Accession Numbers Were Retrieved from SWISS-PROT Database (

Accession Numbers Were Retrieved from SWISS-PROT Database (

Supplementary Table 1. Quantification of protein expression in the amygdala/hypothalamus in control mice (Ctl), mice fed a Mg-restricted diet (Mg-R) and mice fed a Mg-restricted diet chronically treated with paroxetine (Mg-R PAR).

Data are presented as means ± SEM. Proteins displaying significant alteration (p<0.05) between groups are displayed in bold.

Accession numbers were retrieved from SWISS-PROT database (

Quantification of chaperone proteins:

Accession / Name / Ctl / Mg-R / Mg-R PAR
Number / Mean / SEM / Mean / SEM / Mean / SEM
P23927 / Alpha crystallin B chain / 0.09 / 0.01 / 0.11 / 0.01 / 0.10 / 0.01
P38647 / Stress-70 protein, mitochondrial precursor / 0.28 / 0.05 / 0.34 / 0.04 / 0.24 / 0.02
P48722 / Heat shock 70 kDa protein 4L / 0.03 / 0.00 / 0.02 / 0.00 / 0.04 / 0.00
P53810 / Phosphatidylinositol transfer protein alpha isoform / 0.30 / 0.02 / 0.29 / 0.02 / 0.32 / 0.01
P63018 / Heat shock cognate 71 kDa protein / 0.40
1.75 / 0.05
0.25 / 0.38
1.80 / 0.05
0.30 / 0.44
1.93 / 0.05
0.21
P80314 / T-complex protein 1 subunit beta / 0.55 / 0.03 / 0.42 / 0.07 / 0.58 / 0.03
P80316 / T-complex protein 1 subunit epsilon / 0.23
0.06 / 0.01
0.01 / 0.21
0.03 / 0.02
0.01 / 0.22
0.06 / 0.02
0.01
P80317 / T-complex protein 1 subunit zeta / 0.47 / 0.03 / 0.42 / 0.05 / 0.47 / 0.03
Q60864 / Stress-induced-phosphoprotein 1 / 0.65 / 0.27 / 0.65 / 0.09 / 0.57 / 0.03
Q8C2C7 / Heat shock protein HSP 60 / 0.30 / 0.04 / 0.29 / 0.06 / 0.21 / 0.04
Q8C2K3 / Ubiquitin polyprotein (heat shock related) homolog / 1.10 / 0.21 / 1.34 / 0.10 / 1.16 / 0.08
Q8CIV8 / Tubulin-specific chaperone E / 0.09 / 0.01 / 0.11 / 0.02 / 0.10 / 0.01
Q922Z3 / Trap1 protein / 0.06 / 0.01 / 0.08 / 0.01 / 0.07 / 0.01
Q9WV98 / Mitochondrial import inner membrane translocase subunit Tim9 / 0.14 / 0.03 / 0.14 / 0.02 / 0.13 / 0.03

Quantification of hypothetical proteins:

Accession / Name / Ctl / Mg-R / Mg-R PAR
Number / Mean / SEM / Mean / SEM / Mean / SEM
Q8BL86 / hypothetical Metallo-beta-lactamase superfamily containing protein / 0.08 / 0.01 / 0.07 / 0.01 / 0.08 / 0.01
Q8K2T1 / NmrA-like family domain containing 1 / 0.12 / 0.01 / 0.13 / 0.03 / 0.12 / 0.02
Q99K80 / Hypothetical protein / 0.20 / 0.03 / 0.23 / 0.04 / 0.20 / 0.03
Q9CXN1 / Hypothetical HAD-like structure containing protein / 0.20 / 0.02 / 0.20 / 0.02 / 0.22 / 0.01
Q9DB60 / Hypothetical protein / 0.08 / 0.01 / 0.07 / 0.01 / 0.08 / 0.01

Quantification of metabolic proteins:

