Table 1: Participating Cancer Registries

Table 1: Participating Cancer Registries

Country / Registry/Region / Study period / Size of registry population* / National coverage / Region
Czech Republic / Czech Cancer Registrya / 1977-2007 / 10,322,689 / 100% / East
Denmark / Danish Cancer Registrya / 1990-2006 / 5,457,405 / 100% / North
England / United Kingdom Association of Cancer Registries / 1990-2006 / 50,762,945 / 100% / North
Estonia / Estonian Cancer Registry / 1990-2006 / 1,343,314 / 100% / North
Finland / Finnish Cancer Registry / 1990-2007 / 5,288,730 / 100% / North
Germany / Saarland Cancer Registry / 1990-2006 / 1,046,777 / 1.3% / West
Iceland / Icelandic Cancer Registry / 1990-2008 / 315,459 / 100% / North
Ireland / Ireland / 1994-2007 / 4,439,750 / 100% / North
Italy / Modena / 1990-2007 / 677,672 / 1.2% / South
Italy / Sondrio / 1998-2007 / 179,736 / 0.3% / South
Italy / Umbria / 1994-2006 / 811,830 / 1.4% / South
Malta / Malta National Cancer Registry / 1993-2008 / 409,092 / 100% / South
Norway / Norwegian Cancer Registrya / 1990-2006 / 4,709,184 / 100% / North
Portugal / North Region / 1996-2005 / 3,280,199 / 31% / South
Scotland / Scottish Cancer Registrya / 1985-2007 / 5,144,200 / 100% / North
Slovakia / Slovakia / 1990-2005 / 5,387,285 / 100% / East
Slovenia / Slovenia / 1990-2007 / 2,019,406 / 100% / South
Spain / La Rioja / 1993-2005 / 301,084 / 0.7% / South
Girona / 1993-2006 / 658,984 / 1.6% / South
Basque country / 1990-2004 / 2,110,626 / 5.2% / South
Navarra / 1990-2005 / 601,874 / 1.5% / South
Tarragona / 1990-2004 / 663,455 / 1.6% / South
Sweden / Swedish Cancer Registrya / 1990-2006 / 9,148,102 / 100% / North
Switzerland / Geneva / 1990-2006 / 443,145 / 5.9% / West
Switzerland / 1990-2006 / 3,531,102 / 47% / West
Netherlands / Netherlands Cancer Registry / 1989-2007 / 16,381,682 / 100% / West
Wales / 1990-2007 / 2,979,975 / 100% / North

*at the end of the study period

a: downloaded from publicly available website

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Table 2: World-standardized incidence rates (WSR) and estimated annual percentage change (EAPC) of cutaneous melanoma per 100,000 person-years by country and sex since 1990 and projected rates for 2010 and 2015

