DEBBY W. TSUANG, MD, MScFebruary, 2004
CURRICULUM VITAE
DEBBY W. TSUANG, MD, MSc
EDUCATION
1983University of Iowa, Iowa City, IA,
B.S. (Psychology)
1988University of Iowa College of Medicine, Iowa City, IA,
M.D.
1992University of Iowa College of Medicine, Iowa City, IA,
M.Sc. (Preventive medicine/psychiatric epidemiology)
POSTGRADUATE TRAINING
Internship
7/88-7/89Intern, Department of Psychiatry, University of Iowa School of Medicine, Iowa City, IA.
(Combined Internal Medicine/Neurology/Psychiatry)
Residency
7/89-7/92Resident Physician, Department of Psychiatry, University of Iowa School of Medicine, Iowa City, IA.
Fellowship
7/92-7/95Geriatric Psychiatry Fellow, Geriatric Research, Education, and Clinical Center, VA Medical Center, Seattle, WA.
7/94-7/95Medical Genetics Fellow, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA.
CURRENT FACULTY POSITIONS
4/99-presentAssistant Professor, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA.
HOSPITAL POSITIONS
1995--presentStaff Psychiatrist, Mental Health Services and Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA.
HONORS AND AWARDS
1980-1983Dean’s List, Wheaton College and University of Iowa
1991American Psychiatric Association, PMRTP fellowship
1992APA/Dista Products Resident Research Award
1992Second prize, Winokur Resident Research Award
1994Eagles Award for Alzheimer’s Research
1995Geriatric Academic Training Award
2001-2002 Browning Foundation Investigator
BOARD CERTIFICATIONS
5/89Diplomat, National Board of Medical Examiners
6/94Board Certified in Psychiatry
American Board of Psychiatry and Neurology (#39417)
10/95Added Qualifications in Geriatric Psychiatry
American Board of Psychiatry and Neurology (#1606)
Board Eligible, Medical Genetics
LICENSE TO PRACTICE
Washington State Medical License #
PROFESSIONAL MEMBERSHIPS
American Association for Geriatric Psychiatry
American Medical Association
American Psychiatric Association
American Society of Human Genetics
TEACHING RESPONSIBILITIES
1995-presentInstructor, Introduction to Clinical Medicine, University of Washington School of Medicine, Seattle, WA.
1995-presentInstructor, Resident Didactics, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA.
1998, 2001Research Supervisor, Independent Study in Medical Science (ISMS), University of Washington School of Medicine, Seattle, WA.
2000Instructor, Psychosocial Epidemiology, Department of Epidemiology, University of Washington School of Public Health and Community Medicine, Seattle, WA.
Resident/Fellow Mentorship
Primary mentor for:
1995-1997James Chen, Senior Fellow, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine.
1997-1998Alfredo Lim, MD, Senior Fellow, Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine.
Summer 1998 Tina Agustin, MS II, University of Washington School of Medicine.
1998-2000Elizabeth Kiyasu, MD, Acting Instructor, Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine.
1999-2002John Tran, MD, Senior Fellow, Geriatric Education, Research, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA.
1999-2003 Lauren Bonner, MD, Acting Instructor, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine.
1999-present Gail Li, MD, PhD, Acting Instructor, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine.
2000-present Rob Riekse, MD, Senior Fellow, Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine.
Summer 2001Aaron Dalan, MS III, University of Washington School of Medicine.
2001-2003Eugene Wang, MD, Resident (PGY-IV), Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine.
2002-presentKate Simpson, Graduate Student, Department of Epidemiology, University of Washington School of Public Health and Community Medicine.
Other Research and Clinical Teaching:
My teaching experience includes didactics for psychiatry residents on the genetics of schizophrenia as well as mood disorders and non-Alzheimer's dementia. I have additional teaching experience with psychology fellows and epidemiology graduate students in research methodology, geriatric psychiatry, and geriatric medicine.
RESEARCH FUNDING
Principle Investigator:
Current:
Consortium PI, Clinical, Pathologic, and Genetic Characteristics of Dementia with Lewy Bodies: A Multicenter Collaborative Study, National Alzheimer's Disease Coordinating Center, NIH, 7/1/03-6/30/04,
PI, Consortium on the Genetics of Endophenotypes and Schizophrenia, NIH/NIMH (David Braff, Consortium PI), 5/1/03-2/29/08.