Accession / Name / Ctl / Mg-R / Mg-R PAR
Number / Mean / SEM / Mean / SEM / Mean / SEM
O08709 / Peroxiredoxin-6 / 0.58 / 0.02 / 0.57 / 0.04 / 0.60 / 0.02
O08749 / Dihydrolipoamide dehydrogenase / 0.82
0.22
0.13 / 0.06
0.05
0.01 / 0.75
0.24
0.13 / 0.08
0.02
0.01 / 0.81
0.30
0.12 / 0.08
0.03
0.02
O08917 / Flotillin-1 / 0.08 / 0.01 / 0.06 / 0.01 / 0.06 / 0.02
O88544 / COP9 signalosome complex subunit 4 / 0.13 / 0.02 / 0.09 / 0.02 / 0.11 / 0.02
O88844 / Isocitrate dehydrogenase [NADP] cytoplasmic / 1.06 / 0.07 / 1.00 / 0.11 / 1.11 / 0.05
O95101 / Cytochrome C oxidase subunit VIa homolog / 1.11 / 0.10 / 1.00 / 0.16 / 0.92 / 0.13
P00920 / Carbonic anhydrase 2 / 0.62
0.21
0.80 / 0.08
0.01
0.05 / 0.45
0.19
0.64 / 0.11
0.03
0.05 / 0.46
0.16
0.76 / 0.07
0.03
0.07
P05063 / Fructose-bisphosphate aldolase C / 0.17
0.48 / 0.02
0.04 / 0.15
0.46 / 0.01
0.04 / 0.16
0.45 / 0.01
0.04
P05201 / Aspartate aminotransferase / 0.59 / 0.05 / 0.54 / 0.13 / 0.53 / 0.07
P08228 / Superoxide dismutase [Cu-Zn] / 0.77 / 0.07 / 0.80 / 0.09 / 0.78 / 0.09
P08249 / Malate dehydrogenase, mitochondrial precursor / 1.42 / 0.35 / 1.34 / 0.33 / 1.13 / 0.30
P09411 / Phosphoglycerate kinase 1 / 1.08 / 0.14 / 1.44 / 0.18 / 0.61 / 0.17
P09671 / Superoxide dismutase [Mn], mitochondrial precursor / 0.75
0.29 / 0.06
0.02 / 0.73
0.39 / 0.07
0.03 / 0.67
0.29 / 0.07
0.03
P10649 / Glutathione S-transferase Mu 1 / 0.51 / 0.08 / 0.53 / 0.12 / 0.35 / 0.06
P11404 / Fatty acid-binding protein, heart / 0.14 / 0.03 / 0.18 / 0.09 / 0.13 / 0.03
P12787 / Cytochrome c oxidase subunit 5A, mitochondrial precursor / 0.91 / 0.11 / 1.00 / 0.14 / 0.85 / 0.11
P13639 / Elongation factor 2 / 0.16 / 0.02 / 0.13 / 0.02 / 0.16 / 0.03
P14152 / Malate dehydrogenase / 0.07 / 0.01 / 0.08 / 0.01 / 0.09 / 0.01
P15532 / Nucleoside diphosphate kinase A / 0.82 / 0.04 / 0.77 / 0.05 / 0.86 / 0.04
P16125 / L-lactate dehydrogenase B chain / 1.36 / 0.14 / 1.34 / 0.09 / 1.55 / 0.13
P16858 / Glyceraldehyde-3-phosphate dehydrogenase / 0.21 / 0.02 / 0.17 / 0.03 / 0.26 / 0.04
P17182 / Alpha-enolase / 0.86
0.83
0.32 / 0.04
0.04
0.06 / 0.85
0.88
0.30 / 0.07
0.13
0.02 / 0.92
0.81
0.28 / 0.05
0.08
0.03
P17183 / Gamma-enolase / 0.43
0.59
1.50 / 0.06
0.15
0.21 / 0.42
0.45
1.47 / 0.07
0.09
0.21 / 0.75
0.54
1.49 / 0.08
0.11
0.15
P17742 / Peptidyl-prolyl cis-trans isomerase A / 1.12
0.68
0.64
2.19 / 0.19
0.02
0.06
0.13 / 0.99
0.78
0.49
1.83 / 0.26
0.09
0.07
0.28 / 0.87
0.76
0.59
1.78 / 0.12
0.03
0.07
0.21
P17751 / Triosephosphate isomerase / 0.43
0.06
0.90 / 0.02
0.01
0.04 / 0.47
0.07
0.85 / 0.03
0.01
0.06 / 0.47
0.08
0.90 / 0.03
0.01
0.06
P20108 / Thioredoxin-dependent peroxide reductase, mitochondrial precursor / 0.39 / 0.02 / 0.39 / 0.02 / 0.38 / 0.03
P23506 / Protein-L-isoaspartate(D-aspartate) O-methyltransferase / 0.23 / 0.03 / 0.24 / 0.03 / 0.26 / 0.01
P26443 / Glutamate dehydrogenase 1, mitochondrial precursor / 0.54
1.20
0.39
0.26 / 0.03
0.02
0.05
0.02 / 0.48
0.96
0.34
