Muhammad Saleem, Ph.D.

Department of Chemistry, Baghdad-ul-Jadeed Campus

The Islamia Univerisyt of Bahawalpur, Pakistan

Phone # 0302-7710708

E-mail:

PERSONNELS

Name
Father’s name

Date of Birth

N.I.C. No.
Domicile
Marital Status
Nationality / Muhammad Saleem
Muhammad Sadiq
10th. August 1970
42201-0637460-3
Lodhran, Pakistan
Married
Pakistani /

PRESENT POSITION

  • HEC Approved Supervisor
  • Working as Assistant Professor in the department of Chemistry, The Islamia University of Bahawalpur.
  • Team leader of M. Phil. And Ph. D. Rsearch students with 5 indegenous scholors.

ACADEMICS

Postdoctoral Studies (2006): Alexander Von Humboldt Fellow at University of Goettingen, Germany.

Topic of Research:Novel anticancer compounds from marine derived Organisms

Postdoctoral Studies 2003-2005: Korea Organization of Science and Engineering Foundation (KOSEF) fellow at Korea institute of Science and Technology (KIST), Seoul, South Korea.

Topic of Research: Development of Anti-oxidative Neuroprotective Neutralecuticals agents and anti-HIV integrases from higher plants.

Ph. D. Chemistry 1997-2000: H.E.J. Research Institute of Chemistry, InternationalCenter for Chemical Sciences (ICCS), University of Karachi, Pakistan.

Title of Thesis: Chemical and Biological screening of relatives of the Family Lamiaceae (Labiatae) and Marine Green Alga Codium iyengarii.

M.Sc. Chemistry 1995-1997: Islamia UniversityBahawalpur, Pakistan.

Title of Thesis: Isolation of Coumarines from the Leaves of Citrus Aurantifolia.

Bachelors in Science 1992-1994: TheIslamia University of Bahawalpur, Pakistan.

Major Subjects:Chemistry, Botany, Zoology.

RESEARCH/PROFESSIONAL EXPERIENCE

At Present: Working as Assistant Professor in Chemistry Department of The Islamia UniversityBahawalpur, Pakistan

2006 to Feb 2007 Postdoctoral Research: Institute for Organic and Biomolecular Chemistry The Georg-August-University, Göttingen, Germany

Topic:Novelanticancer compounds from marine derived Organisms

2004 to 2005, Visiting Scientist: Medicinal Chemistry Research Center, Division of Life Sciences, Korea Institute of Science and Technology (KIST), Seoul, South Korea

Topic:Development of Anti-oxidative Neuroprotective Neutralecuticals agents and anti-HIV integrases from higher plants.

2003 to 2004, Postdoctoral Research: Medicinal Chemistry Research Center, Division of Life Sciences, Korea Institute of Science and Technology (KIST), Seoul, South Korea.

Topic:Development of Anti-oxidative Neuroprotective Neutralecuticals agents from higher plants.

2001-2003 Senior Scientific Officer:PharmaceuticalResearchCenter, PCSIR Labs Karachi, Pakistan

Responsibilities:Involved in R&D programs and carry out projects as development of hormonal precursors, Cosmaceutical agents, Essential oils and their evaluations, laboratory managements and Industrial analysis.

2000-2001 Scientific Officer: PharmaceuticalResearchCenter, PCSIR Labs Karachi, Pakistan

Responsibilities:: Involved in R&D programs and carry out projects, laboratory managements and Industrial analysis

1997-2000 Junior Research Fellow: H.E.J. Research Institute of Chemistry, University of Karachi, Pakistan.

Title: Chemical and Biological screening of some Members of the Family Lamiaceae (Labiatae) and Marine Green Alga Codium iyengarii

1994-1996 M.Sc. Thesis: Department of Chemistry, Islamia UniversityBahawalpur, Pakistan.

Topic: Isolation of Coumarines from the Leaves of Citrus aurantifolia.

