Stroke rates and hazard ratios from Cox proportional hazards regression for incident stroke as a function of
combinations of traditional clinical risk factors (present/absent) and silent infarcts (present/absent)
RISK FACTOR / STROKES / 1000 PERSON-YEARS (n) / HAZARD RATIOS (HR):each combination of risk factor by silent infarcts
compared to no/no group
(available n=3298; 158 incident strokes**)
UNADJUSTED
HR (95% CI for HR) / ADJUSTED*
HR (95% CI for HR)
SILENT INFARCTS / SILENT INFARCTS / SILENT INFARCTS
yes / no / total / yes / no / yes / no
HYPERTENSION
(self-reported ever):
yes
no / 21.9 (519)
14.6 (392) / 10.7 (1108)
8.6 (1279) / 14.2 (1627)
10.0 (1671) / 2.54 (1.67-3.86)
1.68 (1.02-2.78) / 1.25 (0.83- 1.89)
1.00 / 2.16 (1.41-3.31)
1.43 (0.87-2.39) / 1.14 (0.75-1.73)
1.00
ADA DIABETIC STATUS:
yes
normal/igf / 29.7 (122)
17.1 (789) / 11.4 ( 313)
9.3 (2074) / 16.2 ( 435)
11.4 (2863) / 3.20 (1.78-5.75)
1.82 (1.29-2.58) / 1.23 (0.70-2.18)
1.00 / 2.48 (1.35-4.52)
1.59 (1.12-2.27) / 1.10 (0.62-1.99)
1.00
MI STATUS AT MRI DATE:
yes
no / 22.5 (108)
18.1 (803) / 23.6 ( 179)
8.5 (2208) / 23.2 ( 287)
11.0 (3011) / 2.64 (1.32-5.28)
2.12 (1.50-2.99) / 2.78 (1.62-4.77)
1.00 / 1.95 (0.87-4.37)
1.90 (1.34-2.69) / 2.13 (1.07-4.24)
1.00
CHF STATUS AT MRI DATE:
yes
no / 21.1 ( 54)
18.5 (857) / 22.4 ( 84)
9.1 (2303) / 21.9 ( 138)
11.6 (3160) / 2.31 (0.85-6.31)
2.01 (1.45-2.79) / 2.46 (1.07-4.24)
1.00 / 1.30 (0.47-3.66)
1.77 (1.27-2.46) / 1.38 (0.61-3.14)
1.00
ECG-AFIB (closest MRI visit)
yes
no / 67.7 ( 22)
17.6 (889) / 30.1 ( 64)
9.0 (2323) / 39.1 ( 86)
11.3 (3212) / 7.50 (3.04-18.48)
1.93 (1.39- 2.68) / 3.33 (1.54-7.21)
1.00 / 6.94 (2.75-17.50)
1.63 (1.17 - 2.28) / 2.72 (1.24-5.97)
1.00
*Adjusted for age at MRI, sex, race (white no/yes), smoker status (never/former/current), CHD status at MRI and the four other risk factors noted in table.
**missing values for some variables reduced the total available sample size for these analyses.