0.26 / 0.04
0.02
0.02
0.02 / 0.56
1.01
0.35
0.28 / 0.03
0.02
0.03
0.02
P26638 / Seryl-tRNA synthetase / 0.12
0.07 / 0.01
0.02 / 0.11
0.08 / 0.01
0.02 / 0.13
0.06 / 0.01
0.01
P29758 / Ornithine aminotransferase, mitochondrial precursor / 0.18 / 0.02 / 0.26 / 0.08 / 0.23 / 0.06
P45376 / Aldose reductase / 0.30 / 0.02 / 0.29 / 0.01 / 0.28 / 0.01
P46460 / Vesicle-fusing ATPase / 0.11 / 0.02 / 0.10 / 0.01 / 0.11 / 0.01
P46471 / Proteasome 26S subunit ATPase 2 / 1.18 / 0.08 / 1.15 / 0.14 / 1.19 / 0.08
P47738 / Aldehyde dehydrogenase, mitochondrial precursor / 0.32 / 0.03 / 0.31 / 0.06 / 0.33 / 0.02
P48202 / ATP synthase lipid-binding protein, mitochondrial precursor / 1.56
0.18
1.24
2.68 / 0.17
0.04
0.29
0.47 / 1.71
0.18
1.18
2.20 / 0.10
0.06
0.29
0.59 / 1.31
0.17
1.35
0.91 / 0.30
0.08
0.23
0.26
P49722 / Proteasome subunit alpha type 2 / 0.13
0.36 / 0.02
0.09 / 0.13
0.32 / 0.02
0.02 / 0.13
0.41 / 0.02
0.04
P50171 / Estradiol 17-beta-dehydrogenase 8 / 0.22 / 0.03 / 0.29 / 0.03 / 0.27 / 0.01
P52480 / Pyruvate kinase 3 / 0.69
0.58
0.33
0.29
0.16 / 0.15
0.10
0.06
0.09
0.01 / 0.68
0.47
0.44
0.23
0.14 / 0.15
0.06
0.09
0.09
0.01 / 0.69
0.46
0.30
0.15
0.16 / 0.10
0.04
0.08
0.04
0.01
P54923 / [Protein ADP-ribosylarginine] hydrolase / 3.44 / 0.17 / 3.08 / 0.11 / 3.53 / 0.26
P56480 / ATP synthase subunit beta / 2.17 / 0.22 / 2.00 / 0.23 / 2.37 / 0.16
P60487 / Pyridoxal phosphate phosphatase / 0.26 / 0.02 / 0.13 / 0.02 / 0.25 / 0.03
P61088 / Ubiquitin-conjugating enzyme E2 N / 0.15 / 0.02 / 0.16 / 0.01 / 0.14 / 0.02
P61979 / Heterogeneous nuclear ribonucleoprotein K / 0.13 / 0.02 / 0.16 / 0.02 / 0.14 / 0.02
P62196 / 26S protease regulatory subunit 8 / 0.11 / 0.01 / 0.12 / 0.02 / 0.13 / 0.03
P62815 / Vacuolar ATP synthase subunit B, brain isoform / 0.22
0.32
0.05 / 0.05
0.06
0.01 / 0.23
0.31
0.07 / 0.04
0.06
0.06 / 0.27
0.35
0.06 / 0.05
0.06
0.01
P67779 / Prohibitin / 0.38
0.78 / 0.04
0.06 / 0.30
0.83 / 0.07
0.04 / 0.43
0.85 / 0.06
0.09
P70296 / Phosphatidylethanolamine-binding protein 1 / 0.29
1.61 / 0.07
0.12 / 0.51
1.52 / 0.13
0.15 / 0.31
1.55 / 0.14
0.17
P70333 / Heterogeneous nuclear ribonucleoprotein H' / 0.22
0.12 / 0.02
0.02 / 0.20
0.14 / 0.02
0.01 / 0.18
0.13 / 0.04
0.01
P70349 / Histidine triad nucleotide-binding protein 1 / 0.41 / 0.01 / 0.39 / 0.02 / 0.39 / 0.03
P97807 / Fumarate hydratase, mitochondrial precursor / 0.25
0.19 / 0.03
0.02 / 0.23
0.19 / 0.01
0.02 / 0.23
0.18 / 0.02
0.01
Q00612 / Glucose-6-phosphate 1-dehydrogenase X / 0.19 / 0.02 / 0.20 / 0.03 / 0.20 / 0.02
Q04447 / Creatine kinase B-type / 0.56
0.05
0.48
2.25 / 0.10
0.01
0.06
0.24 / 0.47
0.07
0.54
1.98 / 0.07
0.01
0.18
0.29 / 0.55
0.06
0.40
2.07 / 0.06
0.01
0.07
0.23
Q05816 / Fatty acid-binding protein / 0.11 / 0.03 / 0.15 / 0.04 / 0.15 / 0.02
Q05920 / Pyruvate carboxylase, mitochondrial precursor / 0.13 / 0.02 / 0.12 / 0.01 / 0.11 / 0.01
Q1V1Z7 / Glyceraldehyde-3-phosphate dehydrogenase (Phosphorylating) / 0.59
0.35