Countries# / WSR begin / WSR end / Trend / Projections 2010 / Projections 2015
Year / WSR / Year / WSR / EAPC / 95% CI / WSR / 95%PI / WSR / 95%PI
MALES
Czech Republic / 1990 / 6.6 / 2007 / 12.6 / 3.9* / 3.5;4.3 / 13.9 / 12.9;15.0 / 15.9 / 14.6;17.2
Denmark / 1990 / 10.0 / 2007 / 16.0 / 2.6* / 1.8;3.4 / 16.0 / 14.3;17.7 / 18.0 / 15.8;20.2
England / 1990 / 4.6 / 2006 / 10.7 / 5.2* / 4.7;5.6 / 12.2 / 11.7;12.6 / 14.5 / 13.9;15.1
Estonia / 1990 / 4.2 / 2006 / 7.6 / 3.9* / 1.8;6.0 / 6.8 / 4.4;9.1 / 7.6 / 4.5;10.6
Finland / 1990 / 7.5 / 2007 / 10.6 / 2.3* / 1.7;2.9 / 12.0 / 10.6;13.3 / 13.5 / 11.8;15.2
Germany / 1990 / 5.1 / 2006 / 8.2 / 3.0* / 1.7;4.3 / 10.1 / 7.7;12.4 / 11.1 / 7.8;14.4
Iceland / 1990 / 5.0 / 2008 / 10.8 / 6.1* / 3.1;9.2 / 11.5 / 5.7;17.4 / 12.3 / 5.1;19.4
Ireland / 1993 / 6.2 / 2007 / 11.6 / 4.8* / 3.7;6.0 / 11.8 / 10.3;13.4 / 13.8 / 11.9;15.7
Italy / 1998 / 5.7 / 2007 / 9.2 / 4.2 / -2.5;11.4 / 10.6 / 8.4;12.9 / 12.2 / 8.7;15.7
Malta / 1993 / 2.9 / 2008 / 9.7 / 7.5* / 4.7;10.4 / 11.2 / 6.4;16.0 / 13.5 / 7.6;19.4
Norway / 1990 / 14.7 / 2007 / 15.5 / 0.2 / -0.4;0.8 / 15.6 / 13.9;17.3 / 16.0 / 13.8;18.2
Portugal / 1996 / 1.4 / 2005 / 2.4 / 6.1* / 2.6;9.8 / 3.6 / 2.7;4.6 / 4.3 / 2.9;5.7
Scotland / 1990 / 6.0 / 2007 / 11.3 / 3.8* / 3.3;4.3 / 12.1 / 10.7;13.5 / 13.8 / 12.1;15.6
Slovakia / 1990 / 4.2 / 2005 / 7.4 / 4.9* / 4.0;5.7 / 10.0 / 8.4;11.5 / 11.8 / 9.8;13.9
Slovenia / 1990 / 4.6 / 2007 / 13.3 / 5.9* / 4.7;7.0 / 14.3 / 11.8;16.7 / 16.7 / 13.6;19.7
Spain / 1990 / 3.1 / 2004 / 6.6 / 6.7* / 5.1;8.3 / 8.1 / 6.5;9.7 / 9.3 / 6.9;11.7
Sweden / 1990 / 11.4 / 2007 / 13.5 / 1.4* / 0.8;1.9 / 14.3 / 13.1;15.4 / 15.6 / 14.2;17.0
Switzerland / 1990 / 10.9 / 2006 / 16.1 / 2.6* / 2.0;3.2 / 18.0 / 15.9;20.2 / 19.5 / 16.5;22.5
The Netherlands / 1989 / 7.4 / 2007 / 13.6 / 4.2* / 3.7;4.7 / 15.1 / 14.2;16.0 / 17.5 / 16.4;18.6
