Appendix 1|Guideline Development Group Area of Expertise

Co-Chairs Guideline Development Group

GoceSpasovski is fromSkopje, Republic of Macedonia. His postgraduate studies and training in nephrology were undertaken at the University Hospital in Skopje, and at the University of Antwerp, Katowice and "Laiko" University Hospital in Athens. His Master Degree of Medical Science in Nephrology was earned at the University of Skopje and the PhD at the Universities of Skopje and Antwerp.Professor Spasovski is an active investigator in clinical trials related to anaemia, hyperphosphataemia and bone diseases in patients with chronic kidney disease, especially in bone biopsy based studies. His academic carrier is supported by more than 350 published articles and book chapters in peer-reviewed and national journals, and lectures on topics related to chronic kidney disease, dialysis and mineral and bone disorders, and kidney transplantation.

He is a editor of the BANTAO Journal and Macedonian Medical Review, and a member of the Editorial Board of several international nephrology journals. He finished his term as an ERA-EDTA Ordinary Council Member in 2009, then was a Chairman of the Committee for CME activities at ERA-EDTA until 2013. He is also a President of the Macedonian Society of Nephrology, Dialysis, Transplantation and Artificial Organs, member of the ISN GO Central & East European Committee, EUTox group, ERBP board, co-chair of the ERBP hyponatraemia group as well as the KDIGO Implementation Task leader for Central and Eastern Europe.

Raymond Vanholder has published more than 600 peer-reviewed papers, including reviews on adequacy of dialysis, uremic toxicity and various topics related to clinical nephrology.

He serves as a member of the editorial review board of several journals and is subject editor of Nephrology Dialysis and Transplantation. Up until autumn 2010, he has been chairman of the European Uremic Toxin Work Group (EUTox) and member of the Executive Board and treasurer of Kidney Disease Improving Global Outcomes (KDIGO).

Up till summer 2011 he was member of the Scientific Advisory Board (SAB) of the European Renal Association - European Dialysis and Transplantation Association (ERA-EDTA) and chairman of the European Renal Best Practice (ERBP), the guidance body of ERA-EDTA. Before that, he coordinated the European Best Practice Guidelines (EBPG) on haemodialysis.

He chairs the Renal Disaster Relief Task Force (RDRTF) of the International Society of Nephrology (ISN) and in this function participated as member or coordinator in several international relief operations. ProfessorVanholder was founding president of the Belgian Society of Nephrology (BVN-SBN), is past president of the European Society of Artificial Organs (ESAO) and current president of ERA-EDTA.

Workgroup

Bruno Alloliois Professor of Medicine at the University of Würzburg and Head of the Department of Endocrinology at the University Hospital Würzburg. He trained in Cologne in both clinical and experimental endocrinology. For postdoctoral studies he worked at Bartholomew’s Hospital, London, and at the National Institutes of Health, Bethesda. After Habilitation in 1988 he moved to Würzburg in 1992. In 1988 he received the Schöller-Junkmann Award of the German Society of Endocrinology. In 2011 he received the European Medal of the British Endocrine Society and in 2013 the Berthold Medal of the German Society of Endocrinology. He has served as editor for the European Journal of Endocrinology and the Journal of Clinical Endocrinology and Metabolism. He was the first media spokesman for the German Society of Endocrinology and he served in the first executive committee of the European Society of Endocrinology. He has published over 400 original articles, reviews and book chapters. His research interests focus on adrenal disorders, mineral metabolism, and more recently also on hyponatraemia. He is a founding member of the European Network for the Study of Adrenal Tumours (ENSAT) and served in the Expert Commission of the Deutsche Forschungsgemeinschaft.

DjillaliAnnaneis the Counsellor of the French Minister of Health for Research and Medical Education and Dean of the Faculty of Medicine at the University of Versailles SQY, was the President of the Council of Deans of the Paris Universities, was the Vice-Chancellor of university of Versailles from 2004 to 2007, and is the President of the French Society of Intensive Care Medicine, and the Head of the critical care department at Raymond Poincaré University Hospital (AP-HP) in Garches, Paris, France. He is an editor of the Cochrane Collaboration since 2000, and was the chair of the European Society of Intensive Care Medicine Systematic Review Group from 2010 to 2013. He has contributed to several international and multi-disciplinary guidelines. He has completed MD in 1991, and a PhD in pharmacology in 1995, both at Paris Descartes University. He has contributed to the medical literature with more than 260 peer –reviewed articles, has written about 100 book chapters, has given more than three hundred invited conferences at international scientific meeting, and has been invited as a visiting professor in numerous academic centres in Europe, North America and Australia.