Past:
PI, Genetics of Neurocognition in Families with Schizophrenia, NARSAD, 7/1/01-6/30/03.
PI, A Family Study of Dementia with Lewy Bodies, UW ADRC One-Year Pilot, 5/1/00-4/30/01.
Co-Investigator:
Current:
Characterization of DLB: A Collaborative Study, NIH/NIA (Thomas Montine, PI), 12/1/03-11/30/089/1/03-8/31/08,
Psychopathology of Alzheimer's: APOE and the HPA Axis, NIH/NIA RO1 AG 08419 (Murray Raskind, PI), 9/30/01-6/30/06.
Parkinson's-related Neurodegenerative Dementia in a Community Sample, VA Merit Review (James Leverenz, PI), 10/1/01-9/30/04.
Genomic Analysis of Schizophrenia, VA Merit Review (Gerard Schellenberg, PI), 10/1/00-9/30/05.
Geriatric Psychiatrist, Clinical Core, University of Washington Alzheimer's Disease Research Center, NIH/NIA P50 AG05136 (Murray Raskind, PI), 5/1/00-4/30/05, Clinical Core (Elaine Peskind, PI),
TRAINING GRANT:
Psychopathology and Age of Onset in Huntington’s Disease, Geriatric Academic Program Career Development Award, NIA AG00503 (Itamar Abrass, PI), 9/1/95-10/30/98, $2,796,255, 75% effort.
SCIENTIFIC ACTIVITIES
Journal Reviewer:
American Journal of Medical Genetics (Neuropsychiatric section)
American Journal of Psychiatry
Comprehensive Psychiatry
Journal of Geriatric Psychiatry and Neurology
Molecular Psychiatry
Study Section: N/A
Grant Reviews: Veterans Affairs Post-Doctoral Fellowship Program in Psychiatry Research/Neurosciences
CONSULTING POSITIONS
None
BIBLIOGRAPHY
PUBLICATIONS IN REFEREED JOURNALS (selected publications)
1.Elizabeth McSherry, Steve R. Salisbury, Megan Ciulla, Debby Tsuang. Spiritual resources in older hospitalized men. Soc Compass34:515-537, 1987.
2.Greg Alvine, Donald Black, Debby Tsuang. Case of delirium secondary to phenelzine/L-tryptophan combination. J Clin Psychiatry51:311, 1990.
3.William Coryell and Debby Tsuang. Hypothalamic-pituitary-adrenal axis hyperactivity and psychosis: recovery during an 8-year follow-up. Am J Psychiatry149:1033-1039, 1992.
4.Debby Tsuang and George Winokur. Testing the validity of the neurotic depression concept. J Nerv Ment Dis180:446-450, 1992.
5.Debby Tsuang and William Coryell. An 8-year follow-up of patients with DSM-III-R psychotic depression, schizoaffective disorder, and schizophrenia. Am J Psychiatry150:1182-1188, 1993.
6.Debby Tsuang and George Winokur. Late-onset depression: is it a distinct disorder? Neurology, Psychiatry, Brain Res1:145-149, 1993.
7.Debby Tsuang, Deborah Cowley, Richard Ries, David Dunner, Peter Roy-Byrne. The effects of substance use disorder on the clinical presentation of anxiety and depression in an outpatient psychiatric clinic. J Clin Psychiatry 56:549-555, 1995.
8.Steve Edland, Jeremy Silverman, Elaine Peskind, Debby Tsuang, Ellen Wijsman, John Morris. Increased risk of dementia in mothers of Alzheimer's disease cases: evidence for maternal inheritance. Neurology47:254-256, 1996.
9.Debby Tsuang, Walter Kukull, Lianne Sheppard, Ross Barnhart, Elaine Peskind, Steve Edland, Gerard Schellenberg, Murray Raskind, Eric Larson. Impact of sample selection on APOE epsilon 4 allele frequency: a comparison of two Alzheimer’s disease samples. J Am Geriatr Soc44:704-707, 1996.
10.Marcella Pascualy, Debby Tsuang, Molly Shores, Christina Agustin, Eric Krause, William Spain, Thomas Bird, Elaine Peskind. Frontal-complex partial status epilepticus misdiagnosed as bipolar affective disorder in a 75-year-old man. J Geriatr Psychiatry Neurol10:158-160, 1997.
