MOLECULAR
______PHARMACOLOGY
August 2002Volume 62Number 2 0026-895X
MINIREVIEW
Contributions of Protein Kinase A Anchoring Proteins to Compartmentation of cAMP Signaling in the
Heart
Michael S. Kapiloff193
PERSPECTIVE
The Yin and the Yang of 5-Lipoxygenase Pathway Activation H]
Timothy D. Bigby
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ARTICLES
Fusion Proteins with Anticoagulant and Fibrinolytic Properties: Functional Studies and Structural Considerations
Christian Icke, Bernhard Schlott, Oliver Ohlenschldger, Manfred Hartmann, Karl-Heinz Gilhrs,
and Erika Glusa203
The Ca2+ Channel Antagonists Mibefradil and Pimozide Inhibit Cell Growth via Different Cytotoxic Mechanisms
Gabriel E. Bertolesi, Chanjuan Shi, Lindsy Elbaum, Christine Jollimore, Gabriela Rozenberg,
Steven Barnes, and Melanie E. M. Kelly210
Re-engineering Butyrylcholinesterase as a Cocaine Hydrolase
Hong Sun, Yuan-Ping Pang, Oksana Lockridge, and Stephen Brimijoin220
Insulin-Like Growth Factor-1-Induced Phosphorylation of Transcription Factor FKHRL1 Is Mediated
by Phosphatidylinositol 3-Kinase/Akt Kinase and Role of This Pathway in Insulin-Like Growth
Factor-1-Induced Survival of Cultured Hippocampal Neurons
Wen-Hua Zheng, Satyabrata Kar, and Remi Quirion225
The Zebrafish (Danio rerio) Aryl Hydrocarbon Receptor Type 1 Is a Novel Vertebrate Receptor
Eric A. Andreasen, Mark E. Hahn, Warren Heideman, Richard E. Peterson, and Robert L. Tanguay 234
M Cyclic AMP-Mediated Inhibition of 5-Lipoxygenase Translocation and Leukotriene Biosynthesis in Human Neutrophils
Nicolas Flamand, Marc E. Surette, Serge Picard, Sylvain Bourgoin, and Pierre Borgeat250
Apoptosis in Murine Hepatoma Hepa Iclc7 Wild-Type, C12, and C4 Cells Mediated by Bilirubin
John M. Seubert, Alison J. Darmon, Ayman O. S. El-Kadi, Sudhir J. A. D'Souza, and
John R. Bend257
Molecular Requisites for Drug Binding to Muscle CLC-1 and Renal CLC-K Channel Revealed by the Use of Phenoxy-Alkyl Derivatives of 2-(p-Chlorophenoxy)Propionic Acid
Antonella Liantonio, Alessio Accardi, Giuseppe Carbonara, Giuseppe Fracchiolla, Fulvio Loiodice,
Paolo Tortorella, Sonia Traverso, Patrizia Guida, Sabata Pierno, Annamaria De Luca,
Diana Conte Camerino, and Michael Pusch265
Ethanol Induces Gene Expression via Nuclear Compartmentalization of Receptor for Activated C
Kinase 1
Dao-Yao He, Alicia J. Vagts, Rami Yaka, and Dorit Ron272
Negative and Positive Regulatory Epitopes in the C-Terminal Domains of the Human Bl and B2
Bradykinin Receptor Subtypes Determine Receptor Coupling Efficacy to G9/11-Mediated
Phospholipase Cj3 Activity
Dong Soo Kang and L. M. Fredrik Leeb-Lundberg281
Inhibition of Branched-Chain a-Keto Acid Dehydrogenase Kinase and Slnl Yeast Histidine Kinase by
the Antifungal Antibiotic Radicicol
Paul G. Besant, Michael V. Lasker, Cuong D. Bui, and Christoph W. Turck289
trans -Activation and Repression Properties of the Novel Nonsteroid Glucocorticoid Receptor Ligand 2,5-Dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5-(l-methylcyclohexen-3-yl)-l//-[l]benzopyrano[3,4-/]quinoline (A276575) and Its Four Stereoisomers
Chun Wei Lin, Masaki Nakane, Mike Stashko, Doug Falls, Jane Kuk, Loan Miller, Ruth Huang,
Curtis Tyree, Jeffrey N. Miner, John Rosen, Philip R. Kym, Mike J. Coghlan, George Carter, and
Ben C. Lane297
