This bulletin covers aspects of head and neck cancers and should be of interest to multidisciplinary teams working in this area.

Sections can include:

·  Combined Modality Therapies

·  Drug Therapy

·  Pathology, Staging, Polymorphisms & Biomarkers

·  Prognosis, Survival & Risk Factors

·  Radiotherapy & Imaging

·  Supportive Care & Symptom Management

·  Surgery

Many of the following articles are available online via the NHS Scotland Knowledge Network. Please use the links where provided and your ATHENS password. A complete list of available online journals and registration for ATHENS can be found at www.knowledge.scot.nhs.uk/

If the article you require is not available via the NHS Scotland Knowledge Network and you would like to request a print copy, please submit your request online at www.quest.scot.nhs.uk

This bulletin contains a selection of material gathered from a search of the evidence base, and is not intended to be comprehensive. Professional judgment should be exercised when appraising the material. The Library takes no responsibility for the wording, content and accuracy of the information supplied, which has been extracted in good faith from reputable sources. NHSGGC is not responsible for the content of external internet sites.

Compiled by:

Kirsty Coltart

Subject Librarian

Beatson West of Scotland Cancer Centre

0141 301 7285,

General

Bark, R., Mercke, C., Munck-Wikland, E., et al. (2016). Cancer of the gingiva. European Archives of Oto-Rhino-Laryngology 273,6:1335-1345.

Chua, M.L.K., Wee, J.T.S., Hui, E.P., et al. (2016). Nasopharyngeal carcinoma. Lancet 387,10022:1012-1024.

Deep, N.L., Ekbom, D.C., Hinni, M.L., et al. (2016). High-Grade Neuroendocrine Carcinoma of the Larynx: The Mayo Clinic Experience. Annals of Otology, Rhinology & Laryngology 125,6:464-469.

Edson, M.A., Garden, A.S., Takiar, V., et al. (2016). Outcomes for hypopharyngeal carcinoma treated with organ-preservation therapy. Head & neck 38,Suppl 1:E2091-9.

Glazer, T.A. and Shuman, A.G. (2016). Distant Metastases and Palliative Care. Advances in Oto-Rhino-Laryngology 78,182-188.

Johnston, M.L., Huang, S.H., Waldron, J.N., et al. (2016). Salivary duct carcinoma: Treatment, outcomes, and patterns of failure. Head & neck 38,Suppl 1:E820-6.

Karatayli-Ozgursoy, S., Bishop, J.A., Hillel, A.T., et al. (2016). Non-epithelial tumors of the larynx: a single institution review. American Journal of Otolaryngology 37,3:279-285.

Kiess, A.P. and Quon, H. (2016). Management of Inoperable Malignant Neoplasms. Advances in Oto-Rhino-Laryngology 78,157-167.

Lewis, A.G., Tong, T. and Maghami, E. (2016). Diagnosis and Management of Malignant Salivary Gland Tumors of the Parotid Gland. Otolaryngologic clinics of North America 49,2:343-380.

Marur, S. and Forastiere, A.A. (2016). Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment. Mayo Clinic proceedings 91,3:386-396.

Pagh, A., Grau, C. and Overgaard, J. (2016). Failure pattern and salvage treatment after radical treatment of head and neck cancer. Acta Oncologica 55,5:625-632.

Combined Modality Therapies

Bussu, F., Mura, F., Micciche, F., et al. (2016). Oncologic outcome of hypopharyngeal carcinoma treated with different modalities at 2 different university hospitals. Head & neck 38,4:606-612.

Fury, M.G., Xiao, H., Sherman, E.J., et al. (2016). Phase II trial of bevacizumab+cetuximab+cisplatin with concurrent intensity-modulated radiation therapy for patients with stage III/IVB head and neck squamous cell carcinoma. Head & neck 38,Suppl 1:E566-70.

Gorayski, P., Foote, M., Porceddu, S., et al. (2016). The Role of Postoperative Radiotherapy for Large Nerve Perineural Spread of Cancer of the Head and Neck. Journal of Neurological Surgery Part B Skull Base 77,2:173-181.

Heukelom, J., Lopez-Yurda, M., Balm, A.J.M., et al. (2016). Late follow-up of the randomized radiation and concomitant high-dose intra-arterial or intravenous cisplatin (RADPLAT) trial for advanced head and neck cancer. Head & neck 38,Suppl 1:E488-93.

Hutcheson, K.A., Abualsamh, A.R., Sosa, A., et al. (2016). Impact of selective neck dissection on chronic dysphagia after chemo-intensity-modulated radiotherapy for oropharyngeal carcinoma. Head & neck 38,6:886-893.