11.Debby Tsuang, Murray A. Raskind, James Leverenz, Elaine R. Peskind, Gerard Schellenberg, Thomas D. Bird. The effect of apolipoprotein E genotype on expression of an autosomal dominant schizophreniform disorder with progressive dementia and neurofibrillary tangles. Biol Psychiatry41:191-195, 1997.
12.Ephrat Levy-Lahad, Debby Tsuang, Thomas D. Bird. Recent advances in the genetics of Alzheimer’s disease. J Geriatr Psychiatry Neurol 11:42-54, 1998.
13.Elaine Peskind, Carl Jensen, Marcella Pascualy, Debby Tsuang, Deborah Cowley, Donald Martin, Murray Raskind. Sodium lactate and hypertonic sodium chloride induce equivalent panic incidence, panic symptoms, and hypernatremia in panic disorder. Biol Psychiatry 44:1007-1016, 1998.
14.Debby Tsuang, Lillian DiGiacomo, Hillary Lipe, Thomas D. Bird. Familial aggregation of schizophrenia-like symptoms in Huntington’s disease. AmJ Med Genet (Neuropsychiatry Section) 81:323-327,1998.
15.Alfredo Lim, Debby Tsuang, Walter Kukull, David Nochlin, James Leverenz, Wayne McCormick, James Bowen, Linda Teri, Jill Thompson, Elaine Peskind, Murray Raskind, Eric Larson. Clinico-neuropathological correlation of Alzheimer’s disease in a community-based case series. J Am Geriatr Soc 47:564-569, 1999.
16.Debby Tsuang, Eric B. Larson, James Bowen, Wayne McCormick, Linda Teri, David Nochlin, James Leverenz, Elaine R. Peskind, Alfredo Lim, Murray Raskind, Mary Lou Thompson, Sue Mirra, Marla Gearing, Gerard Schellenberg, Walter Kukull. The utility of apolipoprotein E genotyping in the diagnosis of Alzheimer’s disease in a community-based case series. Arch Neurol 56:1489-1495, 1999.
17.Debby Tsuang, Elisabeth Almqvist, Hillary Lipe, Franc Strgar, Lilly DiGiacomo, David Hoff, Charisma Eugenio, Michael Hayden, Thomas Bird. Familial aggregation of psychotic symptoms in Huntington's disease. Am J Psychiatry157:1955-1959, 2000.
18.Debby Tsuang, Stephen Faraone, Ming Tsuang. Genetic counseling for psychiatric disorders. Curr Psychiatry Rep3:138-143, 2001.
19.Parvoneh Poorkaj, Debby Tsuang, Ellen Wijsman, Ellen Steinbart, Ralph Garruto, Ulla-Katrina Craig, Nicola Chapman, Leojean Anderson, Thomas Bird, Chris Plato, Daniel Perl, Wigbert Weiderholt, Douglas Galasko, Gerard Schellenberg. TAU as a susceptibility gene for amyotropic lateral sclerosis-parkinsonism dementia complex of Guam. Arch Neurol 58:1871-1878, 2001.
20.Allen Radant, Debby Tsuang, Elaine Peskind, Miles McFall, Wendy Raskind. Biological markers and diagnostic accuracy in the genetics of posttraumatic stress disorder. Psychiatry Res 102:203-215, 2001.
21.Debby Tsuang, Andrew Skol, Stephen Faraone, Stephen Bingham, Keith Young, Sarita Prabhudesai, Susan Haverstock, Felicitas Mena, Aerath Sri Kumar Menon, Darren Bisset, John Pepple, Fred Sauter, Charlene Baldwin, David Weiss, Joseph Collins, Michael Boehnke, Gerard Schellenberg, Ming Tsuang. Examination of genetic linkage of chromosome 15 to schizophrenia in a large Veterans Affairs Cooperative Study sample. Am J Med Genet (Neuropsychiatric Section)105:662-668, 2001.
22.Stephen Faraone, Andrew Skol, Debby Tsuang, Stephen Bingham, Keith Young, Sarita Prabhudesai, Susan Haverstock, Felicitas Mena, Aerath Sri Kumar Menon, Darren Bisset, John Pepple, Fred Sautter, Charlene Baldwin, David Weiss, Joseph Collins, Tim Keith, Michael Boehnke, Ming Tsuang, Gerard Schellenberg. Linkage of chromosome 13q32 to schizophrenia in a large veterans affairs cooperative study sample. Am J Med Genet (Neuropsychiatric Section)114:598-604, 2002.
