Supplementary Table 1.Expression levels of selected genes in lung tissue of ferrets infected with A/California/07 (3 d.p.i., n=3) and A/Brisbane/59 (2 d.p.i., n=3) respect to their respective control groups (for each control group n=3).Expression levels are shown in Log2 scale.Statistical differences between infected and control groups were assessed by using the Wilcoxon rank sum test.

Symbol / Full Name / A/California/07 / A/Brisbane/59
Cytokine / Chemokine signaling
CCL19 / chemokine (C-C motif) ligand 19 / 1.17* / 1.55*
CCL2 / chemokine (C-C motif) ligand 2 / 3.40* / 1.58*
CCL8 / chemokine (C-C motif) ligand 8 / 2.42* / 1.02*
CXCL10 / chemokine (C-X-C motif) ligand 10 / 4.13* / 3.18*
CXCR7 / chemokine (C-X-C motif) receptor 7 / 0.68* / n.s.
IL15 / interleukin 15 / 0.90* / n.s.
IL2RG / interleukin 2 receptor. gamma / 2.09* / n.s.
IL6 / interleukin 6 (interferon. beta 2) / 1.93* / n.s.
TNFRSF11B / tumor necrosis factor receptor superfamily. member 11b / 0.77* / n.s.
TNFRSF21 / tumor necrosis factor receptor superfamily. member 21 / 1.58* / n.s.
Interferon-stimulated genes (ISGs)
IRF1 / interferon regulatory factor 1 / 2.04* / 1.03*
IRF2 / interferon regulatory factor 2 / 1.73* / 0.53*
ISG15 / ISG15 ubiquitin-like modifier / 4.73* / 5.25*
ISG20 / interferon stimulated exonuclease gene 20kDa / 2.08* / 0.74*
OAS1 / 2..5.-oligoadenylate synthetase 1. 40/46kDa / 2.71* / 3.24*
OAS2 / 2.-5.-oligoadenylate synthetase 2. 69/71kDa / 0.91* / 1.60*
JAK-STSAT signaling
PIAS1 / protein inhibitor of activated STAT. 1 / 2.11* / n.s.
SOCS1 / suppressor of cytokine signaling 1 / 1.82* / n.s.
STAT1 / signal transducer and activator of transcription 1 / 2.63* / 1.87*
STAT2 / signal transducer and activator of transcription 2 / 1.75* / 1.64*
STAT3 / signal transducer and activator of transcription 3 / 1.18* / 0.71*
STAT5B / signal transducer and activator of transcription 5B / 1.11* / 0.71*
Adhesion molecules
CD274 / CD274 molecule / 1.59* / 1.39*
SDC4 / syndecan 4 / 1.01* / 0.59*
SELL / selectin L / 1.21* / 0.83*
VCAM1 / vascular cell adhesion molecule 1 / 1.14* / n.s.
Complement system
C1QA / complement component 1. q subcomponent. A chain / 1.65* / 1.30*
CFB / complement factor B / 1.59* / 1.08*
LOC484960 / Complement C3 precursor / 0.98* / 1.29*
LOC612714 / Complement C5 precursor / 1.92* / n.s.
Other
FCER1G / Fc fragment of IgE. high affinity I. receptor for; gamma polypeptide / 2.30* / 1.01*
MYD88 / myeloid differentiation primary response gene (88) / 1.84* / 0.77*
SMAD1 / SMAD family member 1 / 1.18* / n.s.
TLR4 / toll-like receptor 4 / 1.82* / 0.86*

*p<0.05, n.s.: non-significant.