOVL family member 5, elongation of long chain fatty acids
(yeast) / 2,4E-02 / 171400
2,16 / Gnai3 / guanine nucleotide binding protein (G protein), alpha inhibiting 3 / 1,9E-03 / 25643
2,16 / MGC105830 ///
rCG_48149 / similar to Ras-related protein Rab-1B /// RAB1B, member
RAS oncogene family / 1,1E-03 / 100126191 ///
361706
2,16 / Cdc23 / CDC23 (cell division cycle 23, yeast, homolog) / 2,2E-03 / 291689
2,15 / Crot / carnitine O-octanoyltransferase / 1,7E-03 / 83842
2,15 / Chp ///
RGD1565588 / calcium binding protein p22 /// similar to calcium
binding protein P22 / 1,4E-03 / 499969 ///
64152
2,15 / RGD1560137 / similar to expressed sequence AU021034 / 2,2E-02 / 290372
2,15 / MGC105830 ///
rCG_48149 / similar to Ras-related protein Rab-1B /// RAB1B, member
RAS oncogene family / 4,2E-03 / 100126191 ///
361706
2,14 / Yipf3 / Yip1 domain family, member 3 / 2,2E-04 / 301245
2,14 / Rnf4 / ring finger protein 4 / 1,4E-04 / 29274
2,12 / Caprin1 / cell cycle associated protein 1 / 2,7E-04 / 362173
2,11 / Plekhb2 / pleckstrin homology domain containing, family B (evectins)
member 2 / 1,7E-02 / 301337
2,10 / Cacng3 / calcium channel, voltage-dependent, gamma subunit 3 / 4,0E-02 / 140724
2,10 / RGD1310352 / similar to HTGN29 protein; keratinocytes associated
transmembrane protein 2 / 1,1E-02 / 303122
2,09 / Rnf187 / ring finger protein 187 / 2,0E-03 / 360533
2,09 / Snapc5 / Small nuclear RNA activating complex, polypeptide 5 / 3,1E-04 / 691501
2,09 / RGD1304825 / similar to RIKEN cDNA 2010309E21 / 2,3E-03 / 297415
2,08 / Stx6 / syntaxin 6 / 1,7E-04 / 60562
2,08 / Klhl22 / kelch-like 22 (Drosophila) / 1,2E-04 / 303792
2,07 / Slc6a9 / solute carrier family 6 (neurotransmitter transporter, glycine),
member 9 / 3,4E-03 / 116509
2,07 / Hsdl2 / hydroxysteroid dehydrogenase like 2 / 6,0E-04 / 313200
2,07 / Top1 / topoisomerase (DNA) I / 6,7E-04 / 64550
2,06 / Tollip / toll interacting protein / 1,0E-05 / 361677
2,06 / Sncb / synuclein, beta / 5,7E-04 / 113893
2,06 / RGD1562846 / similar to Docking protein 5 (Downstream of tyrosine kinase 5)
(Protein dok-5) / 1,2E-03 / 502694
2,06 / MGC105830 ///
rCG_48149 / similar to Ras-related protein Rab-1B /// RAB1B, member
RAS oncogene family / 1,3E-02 / 100126191 ///
361706
2,05 / Pias4 / protein inhibitor of activated STAT, 4 / 7,0E-05 / 362827
2,05 / Trpm7 / transient receptor potential cation channel, subfamily M,
member 7 / 1,7E-04 / 679906
2,05 / Tpm3 / tropomyosin 3, gamma / 1,1E-03 / 117557
2,04 / Zfp313 / zinc finger protein 313 / 8,2E-03 / 362277
2,04 / Ss18 / synovial sarcoma translocation, Chromosome 18 / 6,0E-05 / 361295
2,04 / Pcbp4 / poly(rC) binding protein 4 / 2,4E-04 / 363133
2,04 / Aamp / angio-associated migratory protein / 8,0E-05 / 301512
