Figure S2. Effects of Diet on Food Intake and Weight Changes

1

Supplementary Information

Figure S1 Individual mice clustering of video tracker data using a PhenoChipping approach(1). We used GeneSpring GX (Agilent Technologies, Palo Alto, CA) a microarray gene expression analysis software, for the novel use of analyzing and visualizing phenotypic data. Unsupervised two-way hierarchical clustering of normalized (Z-scored) behavioral data from locomotor pattern test was carried out, using methodology previously described(2) . (a) Male mice (b) Female mice. Center Time-time spent in the center zone; Center entry-number of time entering center zone; V.max-maximal velocity; Red-increased; blue-decreased.

Figure S2. Effects of diet on food intake and weight changes.

Table S1. Female blood top gene expression changes in response to DHA. Red- candidate biomarkers for human studies, changed in expression by DHA in opposite direction to that seen in human blood in mood disorders and stress disorders.

Gene Symbol /Name / Blood Change / Animal Brain Evidence / Animal Blood Evidence / Animal Genetic Evidence / Human Brain Evidence / Human Blood
Evidence / Human Genetic Evidence / CFG Score
FOS
FBJ osteosarcoma oncogene / D / (I)
Alcohol
(3)
(D)
MDD
Fluoxetine(4)
(I)
Anxiety
Plaza-Zabala A
2010
(I)
Stress
(5)
DBP-STAMY (I)(2) / Bipolar (6) / (Transgenic)
Decreased anxiety-related response, abnormal frequency of paradoxical sleep,
/ (I)
BP
(7) /
(I)
PTSD(8)
(I)
Stress (9) / 14q24.3
(Linkage)
BP (10)
Alcohol (11) / 5.5
CD44
CD44 antigen / D / Bipolar CP (12) / Bipolar (6) / QTL
Abnormal eating/drinking behavior;Abnormal circadian rhythm / (D)
Alcohol
(13) / (I)
BP
(14) / 11p13
(Linkage)
Alcohol (15),
/ 5.0
DUSP1
dual specificity phosphatase 1 / D / (I)
Alcohol
(3)
Alcohol AMY, CP,NAC,PFC (16) / Bipolar (6) / QTL
Abnormal eating/drinking behavior;Abnormal circadian rhythm / (D)
BP,MDD
(17) / (I)
Stress (9)
/ 5q35.1
(Linkage)
PD (18)
/ 5.0
MBP
myelin basic protein / D / (I)
BP
(19)
(I)
Anxiety
(20)
DBP-NST PFC (D);DBP-STAMY (I);DBP-STPFC(D); DBP-STAMY(I)(2) / Bipolar (6) / (I)
BP
(21)
(I)
Alcohol (22) / (I) MOOD BIOMARKER (6) / 18q23
(Association)
BP
(23)
/ 5.0
PSEN1
presenilin 1 / D / Alcohol NAC (16) / QTL
Abnormal eating/drinking behavior; Abnormal circadian rhythm / (D)
MDD
(24)
(D)
Alcohol
(25)
(D)
Suicide-MDD
(26) / (D)
BP
(27)
(D)
Chronic stress
(28)
/ 14q24.2
(Association)
Depression(29)
/ 5.0
SPP1
secreted phosphoprotein 1 / D / Bipolar VT (12) / Bipolar (6) / (QTL)
Abnormal emotion/affect behavior
Addiction/drug abuse / (D)
(D)
Suicide-MDD
(26)
(I)
BP
(17) / (D) Hallucinations(30)
/ 4q22.1
(Linkage)
Anxiety (31)
BP (10)
/ 5.0
ATXN1
ataxin 1 / D / (D)
Alcohol
(32)
Bipolar CP(12)
DBP-ST PFC (D) (2) / (QTL)
Abnormal emotion/affect behavior; Addiction/drug abuse / (D)
Alcohol
(33) / (D) Delusion ,Hallucinations (30)
(I) MOOD BIOMARKER (6)
(D)
Chronic stress(28) / 6p22.3
(Association)
BP/substance abuse
(23) / 4.5
GLO1
glyoxalase 1 / I / (D)
Anxiety (34)
Bipolar CP(12) / QTL
Abnormal eating/drinking behavior; Abnormal circadian rhythm / (D)
BP
(35) / (D)
BP,MDD(36) / 6p21.2
(Association)
PD(37),
(38)
/ 4.5
PBRM1
polybromo 1 / I / DBP-ST AMY (I)(2) / (QTL)
Abnormal emotion/affect behavior, Addiction/drug abuse / (I)
BP
(39) / (I) MOOD BIOMARKER (6) / 3p21.1
(Association)
BP/MDD(39)
BP (40) / 4.5
SLC6A4
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 / D / (I)
Avoidance learning (fear)
(41) / (Transgenic)
Abnormal response to novel object/Abnormal anxiety-related response/Behavioal despair/Abnormal sleep pattern/ Cocaine preference / (D)
Suicide-MDD
(42)
(D)
PD
(43)
(D)
Suicide-MDD
(44) / (I)
MDD(45) / 17q11.2
(Association)
Alcohol(46),(47)
Anxiety (48),(49)
BP(50)
MDD
(51, 52),(53) / 4.5
WNK1
WNK lysine deficient protein kinase 1 / I /
Bipolar VT (12)
DBP-STPFC (D); DBP-ST AMY (I)(2) / (QTL)
Abnormal emotion/affect behavior
Addiction/drug abuse / (D)
Alcohol
(54) / (I)
BP
(14)
/ 12p13.33
(Association)
Alcohol(55) / 4.5