Wales / 1990 / 4.4 / 2007 / 11.2 / 5.1* / 3.7;6.6 / 12.5 / 10.6;14.4 / 15.1 / 12.7;17.4
FEMALES
Czech Republic / 1990 / 5.6 / 2007 / 11.5 / 3.4* / 2.6;4.1 / 12.0 / 11.0;13.1 / 13.5 / 12.2;14.9
Denmark / 1990 / 12.8 / 2007 / 19.5 / 2.5* / 1.7;3.4 / 21.1 / 19.1;23.0 / 24.4 / 21.9;26.8
England a / 1990 / 6.0 / 2006 / 12.3 / 3.9* / 3.4;4.5 / 14.2 / 13.6;14.8 / 16.9 / 16.1;17.6
Estonia / 1990 / 3.7 / 2006 / 8.6 / 4.1* / 2.0;6.3 / 8.0 / 5.5;10.5 / 8.6 / 5.4;11.8
Finland / 1990 / 6.3 / 2007 / 9.4 / 2.4* / 2.0;2.9 / 9.9 / 8.6;11.2 / 11.0 / 9.4;12.6
Germany / 1990 / 6.5 / 2006 / 9.6 / 3.9* / 2.4;5.3 / 12.4 / 9.9;14.9 / 14.5 / 10.7;18.4
Iceland b / 1990 / 11.8 / 2008 / 11.8 / 4.4* / 1.8;7.0 / 13.0 / 4.9;21.1 / 7.8 / 0.0;19.4
Ireland / 1993 / 10.6 / 2007 / 13.5 / 2.1* / 1.3;2.9 / 14.2 / 12.5;15.9 / 15.7 / 13.7;17.8
Italy / 1998 / 7.0 / 2007 / 11.7 / 4.0 / -2.4;10.7 / 11.4 / 9.0;13.9 / 13.1 / 9.2;17.0
Malta / 1993 / 3.3 / 2008 / 26.0 / 9.8* / 5.1;14.7 / 19.9 / 12.6;27.1 / 25.4 / 16.8;34.0
Norway / 1990 / 16.3 / 2007 / 16.3 / 0.2 / -0.5;0.9 / 17.1 / 15.3;19.0 / 17.9 / 15.4;20.3
Portugal / 1996 / 2.4 / 2005 / 3.8 / 5.0* / 0.0;10.2 / 4.8 / 3.7;5.8 / 5.5 / 4.0;7.0
Scotland / 1990 / 8.6 / 2007 / 15.3 / 2.9* / 2.0;3.9 / 15.3 / 13.5;17.2 / 17.6 / 15.2;20.0
Slovakia c / 1990 / 4.4 / 2005 / 6.5 / 3.9* / 3.0;4.9 / 8.8 / 6.6;11.1 / 10.2 / 6.5;13.8
Slovenia / 1990 / 5.1 / 2007 / 15.3 / 5.1* / 4.1;6.1 / 16.0 / 13.2;18.7 / 19.3 / 15.9;22.8
Spain / 1990 / 3.6 / 2004 / 8.5 / 6.0* / 4.3;7.8 / 9.5 / 7.1;11.9 / 10.7 / 7.1;14.2
Sweden / 1990 / 13.0 / 2007 / 15.0 / 1.5* / 0.8;2.3 / 15.5 / 14.1;16.8 / 17.1 / 15.4;18.8
Switzerland / 1990 / 10.3 / 2006 / 16.2 / 3.1* / 2.4;3.9 / 18.4 / 16.2;20.5 / 19.9 / 17.0;22.9
The Netherlands / 1989 / 10.7 / 2007 / 17.3 / 3.5* / 2.9;4.1 / 19.0 / 18.0;20.1 / 21.9 / 20.6;23.2
Wales / 1990 / 5.1 / 2007 / 11.2 / 4.6* / 3.2;5.9 / 13.7 / 11.6;15.8 / 16.3 / 13.7;18.9

