Michael Francis Wangler

MICHAEL FRANCIS WANGLER, M.D.

Assistant Professor, Department of Molecular and Human Genetics

Baylor College of Medicine

Mailing Address:

Jan and Dan Duncan Neurological Research Institute

1250 Moursund Street, Suite 1125

Mailstop NR-1125

Houston, TX 77030

Tel: 832-824-8750 Email:

Education

1996-2000 Bachelors of Science (B.S.), University of California San Diego.

2000-2001 Masters of Science (M.S.), Division of Biology, University of California San Diego.

2001-2003 Medical Student at University of New Mexico School of Medicine, Albuquerque

2003-2004 Research Fellow, Doris Duke Clinical Research Fellowship for Medical Students at Washington University in St Louis.

2004-2006 Medical Doctorate (M.D.), Baylor College of Medicine, Houston, Texas.

Residency Training

2006-2009 Pediatric Resident, Baylor College of Medicine

2009-2011 Medical Genetics Fellowship, Department of Molecular and Human Genetics, Baylor College of Medicine

Licensure and Board Certification
American Board of Medical Genetics 2011-present

American Board of Pediatrics 2009-present

Licensed Physician,Texas Medical Board

Academic Appointments

2011-present Assistant Professor, Department of Molecular and Human Genetics, Baylor College of Medicine

Research Training

2013-present Merging fly genetics in application to whole-exome sequencing (WES) data from patients with rare disease. Hugo Bellen’s laboratory and Jim Lupski’s laboratory.

2011-present Visceral myopathy (OMIM 155310) gene discovery using WES. Arthur Beaudet Laboratory and Baylor-Johns Hopkins Centers for Mendelian Genomics.

2009-present Metabolomics of Peroxisomal Biogenesis in Drosophila melanogaster through characterization of the pex genes. Hugo Bellen’s laboratory,

2003-2004 A longitudinal clinical registry for the study of the genetics of preterm delivery. Louis Muglia’s laboratory, Department of Pediatrics, Washington Univeristy in St Louis.

2003-2004 Genetic epidemiology of Beckwith-Wiedemann syndrome. Michael R. DeBaun’s laboratory, Department of Pediatrics, Washington University in St Louis.

1998-2001 Presenilin interacts with two antioxidant proteins in Drosophila melanogaster. Ethan Bier’s laboratory, University of California San Diego, Department of Biology,

Other Experience and Professional Memberships

2014- present Scientific Advisory Board- Global Foundation for Peroxisomal Disorders (GFPD)

2014-present Course Director- Pediatric Resident Education in Medical Genetics

2014-present American Society of Human Genetics

2011-present Member Genetic Society of America

2006-2009 Member, American Academy of Pediatrics

Honors

2011 Baylor College of Medicine Molecular and Human Genetics-“Most Outstanding Fellow”

2009 Baylor College of Medicine Pediatric Residency- “Most Outstanding Research”

2001 UC San Diego Vice-Chancellor Scholar Athlete Award

2000 Phi Beta Kappa UC San Diego

Publications

Wangler MF, Charng WL, Chao YH, Bayat V, Giagtzoglu N, Bacino C, Xia F, Putluri, N, Faust J, McNew J, Sardiello M, Moser A, Lupski JR, Bellen HJ. “Carbohydrate metabolism alterations in Peroxisomal Biogenesis Defects” In preparation.

Chao Y-H, Robak L, Xia F, Koenig M, Adesina A, Bacino CA, Scaglia F, Bellen HJ, Wangler MF. “Missense variants in the middle domain of DNM1L in cases of infantile encephalopathy have distinct specificity based on Drosophila studies”. Submitted.

Yoon WH, Sandoval H, Nagarkar Jaiswal S, Jaiswal M, Yamamoto S, Haelterman NA, Putluri N, Putluri V, Sreekumar A, Tos T, Aksoy A, Donti T, Graham BH, Ohno M, Nishi E, Hunter J, Muzny DM, Carmichael J, Arboleda V, Nelson SF, Wangler MF, Karaca E, Lupski JR, Bellen HJ “Nardilysin chaperones mitochondrial Oxoglutarate dehydrogenase and protects against the demise of neurons in flies and human.” Submitted

Braverman NE, Raymond GV, Rizzo WB, Moser AB, Wilkinson ME, Stone EM, Steinberg SJ, Wangler MF, Hacia JG, Bose M. “Peroxisome Biogenesis Disorders in the Zellweger Spectrum: an overview of current diagnosis, clinical manifestations and treatment guidelines.” Accepted Molecular Genetics and Metabolism

Bacino C , Chao Y-H, Seto E, Lotze T, Xia F, Moser A, Wangler MF (2015) “A homozygous mutation in PEX16 identified by whole-exome sequencing ending a diagnostic oddyssey” Molecular Genetics and Metabolism Reports,December pp15-18. doi:10.1016/j.ymgmr.2015.09.001

Wangler MF, Beaudet AL. ACTG2-Related Disorders. (2015) Jun 11. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2015. Available from: http://www.ncbi.nlm.nih.gov/books/NBK299311/ PMID:26072522

Wangler, MF, Bayat V, Bellen HJ (2015). "A mitochondrial translation defect identified by whole-exome sequencing expands the phenotypic spectrum for MARS2" Human Mutation Jun;36(6):iii. doi: 10.1002/humu.22811.

