IRISH NEUROLOGICAL ASSOCIATION

41st Annual Meeting

13th and 14th May 2005

Croke Park Conference Centre,

Dublin.

Friday, May 13th

08.55  Opening of Meeting and Welcome

Mr. Christopher Pidgeon, President, Irish Neurological Association.

Session 1. Chair: Mr. Christopher Pidgeon

O1 / 09.00 / Decompressive craniectomy for posttraumatic brain swelling: results and review of 35 years literature.
Ali Z., Hanif S, Sattar T, C.Pidgeon, S.Young, J.Phillips, D.Rawluk, D.Allcutt.
O2 / 09.15 / Ligation of the superior sagittal sinus and division of the falx cerebri abolishes cortical retraction and is a safe adjunct to the interhemispheric approach at the coronal suture.
K Aquilina, C Lim, F Taleb, M Kamal, MG O’Sullivan
O3 / 09.30 / Lateral mass screw fixation of the cervical spine: a prospective clinical study.
M.O. Kelleher, L. McEvoy, J. Wang, M.H. Kamel, C Mascott & C. Bolger
O4 / 09.45 / Foramen magnum decompression in Chiari 1 malformation associated with syringomyelia: a retrospective study of surgery related outcome and long term follow up of 54 patients
Sattar MT, Nolan CP, Hanif S, Ali Z, Pidgeon CN
O5 / 10.00 / Surgical Management of Metopic Synostosis – a 15 year experience
M.O. Kelleher, M.H. Kamel, A McGillavery, D. Murray, M.J. Earley & D. Allcutt.
06 / 10.15 / Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase 1 in tPA-treated stroke: temporal profile and relation to stroke severity and outcome.
M Ning, KL Furie, W Koroshetz, H Lee, M Barron, M Lederer, X Wang, M Zhu, AG Sorensen, EH Lo, P Kelly

10.30 Coffee, Exhibits and Posters

Session 2. Chair:

O7 / 11.00 / The social and economic burden of paediatric epilepsy in Ireland: a prospective study.
M McGinn, Y Najam, S Deiratany, D Grant, A Sawyer, P Reeves, J Hughes, D Webb, J McMenamin.
O8 / 11.15 / Epilepsy Nurses Improve Care.
Ena Bingham, Victor Patterson, Kiang Pang, Jim Morrow
O9 / 11.30 / Intermediate and Long-term Follow-up Results of Irish Patients Undergoing Epilepsy Surgery.
Dunlea O, Phillips J, Staunton H, Farrell M, McMackin D, Pender N, Delanty N, Doherty C
O10 / 11.45 / Observation of the course of intractable seizures in patients with delayed or postponed invasive recordings.
Paula Corr, Patricia Ennis, Norman Delanty, Colin P. Doherty
O11 / 12.00 / Add On Therapies for Epilepsy in a General Neurology Setting.
Habib Ur Rahman, Thomas Monaghan, Michael J Hennessy
O12 / 12.15 / Levetiracetam therapy in human pregnancy: preliminary experience from The UK Epilepsy and Pregnancy Register.
Dr S J Hunt, Dr J J Craig, B Irwin, R Waddell, Dr A Russell, Dr E Guthrie, Dr L Parsons, Mr I Robertson, Prof P J Morrison, Dr C McGivern & Dr J I Morrow
O13 / 12.30 / Genetic variation in the GABA C receptor predisposes to vigabatrin (VGB) induced visual field defects.
P. Kinirons, G.P. Cavalleri, D. O’Rourke, B. Liggan, D.B Goldstein, C.P. Doherty, N. Delanty.
O14 / 12.45 / Failure to replicate previously reported genetic associations with sporadic temporal lobe epilepsy: what can we learn? .
Gianpiero L. Cavalleri, John M. Lynch, Chantal Depondt, Mari-Wyn Burley, Nicholas W. Wood, Sanjay M. Sisodiya, David B. Goldstein.