TEACHING EXPERIENCE

  • Assistant Professor in the Department of Chemistry, The IslamiaUniversity of Bahawalpur since July 2007.
  • Prepared and taught a full course to MS and PhD students of International Research and DevelopmentAcademy at Korea Institute of Science and Technology (KIST), Seoul, Korea
SCHOLARSHIPSAWARDED AND DISTINCTIONS

Merit scholarship from directorate of colleges Bahawalpur Division on passing B.Sc. examination with excellence.

Research Fellowship from H.E.J.(1997 to 2000)

Distinction Certificate in M. Sc. Examination, 1997.

Korea Science and Engineering Foundation (KOSEF) Postdoctoral Fellowship for one year, 2003.

Two years Postdoctoral Fellowship from Korea Institute of Science and Technology, Seoul, South Korea, 2004-2005.

One year Postdoctoral Fellowship from Alexander von Humboldt Foundation, Germany, 2006-2007.

PRESENTATIONS/LECTURES

A 15-minute talk on Constituents of Zataria multiflora in 9th.National Chemistry Conference held at Karachi, Pakistan

A 60-minute talk on The Use of Chiral Boron Complexes in Asymmetric Organic Synthesis as per Ph.D. requirement.

A 60-minute talk on Total Synthesis of (+)- Acutiphycin and a Related Compound as per Ph.D. requirement.

A 60-minute talk on Ph.D. work as per Ph.D. requirement.

A poster entitled, "Marine Chemistry" presented in 7th. Eurasia conference held inKarachi, Pakistan on 09-03-2002-12-03-2002.

Delivered a lecture on "Column selection and protection in reversed phase chromatography" in a trainee course at PCSIR Labs. Karachi arranged by Pakistan Council of Science and Technology during 26-03-2002 to 30-03-2002.

A 30 minutes talk on “chemical constituents of Parthenocissus tricuspidata and their antioxidant evaluation”Korea-Magnolia second workshop of Biotechnology held at Korea Institute of Science and Technology (KIST), Seoul, Korea on 10-05-2004 to 12-05-2004.

Taught a full course on Natural Product chemistry at International Research and Development Academy (IRDA), Seoul, Korea

Delivered a 90 minute seminar on Natural product Chemistry and Drug development and utilization of Analytical techniques in Pharmaceutical Analysis at Department of Pharmacy, Faculty of Science, Islamia UniversityBahawalpur, Pakistan.

15 minute talk on “Novel Bioactive Compounds from Marine Bacteria” delivered at University of Bonn, Germany on 26th April 2006 during International meeting of AvH fellows from 25th to 27th April 2006.

A 90 minutes lecture delivered on “Folding Modes in Biosynthesis of Fused Ring Polyketides, A comparison of Fungal and Bacterial Metabolites with that of Higher Plants” at Natural product Section of the Institute of Organic and Biomolecular Chemistry, University of Goettingen, Germany.

SEMINAR, CONFERENCES AND WORKSHOPS ATTENDED

Workshop on the Use of Bioassay Techniques for New Drug Development held at H.E.J. Research Institute (8th. July 1997).

7th. International Symposium on Natural Product Chemistry held at Karachi (28th.December-1st.January 1998).

9th.National Chemistry Conference held at Karachi (6-8th.December 1998)

2nd.National Workshop on The Use of Bioassay Techniques for New Drug Development held at H.E.J.University of Karachi (26-28th. August 1999)

8th. International Symposium on Natural Product Chemistryheld at Karachi(18th. -22nd. January 2000).

Workshop on, "Information handling in Biological Research" held at Biochemistry Department, University of Karachi (4th. - 6th. March 2002).

7th. Eurasia conference on Chemical Sciences held at Hotel Marriott, Karachi, Pakistan on 09-03-2002 to 12-03-2002.

International Symposium on “Inflammatory and Oxidative Cell Death and Tissue Damage; Molecular Mechanism, Biomarkers and Chemoprevention” held at SeoulNationalUniversity, Seoul, Korea (2004).

Korea-Magnolia second workshop of Biotechnology held at Korea Institute of Science and Technology (KIST), Seoul, Korea on 10-05-2004 to 12-05-2004.

Took active part in International meeting of AvH fellows held at BonnGermany from 25th to 27th April 2006.