2,03 / Eif4g2_predicted / eukaryotic translation initiation factor 4, gamma 2 (predicted) / 6,0E-05 / 361628
2,03 / RGD1307682 / similar to hypothetical protein FLJ21827 / 6,5E-03 / 300675
2,02 / Cd55 / CD55 antigen / 1,2E-02 / 64036
2,02 / Elmod2 / ELMO domain containing 2 / 1,4E-02 / 688581
2,02 / Mesdc2 / mesoderm development candidate 2 / 5,0E-05 / 308796
2,01 / Alg2 / asparagine-linked glycosylation 2 homolog
(yeast, alpha-1,3-mannosyltransferase) / 2,8E-03 / 313231
2,00 / Mxi1 / Max interacting protein 1 / 2,0E-03 / 25701
2,00 / Mafg / v-maf musculoaponeurotic fibrosarcoma oncogene family,
protein G (avian) / 3,5E-04 / 64188
Downregulated genes
Fold change / Gene symbol / Gene Title / p-value / Entrez Genestressed control vs. unstressesd control upregulated
-4,66 / RT1-A3 ///
RT1-Aw2 ///
RT1A-2 / RT1 class I, A3 ///
RT1 class Ib, locus Aw2 ///
RT1 class I gene (A-2) / 3,9E-02 / 24737 ///
24974 ///
309627
-4,05 / Hspb8 / heat shock protein 8 / 1,2E-04 / 113906
-3,73 / RGD1560137 / similar to expressed sequence AU021034 / 3,5E-04 / 290372
-3,54 / Cadm4 / cell adhesion molecule 4 / 0,0E+00 / 365216
-3,37 / Max / Max protein / 4,9E-04 / 60661
-3,33 / Eif3s6ip / eukaryotic translation initiation factor 3, subunit 6
interacting protein / 0,0E+00 / 300069
-3,26 / Dnd1 / dead end homolog 1 (zebrafish) / 4,1E-04 / 307492
-3,19 / Bet1l / blocked early in transport 1 homolog (S. cerevisiae) like / 2,0E-05 / 54400
-3,18 / Pigt / phosphatidylinositol glycan anchor biosynthesis, class T / 1,8E-04 / 296360
-3,18 / Ces3 / carboxylesterase 3 / 3,5E-02 / 113902
-3,17 / Rab11b / RAB11B, member RAS oncogene family / 1,3E-04 / 79434
-3,05 / Ak1 / adenylate kinase 1 / 1,0E-04 / 24183
-3,03 / Gnai3 / guanine nucleotide binding protein (G protein),
alpha inhibiting 3 / 5,0E-05 / 25643
-3,01 / Blcap / bladder cancer associated protein homolog (human) / 8,0E-05 / 171113
-3,00 / Rae1 / RAE1 RNA export 1 homolog (S. pombe) / 9,0E-05 / 362281
-2,95 / Camk1g / calcium/calmodulin-dependent protein kinase I gamma / 1,3E-03 / 171358
-2,92 / LOC689619 / similar to nuclear receptor interacting protein 2 / 3,9E-04 / 689619
-2,92 / Gcdh / glutaryl-Coenzyme A dehydrogenase / 2,6E-04 / 364975
-2,81 / Tmem28 / transmembrane protein 28 / 3,6E-03 / 498667
-2,72 / RGD1307682 / similar to hypothetical protein FLJ21827 / 3,3E-04 / 300675
-2,69 / Hpcal1 / hippocalcin-like 1 / 5,8E-04 / 50871
-2,69 / LOC680445 / similar to muscleblind-like 2 isoform 1 / 5,6E-03 / 680445
-2,65 / Pfn2 / profilin 2 / 3,0E-05 / 81531
-2,63 / Pmm2 / phosphomannomutase 2 / 6,0E-05 / 302915
-2,58 / Elmod2 / ELMO domain containing 2 / 1,7E-03 / 688581
-2,58 / Abhd8 / abhydrolase domain containing 8 / 7,6E-03 / 306338
-2,57 / Ada / adenosine deaminase / 1,8E-02 / 24165