13.0  Lunch, Exhibits and Posters.

Session 3. Chair:

O15 / 14.00 / Dose-Related Association of MTHFR 677T Allele with Risk of Ischemic Stroke – Evidence from a Cumulative Meta-analysis
S Cronin, KL Furie, PJ Kelly.
O16 / 14.15 / Familial Hemiplegic Migraine is linked to the FHM2 locus in an Irish Pedigree.
D.M. Fernandez, C.K. Hand, B.J. Sweeney, N.A. Parfrey.
O17 / 14.30 / Evaluation of Cerebral Haemodynamic Reserve Using Post-Acetazolamide SPECT in Intracranial Carotid Disease
A. McKeon, F. Keeling, J. Thornton, J.T. Moroney.
O18 / 14.45 / The evolution of continuous 24-hour video-EEG monitoring in hypoxic-ischaemic encephalopathy.
DM Murray, GB Boylan, CA Ryan, B McNamara, S Connolly.
O19 / 15.00 / The use of cerebral microdialysis to detect Catepsin S cysteine protease in brain tumours in vivo.
T Flannery, RS McConnell, N Simms, S McQuaid, G McGregor, M Mirakhur, B Walker, L Martin, C Scott, C Greenan, PG Johnston.
O20 / 15.15 / In vivo Monitoring of Therapeutic Response in a Murine Model of Glioma.
Sarah C. Jost, and Joel Garbow
O21 / 15.30 / Establishment of Stereotactic Radiosurgery experience in Ireland in treating neurosurgical patients.
Hanif S, Sattar MT, Pidgeon CN, Armstrong J, Jones E, McLean B.

16.0  Coffee and viewing of Posters

16.15  Irish Neurological Association Business Meeting.

17.0  Guest Lecture – Dr. Diederik Dippel

Saturday, May 14th

Session 4. Chair:

O22 / 09.00 / The H63D mutation in the haemochromatosis gene (HFE) is associated with sporadic amyotrophic lateral sclerosis (ALS) in the Irish population.
Matt Greenway, Andrew Green and Orla Hardiman
O24 / 09.20 / Defining Beta-Interferon Failure in Multiple Sclerosis: Clinical Predictors of Progressive Disability.
K.O’Rourke, M. Hutchinson
O25 / 09.30 / Favorable Effect of Immunomodulator Therapy on Bone Mineral Density in Multiple Sclerosis.
M. Shuhaibar, M. J. McKenna, M. Au-Yeong, J. M. T. Redmond.
O26 / 09.40 / Benign Multiple Sclerosis: Results from the Northern Ireland Multiple Sclerosis Registry.
OM Gray, GV McDonnell, SA Hawkins.
O27 / 09.50 / An audit of traumatic nerve injury referrals to a Neurophysiology service over a 12 month period.
O’ Connor G., McNamara B.
O28 / 10.00 / Motor evoked potentials are less facilitated after contralateral homologous muscle activation in Parkinson s disease.
R Renganathan, B Sweeney, R Galvin, K Roy Chowdhury, B McNamara.
O29 / 10.10 / Out come of acute subdural in elderly patients with severe head injury. Influence of patient’s age, anticoagulation and timing of surgery. A review of 130 patients.
S.Hanif, T.Sattar, H. Ali, Z.Ali, C.Pidgeon
O30 / 10.20 / Locked-in syndrome survivors, The experience of the National Rehabilitation Hospital.
Eimear Smith, Mark Delargy.

10.30  Tea and coffee

Session 5 Chair:

031 / 11.00 / The Clinical Spectrum of Lyme Neuroborreliosis in the West of Ireland.
M Elamin, T Monaghan, G Corbett-Feeney, S O’Connell, T Counihan
032 / 11.10 / Friedreich’s ataxia: a different clinical presentation in patients with very small GAA trinucleotide repeats. (<150).
Daniel G Healy, Mary Sweeney, Niall P Quinn, Nicholas Wood.
033 / 11.20 / A practical approach to the evaluation of patients with inherited ataxias.
Chaila EC, Murphy RPM, Connolly S, Cassisy L.
034 / 11.30 / A six month descriptive audit of patients presenting with seizure to the Emergency department of a large Irish tertiary referral center.
J Spencer, B Sweeney, A Merwick, A Neligan, C Luke, R Galvin
035 / 11.40 / Non-Traumatic Headache in A+E- Presentation and Outcome.
Alexander M, Binchy J, and Counihan T.
036 / 11.50 / Concussion on the sports field: overdiagnosed? Don’t forget footballer’s migraine.
Costigan, D
037 / 12.00 / What difference does a Neurologist make in a general hospital?
Roberts K, Costelloe D, Hutchinson M, Tubridy N.
038 / 12.10 / Enthusiasm: pearl or peril? A lesson from the history of psychosurgery.
J J Smith and C S Breathnach.

12.20 Short oral presentations from two best posters

12.50  Announcement of Prizes.

13.0  Lunch and Farewell


Poster Presentations

1.  Headache in Pregnancy- Expect the unexpected.

Alexander M., Hennessy M

2.  Colloid cyst an unusual and potentially lethal cause of childhood headaches: A Case Report and a review of literature.