Alexander von Humboldt Network meeting held at Hotel Marriott, Islamabad, Pakistan on 28th of March 2007.

OTHER SKILLS

Experience in conducting the following Bioassays of Chemicals and Plant extracts:

  • Anti Bacterial Bioassay, Antifungal Bioassay, Insecticidal Bioassay, Phytotoxic Bioassay, Brine shrimp Bioassay and Enzyme inhibition Bioassay.

ANALYTICAL/MICROBIOLOGICAL CHEMISTRY SKILLS

  • Experience in working with HPLC,IR, UV, POLARIMETERY, and NMR techniques
  • Experience in conducting bioassays with microbial agents, making sub-cultures, fermentation and optimizations by biotransformation and culturing procedures.

COMPUTER LITERACY

Proficient in working with: Microsoft Word, Microsoft PowerPoint, Chem. window, Chem. Draw, ISIS Draw, ACD lab., Excel and Internet Tools.

TRAININGS OBTAINED

Attended trainee courses of ISO-9001 held at PCSIR Labs complex Karachi, Pakistan.

Attended trainee courses of ICE/ISO-17025 held at PCSIR Labs. Complex Karachi, Pakistan.

RESEARCH INTERESTS

  • Development of Anti-oxidative Neuroprotective Neutralecuticals agents and anti-HIV integrases from higherplants: Alkaloids, coumarines, flavonoids and lignans.
  • Chemical and Biological studies on marine algae.
  • Isolation, characterization and biological evaluation of terpenoids and steroids obtained from medicinal herbs.
  • Isolation and spectroscopic analysis of new antibiotics from microbial sources, and optimization of active new chemicals by biotransformation and culturing procedures.

PATENTS

1.S. Anjum, M. Saleem, N. Afza, M.A. Kalhoro and S.M.A. Hai, Production of "Medicinally Important Diosgenin" from Dioscorea bulbifera available in Pakistan, 513/2001, SI No 137729, Government of Pakistan Karachi Office.

2.M. Saleem, S. Perveen, R.A. Khan and N. Afza, "Process for the Production of Skin Caring Cream of pH 5.5", 427/2002, SI No 138106, Government of Pakistan Karachi Office.

3.Nighat Afza, Muhammad Saleem, Mahboob Ali Kalhoro and Muhammad Aijaz Anwar, A Process for the Development of an Herbal Inhaler and Cream for the Treatment of Blocked Sinuses, Asthma, Bronchitis, Cough and Cold and other Respiratory Tract Diseases, 800/2003, SI-138571, Government of Pakistan Karachi Office.

TECHNICAL REPORTS

List of Publications of Dr. Muhammad Saleem

Year 2008

  1. Muhammad Shaiq Ali, Shakil Ahmed and Muhammad Saleem (2008), Spirowallichiione: A Rearranged Multiflorane from Euphorbia wallichii Hook F. (Euphorbiaceae). Molecules 2008, 13, (accepted for publication).
  2. Hafizur Rahman, Mohamed Shaaban, Khaled A. Shaaban, Muhammad Saleem, Elisabeth Helmke, Iris Grün-Wollny, and Hartmut Laatsch, Secondary Metabolites from Streptomycetes B7967 and GW 5127. (Submitted to Natural Product Communication, 2008).
  3. Muhammad Saleem, Zhang Qun, Qin Song, and Hartmut LaatschHuanghaimycin, a new macrolide, and Chloenolaene, a chlorinated pyrane derivative, from the marine-derived Streptomycete L196. (Submitted to Journal ofNatural Products, 2008).
  4. Muhammad Saleem, Hafizur Rahman, Gerhard Wolf, and Hartmut Laatsch,Secondary Metabolites from Terrestrial Actinomycetes Wo1. (Submitted to Natural Product Communication, 2008).
  5. Muhammad Saleem, Gerhard Wolf and Hartmut Laatsch,Secondary Metabolites from a Terrestrial Actinomyces sp. Wo 23. (Submitted to Natural Product Communication, 2008).
  6. Qun Zhang, Muhammad Saleem, Fuchao Li, Song Qin, Hartmut Laatsch,Isolation and Structure Determination of Antibacterial Secondary Metabolites from Marine-Derived Streptomyces sp. L158. (Submitted to Journal ofNatural Products, 2008).

