Table S1. Patients’ and tumors characteristics of KIT/PDGFRA wild-type GIST
ID / Gender / Age / Site / Size(cm) / Mitotic
count/50HPF / Multifocal / Histological
Type / KIT
expression / DOG1
expression / Disease status
at diagnosis / Response
to IM
(months) / Clinical
Follow
Up / Material analyzed
GIST_07* / F / 28 / Stomach / 7 / 10 / Yes / Mixed / Diffuse + / Diffuse + / Metastatic / 6 / AWD / T and PB
GIST_10* / M / 30 / Stomach / 7 / 9 / No / Mixed / Diffuse + / NA / Metastatic / 52 / ANED / T and PB
GIST_21 / F / 41 / Stomach / 3 / <5 / NA / NA / NA / NA / Metastatic / NA / AUNK / T
GIST_24 / F / 18 / Stomach / 4,5 / <5 / NA / NA / NA / NA / Metastatic / NA / NA / T
GIST_127 / F / 63 / Ileum / 6,2 / 6 / No / Mixed / Diffuse + / Diffuse + / Localized / ND / ANED / T
GIST_133 / M / 57 / Duodenum / 1 / <5 / No / NA / Diffuse + / NA / Localized / ND / ANED / T
GIST_136 / M / 19 / Stomach / 8 / 8 / No / NA / Diffuse + / NA / Metastatic / 4 / AWD / T
GIST_145 / F / 39 / Stomach / 10,5 / >5 / No / Epitheliod / Diffuse + / Diffuse + / Metastatic / 12 / AWD / T and PB
GIST_174 / M / 59 / Stomach / 10 / NA / No / Mixed / Diffuse+ / Diffuse+ / Metastatic / 4 / AWD / T and PB
GIST_201 / F / 52 / Duodenum/ileum / 7 / >5 / Yes / Spindle / Diffuse + / NA / Metastatic / ND / ANED / T and PB
GIST_202 / F / 33 / Ileum / 8 / <5 / No / NA / Diffuse + / Diffuse + / Localized / 19 / ANED / T and PB
GIST_203 / F / 49 / Stomach / 11 / 4 / No / Mixed / Diffuse + / NA / Localized / ND / ANED / T
GIST_207 / M / 61 / Stomach / 8,5 / <5 / No / Spindle / Focal + / NA / Localized / 36 / DOD / T
GIST_214 / F / 37 / Stomach / 3,7 / 1,2 / No / Epitheliod / Diffuse + / NA / Localized / ND / ANED / T
GIST_218 / F / 56 / Ileum / 7 / 4 / No / NA / Diffuse + / NA / Localized / ND / ANED / T
GIST_219 / M / 44 / Ileum / 6,5 / >5 / No / Spindle / Diffuse + / Diffuse + / Localized / 4 / DOD / PB
GIST_222 / M / 34 / Stomach / 3,8 / 1 / No / Mixed / Negative / NA / Localized / ND / ANED / PB
GIST_225 / F / 34 / Stomach / NA / >5 / No / Mixed / Diffuse + / NA / Metastatic / 4 / AWD / PB
GIST_228 / F / 76 / Ileum / 2,5 / 1 / Yes / Epitheliod / Diffuse + / Diffuse + / Localized / ND / ANED / T and PB
GIST_234 / F / 17 / Stomach / 6 / 1 / Yes / Mixed / Diffuse + / NA / Localized / NA / AUNK / T and PB
GIST_235 / M / 65 / Ileum / 6 / 2 / No / Mixed / Diffuse + / Diffuse + / Localized / 7 / ANED / T
GIST_236 / F / 61 / Ileum / 5 / 2 / No / Epitheliod / Diffuse + / Diffuse + / Localized / ND / ANED / T
GIST_237 / M / 52 / ExtraGIST / 4 / <5 / No / Mixed / NA / NA / Localized / ND / ANED / T
GIST_240 / M / 75 / Duodenum / 1,5 / <5 / No / NA / Diffuse + / Diffuse + / Localized / ND / ANED / T
GIST_241 / M / 73 / Ileum / 11 / >5 / No / Spindle / Diffuse + / NA / Localized / 11 / ANED / T and PB
GIST_245 / F / 75 / Ileum / 8 / >5 / No / Spindle / Diffuse + / NA / Localized / ND / ANED / T
GIST_270 / M / 76 / Colon / 3 / 1 / No / Mixed / Weakly + / Diffuse + / Localized / NA / AUNK / T
GIST_271 / M / 56 / Stomach / 9 / 16 / No / Epitheliod / Weakly + / Diffuse + / Localized / NA / AUNK / T
GIST_275 / F / 59 / Ileum / 10 / >5 / No / NA / Diffuse + / NA / Metastatic / 16 / AWD / T
GIST_276 / M / 59 / Duodenum / 2,5 / 3 / No / Mixed / Weakly + / Diffuse + / Localized / NA / AUNK / T
GIST_279 / F / 41 / Colon / 8 / 80 / No / Spindle / Focal + / Focal + / Localized / 3 / AWD / T and PB
GIST_281 / M / 67 / Duodenum / 4,5 / 1 / No / Spindle / Weakly + / Diffuse + / Localized / NA / AUNK / T
GIST_310 / F / 65 / Ileum / 12 / 25 / No / Epitheliod / Diffuse + / NA / Localized / 1 / AWD / PB
GIST_311 / M / 41 / Stomach / 6,5 / >5 / No / NA / NA / NA / Localized / NA / AUNK / PB
ANED indicates alive, no evidence of disease; AUNK, alive, disease status unknown; AWD, alive with disease; DOD, dead of disease; NA: not available; ND: imatinib not done.*these patients were already described [6]