1.45
1.33
1.14 / 0.10
0.06
0.38
0.50
0.21 / 0.59
0.33
1.78
1.18
1.31 / 0.17
0.10
0.65
0.65
0.19 / 0.76
0.33
1.02
1.02
1.43 / 0.07
0.05
0.28
0.25
0.16
Q3TPR2 / Signal transducing adaptor molecule / 0.13 / 0.04 / 0.07 / 0.03 / 0.08 / 0.03
Q542C5 / Adenylate kinase 1 / 0.34 / 0.02 / 0.41 / 0.02 / 0.35 / 0.02
Q5D098 / Psmb7 protein / 0.19 / 0.01 / 0.19 / 0.02 / 0.21 / 0.02
Q64105 / Sepiapterin reductase / 0.09 / 0.02 / 0.08 / 0.01 / 0.09 / 0.01
Q64513 / Triosephosphate isomerase / 0.05 / 0.00 / 0.06 / 0.01 / 0.05 / 0.01
Q64520 / Guanylate kinase (GMP kinase) / 0.07 / 0.01 / 0.09 / 0.01 / 0.08 / 0.01
Q6PFZ2 / Oxoglutarate dehydrogenase protein / 0.05 / 0.01 / 0.05 / 0.01 / 0.05 / 0.01
Q7TND9 / Dihydrolipoamide branched chain transacylase E2 / 0.14 / 0.02 / 0.14 / 0.03 / 0.14 / 0.01
Q8BFR5 / Elongation factor Tu, mitochondrial precursor / 0.46 / 0.03 / 0.44 / 0.03 / 0.47 / 0.02
Q8BH04 / Phosphoenolpyruvate carboxykinase [GTP], mitochondrial precursor / 0.11 / 0.02 / 0.09 / 0.01 / 0.09 / 0.02
Q8BKZ9 / Pyruvate dehydrogenase protein X component, mitochondrial precursor / 0.12 / 0.02 / 0.13 / 0.01 / 0.12 / 0.01
Q8BWF0 / Succinate semialdehyde dehydrogenase, mitochondrial precursor / 0.08 / 0.02 / 0.12 / 0.02 / 0.10 / 0.02
Q8BWM5 / Glycerol-3-phosphate dehydrogenase / 0.29 / 0.04 / 0.21 / 0.03 / 0.28 / 0.02
Q8C5R8 / Ribose-phosphate pyrophosphokinase / 0.21 / 0.02 / 0.18 / 0.02 / 0.19 / 0.02
Q8C603 / 3-phosphoglycerate dehydrogenase / 0.14
0.22 / 0.02
0.02 / 0.16
0.21 / 0.02
0.02 / 0.13
0.25 / 0.02
0.02
Q8CBX6 / Glycerol phosphate dehydrogenase 1 / 0.17
0.04 / 0.01
0.01 / 0.18
0.03 / 0.02
0.01 / 0.18
0.03 / 0.02
0.01
Q8CD11 / Serine racemase / 0.19
0.09
0.30 / 0.02
0.01
0.05 / 0.23
0.07
0.25 / 0.06
0.01
0.05 / 0.22
0.09
0.40 / 0.03
0.02
0.02
Q8CHX2 / ATPase, H+ transporting, lysosomal V1 subunit A / 1.33 / 0.12 / 1.38 / 0.29 / 1.30 / 0.15
Q8JZR2 / Crk protein / 0.29 / 0.01 / 0.30 / 0.01 / 0.30 / 0.02
Q8K183 / Pyridoxal kinase / 1.39 / 0.18 / 1.48 / 0.10 / 1.63 / 0.13
Q8K1M6 / Dynamin-1-like protein / 0.13 / 0.02 / 0.10 / 0.01 / 0.15 / 0.02
Q8K2L0 / NADH dehydrogenase (Ubiquinone) flavoprotein 2 / 0.14 / 0.01 / 0.14 / 0.02 / 0.15 / 0.01
Q8VC72 / NADH dehydrogenase (Ubiquinone) Fe-S protein 8 / 0.21 / 0.02 / 0.22 / 0.03 / 0.21 / 0.02
Q8VDQ8 / NAD-dependent deacetylase sirtuin-2 / 0.34 / 0.06 / 0.31 / 0.03 / 0.31 / 0.02
Q91V12 / Cytosolic acyl coenzyme A thioester hydrolase (Brain acyl-CoA hydrolase) / 0.12
0.31 / 0.03
0.04 / 0.19
0.24 / 0.04
0.02 / 0.11
0.25 / 0.03
0.03
Q91VC6 / Glutamine synthetase / 1.85
0.71
0.19 / 0.11
0.05
0.02 / 1.79
0.76
0.19 / 0.22
0.02
0.03 / 1.81
0.75
0.16 / 0.13
0.05
0.03
Q91VW4 / Uroporphyrinogen decarboxylase / 0.09 / 0.01 / 0.07 / 0.02 / 0.09 / 0.01
Q91WP2 / Oxoglutarate dehydrogenase / 0.04 / 0.01 / 0.05 / 0.01 / 0.04 / 0.01
Q91XF0 / Pyridoxine-5'-phosphate oxidase / 0.10 / 0.01 / 0.09 / 0.01 / 0.09 / 0.01
Q91ZA3 / Propionyl-CoA carboxylase alpha chain, mitochondrial precursor / 0.13