23.James Leverenz, Christina Agustin, Debby Tsuang, Elaine Peskind, Steve Edland, David Nochlin, Lillian DiGiacomo, James Bowen, Wayne McCormick, Linda Teri, Murray Raskind, Walter Kukull, Eric B. Larson. Clinical and neuropathological characteristics of hippocampal sclerosis: a community-based study. Arch Neurol 59:1099-1106, 2002.
24.Debby Tsuang and Thomas D. Bird. Genetics of dementia. Medical Clinics of North America86:591-614, 2002.
25.Debby Tsuang, Aaron Dalan, Charisma Eugenio, Parvoneh Poorkaj, Pornprot Limprasert, Albert La Spada, Ellen Steinbart, Thomas Bird, James Leverenz. Familial dementia with Lewy bodies: a clinical and neuropathological study of 2 families. Arch Neurol 59:1622-1630, 2002.
26.Debby Tsuang, Stephen V. Faraone, Ming T. Tsuang. Implications of genetics and the use of genetic counseling. Directions in Psychiatry22:155-164, 2002.
27.Lauren Bonner, Debby Tsuang, Monique Cherrier, Charisma Eugenio, Jennifer Du, Ellen Steinbart, Pornprot Limprasert, Albert La Spada, Benjamin Seltzer, Thomas Bird, James Leverenz. Familial dementia with Lewy bodies with an atypical clinical presentation. J Geriatr Psychiatry and Neurol 16:59-64, 2003.
28.Andrew Skol, Keith Young, Debby Tsuang, Stephen Faraone, Susan Haverstock, Steven Bingham, Sarita Prabhudesai, Felicitas Mena, Aerath Sri Kumar Menon, Chang-En Yu, Paul Rundell, John Pepple, Fred Sautter, Charlene Baldwin, David Weiss, Joseph Collins, Tim Keith, Michael Boehnke, Gerard Schellenberg, Ming Tsuang. Modest evidence for linkage and possible confirmation of association between NOTCH4 and schizophrenia in a large Veterans Affairs Cooperative Study sample. Am J Med Genet (Neuropsychiatric Section)118B:8-15, 2003.
29.Debby Tsuang, Lillian DiGiacomo, Thomas Bird. Familial occurrence of DLB. Am J Geriatr Psychiatry, 12:179-189, 2004.
30.Robert Riekse, James Leverenz, Wayne McCormick, James Bowen, Linda Teri, David Nochlin, Kate Simpson, Charisma Eugenio, Eric B. Larson, Debby Tsuang. Impact of vascular lesions on cognition in Alzheimer's disease: a community-based study. J Am Geriatr Soc, (in press).
BOOK CHAPTERS
31.Debby Tsuang, Stephen Faraone, Ming Tsuang. Psychiatric genetic counseling. In:Watson S. Psychopharmacology: The Fourth Generation of Progress/CD ROM. American College of Neuropsychopharmacology, 2000 <
32.Steven V. Faraone, Debby Tsuang, Ming T. Tsuang. Methods in psychiatric genetics. In: Tsuang M, Tohen M. Textbook in Psychiatric Epidemiology, Second edition. New York: John Wiley & Sons, 2002.
33.Debby Tsuang, Stephen V. Faraone, Ming T. Tsuang. The role of genetic counseling. In: Stone W, Faraone S, Tsuang M. Early Clinical Intervention and Prevention in Schizophrenia. Totowa: Humana Press, 2004.
34.Debby Tsuang and Thomas D. Bird. Genetics of dementia. In: Sadavoy J, Lazarus L, Jarvik L, Grossberg G. Comprehensive Review of Geriatric Psychiatry, Third edition. New York: W.W. Norton and Company, 2004.
PUBLISHED BOOKS
35.Stephen V. Faraone, Ming T. Tsuang, Debby W. Tsuang. Genetics of mental disorders: What practitioners and students need to know. New York: Guilford Press, 1999.
OTHER PUBLICATIONS
36.George Winokur and Debby Tsuang. Response to a Letter to the Editor. J Nerv Ment Dis181:458-459, 1993.
37.Debby Tsuang and Thomas D. Bird. Guest Editorial: Genetics of Dementia. J Geriatric Psychiatry Neurol 11:41, 1998.
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