Z. Ali, TM. Murphy, S. Hanif, T.Sattar, S.Young

3.  Primitive neuroectodermal tumours (PNET’s) presenting as spinal dumbbell tumours.

K Aquilina, J Cahill, G F Kaar, M G O’Sullivan, C Keohane.

4.  Langerhan’s cell histiocytosis with predominant CNS and ocular involvement in an adult.

Bermingham N, Townley D, Fenton S and Keohane C.

5.  Craniotomy With Prosthetic Heart Valves: When To Re-anticoagulate?

J Caird, C Chukwunyerenwa, Z Ali, D Rawluk

6.  How are we managing Convulsive Status Epilepticus? – results of a 5-year audit

N Conlon, R Renganathan, B Sweeney

7.  A prospective study on the impact of a child’s epilepsy on their quality of life and their family.

S Deiratany, Y Najam, D Grant, A Sawyer, J Hughes, J McMenamin, D Webb.

8.  Transverse myelitis secondary to Schistosomiasis of spinal cord.

C Dewhurst, R Renganathan, M Horgan, C Marks, H Harrington.

9.  Case Report: Metastatic Paraganglionoma to Lumbar spine

Dewhurst C, Lim C, Taleb F, Keohane C, O’Sullivan MGJ.

10.  Stereological estimation of surface area in Tuberous Sclerosis Complex: A Tesla imaging study.

Colin Doherty, Lisa Ronan, Mary Fitzsimons, P. Ellen Grant, Norman Delanty, Elizabeth A. Thiele.

11.  Estimation of the prevalence of motor neurone disease (MND) in Northern Ireland using capture-recapture methodology

Donaghy C1, Forbes RB2, Dick A1, Hardiman O3, Patterson V1.

12.  A case of an unusual cause for focal neurological signs

Dr Amy Hinder, Dr Donncha Hanrahan.

13.  Tetraparaesis secondary to cerebellar arteriovenous malformation – a case report and review of the literature

Jafar Mohammadi B, O’ Connor G, Ryan A., Fitzgerald P, Ryder DQ, Galvin R.

14.  A case of subacute bilateral foot-drop.

A Johnston and GV McDonnell

15.  Quantitative evaluation of the effects of ageing on neuronal numbers in the human interstitial nucleus of Cajal.

Ahmed Kandil, Francesca M Brett, Hugh Staunton.

16.  Awake Craniotomy for resection of a low grade glioma: A review of the first two cases performed in Beaumont Hospital.

M.O. Kelleher, L. McEvoy, M.H. Kamel, J. Wang, S. Maguire, A. Healy, C. Mascott , C. O’ Hagan & C. Bolger

17.  Starvation induced Wernicke’s Encephalopathy in an 11 year old girl

Kennedy MN, Hicks E, Cooke CA, McKinstry S.

18.  A (very) rare cause of visual loss and other cranial neuropathies.

Desmond Kidd

19.  Neurological complications of systemic sarcoidosis.

Kidd, D

20.  Is vigabatrin retinopathy related to dosing factors

P. Kinirons, D. O’Rourke, B. Liggan, C.P. Doherty, N. Delanty

21.  Persistent High Rates of Sodium Valproate Use in Irish Women of Child-Bearing Age with Epilepsy. A Need for Change?

Brenda Liggan, Maire White, Cora Flynn, Colin Doherty, Norman Delanty.

22.  Ability of medical personnel to accurately differentiate neonatal seizures from non-seizure movements.

Malone A., Boylan G B., Ryan CA, Connolly S

23.  Steroid-responsive recurrent encephalopathy in a patient with Cerebral Amyloid Angiopathy without vasculitis.

J McHugh, A Ryan, T Lynch, J Stack, M Farrell, P Kelly.

24.  Outcome measurement post Vagal Nerve Stimulation therapy – proposal of a new classification.

J.C. McHugh, H.W. Singh, J. Phillips, K. Murphy, C.P. Doherty, N. Delanty.

25.  Topiramate: an audit of adverse effects.

McKeon, J. Bhangu, C.P. Doherty, N. Delanty.

26.  Building for the future with the epilepsy electronic patient record.

Louise Mc Quaid, Colin Doherty, Maire White, Cora Flynn, Norman Delanty, Tony Kenny, Patricia King, Norman Delanty, Mary Fitzsimons.