0.05 / 0.01
0.01 / 0.12
0.06 / 0.01
0.01 / 0.12
0.03 / 0.01
0.01
Q91ZB1 / Dihydrolipoamide S-acetyltransferase / 0.29
0.07 / 0.06
0.01 / 0.28
0.05 / 0.06
0.01 / 0.31
0.07 / 0.05
0.01
Q91ZR9 / Heterogeneous nuclear ribonucleoprotein A2/B1 / 0.28
0.42
0.13 / 0.06
0.04
0.04 / 0.22
0.45
0.17 / 0.05
0.06
0.08 / 0.17
0.33
0.13 / 0.04
0.07
0.03
Q921P5 / Succinate dehydrogenase flavoprotein / 0.08 / 0.01 / 0.08 / 0.01 / 0.06 / 0.01
Q99J99 / 3-mercaptopyruvate sulfurtransferase / 0.20 / 0.02 / 0.18 / 0.02 / 0.21 / 0.01
Q99KI0 / Aconitate hydratase, mitochondrial precursor / 0.67 / 0.14 / 0.65 / 0.11 / 0.63 / 0.06
Q99LD0 / VATPase, H+ transporting, lysosomal V1 subunit E1 / 1.47 / 0.09 / 1.38 / 0.12 / 1.35 / 0.15
Q99LF6 / Protein disulfide isomerase associated 3 / 0.09 / 0.01 / 0.08 / 0.01 / 0.08 / 0.00
Q99LX0 / Protein DJ-1 / 0.37 / 0.02 / 0.37 / 0.03 / 0.38 / 0.02
Q9D051 / Pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor / 0.30 / 0.04 / 0.36 / 0.06 / 0.37 / 0.05
Q9D3D9 / ATP synthase delta chain, mitochondrial precursor / 0.86 / 0.04 / 0.88 / 0.06 / 0.78 / 0.03
Q9D6R2 / Isocitrate dehydrogenase [NAD] subunit alpha / 0.20
0.27
0.29
1.06
0.32 / 0.02
0.04
0.03
0.12
0.03 / 0.19
0.26
0.22
1.00
0.44 / 0.04
0.02
0.04
0.10
0.08 / 0.21
0.29
0.30
1.11
0.31 / 0.03
0.02
0.03
0.10
0.03
Q9D967 / Magnesium-dependent phosphatase 1 / 0.15 / 0.07 / 0.13 / 0.15 / 0.10 / 0.06
Q9DBB8 / Dimeric dihydrodiol dehydrogenase / 0.08 / 0.02 / 0.08 / 0.02 / 0.09 / 0.01
Q9DBF1 / Aldehyde dehydrogenase family 7 member A1 / 0.15 / 0.01 / 0.19 / 0.03 / 0.13 / 0.01
Q9DBJ1 / Phosphoglycerate mutase 1 / 0.13
0.33
2.01 / 0.02
0.02
0.08 / 0.15
0.33
1.80 / 0.02
0.03
0.16 / 0.13
0.32
1.89 / 0.02
0.03
0.10
Q9DBP5 / Uridine monophosphate/cytidine monophosphate kinase / 0.30 / 0.05 / 0.34 / 0.05 / 0.36 / 0.05
Q9EQ20 / Methylmalonate-semialdehyde dehydrogenase / 0.58
0.38 / 0.07
0.04 / 0.49
0.31 / 0.09
0.02 / 0.51
0.35 / 0.06
0.04
Q9JHI5 / Isovaleryl-CoA dehydrogenase, mitochondrial precursor / 0.17 / 0.02 / 0.18 / 0.03 / 0.18 / 0.01
Q9JHU9 / Myo-inositol 1-phosphate synthase A1 / 0.04 / 0.01 / 0.04 / 0.01 / 0.03 / 0.01
Q9JHW2 / Nit protein 2 / 0.09 / 0.01 / 0.08 / 0.01 / 0.09 / 0.02
Q9JII6 / Alcohol dehydrogenase [NADP+] / 0.31 / 0.02 / 0.27 / 0.03 / 0.27 / 0.05
Q9QUM9 / Proteasome subunit alpha type 6 / 0.33 / 0.02 / 0.30 / 0.03 / 0.32 / 0.03
Q9QZ88 / Vacuolar protein sorting-associated protein 29 / 0.07 / 0.01 / 0.08 / 0.01 / 0.07 / 0.01
Q9R0P9 / Ubiquitin carboxyl-terminal hydrolase isozyme L1 / 0.65
0.91 / 0.10
0.13 / 0.59
1.01 / 0.07
0.16 / 0.51
1.23 / 0.06
0.14
Q9R1P1 / Proteasome subunit beta type 3 / 0.23 / 0.04 / 0.24 / 0.06 / 0.27 / 0.02
Q9R1P3 / Proteasome subunit beta type 2 / 0.36 / 0.02 / 0.33 / 0.02 / 0.34 / 0.02
Q9R1P4 / Proteasome subunit alpha type 1 / 0.34 / 0.03 / 0.32 / 0.03 / 0.38 / 0.03
Q9WV34 / MAGUK p55 subfamily member 2 / 0.04 / 0.01 / 0.05 / 0.01 / 0.03 / 0.00