Lee, J.Y., Sun, J., Oh, D.R., et al. (2016). Comparison of weekly versus triweekly cisplatin delivered concurrently with radiation therapy in patients with locally advanced nasopharyngeal cancer: A multicenter randomized phase II trial (KCSG-HN10-02). Radiotherapy & Oncology 118,2:244-250.

Lorch, J.H., Hanna, G.J., Posner, M.R., et al. (2016). Human papillomavirus and induction chemotherapy versus concurrent chemoradiotherapy in locally advanced oropharyngeal cancer: The Dana Farber Experience. Head & neck 38,Suppl 1:E1618-24.

Nien, H., Sturgis, E.M., Kies, M.S., et al. (2016). Comparison of systemic therapies used concurrently with radiation for the treatment of human papillomavirus-associated oropharyngeal cancer. Head & neck 38,Suppl 1:E1554-61.

Paderno, A., Piazza, C., Bresciani, L., et al. (2016). Microvascular head and neck reconstruction after (chemo)radiation: facts and prejudices. Current Opinion in Otolaryngology & Head & Neck Surgery 24,2:83-90.

Rosenthal, D.I., Harari, P.M., Giralt, J., et al. (2016). Association of Human Papillomavirus and p16 Status With Outcomes in the IMCL-9815 Phase III Registration Trial for Patients With Locoregionally Advanced Oropharyngeal Squamous Cell Carcinoma of the Head and Neck Treated With Radiotherapy With or Without Cetuximab. Journal of Clinical Oncology 34,12:1300-1308.

Strojan, P., Vermorken, J.B., Beitler, J.J., et al. (2016). Cumulative cisplatin dose in concurrent chemoradiotherapy for head and neck cancer: A systematic review. Head & neck 38,Suppl 1:E2151-8.

Drug & Targeted Therapies

Janoray, G., Pointreau, Y., Garaud, P., et al. (2016). Long-term Results of a Multicenter Randomized Phase III Trial of Induction Chemotherapy With Cisplatin, 5-fluorouracil, +/- Docetaxel for Larynx Preservation. Journal of the National Cancer Institute 108,4:

Mockelmann, N., Kriegs, M., Lorincz, B.B., et al. (2016). Molecular targeting in combination with platinum-based chemoradiotherapy in head and neck cancer treatment. Head & neck 38,Suppl 1:E2173-81.

Msaouel, P. and Massarelli, E. (2016). Immune Checkpoint Therapy in Head and Neck Cancers. Cancer Journal 22,2:108-116.

Rischin, D., Spigel, D.R., Adkins, D., et al. (2016). PRISM: Phase 2 trial with panitumumab monotherapy as second-line treatment in patients with recurrent or metastatic squamous cell carcinoma of the head and neck. Head & neck 38,Suppl 1:E1756-61.

Szturz, P., Specenier, P., Van Laer, C., et al. (2016). Long-term remission of locally recurrent oropharyngeal cancer after docetaxel-based chemotherapy plus cetuximab. European Archives of Oto-Rhino-Laryngology 273,6:1629-1636.

Pathology, Staging, Polymorphisms & Biomarkers

Amit, M., Eran, A., Billan, S., et al. (2016). Perineural Spread in Noncutaneous Head and Neck Cancer: New Insights into an Old Problem. Journal of Neurological Surgery Part B Skull Base 77,2:86-95.

Bishop, J.A. (2016). Recently described neoplasms of the sinonasal tract. Seminars in diagnostic pathology 33,2:62-70.

Daniele, L., Nikolarakos, D., Keenan, J., et al. (2016). Clear cell carcinoma, not otherwise specified/hyalinising clear cell carcinoma of the salivary gland: The current nomenclature, clinical/pathological characteristics and management. Critical Reviews in Oncology-Hematology 102,55-64.

Fives, C., Feeley, L., O'Leary, G., et al. (2016). Importance of lymphovascular invasion and invasive front on survival in floor of mouth cancer. Head & neck 38,Suppl 1:E1528-34.

Ha, P.K. and Stenman, G. (2016). Molecular Pathology and Biomarkers. Advances in Oto-Rhino-Laryngology 78,17-24.

Haderlein, M., Scherl, C., Semrau, S., et al. (2016). High-grade histology as predictor of early distant metastases and decreased disease-free survival in salivary gland cancer irrespective of tumor subtype. Head & neck 38,Suppl 1:E2041-8.