Year 2007

  1. Muhammad Saleem, Muhammad Shaiq Ali, Shaftqat Hussain, Abdul Jabbar, Muhammad Ashraf, Yong Sup Lee, Marine Natural products of Fungal Origin. Natural product Report (2007), 24, 1142-1152, (ISSN 0265-0568, Published in England)). Impact factor = 7.89.
  2. Muhammad Saleem, Hyoung Ja Kim, Changbae Jin and Yong Sup Lee. New antioxidant secondary metabolites from various parts of Parthenocissus tricuspidata. Pharmacy in New Era, 1st National Pharmacy Conference held at Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur on March 02-04, 2007 (abstract published).

Year 2006

  1. Muhammad Saleem, Hyoung Ja Kim, Chang Kyun Han and Changbae Jin, Yong Sup Lee (2006), New secondary metabolites from Opuntia ficus-indica var. saboten. Phytochemistry(ISSN: 0031-9422, Published in England)67(13), 1390-4. Impact factor = 2.780
  2. M. Shaiq Ali, Waqar Ahmed and M. Saleem (2006), Longifoamide-A and B: Two new ceramides from Mentha longifolia (Lamiaceae), Nat. Prod. Research (ISSN: 1478-6419, Published in England)), 20(10), 953-60. Impact factor = 0. 572.

Year 2005

  1. Muhammad Saleem, Nighat Afza, M. Aijaz Anwar, Syed Muhammad Abdul Hai and Muhammad Shaiq Ali (2005): Aromatic Constituents from Fruit Peels of Citrus reticulata, Nat. Prod. Res. (ISSN 1478-6419, Published in England), 19 (6), 633-638. Impact factor = 0.572
  2. Muhammad Saleem, Hyoung Ja Kim, Muhammad Shaiq Ali and Yong Sup Lee (2005): An Update on Bioactive Lignans. Natural Product Reports (ISSN 0265-0568, Published in England), 22 (6), 696-716. Impact factor = 7.89
  3. Hyoung Ja Kim, Muhammad Saleem, Seon Hee Seo,Changbae Jin, and Yong Sup Lee (2005): Two New Antioxidant Stilbene Derivatives, ParthenostilbeninsA and B from Parthenocissus tricuspidata.Planta Medica, (ISSN 0032-0943, Published in Germany), 71, 973-976. Impact factor = 2.289
  4. M. Shaiq Ali, Waqar Ahmed and M. Saleem (2005), Longifoside-A and B: Two new cerebrosides from Mentha longifolia (Lamiaceae), Nat. Prod. Research., (ISSN 1478-6427, Published in England) (Online) 1–9. Impact factor = 0. 572.
  5. Yong Sup Lee, Hyoung Ja Kim, Kyung Ja Jung, Muhammad Saleem, Jungsook Cho, Changbae Jin (2005), Neuroprotective Anti-oxidative Flavonoids Isolated from Opuntia ficus indica var. saboten. 11th Asian Cheical Congress for the Quantum Leap of Asian Chemistry, Korea University, South Korea, August 24-26. Page 108. Chemical Abstract

Year 2004

  1. Muhammad Saleem, Hyoung Ja Kim, Changbae Jin and Yong Sup Lee (2004): Antioxidant Caffeic acid Derivatives from Leaves of Parthenocissus tricuspidata. Archives of Pharmacal Research (ISSN: 0253-6269, Published in South Korea),27 (3), 300-304. Impact factor = 0.818
  2. Ali, M. S., Pervez, M. K., Ahmed, F. and Saleem, M. (2004): Dichotenol-A, B and C: The C-16 oxidized seco-dolastanes from the marine brown alga Dictyota dichotoma (Huds.) Lamour. Nat. Prod. Res. (ISSN: 1478-6419, Published in England) 18(6), 543-549. Impact factor = 0. 572
  3. Muhammad Saleem, Rahila Nazli, Nighat Afza, Amtul Sami and Muhammad Shaiq Ali (2004): Biological Significance of essential oil of Zataria multiflora Bioss. Nat. Prod. Res. (ISSN: 1478-6419, Published in England),18 (6), 493-497. Impact factor = 0. 572
  4. Muhammad Saleem, Hyoung Ja Kim, Seon Hee Seo, and Yong Sup Lee (2004): Chemical Constituents of Parthenocissus tricuspidata and Their Antioxidant Evaluation. Proceedings, Second workshop on Korea-Mangolia Science and Technology cooperation, p 28-36, May 10-12. Proceedings