Quantification of miscellaneous proteins:

Accession / Name / Ctl / Mg-R / Mg-R PAR
Number / Mean / SEM / Mean / SEM / Mean / SEM
P42669 / Transcriptional activator protein Pur-alpha / 0.09 / 0.02 / 0.07 / 0.02 / 0.08 / 0.01
Q8BGH2 / 93% Identity to: Transformation-related protein 3 (Q56VW7) / 0.11 / 0.01 / 0.11 / 0.02 / 0.12 / 0.04
Q8C7C3 / Tropomyosin 3, gamma / 0.78 / 0.26 / 1.09 / 0.21 / 0.58 / 0.22
Q8C7C7 / Albumin 1 / 0.55 / 0.03 / 0.57 / 0.05 / 0.53 / 0.02
Q8CAQ8 / Mitochondrial inner membrane protein (Mitofilin) / 0.07
0.11 / 0.00
0.01 / 0.08
0.13 / 0.01
0.02 / 0.07
0.14 / 0.01
0.02
Q9CPX4 / Ferritin light chain 1 / 0.14 / 0.03 / 0.17 / 0.02 / 0.15 / 0.03
Q9CXW2 / Mitochondrial 28S ribosomal protein S22 / 0.09 / 0.01 / 0.07 / 0.01 / 0.08 / 0.01
Q9CY12 / Hemoglobin, beta / 1.28
5.14 / 0.12
0.40 / 1.36
4.93 / 0.07
0.47 / 1.70
5.05 / 0.32
0.98