Table S2. Male blood top gene expression changes in response to DHA. Red- candidate biomarkers for human studies, changed in expression by DHA in opposite direction to that seen in human blood in mood disorders and stress disorders.

Gene Symbol /Name / Blood
Change / Animal Brain Evidence / Animal Blood Evidence / Animal Genetic Evidence / Human Brain Evidence / Human Blood
Evidence / Human Genetic Evidence / CFG Score
APOE
apolipoprotein E / D / (I)
Stress(56)
(I)
Alcohol (McBride, Kimpel et al. 2010
Alcohol HIP(16) / (Transgenic)
Increased anxiety-related response / (D)
Alcohol
(13)
Alcohol
(57) / (D) Delusion(30) / 19q13.32
(Association)
MDD(51)
PTSD(58) / 5.0
GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1 / D / (I)
Alcohol
(McBride, Kimpel et al. 2010
(I)
Anxiety
(59)
Bipolar CP(12) / (Transgenic)
Impaired passive avoidance behavior, depression-related behavior / (I)
BP
(60)
(I)
Alcohol
(54), (25) / (D)
PTSD
(8) / 6p22.1
(Association)
MDD
(52)
OCD(61) / 5.0
MBP
myelin basic protein / D / (I)
BP(19)
(I)
Anxiety(20)
(I)
Anxiety;DBP-ST AMY (I);DBP-ST PFC(D); DBP-ST AMY(I)(2) / Bipolar (6) / (I)
BP
(21)
(I)
Alcohol (22) / (I) MOOD BIOMARKER (6) / 18q23
(Association)
BP
(23) / 5.0
PTGDS
prostaglandin D2 synthase (brain) / D / (I)
Anxiety
(34)
Bipolar AMY (12) / (Transgenic)
Decreased aggression / (D)
Alcohol
(13) / (D)
BP
(62) / 9q34.3
(Association)
Anxiety(63) / 5.0
SNCA
synuclein, alpha / I / (D)
Alcohol
Liang 2010
(D)
Response to antidepressant(64)
(D)BP(65)
DBP ST AMY (D)(2)
Alcohol AMY,HIP(16) / Bipolar (6)
DBP-ST BLOOD (D)(2) /
(D)
Alcohol (33),
(66) / 4q22.1
(Association)
Alcohol (67) / 5.0
GLO1
glyoxalase 1 / I / (D)
Anxiety(34)
(D)
Anxiety(68),(69)
Bipolar CP (12) / QTL
Abnormal eating/drinking behavior;Abnormal circadian rhythm / (D)
BP
(35) / (D)
BP
(36) / 6p21.2
(Association)
PD(37),(70) / 4.5
GPM6A
glycoprotein m6a / D / (I)
Alcohol (3) / Bipolar (6) / QTL
Abnormal emotion/affect behavior Abnormal circadian rhythm / (D)
Alcohol
(13) / (D) Delusion (30) / 4q34.2
(Linkage)
Alcohol MDD(71)
Anxiety (31)
BP (72) / 4.5

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