Steve Ballstudied basic science as an undergraduate at Birmingham University, where he went on to complete a PhD in Molecular Endocrinology before pursuing undergraduate and postgraduate medical studies in London. He completed middle grade training in Diabetes and Endocrinology before spending 2 years in the USA as a Medical Research Council (UK) and Howard Hughes Fellow, subsequently returning to his current post.

Steve combines clinical medicine, research and teaching in Newcastle where he is senior lecturer and the head of the Endocrine Unit. He is passionate about translational research contributing to service development and patient care. He is a member of Council of the Society for Endocrinology (UK) and a Senior Editor of Clinical Endocrinology.

Daniel Bichetis professor at the faculty of Medicine of the Unirversity of Montreal, Canada. His involvement in Nephrogenic Diabetes Insipidus was a natural progression from his medical school interest in physiology mechanisms and hormonal actions and further study of the antidiuretic hormone vasopressin. Of particular interest to him now is the V2 receptor. His lab is currently involved in examining the 3-dimensional structure and crystallization of the V2 receptor. He hopes that its physical structure will reveal important information on the its function and the way it sends signals inside the collecting duct.

Guy Decauxis a general internist, with a PhD in internal medicine on electrolytes disorders. Heis Director of the research unit on hydromineral metabolism at the Free University of Brussels, ULB, Belgium. Heis currently board member of the European Society of Internal Medicine, has been president of the Belgium Society of Internal Medicine and has authored 158 articles published in peer-review journals.

WiebkeFenskeis a specialist registrar in Endocrinology and Diabetology at the University Hospital of Würzburg, Germany, currently pursuing a PhD in molecular Physiology. Her research interests include basic and clinical aspects of the physiology and pathophysiology of hypothalamic peptide regulation and the related implications of neuropeptinergic dysfunction for human disease in electrolyte, neurohypophyseal and adiposity disorders. Her research is supported by the German Comprehensive Heart Failure Center and the German Research Society (DFG) for her training at the Imperial College London.

Ewout Hoorn is a nephrologist at the Erasmus Medical Center in Rotterdam, The Netherlands. His research interests include basic and clinical aspects of kidney tubule transport and the link with human disease, including electrolyte disorders and hypertension. He trained in Canada and the USA with Mitch Halperin, Mark Knepper and David Ellison. His research is supported by the Dutch Kidney Foundation and the Netherlands Organisation for Scientific Research.

Carole Ichaiis professor of Anaesthesiology and Intensive Care Medicine at the medical Nice university in France. She has completed the M.D. in 1988, obtaining both cardiology and anaesthesiology-intensive care medicine specialities and a Ph.D. in biology in 2000 at Joseph Fourier University in Grenoble, France. She is the actual chair of the mixed intensive care unit of Nice university hospital. She has successively been an active member of the scientific committee and the intensive care medicine committee of the French society of anaesthesiology and intensive care medicine (SFAR) for 12 years. She is author/co-author of 80 peer-reviewed articles, and of 75 reviews/book chapters. She has given more than one hundred and fifty invited conferences at national and international congresses. She is a regular reviewer of scientific papers focused on metabolic disturbances and acute renal failure in critically ill patients.

Michael Joannidisis Professor of Medicine (Intensive Care and Emergency Medicine) at Medical University Innsbruck holding the position of a director of the Division of Medical Intensive Care and Emergency Medicine, Department Internal Medicine, University Hospital, Innsbruck, Austria. He is a certified specialist in Critical Care Medicine, Nephrology and Cardiology.

His research interests cover several topics of Critical Care Medicine with a major focus on acute kidney injury, renal tubular epithelial pathophysiology, renal replacement therapy and sepsis represented by over 140 per reviewed articles in the field.