Marques, A.E.M., Elias, S.T., Porporatti, A.L., et al. (2016). mTOR pathway protein immunoexpression as a prognostic factor for survival in head and neck cancer patients: a systematic review and meta-analysis. Journal of Oral Pathology & Medicine 45,5:319-328.

Matsumoto, F., Ohba, S., Fujimaki, M., et al. (2016). The value of insulin-like growth factor-1 receptor for predicting early glottic carcinoma response to radiotherapy. Auris, Nasus, Larynx 43,4:440-445.

Roberts, T.J., Colevas, A.D., Hara, W., et al. (2016). Number of positive nodes is superior to the lymph node ratio and American Joint Committee on Cancer N staging for the prognosis of surgically treated head and neck squamous cell carcinomas. Cancer 122,9:1388-1397.

Seoane, J., Alvarez-Novoa, P., Gomez, I., et al. (2016). Early oral cancer diagnosis: The Aarhus statement perspective. A systematic review and meta-analysis. Head & neck 38,Suppl 1:E2182-9.

Simons, S.A., Bridge, J.A. and Leon, M.E. (2016). Sinonasal small round blue cell tumors: An approach to diagnosis. Seminars in diagnostic pathology 33,2:91-103.

Prognosis, Survival & Risk Factors

Cohen, E.E.W., LaMonte, S.J., Erb, N.L., et al. (2016). American Cancer Society Head and Neck Cancer Survivorship Care Guideline. CA: a Cancer Journal for Clinicians 66,3:203-239.

Farnebo, L., Malila, N., Makitie, A., et al. (2016). Early death among head and neck cancer patients. Current Opinion in Otolaryngology & Head & Neck Surgery 24,2:115-120.

Gooi, Z., Chan, J.Y.K. and Fakhry, C. (2016). The epidemiology of the human papillomavirus related to oropharyngeal head and neck cancer. Laryngoscope 126,4:894-900.

Kjaer, T.K., Johansen, C., Andersen, E., et al. (2016). Influence of social factors on patient-reported late symptoms: Report from a controlled trial among long-term head and neck cancer survivors in Denmark. Head & neck 38,Suppl 1:E1713-21.

Kjaer, T., Johansen, C., Andersen, E., et al. (2016). Do we reach the patients with the most problems? Baseline data from the WebCan study among survivors of head-and-neck cancer, Denmark. Journal of Cancer Survivorship 10,2:251-260.

Kutler, D.I., Patel, K.R., Auerbach, A.D., et al. (2016). Natural history and management of Fanconi anemia patients with head and neck cancer: A 10-year follow-up. Laryngoscope 126,4:870-879.

Schwam, Z.G., Sosa, J.A., Roman, S., et al. (2016). Receipt of Care Discordant with Practice Guidelines is Associated with Compromised Overall Survival in Nasopharyngeal Carcinoma. Clinical Oncology (Royal College of Radiologists) 28,6:402-409.

Zhou, J., Zhang, D., Yang, Y., et al. (2016). Association between helicobacter pylori infection and carcinoma of the larynx or pharynx. Head & neck 38,Suppl 1:E2291-6.

Radiotherapy & Imaging

Chung, C., Lo, W., Lee, Y., et al. (2016). Image-enhanced endoscopy for detection of second primary neoplasm in patients with esophageal and head and neck cancer: A systematic review and meta-analysis. Head & neck 38,Suppl 1:E2343-9.

Co, J., Mejia, M.B. and Dizon, J.M. (2016). Evidence on effectiveness of intensity-modulated radiotherapy versus 2-dimensional radiotherapy in the treatment of nasopharyngeal carcinoma: Meta-analysis and a systematic review of the literature. Head & neck 38,Suppl 1:E2130-42.

Cote, M., Trudel, M., Wang, C., et al. (2016). Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial. Annals of Otology, Rhinology & Laryngology 125,4:317-324.

Cuaron, J., Rao, S., Wolden, S., et al. (2016). Patterns of failure in patients with head and neck carcinoma of unknown primary treated with radiation therapy. Head & neck 38,Suppl 1:E426-31.

Davis, C., Sikes, J., Namaranian, P., et al. (2016). Neutron Beam Radiation Therapy: An Overview of Treatment and Oral Complications When Treating Salivary Gland Malignancies. Journal of Oral & Maxillofacial Surgery 74,4:830-835.

de Bree, R., van der Putten, L., van Tinteren, H., et al. (2016). Effectiveness of an (18)F-FDG-PET based strategy to optimize the diagnostic trajectory of suspected recurrent laryngeal carcinoma after radiotherapy: The RELAPS multicenter randomized trial. Radiotherapy & Oncology 118,2:251-256.