Year 2003

  1. Saleem, M. Afza, N., Anwar, M. A., Hai, S. M. A., Ali, M. S. Shujaat, S. and Rahman, A. (2003): Chemistry and Biological Significance of Essential Oils of Cymbopogon Citratus From Pakistan. Nat. Prod. Res. (ISSN: 1478-6419, Published in England), 17(3), 159-163.Impact factor = 0. 572
  2. Ali, M. S., Pervez, M. K., Saleem, M. and Ahmed, F. (2003): Dichotenone-A and B: Two new enones from the marine brown alga Dictyota dichotoma (Hudson) Lamour. Nat. Prod. Res. (ISSN: 1478-6419, Published in England), 17 (5), 301. Impact factor = 0. 572
  3. Saleem, M., Afza, N., Anwar, M. A., Hai, S. M. A. andAli,M. S. (2003): A Comparative study of essential oils of Cymbopogon citratus and some members of the genus Citrus.Nat. Prod. Res. (ISSN: 1478-6419, Published in England),17, 369-373. Impact factor = 0. 572
  4. Ali, M.S., Jahangir, M., Saleem, M. (2003): Structural distinction between sabandin-A and B from Artemisia scoparia Waldst (Asteraceae).Nat. Prod. Res. (ISSN: 1478-6419, Published in England),17(1), 1-4. Impact factor = 0. 572

Year 2002

  1. Ali, M.S., and Saleem, M. (2002): Role of the Family Lamiaceae in Human Life, Hamdard Medicus, (Published in Pakistan) XLV (2), 16-17.
  2. Kalhoro, M. A., Afza, N. Saleem, M. and Malik, A. (2002): Pharmacochemical studies of the oil, aerial parts, puep and peel of Citrullus colocynthis, J. Chem. Soc. Pak. (ISSN: 0932-0776, Published in Pakistan), 24, 274. Impact factor = 0.173
  3. Ali, M.S., Saleem, M. Pervez, M. and Yamdagni, R. (2002):A chlorinated monoterpen ketone, acylated β-sitosterol glycosides and a flavone glycoside from Mentha longifolia (Lamiaceae). Phytochemistry, (ISSN: 0031-9422, Published in England) 59, 889-95. Impact factor = 2.780
  4. Ali, M. S., Saleem, M., Yamdagni, R. and Ali, M. A. (2002): Steroids and antibacterial steroidal-glycosides from marine green alga Codium iyengarii Borgesen. Nat. Prod. Lett. (ISSN: 1057-5634, Published in England), 16(6), 407-413. Impact factor = 0. 572

Year 2001

  1. Ali, M. S., Saleem M. and Erian, A. W. (2001): A new acylated steroid glucoside from Perovskia atriplicifolia (Lamiaceae). Fitoterapia (ISSN: 0367-326X, Published in Netherlands), 72, 712-14. Impact factor = 1.042
  2. Ali,M.S., Pervez, M. K., Saleem, M. and Tareen, R.B. (2001): Haplophytin-A and B: The new alkaloidal constituents from Haplophyllum acutifolium. Phytochemistry (ISSN: 0031-9422, Published in England), 57,1277-80. Impact factor = 2.780
  3. Ali,M. S., Saleem, M. and Ahmad,V. U. (2001): Phytol and glycerol derivatives from marine green alga Codium iyengarii of Karachi-coast (Arabian Sea). Z. Natureforsch. (ISSN: 0932-0776, Published in Germany), 56b, 837-41. Impact factor = 0.774