Wangler, MF, Yamamoto S, Bellen, H. (2015) “Fruitflies in Biomedical Research” Genetics, Jan 26. pii: genetics. 114.171785. PMID:25624315; PMCID: PMC4349060 (Faculty of 1000)

Yamamoto S, Jaiswal M, Charng WL, Gambin T, Karaca E, Mirzaa G, Wiszniewski W, Sandoval H, Haelterman NA, Xiong B, Zhang K, Bayat V, David G, Li T, Chen K, Gala U, Harel T, Pehlivan D, Penney S, Vissers LM, de Ligt J, Jhangiani S, Xie Y, Tsang S, Parman Y, Sivaci M, Battaloglu E, Muzny DM, Wan YW, Liu Z, Lin-Moore AT, Clark RD, Curry CJ, Schulze KL, Boerwinkle EA, Dobyns WB, Allikmets R, Gibbs RA, Chen R, Lupski JR, Wangler MF#, Bellen HJ#. (2014). “A Drosophila genetic resource to study human disease genes and its use for gene discovery in human exome data” Cell, Sep 25;159(1):200-14. doi: 10.1016/j.cell.2014.09.002. PMID: 25259927; PMCID:PMC4298142 #Corresponding Authors. (Faculty of 1000).

Faust, JE, Manisundaram A, Ivanova PT, Milne SB, Summerville JB, Brown HA, Wangler MF, Stern M, McNew JA. (2014) “Peroxisomes are Required for Lipid Metabolism and Muscle Function in Drosophila melanogaster.” PLOS One Jun 19;9(6):e100213. PMID:24945818; PMCID:PMC4063865

Xia F, Bainbridge M, Tan TY, Wangler MF, Scheuerle A, Zackai EH, Sutton VR, Nalam R, Zhu W, Nash M, Ryan M, Lee J, Lupski JR, Beaudet AL, Plon SE, Boerwinkle EA, Eng CM, Muzny DM, Yang Y, Gibbs RA. (2014). “De novo truncating mutations in the AHDC1 gene in patients with syndromic speech disability and sleep apnea” American Journal of Human Genetics May 1;94(5):784-9. PMID: 24791903; PMCID: PMC4067559

Wangler MF, Gonzaga-Jauregui C, Gambin T, Penney S, Moss T, Chopra A, Probst FJ, Xia F, Yang Y, Werlin S, Eglite I, Kornejeva L, Bacino CA, Baldridge D, Neul J, Lehman EL, Larson A, Beuten J, Muzny DM, Jhangiani S, Baylor-Hopkins Center for Mendelian Genomics, Gibbs RA, Lupski JR, Beaudet A. (2014) “Heterozygous de novo and inherited mutations in ACTG2 underly Megacystis-microcolon intestinal hypoperistalsis syndrome.” PLOS Genetics Mar 27;10(3):e1004258 PMID:24676022; PMCID:PMC3967950

Wangler MF, Chavan R, Hicks MJ, Nuchtern JG, Hegde M, Plon SE, Thompson PA. (2013) “Unusually early presentation of small-bowel adenocarcinoma in a patient with Peutz-Jeghers syndrome.” J Pediatri Hematol Oncol. May; 35(4): 323-8. PMID:23426006; PMCID:

PMC3708690

Wangler MF, Reiter LT, Zimm G, Trimble-Morgan J, Wu J, Bier E. (2011) “The antioxidant proteins TSA and PAG interact synergistically with Presenilin to modulate Notch signaling in Drosophila.” Protein & Cell Jul; 2(7): 554-63. PMID:21822800; PMCID:PMC3702159

Fruhman G, Landsverk ML, Lotze TE, Hunter JV, Wangler MF, Wong LJ, Scagllia F. (2011) “Atypical presentation of Leigh-like encephalopathy associated with a Leber Herediatry Optic Neuropathy primary mitochondrial DNA mutation” Molecular Genetics and Metabolism Jun;103(2):153-60. PMID:21414825

Tompson SW, Bacino CA, Safina NP, Bober MB, Proud VK, Funari T, Wangler MF, Nevarez L, Ala-Kokko L, Wilcox WR, Eyre DR, Krakow D, Cohn DH. (2010) “Fibrochondrogenesis results from mutations in the COL11A1 type XI collagen gene.” Am J Hum Genet. 87(5): 708-712. PMCID: PMC2978944

Plunkett J, Feitosa MF, Trusgnich M, Wangler M, Palomar L, Kistka ZA, DeFranco EA, Shen T, Stormo A, Puttonen H, Hallman M, Haataja R, Fellman V, Peltonen L, Palotie A, Daw EW, An P, Rice T, Teramo K, Borecki I, Muglia LJ. (2009) Mother’s genome or maternally-inherited genes acting in the fetus influence gestational age in familial preterm birth. Human Heredity 68(3)209-219. PMCID: PMC2869074

Kistka ZA, Palomar L, Lee KA, Boslaugh S, Wangler MF, Cole FS, DeBaun MR, Muglia LJ. (2007) Racial Disparity in Recurrence of Preterm Birth. Am J Ob Gynecol. 196(2): 131.e1-6.

