Table 2: Curve fitting for MI probability density to MI incidence for the total population of patients as for the excluding subgroups.
SUBGROUPS / N / CosinorA + B * cos(24* (t -tacrophase)) / Gaussian
(C/((2*)1/2* )) * exp-((t-tm)2/ 2* 2) / P (cosinor)
vs P (gaussian) / Fit
A
(%/h) / B
(%/h) / tacrophase
(hh:mm) / A*24 h (%) / C
(%) / tm
(hh:mm) /
(hh:mm) / (A * 24h. vs 50%)
(C vs 50%) / r / % of variance explained
Total population / 1063 / 2.60.3 / 2.30.4 / 18:490:25 / 637 / 377 / 9:520:14 / 2:020:15 / p < 0.024 / 0.92 / 85
> 70 years old / 213 / 3.50.3 / 2.20.5 / 17:241:02 / 837 / 177 / 10:050:31 / 1:370:26 / p < 0.00001 / 0.81 / 65
70 years old / 850 / 2.40.2 / 2.40.4 / 19:080:41 / 584 / 424 / 9:500:16 / 2:050:14 / p < 0.023 / 0.89 / 80
No previous symptoms / 639 / 2.80.3 / 2.40.5 / 18:500:38 / 666 / 346 / 9:470:20 / 2:010:17 / p < 0.005 / 0.89 / 79
With previous symptoms / 424 / 2.30.3 / 2.30.5 / 18:550:48 / 567 / 447 / 9:590:20 / 2:060:17 / NS / 0.91 / 83
Diabetic / 170 / 3.00.4 / 2.50.6 / 18:480:57 / 719 / 299 / 9:140:28 / 1:380:28 / p < 0.008 / 0.79 / 62
Non diabetic / 893 / 2.70.3 / 2.20.4 / 18:430:43 / 646 / 376 / 10:020:20 / 2:010:16 / p < 0.016 / 0.91 / 83
Q type / 910 / 2.70.37 / 2.30.4 / 18:380:40 / 646 / 366 / 9:540:16 / 2:020:16 / p < 0.015 / 0.91 / 83
Non-Q type / 132 / 2.70.3 / 2.30.5 / 18:190:48 / 657 / 357 / 9:420:17 / 1:480:17 / p < 0.011 / 0.90 / 80
Anterior / 520 / 3.00.2 / 1.80.4 / 18:241:00 / 726 / 286 / 10:060:16 / 1:400:16 / p < 0.0001 / 0.88 / 78
Inferior / 480 / 2.50.2 / 2.50.3 / 18:180:40 / 614 / 394 / 9:440:18 / 2:080:16 / p < 0.006 / 0.91 / 83
Shown are means SEM of MI incidence (% / h) values, calculated as (100 * MI's per hour / total N). Cosinor and gaussian componentsare shown separately to illustrate the contribution of each parameter in fitting the function y(t). Curve fitting = cosinor + Gaussian for n = 24 time points. The correlation coefficient r and the percent of total variance r2 explained are shown. P(cosinor) vs P(gaussian): comparison between total probability of cosinor component and total probability of gaussian component. assuming normal distribution. NS: non significant.