Influence of Ceramide Metabolism on P-Glycoprotein Function in Immature Acute Myeloid Leukemia KGla Cells
Isabelle Plo, Gustav Lehne, Karen Johanne Beckstr0m, Nicolas Maestre, All Bettaieb, Guy Laurent,
and Dominique Lautier304
7,12-Dimethylbenz [a] anthracene Induces Apoptosis in Murine Pre-B Cells through a
Caspase-8-Dependent Pathway
Todd J. Page, Scott O'Brien, Colin R. Jefcoate, and Charles J. Czuprynski313
Alternative Processing of the Human FMO6 Gene Renders Transcripts Incapable of Encoding a
Functional Flavin-Containing Monooxygenase
Ronald N. Hines, Kathleen A. Hopp, Jose Franco, Kia Saeian, and Frank P. Begun320
Transcriptional Regulation of Basal Cyclooxygenase-2 Expression in Murine Lung Tumor-Derived Cell Lines by CCAAT/Enhancer-Binding Protein and Activating Transcription Factor/cAMP Response Element-Binding Protein
Sarah A. Wardlaw, Na Zhang, and Steven A. Belinsky326
A Polymorphism in the Mouse Neuronal a4 Nicotinic Receptor Subunit Results in An Alteration in Receptor Function
Peter Dobelis, Michael J. Marks, Paul Whiteaker, Seth A. Balogh, Allan C. Collins, and
Jerry A. Stitzel334
The Intracellular Loops of the GB2 Subunit Are Crucial for G-Protein Coupling of the Heteromeric -y-Aminobutyrate B Receptor
Michaela Havlickova, Laurent Prezeau, Beatrice Duthey, Bernhard Bettler, Jean-Philippe Pin, and
Jaroslav Blahos343
Pharmacophore Model for Novel Inhibitors of Ubiquitin Isopeptidases That Induce p53-Independent Cell Death J. E. Mullally and F. A. Fitzpatrick
Transcriptional Regulation of the Human CYP3A4 Gene by the Constitutive Androstane Receptor Bryan Goodwin, Ecushla Hodgson, Daniel J. D'Costa, Graham R. Robertson, and Christopher Liddle
Modulation of Mouse and Human Phenobarbital-Responsive Enhancer Module by Nuclear Receptors Janne Mdkinen, Christian Frank, Johanna Jyrkkdrinne, Jukka Gynther, Carsten Carlberg, and Paavo Honkakoski
Oxidative Stress Decreases G Protein-Coupled Receptor Kinase 2 in Lymphocytes via a Calpain-Dependent Mechanism
Maria Stella Lombardi, Annemieke Kavelaars, Petronila Penela, Elisabeth J. Scholtens, Marta Roccio, Reinhold E. Schmidt, Manfred Schedlowski, Federico Mayor, Jr., and Gobi J. Heijnen
Behavioral Characterization of Mice Lacking Histamine H3 Receptors
Hiroshi Toyota, Christine Dugovic, Muriel Koehl, Aaron D. Laposky, China Weber, Karen Ngo, Ying Wu, Doo Hyun Lee, Kazuhiko Yanai, Eiko Sakurai, Takehiko Watanabe, Changlu Liu, Jingcai Chen, Ann J. Barbier, Fred W. Turek, Wai-Ping Fung-Leung, and Timothy W. Lovenberg
Destabilization of the HIV-1 Reverse Transcriptase Dimer upon Interaction with iV-Acyl Hydrazone Inhibitors
Nicolas Sluis-Cremer, Dominique Arion, and Michael A, Pamip,k
Nicotinic Receptor M3 Transmembrane Domain: Position 8' Contributes to Channel Gating Maria Jose De Rosa, Diego Rayes, Guillermo Spitzmaul, and Cecilia Bouzat
Prenylamine Block of Navl.5 Channel is Mediated via a Receptor Distinct from That of Local
Anesthetics
Mustafa G. Mujtaba, Sho-Ya Wang, and Ging Kuo Wang
Inflammation Modulates the Interaction of Heterogeneous Nuclear Ribonucleoprotein (hnRNP) I/Polypyrimidine Tract Binding Protein and hnRNP L with the 3'Untranslated Region of the Murine Inducible Nitric-Oxide Synthase mRNA
Malin Soderberg, Francoise Raffalli-Mathieu, and Matti A. Lang