Quantification of neurotransmission related proteins:

Accession / Name / Ctl / Mg-R / Mg-R PAR
Number / Mean / SEM / Mean / SEM / Mean / SEM
O88935 / Synapsin-1 / 0.13 / 0.01 / 0.12 / 0.03 / 0.09 / 0.02
P60878 / Synaptosomal-associated protein 25 / 1.70 / 0.29 / 2.28 / 0.28 / 1.78 / 0.30
P61765 / Syntaxin-binding protein 1 / 0.17 / 0.02 / 0.14 / 0.03 / 0.17 / 0.02
Q60829 / Dopamine- and cAMP-regulated neuronal phosphoprotein / 0.52 / 0.07 / 0.32 / 0.03 / 0.52 / 0.05
Q64332 / Synapsin-2 / 0.28
0.35
0.41
0.22
0.33 / 0.07
0.03
0.06
0.04
0.04 / 0.27
0.36
0.32
0.21
0.26 / 0.08
0.03
0.05
0.04
0.05 / 0.21
0.34
0.37
0.16
0.31 / 0.04
0.02
0.04
0.03
0.05

Quantification of signalling proteins:

Accession / Name / Ctl / Mg-R / Mg-R PAR
Number / Mean / SEM / Mean / SEM / Mean / SEM
O08553 / Dihydropyrimidinase-related protein 2 / 0.19
0.06
0.13
0.07
0.05
0.43
0.06
0.09
0.82
0.12 / 0.02
0.01
0.01
0.01
0.01
0.03
0.01
0.01
0.07
0.03 / 0.23
0.05
0.14
0.07
0.08
0.45
0.05
0.10
0.83
0.12 / 0.02
0.01
0.01
0.00
0.01
0.03
0.01
0.01
0.09
0.01 / 0.21
0.06
0.14
0.07
0.07
0.48
0.05
0.11
0.91
0.09 / 0.02
0.01
0.01
0.01
0.01
0.04
0.00
0.02
0.06
0.01
P08226 / Apolipoprotein E, precursor / 0.24 / 0.04 / 0.31 / 0.14 / 0.18 / 0.03
P14211 / Calreticulin precursor / 0.25 / 0.04 / 0.30 / 0.08 / 0.27 / 0.04
P31938 / Dual specificity mitogen-activated protein kinase kinase 1 / 0.21
0.25 / 0.03
0.05 / 0.18
0.25 / 0.04
0.03 / 0.22
0.23 / 0.01
0.01
P50396 / Rab GDP dissociation inhibitor alpha / 0.07 / 0.01 / 0.10 / 0.02 / 0.08 / 0.02
P57759 / Endoplasmic reticulum protein ERp29 / 0.11 / 0.01 / 0.12 / 0.01 / 0.11 / 0.01
P61981 / 14-3-3 protein gamma (Protein kinase C inhibitor protein 1) / 1.64 / 0.28 / 2.11 / 0.35 / 2.25 / 0.52
P62137 / Serine/threonine-protein phosphatase PP1-alpha catalytic subunit / 0.05 / 0.01 / 0.07 / 0.03 / 0.07 / 0.01
P62140 / Serine/threonine-protein phosphatase PP1-beta catalytic subunit / 0.13 / 0.01 / 0.13 / 0.02 / 0.12 / 0.01
P62157 / Calmodulin / 1.78 / 0.36 / 1.64 / 0.60 / 1.85 / 0.34
P62259 / 14-3-3 protein epsilon / 0.59
0.50 / 0.18
0.11 / 0.80
0.81 / 0.24
0.22 / 0.79
0.64 / 0.15
0.10
P62879 / Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 / 0.63
1.25
0.37 / 0.02
0.18
0.17 / 0.49
1.00
0.67 / 0.05
0.10
0.18 / 0.51
1.17
0.33 / 0.05
0.24
0.06
Q08331 / Calretinin / 2.54 / 0.28 / 3.30 / 0.20 / 3.47 / 0.27
Q3UM45 / Protein phosphatase 1 regulatory subunit 7 / 0.43 / 0.03 / 0.39 / 0.04 / 0.31 / 0.05
Q60631 / Growth factor receptor-bound protein 2 / 0.17 / 0.01 / 0.15 / 0.02 / 0.14 / 0.01
Q62108 / Discs large homolog 4 (Postsynaptic density protein 95) / 0.06 / 0.01 / 0.05 / 0.01 / 0.05 / 0.01
Q62188 / Dihydropyrimidinase-related protein 3 / 0.10
0.05
0.05 / 0.01
0.00
0.01 / 0.11
0.06
0.05 / 0.04
0.01
0.01 / 0.10
0.05
0.05 / 0.01
0.01
0.01
Q78MH6 / Voltage-dependent anion channel 2 / 0.97 / 0.05 / 0.97 / 0.07 / 1.28 / 0.10
Q8BGX9 / Tropomodulin 2 / 0.20
0.37 / 0.02
0.02 / 0.29
0.36 / 0.02
0.03 / 0.21
0.43 / 0.03
0.03
Q9CWS0 / NG,NG-dimethylarginine dimethylaminohydrolase 1 / 0.56 / 0.05 / 0.38 / 0.04 / 0.59 / 0.04
Q9EQF6 / Dihydropyrimidinase-related protein 5 / 0.49
0.25 / 0.11
0.04 / 0.37
0.28 / 0.04
0.03 / 0.44
0.24 / 0.03
0.06
Q9WU78 / Programmed cell death 6-interacting protein / 0.09
0.26 / 0.02
0.04 / 0.04
0.25 / 0.03
0.04 / 0.10
0.28 / 0.02
0.03
Q9Z2L0 / Voltage-dependent anion-selective channel protein 1 / 0.10
0.42
0.80
0.85
1.10
0.31
0.12 / 0.01
0.10
0.12
0.15
0.30
0.02
0.02 / 0.18
0.34
0.78
0.74
1.16
0.31
0.14 / 0.01
0.04
0.12
0.26
0.34
0.02
0.01 / 0.18
0.34
0.69
0.69
1.64
0.31
0.11 / 0.01
0.02
0.14
0.22
0.14
0.02
0.02

Quantification of structural proteins:

