Table S4. Genes and Qtls That Influence Age-Related Hearing Loss in Laboratory Strains

Table S4. Genes and Qtls That Influence Age-Related Hearing Loss in Laboratory Strains

Table S4. Genes and QTLs that influence age-related hearing loss in laboratory strains of mice.

AHL / Strains used for genetic mapping
Locus (Gene) / Chr / Location / Mapping Methods * / Susceptibility Allele / Protective Allele / References
ahl (Cdh23) / 10 / 60 Mb / backcross, haplotypes / >10 strains / CBA/CaJ, CAST/Ei / 1-3
ahl2(QTL) / 5 / 65-100 Mb / backcross / NOD/LtJ / C57BL/6J, CAST/Ei / 4
ahl3(QTL) / 17 / 65-69 Mb / CS strains, backcross / C57BL/6J / MSM / 5,6
ahl4 (Cs) / 10 / 128 Mb / RI, CS strains, backcross / A/J / C57BL/6J, CAST/Ei / 7,8
ahl5 (Gipc3) / 10 / 81 Mb / backcross, intercross / Black Swiss / CAST/Ei / 9,10
ahl6(QTL) / 18 / 64-76 Mb / backcross / Black Swiss / CAST/Ei / 9
ahl8 (Fscn2) / 11 / 120 Mb / RI strains, backcross / DBA/2J / C57BL/6J, CAST/Ei / 11
ahl9(QTL) / 18 / 73-77 Mb / RI strains / DBA/2J / C57BL/6J / 12
Hfhl1(QTL) / 7 / 20-38 cM / line selection and backcross / NIH Swiss / C3HeB/FeJ / 13
Hfhl2(QTL) / 8 / 20-32 cM / line selection and backcross / NIH Swiss / C3HeB/FeJ / 13
Hfhl3(QTL) / 9 / 30-50 cM / line selection and backcross / NIH Swiss / C3HeB/FeJ / 14
nphl (QTL) / 17 / 8-26 Mb / CBACa.129S6 congenic strain / 129S6/SvEvTac / CBA/CaJ / 15
Phl1(QTL) / 17 / 8-29 Mb / intercross / 101/H / MAI/Pas, MBT/Pas / 16
Phl2 (QTL) / 10 / 48-70 Mb / intercross / 101/H / MAI/Pas, MBT/Pas / 16
Snhl1 (QTL) / 10 / 54-60 Mb / RI strains / ISS (DBA/2J-derived) / ILS (C3H/HeJ-derived) / 17
Snhl2 (QTL) / 1 / 133-172 Mb / backcross / ALR/LtJ / C3HeB/FeJ / 18
Snhl3 (QTL) / 6 / 121-143 Mb / backcross / ALR/LtJ / C3HeB/FeJ / 18
Snhl4 (QTL) / 10 / 49-90 Mb / backcross / ALR/LtJ / C3HeB/FeJ / 18
mtDNA (mt-Tr) / mitochondria / backcross / A/J / CAST/Ei / 19

* CS= chromosome substitution; RI = recombinant inbred

References

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