Chang AS, Moley KH, Wangler M, Feinberg AP, DeBaun MR. (2005) Association between Beckwith-Wiedemann syndrome and assisted reproductive technology: a case series of 19 patients. Fertil Steril. 2005 83(2): 349-54. PMID:15705373

Wangler MF, An P, Feinberg AP, Province M, DeBaun MR. (2005) The Inheritance Pattern of Beckwith Wiedemann syndrome is Heterogeneous in 291 Families with an affected Proband. Am J Med Genet A.137(1): 16-21. PMID:16007611 PMCID:PMC3947567

Wangler MF, Chang AS, Moley KH, Feinberg AP, DeBaun MR. (2005) Factors associated with preterm delivery in mothers of children with Beckwith-Wiedemann syndrome: a case cohort study from the BWS registry. Am J Med Genet A.134(2): 187-91. PMID:15723285

Book Chapters

Wangler, MF, Bellen HJ Drosophila models of human disease. Basic Science Methods for Clinical Researchers. Elsevier. In Press.

Chang AS, Moley KH, Wangler M, DeBaun MR. (2006) Evidence for and Against Associations between ART and Congenital Malformation Syndromes. Epigenetic Risks of Cloning. Akio Inui ed. Taylor & Francis Publishing, Boca Raton 2006.

Schaaf C, Wangler MF, Sutton VR, Bacino CA, Belmont JW, Craigen W. (2011) Genetics In: Lowry AW, Nag PK, Bhakta KY, eds. Texas Children's Hospital Handbook of Pediatrics and Neonatology. New York, NY: McGraw-Hill Professional Inc.

Platform Presentations

Wangler MF, Gonzaga-Jauregui C, Gambin T, Gibbs RA, Lupski JR, Beaudet A. (2014) “Heterozygous de novo and inherited mutations in ACTG2 underly Megacystis-microcolon intestinal hypoperistalsis syndrome.” Cold Spring Harbor Personal Precision Medicine: Personal Genomes and Pharmacogenomics November 13-16, 2013.

Wangler MF, Yamamoto S, Jaiswal M, Charng WL, Gambin T, Karaca E, Mirzaa G, Wiszniewski W, Sandoval H, Haelterman N, Bayat V, Pehlivan D., Penney S, Vissers L, Jhangiani S, Tsang S, Xie Y, Parman Y, Battaloglu E, Muzny D, Liu Z, Clark R, Curry C, Boerwinkle E, Dobyns W, Allikmets R, Gibbs R, Chen R, Lupski JR, Bellen H. “A Drosophila genetic resource to study human disease genes and its use for gene discovery in human exome data.”

October 19th, ASHG 2014 [Due to a severe injury, talk was given by a co-author].

Robak L, Chao, Y-H, Xia F, Koenig M, Adesina A, Bacino C, Scaglia F, Bellen HJ, Wangler MF. “Missense mutations in the middle domain of DNM1L cause infantile encephalopathy in humans and peroxisomal and mitochondrial defects in Drosophila and humans” October 9th, ASHG 2015

Grant Support

1K08NS076547 Michael Wangler (PI) 9/30/2011-8/31/2016

The proposal describes a five-year mentored laboratory training experience designed to lead to an independent academic career in clinically-relevant basic science. The research seeks to improve our understanding of peroxisomal biogenesis disorders at the molecular level by focusing on peroxisomal biogenesis in Drosophila.

Role: PI

Simons Foundation: SFARI Functional Screen of Autism-Associated Variants

“In Vivo Functional Analysis of Autism Candidate Genes,”

Michael Wangler (PI) 8/1/2015-1/31/2017*.

The goal of this project is to study Autism associated variants from the Simons Simplex collection study. We will provide in vivo functional information of conserved genes using a combination of human genomics and Drosophila studies.

* 18months of funding at the level of $370,313,including indirect costs as follows: $247,500 for the period of August 1, 2015 to July 31, 2016 and $122,813 for the period of August 1, 2016 to January 31, 2017. Continued funding for the remaining six months of year two and year three contingent on progress made during the first year.

U54 NS093793 Hugo Bellen (PI) 7/1/2015-6/30/2018

The major goal of this project is to establish a model organism screening center that will provide valuable in vivo function information of conserved genes that are likely to be involved in rare human diseases from the Undiagnosed Diseases Network (UDN) by performing genetic experiments in Drosophila and Zebrafish. Role: Drosophila Resource Core PI.

COMPLETED

Simmons Family Foundation Collaborative Research Grant Michael Wangler (PI) 03/15/2013-03/15/2014

The goal of this proposal is to utilize Drosophila melanogaster to identify metabolomic signatures and cellular pathways related to peroxisomal biogenesis defects. These identified biochemical pathways can then be validated in human cells and ultimately in human studies. Role: PI