-2,55 / Dusp1 / dual specificity phosphatase 1 / 4,4E-03 / 114856
-2,52 / RGD1312005 / similar to DD1 / 1,3E-04 / 291580
-2,52 / Abhd14b / abhydrolase domain containing 14b / 5,0E-05 / 300983
-2,51 / Thy1 / thymus cell antigen 1, theta / 4,2E-04 / 24832
-2,49 / RGD1304825 / similar to RIKEN cDNA 2010309E21 / 3,2E-04 / 297415
-2,46 / Hes5 / hairy and enhancer of split 5 (Drosophila) / 1,5E-03 / 79225
-2,43 / MGC105830 ///
rCG_48149 / similar to Ras-related protein Rab-1B ///
RAB1B, member RAS oncogene family / 2,6E-04 / 100126191 ///
361706
-2,43 / Lancl1 / lanC (bacterial lantibiotic synthetase component C)-like 1 / 7,1E-04 / 114515
-2,42 / Grem2 / gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis) / 1,6E-03 / 289264
-2,42 / Tufm / Tu translation elongation factor, mitochondrial / 3,4E-04 / 293481
-2,42 / Tle4 / transducin-like enhancer of split 4, homolog of Drosophila E
(spl) / 2,0E-05 / 25565
-2,39 / Anxa4 / annexin A4 / 6,0E-03 / 79124
-2,38 / Scn1b / sodium channel, voltage-gated, type I, beta / 1,6E-02 / 29686
-2,37 / Tpm3 / tropomyosin 3, gamma / 2,1E-04 / 117557
-2,37 / Scoc / short coiled-coil protein / 2,0E-05 / 364981
-2,37 / Sfrs12ip1 / SFRS12-interacting protein 1 / 2,6E-04 / 361888
-2,36 / Mapk1 / mitogen activated protein kinase 1 / 1,0E-05 / 116590
-2,35 / Plekhb2 / pleckstrin homology domain containing, family B (evectins)
member 2 / 7,4E-03 / 301337
-2,34 / Yipf3 / Yip1 domain family, member 3 / 7,0E-05 / 301245
-2,32 / Grinl1a / glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A / 9,0E-05 / 192147
-2,32 / Zfp313 / zinc finger protein 313 / 2,5E-03 / 362277
-2,32 / Pygm / muscle glycogen phosphorylase / 3,5E-03 / 24701
-2,32 / Cops3 / COP9 (constitutive photomorphogenic) homolog, subunit 3
(Arabidopsis thaliana) / 1,1E-02 / 287367
-2,31 / Tpm3 / tropomyosin 3, gamma / 2,4E-04 / 117557
-2,31 / MGC105830 ///
rCG_48149 / similar to Ras-related protein Rab-1B /// RAB1B,
member RAS oncogene family / 2,1E-03 / 100126191 ///
361706
-2,30 / Nedd4 / neural precursor cell expressed, developmentally
down-regulated gene 4 / 3,4E-04 / 25489
-2,29 / Rnf187 / ring finger protein 187 / 7,4E-04 / 360533
-2,28 / Sdccag3 / serologically defined colon cancer antigen 3 / 2,2E-03 / 306322
-2,27 / MGC105830 ///
rCG_48149 / similar to Ras-related protein Rab-1B ///
RAB1B, member RAS oncogene family / 5,8E-03 / 100126191 ///
361706
-2,26 / Vapb / vesicle-associated membrane protein, associated protein
B and C / 1,8E-04 / 60431
-2,26 / Gtf2f1 / general transcription factor IIF, polypeptide 1 / 0,0E+00 / 316123
-2,26 / Chp ///
RGD1565588 / calcium binding protein p22 /// similar to calcium binding
protein P22 / 7,8E-04 / 499969 /// 64152
-2,26 / Rab5a / RAB5A, member RAS oncogene family / 4,0E-05 / 64633