27.  Malignant Transformation In patients with Low Grade Gliomas; is epilepsy predictive of improved outcome?

K.A. Mears, M.O. Kelleher, J. Nagaria, M.H. Kamel, N. Mansour & D Rawluk.

28.  Meningiomas in Ireland - Initial results of a 4 year study

Mohd nor Nurul khasri, Lim Chris, Jordain Iain, Comber HJ, Farrell M.A., Keohane Catherine.

29.  Prospective Study of Speech and Language Deficits in Acute Ischaemic Stroke: Preliminary findings in 10 patients.

Sinead Murphy, Colin Doherty, Joan Moroney.

30.  Endovascular Stenting with Distal Protection of Intraluminal Carotid Thrombus: A Novel treatment Approach

S. Murphy, J. Thornton, P. Brennan, and J.T. Moroney

31.  Management of Hypertension as Secondary Prevention in Patients presenting with Acute Cerebro-Vascular Events

A. Neligan, R. Renganathan, J. Spencer and BJ Sweeney.

32.  Compression Neuropathy: How big a problem is it?

A Neligan, J. Kinsella, A. McCarthy and B. McNamara.

33.  Incidence of anticoagulant/antiplatelet agent usage amongst patients with intracranial haemorrhage

Nolan CP, Sattar MT, Caird J, Jost S, Rawluk D

34.  A review of neurological abnormalities associated with the practise of music in the Irish context

O’ Connor G., McNamara B., Moore H., Sweeney B.

35.  A study of the effect of age on the spatial discrimination threshold- normative data for the study of multiplex adult onset primary torsion dystonia families

John Philip O’Dwyer, Iftikhar Sheikh, Fiona Molloy, Michael Hutchinson.

36.  Sensory abnormalities in familial adult-onset primary torsion dystonia: an endophenotype?

John Philip O’Dwyer, Sean O’Riordan, Fiona Molloy, Susan Bressman, Rachael Saunders-Pullman, Tim Lynch, Michael Hutchinson.

37.  The posterior surgical approach to the cervical neural foramen. A clinical outcome study.

C O’Riordan, K Aquilina, G. O’Connor, M Kamel, C Lim, MG O’Sullivan.

38.  Potential Efficacy of Zonisamide in Refractory Juvenile Myoclonic Epilepsy.

D O’Rourke, C Flynn, M White, C Doherty, N Delanty.

39.  Defining Beta-Interferon Failure in Multiple Sclerosis: Clinical Predictors of Progressive Disability

K.O’Rourke, M. Hutchinson.

40.  Detection rates of sexual dysfunction amongst patients with Multiple Sclerosis in outpatient setting – can this be improved?

O’Sullivan SS, Hardiman O.

41.  Nephrotic syndrome and Guillain-Barre: is there an association? Report of 2 cases

F Pettit, R Renganathan, B Sweeney, R Galvin

42.  Tumefactive demyelinating lesion - a diagnostic challenge

R Renganathan, P Hodnett, P Fitzgerald, R Galvin, D Ryder

43.  A Normal MRI of Brachial plexus does not rule out a Metastatic plexopathy in a suspected case: Lessons to be learnt.

R Renganathan, A McCarthy, B McNamara, R Galvin.

44.  Ross syndrome – 1st documented case in Ireland

R Renganathan, M Brassill, F Pettit, M James, M Watts, B McNamara, B Sweeney.

45.  Coeliac associated vacuolar leukoencephalopathy.

Ryan, M. Ahmed, G. O’Connor, J. Ryan, O. Hardiman, M. Farrell, B. McNamara, B Sweeney.

46.  Vascular dysplasia in neurofibromatosis type 2.

A. Ryan, M. Hurley, P. Brennan, JT Moroney.

47.  Non-convulsive status epilepticus in a regional centre.

A. Ryan, B. McNamara.

48.  Further evidence of sensory abnormality as an endophenotype in dystonia: a population-based study.

Iftikhar Sheikh, John Philip O’Dwyer, Michael Hutchinson

49.  Neuroendoscopy for diffuse subependymal tumour

F Taleb, C Dewhurst, K Aquilina, G Kaar.

50.  Fatal Devic’s Syndrome associated with pulmonary atypical mycobacterial infection.

Steve Tate, Naomi Chapman, Raeburn Forbes, Brian Herron, Rory Convery.

51.  When a stroke is not a stroke; Posterior leukoencephalopathy syndrome mimicking posterior circulation stroke

Frank Waldron-Lynch, Conor Meehan, Claire Roche, Joe Murphy and

Timothy J Counihan,