Dr. Teresa V. Bowman Is an Assistant Professor in the Departments of Developmental And

Dr. Teresa V. Bowman is an Assistant Professor in the Departments of Developmental and Molecular Biology and Medicine (Oncology) at Albert Einstein College of Medicine. She is a member of the Gottesman Institute for Stem Cell Biology and Regenerative Medicine and the Albert Einstein Cancer Center. She received her PhD from Baylor College of Medicine in 2005 in the laboratory of Dr. Margaret “Peggy” Goodell. During her graduate studies, she defined the transcriptional changes occurring as quiescenthematopoietic stem cells are activated, identifying CD48 as a critical regulator of proliferation and also showing a novel role for splicing regulation in stem cell activation.Dr. Bowman conducted her postdoctoral research in Dr. Leonard Zon’s laboratory at Children’s Hospital Boston, Harvard Medical School. There, she combined zebrafish, murine, and human systems to study how signaling pathways mediate hematopoietic stem cell regeneration. Her studies demonstrated the cooperation between tissue-specific and signaling-activated transcription factors during regeneration. Dr. Bowman’s laboratory focuses onthe regulation of gene expression in hematopoietic stem cells and how dysfunction of this process leads tomyelodysplastic syndrome and leukemia.Genome wide analyses in these diseases have identified a number of mutations in splicing, epigenetic, and DNA repair factors, but how these mutations result in hematopoietic malfunctioning is unclear. Dr. Bowman’s group is tackling this problem by establishing zebrafish and human genetic systems to define the in vivoconsequences and potential cross talk among splicing, epigenetics, and DNA repair in stem cells. These studies will help to define the mechanisms of gene regulation in hematopoietic stem cells and provide potential new therapeutic avenues for diseases like MDS and leukemia. Work in the Bowman lab is funded by the Gabrielle’s Angel Foundation, the Aplastic Anemia and MDS International Foundation, and the National Institutes of Health. Dr. Bowman is committed to supporting ISEH and has served on the ISEH New Investigator committee since 2010 and has served as the chair of the committee since 2012.