-2,26 / Cav1 / caveolin, caveolae protein 1 / 2,0E-02 / 25404
-2,26 / Smoc1 / SPARC related modular calcium binding 1 / 1,7E-02 / 314280
-2,25 / Vamp1 / vesicle-associated membrane protein 1 / 6,2E-04 / 25624
-2,25 / Hsdl2 / hydroxysteroid dehydrogenase like 2 / 2,1E-04 / 313200
-2,24 / Impact / imprinted and ancient / 5,4E-04 / 497198
-2,23 / Nmt1 / N-myristoyltransferase 1 / 5,8E-04 / 259274
-2,23 / Tmed2 / transmembrane emp24 domain trafficking protein 2 / 4,0E-03 / 65165
-2,21 / Kidins220 / kinase D-interacting substrate of 220 kDa / 7,0E-05 / 116478
-2,21 / Cops7a / COP9 (constitutive photomorphogenic) homolog, subunit 7a
(Arabidopsis thaliana) / 3,3E-04 / 312710
-2,20 / Rnase4 / ribonuclease, RNase A family 4 / 6,0E-05 / 56759
-2,20 / Iiig9 / IIIG9 protein / 1,3E-03 / 252958
-2,20 / Cacng3 / calcium channel, voltage-dependent, gamma subunit 3 / 3,1E-02 / 140724
-2,20 / St7l / suppression of tumorigenicity 7-like / 8,6E-04 / 295344
-2,19 / Aamp / angio-associated migratory protein / 3,0E-05 / 301512
-2,18 / Tpm3 / tropomyosin 3, gamma / 1,9E-04 / 117557
-2,17 / Eif2s3x / eukaryotic translation initiation factor 2, subunit 3, structural
gene X-linked / 1,0E-03 / 299027
-2,15 / RGD1306613 / similar to RIKEN cDNA 1600012F09 / 4,3E-04 / 306994
-2,14 / Hrasls / HRAS-like suppressor / 0,0E+00 / 288025
-2,13 / Oprl1 / opioid receptor-like 1 / 4,2E-04 / 29256
-2,13 / Ss18 / synovial sarcoma translocation, Chromosome 18 / 3,0E-05 / 361295
-2,13 / Stx6 / syntaxin 6 / 1,2E-04 / 60562
-2,13 / RGD1310352 / similar to HTGN29 protein; keratinocytes associated
transmembrane protein 2 / 1,0E-02 / 303122
-2,12 / MGC94600 / scotin / 6,0E-05 / 301013
-2,12 / Prosc / proline synthetase co-transcribed / 4,6E-03 / 306544
-2,10 / Gdpd1 / glycerophosphodiester phosphodiesterase domain containing 1 / 1,6E-03 / 303407
-2,10 / Nkx2-1 / NK2 homeobox 1 / 4,0E-02 / 25628
-2,09 / Isl1 / ISL1 transcription factor, LIM/homeodomain 1 / 4,2E-02 / 64444
-2,09 / Osbpl2 / oxysterol binding protein-like 2 / 1,7E-03 / 296461
-2,08 / Tfpt / TCF3 (E2A) fusion partner / 5,0E-03 / 85423
-2,08 / Uqcrc2 / ubiquinol cytochrome c reductase core protein 2 / 3,1E-04 / 293448
-2,07 / Zfp68 / zinc finger protein 68 / 7,8E-03 / 304337
-2,06 / Arl2bp / ADP-ribosylation factor-like 2 binding protein / 5,0E-05 / 498910
-2,06 / Hdac1 ///
Hdac1_predicted / histone deacetylase 1 /// histone deacetylase 1 (predicted) / 1,1E-03 / 297893 ///
84576
-2,06 / Mxi1 / Max interacting protein 1 / 1,4E-03 / 25701
-2,06 / Fhit / fragile histidine triad gene / 4,1E-04 / 60398
-2,05 / Arl1 / ADP-ribosylation factor-like 1 / 9,0E-05 / 64187
-2,05 / Snapc5 / Small nuclear RNA activating complex, polypeptide 5 / 4,1E-04 / 691501
-2,04 / Bbox1 / butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1