Currently he is the president of the Austrian Society of Medical and General Intensive Care and Emergency Medicine (ÖGIAIN) and serves as a chair of the section acute kidney injury (AKI) of the European Society of Intensive Care Medicine (ESICM) and as associate editor of the journal Intensive Care Medicine.

Alain Soupartcompleted his speciality in Internal Medicine in 1987 and a PhD in Internal Medicine on electrolytes disorders and neurology in 1997, both at Erasmus University Hospital and the Faculty of Medicine of the Free University of Brussels, ULB,Belgium.He is currently member of the Department of Internal Medicine in Jolimont/Tubize hospital and Erasmus University Hospital.He is co-responsible of the Research Unit of Hydromineral Metabolism of the Faculty of Medicine at the Free University of Brussels. He has been president of the Belgian Society of Internal Medicine (SBMI) from 2007 to 2009 and member of its Board since 2000.He received the Honorary Fellowship of the European Society of Internal Medicine and ofthe American College of Physician, respectively in 2007 and 2009.He is author and co-author of more than 110 communications and 60 peer- review papers.He is often invited in International conferences and meetings and is a regular reviewer of papers focused on electrolytes and metabolism disorders and in the field of Internal Medicine.

BobZietsewas born in 1958 in Willemstad (Netherlands Antilles). He completed his medical degree at the State University Leiden in 1982. After his registration as an internist he completed his PhD Thesis on: “Pharmacological manipulation of glomerular barrier function” in 1995. From 1990 onwards he has been a faculty member of the department of Internal Medicine, and he became training program director and head of the Nephrology section in 2000. In 2008 he was appointed as full Professor of Medicine. He is actively involved in teaching, both within the Erasmus Medical School and in the postgraduate setting. His main research interest is the pathophysiology of water and electrolyte disorders. He has (co) authored over 120 papers in the field, is the editor of several books and has contributed to several book chapters. He is active in teaching integrative physiology, both in a national and international setting.

ERBP Methods Support Team

Evi Nagleris a specialist registrar in Nephrology at the University of Ghent, Belgium, currently pursuing a PhD in clinical epidemiology. She was the first of four fellows to be enrolled in a fellowship program,awarded by European Renal Best Practice, to train in guideline development methodology.As member of the methods support teamshe is primarily responsible for providing methodological support to the guideline development working groups. In addition she is involved with process management and as such engaged in optimizing the tools and techniques used in the management of the guideline development process.

Maria Hallergraduated from the Medical University Vienna in 2006 and started her renal fellowship in 2008 with Professor Rainer Oberbauer. Along with her clinical training Dr. Haller worked on renal research projects, such as a cost effectiveness analysis of renal replacement therapy and the molecular mechanisms of sirolimus induced phosphaturia at the University of Zurich. Additionally Maria obtained a Master’s degree in Health Care Management at the Vienna University of Economics and Business in 2012. A description of her PhD Plan and full CV can be viewed through this link

Maria joined the ERBP fellow group in June 2012.

Sabine van der Veerworked as an IT project manager in the Academic Medical Centre (Amsterdam, the Netherlands) after obtaining her degree in medical informatics at the University of Amsterdam. In 2007, she started a PhD project under the supervision of Kitty Jager, entitled Systematic quality improvement in healthcare: clinical performance measurement and registry-based feedback. Within this project she developed an instrument to measure dialysis patient experience, investigated implementation of best renal practice as a NephroQUEST research fellow at the UK Renal Registry (Bristol, UK), and conducted a cluster RCT among Dutch intensive care units to evaluate the effectiveness of clinical performance feedback. She defended her PhD thesis in June 2012.

She joined the ERBP fellow group since February 2012. Her focus is on investigating and improving the dissemination and implementation of guidance on renal best practice in Europe; this includes documents produced by the ERBP as well as by other organisations.

Wim Van Biesenis professor of nephrology at the Ghent University Hospital, Belgium.

He is author and co-author of more than 200 articles dealing with a wide variety of topics in nephrology (peritoneal dialysis, haemodialysis, chronic kidney disease management), intensive care nephrology. He is the actual chair of ERBP. He is also Subject Editor for dialysis for Nephrology, Dialysis and Transplantation and is member of the editorial board of different other journals. He is a regular reviewer of scientific papers for different journals on nephrology, intensive care and epidemiology.