Detailed Reasons for Excluded Trials

Detailed Reasons for Excluded Trials

Supplementaary Table 1

Detailed reasons for excluded trials

Study / Exclusion reason
Naruszewicz, 2002 1 / Intervention not fermented milk
Mizuno, 2005 2 / Enzymatically hydrolyzed milk as intervention
Sano, 2005 3 / Enzymatically hydrolyzed milk as intervention
Lee, 2007 4 / Milk drink but not probiotic fermented
Alonso, 2009 5 / Milk drink but not probiotic fermented
de leeuw, 2009 6 / Enzymatically hydrolyzed milk as intervention
Cicero, 2010 7 / Enzymatically hydrolyzed milk as intervention
Germino, 2010 8 / Enzymatically hydrolyzed milk as intervention
Usinger, 2010 9 / Duplicate report
Yamasue, 2010 10 / Enzymatically hydrolyzed milk as intervention
Chang, 2011 11 / Probiotic yogurt as control
Cicero, 2011 12 / Enzymatically hydrolyzed milk as intervention
Savard, 2011 13 / Combined intervention with other supplementations
Turpeinen, 2011 14 / Acute effect within 8 hours

REFERENCES

1. Naruszewicz M, Johansson ML, Zapolska-Downar D et al. (2002) Effect of Lactobacillus plantarum 299v on cardiovascular disease risk factors in smokers. Am J Clin Nutr76, 1249-1255.

2. Mizuno S, Matsuura K, Gotou T et al. (2005) Antihypertensive effect of casein hydrolysate in a placebo-controlled study in subjects with high-normal blood pressure and mild hypertension. Br J Nutr94, 84-91.

3. Sano J, Ohki K, Higuchi T et al. (2005) Effect of casein hydrolysate, prepared with protease derived from Aspergillus oryzae, on subjects with high-normal blood pressure or mild hypertension. J Med Food8, 423-430.

4. Lee YM, Skurk T, Hennig M et al. (2007) Effect of a milk drink supplemented with whey peptides on blood pressure in patients with mild hypertension. Eur J Nutr46,21-27.

5. Alonso A, Zozaya C, Vazquez Z et al. (2009) The effect of low-fat versus whole-fat dairy product intake on blood pressure and weight in young normotensive adults. J Hum Nutr Diet22, 336-342.

6. de Leeuw PW, van der Zander K, Kroon AA et al.(2009) Dose-dependent lowering of blood pressure by dairy peptides in mildly hypertensive subjects. Blood Press18, 44-50.

7. Cicero AF, Rosticci M, Veronesi M et al.(2010) Hemodynamic effects of lactotripeptides from casein hydrolysate in Mediterranean normotensive subjects and patients with high-normal blood pressure: a randomized, double-blind, crossover clinical trial. J Med Food13:1363-1368.

8. Germino FW, Neutel J, Nonaka M et al. (2010) The impact of lactotripeptides on blood pressure response in stage 1 and stage 2 hypertensives. J Clin Hypertens (Greenwich)12, 153-159.

9. Usinger L, Jensen LT, Flambard B et al.(2010) The antihypertensive effect of fermented milk in individuals with prehypertension or borderline hypertension. J Hum Hypertens24, 678-683.

10. Yamasue K, Morikawa N, Mizushima S et al.(2010) The blood pressure lowering effect of lactotripeptides and salt intake in 24-h ambulatory blood pressure measurements. Clin Exp Hypertens32, 214-220.

11. Chang BJ, Park SU, Jang YS et al.(2011) Effect of functional yogurt NY-YP901 in improving the trait of metabolic syndrome. Eur J Clin Nutr65, 1250-1255.

12. Cicero AF, Rosticci M, Gerocarni B et al. (2011) Lactotripeptides effect on office and 24-h ambulatory blood pressure, blood pressure stress response, pulse wave velocity and cardiac output in patients with high-normal blood pressure or first-degree hypertension: a randomized double-blind clinical trial. Hypertens Res34, 1035-1040.

13. Savard P, Lamarche B, Paradis ME et al. (2011) Impact of Bifidobacterium animalis subsp. lactis BB-12 and, Lactobacillus acidophilus LA-5-containing yoghurt, on fecal bacterial counts of healthy adults. Int J Food Microbiol149, 50-57.

14. Turpeinen AM, Ehlers PI, Kivimaki AS et al. (2011) Ile-Pro-Pro and Val-Pro-Pro tripeptide-containing milk product has acute blood pressure lowering effects in mildly hypertensive subjects. Clin Exp Hypertens33, 388-396.