*statistically significant (p≤0.05) PI Prediction Interval

#Italy includes the region of Modena, Umbria and Sondrio; Portugal includes only the Northern region; Switzerland includes the Kantones of Basel, Geneva, Graubünden and Glarus, Sankt-Gallen, Appenzell, Ticino, Valais and Zürich; Spain: includes the regions: La Rioja, Basque country, Navarra, Girona and Tarragona.

a: predictions based on period 1998-2006, because of joinpoint in 1998
b: predictions based on period 2001-2008, because of joinpoint in 2001
c: predictions based on period 2001-2005, because of joinpoint in 2001

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Table 3: Age-specific incidence rates (ASIR) and estimated annual percentage change (EAPC) of cutaneous melanoma per 100,000 person-years by country and sex since 1990

Country / Year begin / Year end / Age 25-49 / Age 50-69 / Age 70+
ASIR begin / ASIR end / EAPC / 95%CI / ASIR begin / ASIR end / EAPC / 95%CI / ASIR begin / ASIR end / EAPC / 95%CI
MALES
Czech Republic / 1990 / 2007 / 1.9 / 2.9 / 2.9* / 2.1;3.7 / 3.3 / 6.1 / 3.6* / 3.0;4.2 / 1.1 / 3.5 / 6.1* / 5.3;6.9
Denmark / 1990 / 2007 / 3.8 / 4.9 / 1.6* / 0.4;2.8 / 4.3 / 6.6 / 2.8* / 1.9;3.7 / 1.5 / 3.6 / 4.0* / 2.9;5.1
England / 1990 / 2006 / 1.7 / 3.3 / 4.1* / 3.5;4.7 / 2.0 / 4.8 / 5.4* / 5.0;5.8 / 0.7 / 2.2 / 7.1* / 6.7;7.5
Estonia / 1990 / 2006 / 1.2 / 1.7 / 4.5* / 1.4;7.7 / 1.2 / 3.9 / 4.2* / 0.7;7.9 / 0.8 / 1.8 / 5.9* / 3.3.;8.5
Finland / 1990 / 2007 / 2.3 / 2.7 / 1.5* / 0.3;2.6 / 3.4 / 5.2 / 2.4* / 1.5;3.3 / 1.4 / 2.6 / 3.5* / 2.3;4.7
Germany / 1990 / 2006 / 1.5 / 2.6 / 3.4* / 0.0;6.9 / 2.6 / 3.7 / 2.5* / 0.6;4.4 / 1.0 / 1.6 / 5.7* / 1.5;10.0
Iceland / 1990 / 2008 / 3.1 / 2.1 / 3.1 / -1.3;7.7 / 0.0 / 6.2 / 13.3* / 4.1;23.4 / 0.9 / 1.8 / 13.7* / 0.2;29.1
Ireland / 1993 / 2007 / 1.3 / 2.4 / 3.4* / 1.0;5.9 / 2.6 / 5.2 / 5.5* / 3.5;7.4 / 2.0 / 3.5 / 6.0* / 3.5;8.5
Italy / 1998 / 2007 / 2.2 / 3.5 / 5.5 / -0.7;12.2 / 2.0 / 3.3 / 3.2 / -5.4;12.6 / 1.0 / 2.0 / 7.3 / -1.4;16.7
Malta / 1993 / 2008 / 1.5 / 3.4 / 9.4* / 3.2;15.9 / 1.4 / 3.8 / 3.8 / -2.0;9.9 / 0.0 / 2.4 / 31.0* / 8.4;58.3
Norway / 1990 / 2007 / 5.5 / 3.4 / -2.8* / -3.6;-2.0 / 6.8 / 8.1 / 0.8* / 0.0;1.6 / 2.1 / 3.8 / 3.8* / 3.0;4.7
Portugal / 1996 / 2005 / 0.4 / 0.5 / 5.5 / -5.0;17.0 / 0.7 / 1.3 / 4.5* / 0.2;8.9 / 0.2 / 0.5 / 13.0* / 3.1;23.8
Scotland / 1990 / 2007 / 2.2 / 3.1 / 2.4* / 1.3;3.4 / 2.4 / 5.0 / 4.1* / 3.1;5.2 / 1.1 / 2.9 / 6.9* / 5.7;8.1
Slovakia / 1990 / 2005 / 1.2 / 2.1 / 3.2* / 1.6;4.8 / 2.4 / 3.4 / 5.1* / 3.3;6.9 / 0.6 / 1.8 / 6.2* / 3.4;8.9
Slovenia / 1990 / 2007 / 1.7 / 4.0 / 4.0* / 1.8;6.2 / 1.6 / 6.2 / 7.2* / 5.4;9.1 / 1.2 / 2.6 / 6.4* / 4.4;8.4
Spain / 1990 / 2004 / 1.4 / 2.1 / 4.3* / 2.0;6.7 / 1.1 / 2.9 / 7.3* / 4.9;9.8 / 0.6 / 1.3 / 7.8* / 4.8;11.0