Year 2000

  1. Dar, A., Roome, T., Rezapour,F., Behanian, S., Sherkheli A., Choudhary,M.I., Ali, S.A., Anjum,S., Ali, S., Swaleh, R., Rahman, A., Ali, M.S., Saleem, M. and Pervez, K. (2000): Preliminary Pharmacological Evaluation of Marine Organisms collected from Coastal Areas of Karachi, Proceedings of ONR National Symposium, 18-20 held at University of Karachi (Ed. V.U. Ahmad) Printed at Karachi University press, 1-10. Proceedings
  2. Ali, M. S., Mazhar, F., Saleem, M., Jahangir, M., Pervez, K., Usmanghani, K. and Ahmad, V. U. (2000): Algal bioactive chemical constituents, ONR Proceedings, 18-20 held at University of Karachi (Ed. V.U. Ahmad) Printed at Karachi University press, 33-44. Proceedings
  3. Ali, M.S., Saleem, M. and Ahmad, V.U. (2000) Aromatic constituents of Zataria multiflora, Proceedings of 9th National Chemistry Conference, held at University of Karachi. Proceedings
  4. Ali, M.S., Dardass, A.Q.Y., Ahmed, S., Saleem, M., Firdous, S. and Ahmad, V.U. (2000): Two new diterpenoids from Salvia triloba. Fitoterapia (ISSN: 0367-326X, Published in Netherlands),71, 347-352. Impact factor = 1.042
  5. Ali, M.S., Saleem, M., Jahangir, M., Pervez, M.K., Hameed, S. and Ahmad, V.U. (2000): Metabolites of marine algae collected from Karachi coasts of Arabian Sea. Nat. Prod. Sci.6 (2), 61-65.
  6. Ali, M. S., Saleem, M. Ali, Z. and Ahmad, V. U. (2000): Chemistry of Zataria multiflora ( Lamiaceae ). Phytochemistry (ISSN: 0031-9422, Published in England), 55(8), 933-936.Impact factor = 2.780

Year 1999

  1. Ali, M.S., Saleem, M. and Ahmad, V.U. (1999): Zetatriol: A new aromatic constituent from Zataria multiflora. Z. Natureforsch (ISSN: 0932-0776, Published in Germany),54b, 807-810. Impact factor = 0.774
  2. Ali, M. S., Saleem, M., Akhtar, F., Jahangir, M., Parvez, M. and Ahmad, V. U. (1999): Three p-cymene derivatives from Zataria multiflora. Phytochemistry (ISSN: 0031-9422, Published in England), 52, 685-688. Impact factor = 2.780
  3. Ali, M.S., Jahangir, M., Saleem, M. and Ahmad, V. U. (1999): Chemical constituents of Pulicaria gnaphalodes. Nat. Prod. Sci.5(3), 134-137.

Year 1997

  1. Jabbar, A, Saleem, M., Khan M.S. and Khatoon, T., J. (1997): Pure Appl. Sci. (Published in Pakistan), 16 (1), 1-4.

Total publications40

International Publications 30

Local Publications 10

Papers in SCI Journals 11

Patents 03

International Impact factor 41.234

REFERNCES

M.Sc. Advisor

Dr. Abdul Jabbar (Professor)

Department of Chemistry, Islamia University, Bahawalpur

Pakistan

Ph.D. Advisor:

Dr. Muhammad Shaiq Ali (Associate Professor)

HEJ Research Institute of Chemistry, InternationalCenter for Chemical Sciences

University of Karachi, Pakistan

E-mail: and

Ex-Postdoctoral Advisor:

Dr. Young Sup Lee (Professor)

Department of Pharmaceutical Science, College of Pharmacy

KyungHeeUniversity, Dongdaemun-Ku, 1 Hoegi-Dong

Seoul130-701, Korea

E-mail:

Present Postdoctoral Advisor:

Dr. Hartmut Laatsch (Professor)

Institute for Organic an Biomolecular Chemistry, University of Göttingen,

Tammannstrasse 2, D-37077, Göttingen, Germany

Web:

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