(gamma-butyrobetaine hydroxylase) / 4,4E-04 / 64564
-2,04 / Grhl3 / grainyhead-like 3 (Drosophila) / 2,3E-02 / 298555
-2,03 / RGD1306233 / similar to hypothetical protein MGC29761 / 2,5E-03 / 296608
-2,03 / Rnf4 / ring finger protein 4 / 2,9E-04 / 29274
-2,03 / Spint2 / serine protease inhibitor, Kunitz type 2 / 3,7E-03 / 292770
-2,03 / Mapre1 / microtubule-associated protein, RP/EB family, member 1 / 1,3E-02 / 114764
-2,03 / Rab3a / RAB3A, member RAS oncogene family / 1,3E-03 / 25531
-2,03 / RGD1563441 / similar to RIKEN cDNA A030009H04 / 2,2E-02 / 497935
-2,03 / Armcx3 / armadillo repeat containing, X-linked 3 / 6,4E-03 / 367902
-2,02 / LOC498972 / similar to copine II / 8,9E-04 / 498972
-2,02 / Rras / Harvey rat sarcoma oncogene, subgroup R / 8,7E-03 / 361568
-2,01 / Top1 / topoisomerase (DNA) I / 9,9E-04 / 64550
-2,01 / Tpm4 / tropomyosin 4 / 2,4E-03 / 24852
-2,01 / Efemp2 / EGF-containing fibulin-like extracellular matrix protein 2 / 4,7E-02 / 293677
-2,00 / Rab7 / RAB7, member RAS oncogene family / 1,0E-05 / 29448
-2,00 / RGD1310686 / similar to chromosome 16 open reading frame 5 / 3,0E-05 / 360480
fluoxetine 10 mg/kg vs. stressed control
-2,85 / Tpr / translocated promoter region / 7,8E-03 / 304862
-2,75 / Med13 / mediator complex subunit 13 / 3,5E-04 / 303403
-2,69 / Kcnc2 / potassium voltage gated channel, Shaw-related subfamily,
member 2 / 4,2E-03 / 246153
-2,66 / Nrg1 / neuregulin 1 / 1,2E-02 / 112400
-2,59 / Mapk8 / Mitogen-activated protein kinase 8 / 2,7E-03 / 116554
-2,53 / Tmie / transmembrane inner ear / 1,0E-05 / 501061
-2,48 / Tacstd2 / tumor-associated calcium signal transducer 2 / 5,4E-04 / 494343
-2,46 / Slbp / stem-loop binding protein / 1,2E-02 / 681062
-2,33 / F13a1 / coagulation factor XIII, A1 subunit / 4,0E-02 / 60327
-2,31 / Kcnma1 / potassium large conductance calcium-activated channel,
subfamily M, alpha member 1 / 1,4E-02 / 83731
-2,24 / Abp10 / annexin V-binding protein ABP-10 / 2,8E-03 / 207118
-2,23 / Ddef1 / development and differentiation enhancing / 1,4E-02 / 314961
-2,23 / Usp7 / ubiquitin specific peptidase 7 / 1,7E-02 / 360471
-2,23 / Kcnc2 / potassium voltage gated channel, Shaw-related subfamily,
member 2 / 1,9E-02 / 246153
-2,22 / Nexn / nexilin / 2,8E-02 / 246172
-2,19 / RGD1560157 / similar to hypothetical protein LOC168850 / 1,6E-04 / 500057
-2,16 / Osap / ovary-specific acidic protein / 6,7E-03 / 689931
-2,15 / rCG_32844 / ubiquitin specific protease 43 / 6,6E-03 / 100147704
-2,13 / Nexn / nexilin / 3,7E-02 / 246172
-2,12 / RGD1559930 / similar to mKIAA0256 protein / 2,0E-03 / 296115
-2,10 / Col11a1 / collagen, type XI, alpha 1 / 8,3E-03 / 25654
-2,08 / Apbb1ip / amyloid beta (A4) precursor protein-binding, family B,
member 1 interacting protein / 3,0E-03 / 307171