Fortin, B., Khaouam, N., Filion, E., et al. (2016). Palliative Radiation Therapy for Advanced Head and Neck Carcinomas: A Phase 2 Study. International journal of radiation oncology, biology, physics 95,2:647-653.

Garg, S., Kilburn, J.M., Lucas, J.T.J., et al. (2016). Reirradiation for second primary or recurrent cancers of the head and neck: Dosimetric and outcome analysis. Head & neck 38,Suppl 1:E961-9.

Gutiontov, S.I., Shin, E.J., Lok, B., et al. (2016). Intensity-modulated radiotherapy for head and neck surgeons. Head & neck 38,Suppl 1:E2368-73.

Henriques de Figueiredo, B. and Gregoire, V. (2016). How to minimize morbidity in radiotherapy of pharyngolaryngeal tumors?. Current Opinion in Otolaryngology & Head & Neck Surgery 24,2:163-169.

Karam, I., Huang, S.H., McNiven, A., et al. (2016). Outcomes after reirradiation for recurrent nasopharyngeal carcinoma: North American experience. Head & neck 38,Suppl 1:E1102-9.

Katsoulakis, E., Riaz, N., Hu, M., et al. (2016). Hypopharyngeal squamous cell carcinoma: Three-dimensional or Intensity-modulated radiotherapy? A single institution's experience. Laryngoscope 126,3:620-626.

Ku, Y., Wong, Y., Fu, C., et al. (2016). Timely Antecedent CT or MRI Can Help Predict Hemorrhage Site of Posttreatment Head and Neck Cancer, With Digital Subtraction Angiography Used as the Reference Standard. AJR.American Journal of Roentgenology 206,4:829-836.

Lee, S., Kang, K.W. and Wu, H. (2016). Prospective investigation and literature review of tolerance dose on salivary glands using quantitative salivary gland scintigraphy in the intensity-modulated radiotherapy era. Head & neck 38,Suppl 1:E1746-55.

Li, C., Zhang, C., Li, N., et al. (2016). Compression Real-time Elastography for Evaluation of Salivary Gland Lesions: A Meta-analysis. Journal of Ultrasound in Medicine 35,5:999-1007.

Mehanna, H., Wong, W., McConkey, C.C., et al. (2016). PET-CT Surveillance versus Neck Dissection in Advanced Head and Neck Cancer. New England Journal of Medicine 374,15:1444-1454.

Min, M., Lin, P., Lee, M., et al. (2016). Prognostic Value of 2-[(18)F] Fluoro-2-deoxy-D-glucose Positron Emission Tomography-Computed Tomography Scan Carried out During and After Radiation Therapy for Head and Neck Cancer Using Visual Therapy Response Interpretation Criteria. Clinical Oncology (Royal College of Radiologists) 28,6:393-401.

Nyqvist, J., Fransson, P., Laurell, G., et al. (2016). Differences in health related quality of life in the randomised ARTSCAN study; accelerated vs. conventional radiotherapy for head and neck cancer. A five year follow up. Radiotherapy & Oncology 118,2:335-341.

Saade, C., El-Merhi, F., Mayat, A., et al. (2016). Comparison of Standard and Quadruple-Phase Contrast Material Injection for Artifacts, Image Quality, and Radiation Dose in the Evaluation of Head and Neck Cancer Metastases. Radiology 279,2:571-577.

Seol, K.H. and Lee, J.E. (2016). Patterns of failure after the reduced volume approach for elective nodal irradiation in nasopharyngeal carcinoma. Radiation Oncology Journal 34,1:10-17.

Shaw, S.M., Skoretz, S.A., O'Sullivan, B., et al. (2016). Valid and reliable techniques for measuring fibrosis in patients with head and neck cancer postradiotherapy: A systematic review. Head & neck 38,Suppl 1:E2322-34.

Sun, Y., Yu, X., Zhang, G., et al. (2016). Reduction of clinical target volume in patients with lateralized cancer of the nasopharynx and without contralateral lymph node metastasis receiving intensity-modulated radiotherapy. Head & neck 38,Suppl 1:E468-72.

Sychev, Y.V., McInnis, C.P. and Francis, C.E. (2016). Abducens ocular neuromyotonia as a delayed complication of oropharyngeal carcinoma treated with radiation. Head & neck 38,Suppl 1:E2428-31.