Accession / Name / Ctl / Mg-R / Mg-R PAR
Number / Mean / SEM / Mean / SEM / Mean / SEM
O08917 / Flotillin-1 / 0.11 / 0.03 / 0.07 / 0.01 / 0.09 / 0.02
O88342 / WD repeat protein 1 (Actin-interacting protein ) / 0.23
0.19 / 0.02
0.03 / 0.20
0.17 / 0.02
0.01 / 0.22
0.17 / 0.02
0.01
O89053 / Coronin-1A / 0.48 / 0.04 / 0.58 / 0.10 / 0.52 / 0.05
P04370 / Myelin basic protein / 0.10 / 0.01 / 0.04 / 0.01 / 0.05 / 0.02
P08551 / Neurofilament triplet L protein / 0.33 / 0.05 / 0.44 / 0.05 / 0.43 / 0.05
P18760 / Cofilin-1 / 0.15 / 0.01 / 0.17 / 0.02 / 0.13 / 0.03
P26040 / Ezrin / 0.05 / 0.00 / 0.06 / 0.03 / 0.07 / 0.00
P39053 / Dynamin-1 / 0.33
0.17 / 0.05
0.03 / 0.28
0.16 / 0.06
0.02 / 0.29
0.16 / 0.08
0.02
P47753 / F-actin capping protein alpha-1 subunit / 1.03 / 0.04 / 1.16 / 0.08 / 1.22 / 0.06
P47754 / F-actin capping protein alpha-2 subunit / 0.84 / 0.12 / 0.80 / 0.07 / 0.86 / 0.07
P47757 / F-actin capping protein subunit beta / 1.13 / 0.08 / 1.10 / 0.08 / 1.08 / 0.14
P54227 / Stathmin / 0.47 / 0.07 / 0.62 / 0.10 / 0.42 / 0.06
P60710 / Actin, cytoplasmic 1 (beta-actin) / 4.95
1.13 / 0.50
0.11 / 3.29
0.84 / 0.46
0.12 / 3.77
1.11 / 0.41
0.17
P61163 / Alpha-centractin / 0.41 / 0.05 / 0.39 / 0.03 / 0.44 / 0.04
P68361 / Tubulin alpha-1 chain / 0.06 / 0.02 / 0.05 / 0.01 / 0.05 / 0.01
P68368 / Tubulin alpha-4 chain / 0.08 / 0.01 / 0.13 / 0.01 / 0.09 / 0.01
P68372 / Tubulin beta-2C chain / 0.06 / 0.01 / 0.05 / 0.01 / 0.05 / 0.01
P68373 / Tubulin alpha-6 chain / 0.15 / 0.03 / 0.10 / 0.05 / 0.10 / 0.01
Q7TN32 / Fascin / 0.11 / 0.01 / 0.11 / 0.01 / 0.13 / 0.02
Q7TNT7 / Sept3 protein / 0.19 / 0.02 / 0.18 / 0.02 / 0.18 / 0.02
Q80V75 / Fscn1 protein / 0.37 / 0.02 / 0.31 / 0.03 / 0.38 / 0.02
Q8BQ20 / Neurofilament triplet protein / 0.24 / 0.03 / 0.22 / 0.05 / 0.30 / 0.04
Q8C1B7 / Septin-11 / 0.35
0.19
0.18 / 0.01
0.02
0.01 / 0.35
0.18
0.18 / 0.02
0.02
0.02 / 0.33
0.19
0.22 / 0.02
0.03
0.04
Q8CHH9 / Septin-8 / 0.15
0.04
0.07 / 0.04
0.01
0.01 / 0.14
0.06
0.11 / 0.01
0.01
0.01 / 0.11
0.03
0.08 / 0.02
0.00
0.01
Q8R5C5 / Beta-centractin / 0.42 / 0.03 / 0.43 / 0.03 / 0.47 / 0.02
Q9CQI6 / Coactosin-like protein / 0.22 / 0.04 / 0.20 / 0.04 / 0.15 / 0.03
Q9CXF8 / Synuclein, alpha / 1.02 / 0.28 / 1.46 / 0.10 / 1.30 / 0.15
Q9JJV2 / Profilin-2 / 0.62 / 0.04 / 0.63 / 0.08 / 0.67 / 0.03
Q9R1Q8 / Transgelin-3 (Neuronal protein NP25) / 0.47 / 0.02 / 0.44 / 0.02 / 0.47 / 0.01
Q9Z0Y1 / Dynactin subunit 3 / 0.47 / 0.06 / 0.49 / 0.05 / 0.49 / 0.05
Q9Z2Q6 / Septin-5 / 0.10
0.43 / 0.02
0.05 / 0.10
0.49 / 0.02
0.04 / 0.10
0.48 / 0.02
0.02
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