-2,06 / Zfyve20 / zinc finger, FYVE domain containing 20 / 1,9E-03 / 312562
-2,06 / Stox2 / storkhead box 2 / 3,7E-04 / 306459
-2,05 / Ces7 / carboxylesterase 7 / 5,6E-04 / 307660
-2,05 / Dnm1l / dynamin 1-like / 1,2E-02 / 114114
-2,05 / Pnpla8 / Patatin-like phospholipase domain containing 8 / 5,1E-03 / 314075
-2,03 / Akap2 / A kinase (PRKA) anchor protein 2 / 9,9E-04 / 298024
-2,02 / Chd2 / chromodomain helicase DNA binding protein 2 / 7,7E-03 / 308738
-2,02 / Inpp4b / inositol polyphosphate-4-phosphatase, type II / 1,2E-02 / 116699
-2,02 / Sema3d / sema domain, immunoglobulin domain (Ig), short basic
domain, secreted, (semaphorin) 3D / 1,0E-03 / 246262
-2,02 / Lap3 / leucine aminopeptidase 3 / 7,9E-04 / 289668
-2,01 / RGD1562339 / RGD1562339 / 9,1E-03 / 498107
-2,00 / Elavl2 / ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2
(Hu antigen B) / 2,3E-03 / 286973
SJW 250mg/kg vs. stressed control
-3,01 / Mapk8 / Mitogen-activated protein kinase 8 / 7,7E-04 / 116554
-2,78 / F13a1 / coagulation factor XIII, A1 subunit / 1,5E-02 / 60327
-2,55 / LOC680726 / Similar to RNA binding motif, single stranded interacting
protein 3 isoform 1 / 2,0E-04 / 680726
-2,54 / Slc22a3 / solute carrier family 22 (organic cation transporter), member 3 / 4,0E-04 / 29504
-2,50 / Pcdh21 / protocadherin 21 / 7,9E-04 / 93662
-2,33 / Pxmp4 / peroxisomal membrane protein 4 / 5,0E-02 / 282634
-2,33 / rCG_32844 / ubiquitin specific protease 43 / 3,3E-03 / 100147704
-2,26 / Tox / Thymocyte selection-associated high mobility group box / 0,0E+00 / 362481
-2,25 / Tchh / Trichohyalin / 3,6E-04 / 310588
-2,18 / Nrg1 / neuregulin 1 / 4,2E-02 / 112400
-2,15 / Vash2 / vasohibin 2 / 1,3E-03 / 498309
-2,13 / Cml3 / camello-like 3 / 6,4E-03 / 113892
-2,12 / Tacstd2 / tumor-associated calcium signal transducer 2 / 2,8E-03 / 494343
-2,12 / Chst5 / carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 / 1,0E-05 / 307859
-2,12 / Klf5 / Kruppel-like factor 5 / 9,5E-03 / 84410
-2,06 / MGC116197 / similar to RIKEN cDNA 1700001E04 / 2,0E-05 / 367620
-2,03 / Ces7 / carboxylesterase 7 / 6,5E-04 / 307660
-2,01 / Osap / ovary-specific acidic protein / 1,2E-02 / 689931
SJW 500 mg/kg vs. stressed control
-2,92 / Mapk8 / Mitogen-activated protein kinase 8 / 1,0E-03 / 116554
-2,48 / Akap5 / A kinase (PRKA) anchor protein 5 / 4,3E-02 / 171026
-2,48 / Tacstd2 / tumor-associated calcium signal transducer 2 / 5,3E-04 / 494343
-2,38 / Pxmp4 / peroxisomal membrane protein 4 / 4,4E-02 / 282634
-2,24 / Meis2 / Meis1, myeloid ecotropic viral integration site 1 homolog 2 / 2,8E-03 / 311311
-2,21 / Tox / Thymocyte selection-associated high mobility group box / 0,0E+00 / 362481
-2,07 / LOC500991 / hypothetical protein LOC500991 / 1,1E-03 / 500991
1