Sweden / 1990 / 2007 / 3.6 / 4.0 / 0.5 / -0.4;1.4 / 5.3 / 6.1 / 1.3* / 0.7;1.9 / 2.3 / 3.2 / 2.9* / 2.0;3.9
Switzerland / 1990 / 2006 / 3.4 / 4.7 / 3.0* / 1.7;4.2 / 4.8 / 6.6 / 2.2* / 1.0;3.4 / 2.3 / 4.1 / 2.8* / 1.9;3.8
The Netherlands / 1989 / 2007 / 3.1 / 4.6 / 2.7* / 2.2;3.2 / 3.0 / 6.4 / 5.4* / 4.7;6.1 / 0.8 / 2.2 / 5.6* / 4.9;6.2
Wales / 1990 / 2007 / 2.0 / 3.7 / 4.5* / 2.3;6.7 / 1.6 / 4.6 / 5.4* / 3.3;7.6 / 0.6 / 2.6 / 7.1* / 5.7;8.6
FEMALES
Czech Republic / 1990 / 2007 / 2.2 / 3.8 / 2.7* / 1.6;3.8 / 2.3 / 5.2 / 3.7* / 2.7;4.7 / 0.8 / 1.9 / 4.3* / 3.6;5.0
Denmark / 1990 / 2007 / 6.3 / 9.5 / 2.5* / 1.3;3.7 / 3.9 / 6.7 / 2.6* / 1.9;3.2 / 1.6 / 1.5 / 2.0* / 0.7;3.2
England / 1990 / 2006 / 2.6 / 5.3 / 3.6* / 2.9;4.4 / 2.2 / 4.7 / 4.4* / 3.9;4.9 / 0.7 / 1.6 / 4.4* / 3.9;5.0
Estonia / 1990 / 2006 / 1.0 / 3.3 / 3.7* / 0.1;7.3 / 1.7 / 3.8 / 3.8* / 1.0;6.7 / 0.4 / 1.1 / 6.7* / 3.5;9.9
Finland / 1990 / 2007 / 2.7 / 3.4 / 1.9* / 0.8;3.0 / 2.2 / 3.6 / 2.8* / 2.0;3.6 / 1.0 / 2.0 / 3.3* / 2.3;4.2
Germany / 1990 / 2006 / 2.5 / 4.3 / 5.1* / 3.3;7.0 / 2.8 / 3.8 / 1.8* / 0.1;3.4 / 0.6 / 1.2 / 4.2* / 1.2;7.2
Iceland / 1990 / 2008 / 2.4 / 5.7 / 6.8* / 3.1;10.6 / 8.2 / 3.7 / 3.2 / -1.4;8.1 / 1.1 / 0.8 / 1.4 / -4.7;8.0
Ireland / 1993 / 2007 / 4.1 / 4.7 / 2.7* / 1.3;4.1 / 4.2 / 4.8 / 0.9 / -0.3;2.1 / 1.7 / 3.2 / 4.1* / 2.7;5.6
Italy / 1998 / 2007 / 4.0 / 5.0 / 2.2 / -8.4;14.0 / 2.0 / 4.0 / 3.2 / -4.5;11.5 / 0.7 / 1.4 / 6.2* / 0.9;11.7
Malta / 1993 / 2008 / 1.9 / 13.9 / 8.7* / 2.2;15.5 / 0.5 / 5.8 / 10.4* / 6.0;15.0 / 0.8 / 1.4 / 25.7* / 5.4;49.9
Norway / 1990 / 2007 / 7.0 / 5.8 / -0.7 / -1.6;0.3 / 6.5 / 7.3 / 0.9 / -0.1;2.0 / 1.8 / 2.6 / 2.6* / 1.7;3.4
Portugal / 1996 / 2005 / 1.0 / 1.3 / 4.2 / -1.6;10.3 / 1.1 / 1.8 / 4.7 / -3.4;13.5 / 0.3 / 0.6 / 7.0* / 1.5;12.8
Scotland / 1990 / 2007 / 4.5 / 7.0 / 2.5* / 1.5;3.6 / 2.4 / 5.0 / 3.4* / 2.2;4.7 / 1.1 / 2.1 / 2.9* / 1.9;4.0
Slovakia / 1990 / 2005 / 1.8 / 2.0 / 1.9* / 0.3;3.4 / 1.8 / 3.1 / 4.6* / 3.0;6.2 / 0.5 / 1.2 / 5.2* / 3.3;7.1
Slovenia / 1990 / 2007 / 2.0 / 8.0 / 5.7* / 4.0;7.6 / 2.1 / 5.5 / 4.6* / 3.4;5.7 / 0.6 / 1.4 / 5.6* / 3.3;8.0
Spain / 1990 / 2004 / 1.5 / 3.8 / 5.6* / 3.8;7.5 / 0.9 / 2.9 / 5.7* / 3.4;7.9 / 0.6 / 1.4 / 4.5* / 1.7;7.3
Sweden / 1990 / 2007 / 6.2 / 6.2 / 0.9 / -0.1;2.0 / 4.4 / 6.2 / 2.5* / 1.8;3.2 / 1.6 / 2.1 / 2.6* / 1.6;3.6
Switzerland / 1990 / 2006 / 4.9 / 6.7 / 3.2* / 1.8;4.6 / 3.4 / 6.0 / 2.6* / 1.7;3.4 / 1.4 / 2.3 / 2.5* / 1.3;3.8
The Netherlands / 1989 / 2007 / 5.0 / 8.3 / 3.2* / 2.7;3.7 / 3.8 / 6.2 / 3.9* / 3.1;4.7 / 1.0 / 1.8 / 4.5* / 3.8;5.2
Wales / 1990 / 2007 / 3.0 / 4.9 / 3.9* / 1.9;5.9 / 1.2 / 4.1 / 5.8* / 4.0;7.6 / 0.7 / 1.4 / 4.8* / 3.4;6.2

*statistically significant (p≤0.05)

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